• 대한한방내과학회지
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• 제21권5호
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• pp.739-745
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• 2000

xWe studied about the causes of hypertension in the occidental and oriental medical records and the results are as follows. 1. The causes of hypertension in oriental medicine can be divided into wind, fire, phlegm and deficiency of Qi in our body, and broadly into three categories as emotions in excess, improper diet and damages of endogenous etiological factors. 2. Hypertension is the disease of undermining of fundamental aspects while prevailing incidental aspects and liver, heart and kidneys are the organs mainly related to hypertension. 3. The main pathological factors of hypertension are as follows; the disorder of Yin and Yang makes the situation of the deficiency of the vital essence of kidneys and the exuberance of the vital essence of liver and they are the fundamentals to be taken hypertension and finally make the state of the deficiency of both Yin and Yang. 4. In the point of occidental medical view, the essential hypertension is a disease of unknown etiology and we think it occurs not on the only one factor but on the various factors and secondary hypertension occurs from the diseases of the substances and the vessels of kidneys.

• Archives of Pharmacal Research
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• 제29권2호
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• pp.113-122
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• 2006

Among the effector molecules connected with the group of cell surface receptors, Ras proteins have essential roles in transducing extracellular signals to diverse intracellular events, by controlling the activities of multiple signaling pathways. For over 20 years since the discovery of Ras proteins, an enormous amount of knowledge has been accumulated as to how the proteins function in overlapping or distinct fashions. The signaling networks they regulate are very complex due to their multiple functions and cross-talks. Much attention has been paid to the pathological role of Ras in tumorigenesis. In particular, human tumors very frequently express Ras proteins constitutively activated by point mutations. Up to date, three members of the Ras family have been identified, namely H-Ras, K-Ras (A and B), and N-Ras. Although these Ras isoforms function in similar ways, many evidences also support the distinct molecular function of each Ras protein. This review summarizes differential functions of Ras and highlights the current view of the distinct signaling network regulated by each Ras for its contribution to the malignant phenotypic conversion of breast epithelial cells. Four issues are addressed in this review: (1) Ras proteins, (2) membrane localization of Ras, (3) effector molecules downstream of Ras, (4) Ras signaling in invasion. In spite of the accumulation of information on the differential functions of Ras, much more remains to be elucidated to understand the Ras-mediated molecular events of malignant phenotypic conversion of cells in a greater detail.

• 대한한방부인과학회지
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• 제25권3호
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• pp.103-116
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• 2012

Objectives: The aim of this study is to differentiate women from men on breast diseases. Methods: We have searched antique books, texts and references of oriental obstetric & gynecology and checked into present conditions of oriental medicine hospitals in republic of Korea. Results: In physiological, pathological and epidemiological viewpoint of both oriental and western medicine, it was accepted that women were different with men on breast disease. Among references published in the Journal of Oriental Obstetrics and Gynecology from 1987, the number of references concerned breast disease was fifty divided into 29 original articles(58%) in types and 26 breast cancer(52%), 13 postpartum lactation(26%) in categorizations. and woman's breast disease and cancer taken charge on oriental obstetrics and gynecology in oriental medicine hospitals were 25(86%) and 19(66%) respectively. Conclusions: We could not realize that woman's breast disease already were accepted woman's particularity in various aspects until conducting our study. Accordingly, it is suggested that more researches would be conducted on the needs of female patients with breast disease through questionnaire or research and on the association reproductive factor and breast disease of women.

• 대한의료기공학회지
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• 제1권1호
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• pp.111-148
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• 1996

Recently, many study of the Kigong, but that is in the point of the view in Taoism and Ki itself. So, it thought that the study in comparison Kigong(Taoism) to Oriental Medicine is insufficient. I thought much of that there are many description of the movement and the effect in the the body in the old book written Taoism, Doinbub(Physical and breathing exercise), and that there are many relation 'the circulation of the Ki to 12 Jung-kyung(12 regular meridians). Then I give a report of the result that the study is compared in Taoism with in Oriental Medicine. The result were as follows ; 1. In the training of Doinbub, the effect is regulating muscle and skeleton, promote wi(constructive) system and ki(superficial) system, promote the ki and blood, strengthen the body resistance and dispel the invading pathogenic factors and preventive treatment. 2. In the training of Doinbub, the movements were much related to 12 regular Meridians and Muscles along the 12 meridians. 3. In the training of Doinbub, the effect were much related to 12 regular Meridians and Muscles along the 12 meridians. 4. It is possible that we set pathological syndrome to Doinbub(Physical and breathing exercise).

• BMB Reports
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• 제55권2호
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• pp.65-71
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• 2022

Regenerative medicine is a research field that develops methods to restore damaged cell or tissue function by regeneration, repair or replacement. Stem cells are the raw material of the body that is ultimately used from the point of view of regenerative medicine, and stem cell therapy uses cells themselves or their derivatives to promote responses to diseases and dysfunctions, the ultimate goal of regenerative medicine. Stem cell-derived extracellular vesicles (EVs) are recognized as an attractive source because they can enrich exogenous microRNAs (miRNAs) by targeting pathological recipient cells for disease therapy and can overcome the obstacles faced by current cell therapy agents. However, there are some limitations that need to be addressed before using miRNA-enriched EVs derived from stem cells for multiplexed therapeutic targeting in many diseases. Here, we review various roles on miRNA-based stem cell EVs that can induce effective and stable functional improvement of stem cell-derived EVs. In addition, we introduce and review the implications of several miRNA-enriched EV therapies improved by multiplexed targeting in diseases involving the circulatory system and nervous system. This systemic review may offer potential roles for stem cell-derived therapeutics with multiplexed targeting.

• 대한한방내과학회지
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• 제15권2호
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• pp.48-59
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• 1994

This study has been carried out to investigate the influences that Chiljung(七情) exert upon the liver system, and Spleen-Stomach functions. In oriental medicine regard stress as Chiljung(七情). No(怒), among the Chiljungs(七情) is a Shinji(神志) that the primary factors to develop the Kan(肝)s pathological process. The stress stimulates Hypothalamic Corticotpopin Releasing Center. This is why gastrin is more released than normal limit. It is caused disfunction of stomach. In result of No(怒), KanJuSoSeol(肝主疏泄)cannot do it's function. It results that KanKiBeomYi(肝氣犯胃) and KanKiSuingBi(肝氣乘脾) KanKiBeomYi caused to AiKi(曖氣), TanSan(呑酸), KanKiSuingBi caused to abdominal pain, diarrhea. In this point of view, It is important to take emotional stability, and escape from all this stress.

• Journal of Acupuncture Research
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• 제20권1호
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• pp.22-34
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• 2003

Objective : To ascertain whether the concept of the treatment side is associated with changes in the blind spot mapping that represents the brain function. Methods : Among the outpatients who visited to Department of Acupuncture & Moxibustion, National Medical Center from March 2002 to October 2002, we selected 40 clinical trial volunteers that showed right side physiological blind spot more enlarged than left, and underwent the examinations of Department of Opthalmology, National Medical Center for ruling out the pathological conditions. Physiological blind spot maps were used as an integer of brain activity before and after electroacupuncture application on the unilateral ST36 meridian point by dividing 40 subjects into two comparative groups for double-blind controlled study. Results: The significant changes in the blind spots were observed. Electroacupuncture application on the ipsilateral or contralateral ST36 of an enlargement cortical map were associated with the concept of determining the treatment side. In the case of electroacupuncture application on the ipsilateral side of an enlarged blind spot, there were decrease of $4.11{\pm}8.56cm$(17.3%) in blind spot perimetry length(p < 0.05). In the case of contralateral side, there were increase of $3.19{\pm}5.40cm$(13.7%) in blind spot perimetry length(p<0.05). The Differences were statistically significant(p<0.05). Conclusions: We found that eletroacupuncture application was associated with an increase or decrease in the brain function in the view of blind spot changes depending on the treatment side. These results suggest that the traditional acupuncture therapeutic strategy with determining the treatment side has clinical significance in the view of the brain function.

• 동의신경정신과학회지
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• 제5권1호
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• pp.9-15
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• 1994

홧병은 민간에서 많이 통용되는 한국의 문화관련질환으로 그간 정신과의사와 한의사 사이에서 많은 연구가 진행되어 왔다. 정신과의사는 홧병을 특유한 병리적인 경과를 밟는 '병'으로의 의미로 설명한데 반해 한의사는 화의 양상을 가진 '증'의 개념으로 이를 해석하고 있는 것을 볼 수 있다. 저자는 기존의 홧병연구를 바탕으로 한의학적으로 해석을 하여볼 때, 발병원인은 지속된 억울된 감정으로 인한 간기울결로 말미암고, 홧병의 발생이 여성에게 많은 까닭은 여성이 스트레스를 잘 풀지 못하며 생리적, 장기적 취약점이 있으며, 화의 위로 상승하는 성질과 병이 신수가 심화를 억제하지 못하는데서 비롯하므로 증상이 화의 역동성과 연관된다는 점, 그리고 발병이 만성화의 경과를 밟는 이유는 복합감정이 문제가 되고 또 감정이 오래되어 화로 바뀌며 나이가 들어 수가 화를 억제하지 못하는 시기에 발병한다는 점으로 홧병을 해석할 수 있었다. 이는 정신과의사의 임상적 경과의 관찰과 한의사의 화에 대한 연구가 상호의 협조가 병의 경과와 병리기전 예후 및 치료대책을 정립해 나가는데 있어서 더욱 필요함을 제시해 주고 있다.

• Journal of Korean Neurosurgical Society
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• 제61권6호
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• pp.680-688
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• 2018

Objective : To mitigate the risk of iatrogenic instability, new posterior decompression techniques able to preserve musculoskeletal structures have been introduced but never extensively investigated from a biomechanical point of view. This study was aimed to investigate the impact on spinal flexibility caused by a unilateral laminotomy for bilateral decompression, in comparison to the intact condition and a laminectomy with preservation of a bony bridge at the vertebral arch. Secondary aims were to investigate the biomechanical effects of two-level decompression and the quantification of the restoration of stability after posterior fixation. Methods : A universal spine tester was used to measure the flexibility of six L2-L5 human spine specimens in intact conditions and after decompression and fixation surgeries. An incremental damage protocol was applied : 1) unilateral laminotomy for bilateral decompression at L3-L4; 2) on three specimens, the unilateral laminotomy was extended to L4-L5; 3) laminectomy with preservation of a bony bridge at the vertebral arch (at L3-L4 in the first three specimens and at L4-L5 in the rest); and 4) pedicle screw fixation at the involved levels. Results : Unilateral laminotomy for bilateral decompression had a minor influence on the lumbar flexibility. In flexion-extension, the median range of motion increased by 8%. The bone-preserving laminectomy did not cause major changes in spinal flexibility. Two-level decompression approximately induced a twofold destabilization compared to the single-level treatment, with greater effect on the lower level. Posterior fixation reduced the flexibility to values lower than in the intact conditions in all cases. Conclusion : In vitro testing of human lumbar specimens revealed that unilateral laminotomy for bilateral decompression and bone-preserving laminectomy induced a minor destabilization at the operated level. In absence of other pathological factors (e.g., clinical instability, spondylolisthesis), both techniques appear to be safe from a biomechanical point of view.

• 동의신경정신과학회지
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• 제8권1호
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• pp.111-125
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• 1997

This study was done in order to investigate Oriental Medicine's meaning on stress, the stress is due to animal experiments.Methods:This research was done by animal experiments's results based on 41 animal experiment treatises carried out by 24 prescriptions about stress control. Each experiments were compared with same conditions, minimizing the experiments differences. The results were analyzed by p-value and Increas e·Decrease percentage of experiments result's numerical value. Results:1. Inquire into frequency in use of each stress stimulus and measuring items, the restriction stimulus stress and measuring the content of catecholamines are numerous.2. Significance of stress stimuluses based on experments's results is good by restriction stimulus.3. Oriental Medicine's meaning for stress is pathological phenomenon of Seven Emotion(七情). Stagnant the Energy(氣鬱), the Fire(火), Dam(痰), Lack of the general Blood thing(血虛), and reaction of an individual body.4. Inguire into the effects of frequency in use of experiments's Herb drugs, Herb Drugs of Tonifing the general Blood thing depend on stabilized Mind(補血安神), Circulated the Energy and Digest(理氣消導), Tonifing the general Blood thing(補血), Clearing the Mind(淸心), Removing the Dam(祛痰) are numerous.5. From a Sasang Medical point of view, experimental use of Herb Drugs are Soeum-in(少陰人) Herb Drugs are numerous.According to above results, it is considered that Herb Drugs of Tonifing the general Blood thing depend on stabilized Mind(補血安神), Circulated the Energy and Digest(理氣消導), Tonifing the general Blood thing(補血), Clearing the Mind(淸心), Removing the Dam(祛淡), and Soeum-in(少陰人) Herb Drugs are used to prevent stress and related diseases.