• Parasites, Hosts and Diseases
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• v.47 no.1
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• pp.53-56
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• 2009

The authors report here a rare case of cerebellar schistosomiasis identified by pathological diagnosis, lacking extracranial involvement. The clinical symptoms included headache, dizziness, and nausea. Studies in blood were normal and no parasite eggs were detected in stool. Computed tomography of brains showed hypodense signal, and magnetic resonance imaging showed isointense signal on T1-weighted images, hyperintense signal on T2-weighted images, and intensely enhancing nodules in the right cerebellum after intravenous administration of gadolinium. A high-grade glioma was suspected, and an operation was performed. The pathologic examination of the biopsy specimen revealed schistosomal granulomas scattered within the parenchyma of the cerebellum. The definitive diagnosis was cerebellar schistosomiasis japonica. A standard use of praziquantel and corticosteroid drugs was applied, and the prognosis was good. When the pattern of imaging examinations is present as mentioned above, a diagnosis of brain schistosomiasis should be considered.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.22-27
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• 2004

Seop-Gye divided up the constitution's strength and weakness, and so he cured disease by the 'cold and heat'. 'deficiency and excessiveness' means on the basis of the YINㆍYANG of constitution. He classified constitution with pathogenesis grounding in body formal distinction, flesh hardness and softness, face color and form, skin color. Therefore he grasped the rule of constitution connected with physiological function and pathological distinction, applied the rule of constitution in the diagnosis and cure of the chronic & epidemic febrile disease.

• Journal of Korean Neurosurgical Society
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• v.30 no.sup2
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• pp.344-347
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• 2001

Intramedullary spinal tuberculoma is a rare form of central nervous system tuberculosis. The authors presented a case of 41 years old male with intramedullary and intradural extramedullary tuberculoma of the thoracic spinal cord without systemic involvement. The preoperative diagnosis was a metastatic cancer. Subtotal removal of intradural extramedullary and intramedullary mass was performed and pathological diagnosis was tuberculosis granuloma. We suggest that Intramedullary spinal tuberculoma must be considered in the differential diagnosis of the spinal cord compressive lesions in our country.

• Journal of the Korean Society of Systems Engineering
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• v.17 no.2
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• pp.91-97
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• 2021

User interface for cancer classification system is a software application with clinician's friendly tools and functions to diagnose cancer from pathology images. Pathology evolved from manual diagnosis to computer-aided diagnosis with the help of Artificial Intelligence tools and algorithms. In this paper, we explained each block of the project life cycle for the implementation of automated breast cancer classification software using AI and machine learning algorithms to classify normal and invasive breast histology images. The system was designed to help the pathologists in an automatic and efficient diagnosis of breast cancer. To design the classification model, Hematoxylin and Eosin (H&E) stained breast histology images were obtained from the ICIAR Breast Cancer challenge. These images are stain normalized to minimize the error that can occur during model training due to pathological stains. The normalized dataset was fed into the ResNet-34 for the classification of normal and invasive breast cancer images. ResNet-34 gave 94% accuracy, 93% F Score, 95% of model Recall, and 91% precision.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.49 no.2
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• pp.96-99
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• 2023

Oral spindle cell/sclerosing rhabdomyosarcoma (SCRMS) with anaplastic lymphoma kinase (ALK) expression is extremely rare, and its diagnosis is very challenging in the absence of clinical or pathological indicators. This case presented with gingival swelling and alveolar bone resorption and was suspected clinically to be periodontitis. A biopsy was performed and, due to immunoreactivity with ALK, the patient was misdiagnosed with inflammatory myofibroblastic tumor. However, based on the combined histological and immunohistochemical features, a revised diagnosis of SCRMS with ALK expression was finally concluded. We believe that this report makes a significant contribution to the precise diagnosis of this rare disease for proper treatment.

• The Journal of Korean Medicine
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• v.26 no.3 s.63
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• pp.80-97
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• 2005

Backgrounds : In recent years there has teen renewed interest in the importance of 8-constitution medicine as evidenced by growth of research in this field. Although diagnosis by 8-constitution depends on pulse types, it still is subjective and thus could be insignificant. Therefore, diagnosis based on objective characteristics is essential. Objectives : The purpose of this study was to find objective characteristics of the 4-constitution groups {木(Mok; hepatonia, cholecystonia), {土(To; pancreotonia, gastrotonia), {金(Gum; pulmotonia, colonotonia), {水(Soo; renotonia, vesicotonia)} in 8-constitution for further diagnosis and therapy. Also, some significant clinical tendencies of 4-constitution groups were studied. Methods : From Nov. 2001 to Apr. 2004, data were collected through a questionnaire given to 720 patients who were classified into one of 8 constitutions according to their pulse types and their responses to constitution-based acupuncture therapy. The questionnaire was composed of 80 items which were about personality, physical shape, habit, physiological and pathological symptoms, response to drugs, favorites and responses to various foods. The data were statistically analyzed by cross-tabulation and one-way analysis of variance, and SPSS V10.0.7PC was used. Results : The results are summarized as follows: 1) Among participants, proportions of hepatotonia, pancreotonia, and cholecystotonia were higher than those of vesicotonia, pulmotonia, colonotonia, renotonia, grstrotonia. 2) 52 items of 80 variances showed significant differences by gender, 3) 13 items were highly correlated with 4-constitution groups in males, and 26 items in fremales. 4) 22 items showed significant group differences among 4-constitution groups in males, and 41 items in females. Also, for each item 4-constitution groups were sorted according to their means, so that the constitutional tendencies were objectively figured out by personality, shape, habit, physiological and pathological symptoms, response to drugs, favorites and responses to foods. Conclusions : Most clinical characteristics of 4-constitution groups found in this study coincided with those from the previous ones in this fold. Thus, classifying patients into one of the 4-constitution groups based on significant objective characteristics is of great benefit to diagnosis and therapy. further study should be followed to improve proper therapy for each constitution.

• Journal of Korean Neurosurgical Society
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• v.29 no.1
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• pp.15-22
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• 2000

Objective : This study was undertaken to evaluate the benefits and risks of the stereotactic biopsy in brain lesions. We assessed the diagnostic accuracy and morbidity rate associated with the stereotactic biopsy. Methods : The authors present a review of 47 patients, who underwent stereotactic biopsy using Cosman-Roberts-Wells(CRW) stereotactic apparatus during last six years. Results : Target locations were supratentorial in 36 cases, infratentorial in 9 and multiple in 2. According to pathological diagnosis, the largest group was neoplasm(29) followed by infection(9), infarction(2), cyst(2), and non-specific(5). Definitive diagnosis could be made in 42 of 47 cases(89.4%). When the mass lesion had been suspected as neoplastic condition, the diagnostic rate was 96.7%(29/30). It was being much higher than that of non-neoplastic lesion, 76.5%(13/17). The treatment modality was changed in 15 cases(32%) because the result of stereotactic biopsy was different from clinical diagnosis. Subsequent craniotomy after stereotactic biopsy was then performed in 6 cases, and the pathological diagnoses were precisely coincident in all of these cases. There were two complications(4.3%) : One intratumoral hemorrhage in glioblastoma and a transient hemiparesis in benign astrocytoma. There was no mortality in this series. Conclusion : The precise histological verification is crucial to determine the adequate treatment modality in intracranial lesions. Stereotactic biopsy is a safe and accurate diagnostic procedure for intracranial lesions with a low complication rate.

• Archives of Plastic Surgery
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• v.38 no.1
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• pp.109-112
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• 2011

Purpose: Neurofibromas may present as multiple or solitary lesions. Although there is no predilection site for solitary lesions, they are rare on the hand. In addition, solitary intramuscular neurofibromas are a very rare pathological type. Here, we report a rare solitary intramuscular neurofibroma in the hand. This paper examines the clinical characteristics of intramuscular neurofibroma arising from the lumbricalis in order to enable a correct diagnosis and treatment. Methods: A 32-year-old male presented with a painless mass on the palm. The physical examination revealed a $3{\times}2$ cm protruding mass that was non-tender to palpation. The vascular and sensory examinations were unremarkable, while the motor examination showed mild difficulty with flexion and extension. Magnetic resonance imaging demonstrated an enhancing solid mass between the thenar eminence and second metacarpophalangeal joint. The diagnosis of an intramuscular neurofibroma was confirmed following surgical excision and histological evaluation. Results: The pathological examination was consistent with a neurofibroma, with delicate fascicles and loose fusiform cells in a fibrous stroma, with oval or spindle-shaped nuclei and scant cytoplasm. The background matrix was pale staining and had focal myxoid stroma. There was no significant nuclear pleomorphism and no mitoses. Immunohistochemistry with S-100 was slightly positive. At the 6-month follow-up, motor and sensory function were intact and the range of motion was full. Conclusion: A neurofibroma is a rare tumor of the hand, especially the intramuscular type. Hand surgeons should consider the diagnosis of this tumor based on the examination and imaging.

• Journal of Sasang Constitutional Medicine
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• v.21 no.2
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• pp.79-86
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• 2009

1. Objective : This study aimed to know the concordance coefficient and diagnostic trend of 6 Sasang constitution diagnosis factors among experts, which are important to diagnose Sasang constitution. 2. Methods : We suggested each 100 cases containing body shape, face, temperament, physiological and pathological symptom and constitutional drug response to 2 groups experts, and researched expert opinions. We analyzed concordance coefficient with Kendall's coefficient of concordance W. 3. Results : 1) Experts agreed with 167(82.5%) diagnosis results of cases, but there were 33 cases(17.5%), with which even one expert disagreed 2) The concordance of priority order of Sasang constitutional factors was significantly associated within expert. 3) Experts put the priority concordance to drug response and Face, body shape, voice and Pathological and physiological symptoms in order. 4) In case by case, concordance coefficient was 47(55.9%) in group 1, 9(10.8%) in group 2, 56 (33.5%) in total. 4. Conclusions : Experts made much account of drug responses and faces in diagnosing Sasang constitution. but there were different opinions in concordance coefficient. So Sasang Constitution Diagnosis Guideline is necessary to integrate experts opinions.

• Journal of Sasang Constitutional Medicine
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• v.12 no.2
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• pp.94-103
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• 2000

The purpose of this study is to examine validity to Soeum scales by QSCC II. For this study, the objects are 336 patients who were made a diagnosis of Soeumin and 422 patients of other constitutions in Oriental Medicine & Western Medicine Cooperative Health Examination Center KyungHee University Medical Center. A systematic analysis has been made and the results are as follows. 1. We made a frequency analysis in 758 examinees' questions and concluded that 35 questions, among which 30 questions were existing and 5 were new, had statistical significance in making a diagnosis of Soeumin by more than 10% in comparison with answer frequency of other constitutions. 2. Because confidence coefficient of 0.8011 revised Soeum scales(35) rises up as compared with that of 0.6319 existing Soeum scales(51), I think revised Soeum scales reflect trait of Soeumin well and it is liable to shorten question time by controling questions. 3. Soeumin's discrimination probability in Soeumin was 55.4% by QSCCII, but that rises up to 64.3% by discriminant function made by revised Soeum scales. So there is statistical significance in discriminant function. 4. When questions in QSCCII are divided into body-spirit(體形氣像), looks-attitude(容貌詞氣), temper- talent(性質才幹), continuous mind(恒心), avarice(心慾), physiological symptoms(生理的 證) and pathological symptoms(病理的 證), response frequency and constitution discrimination probability falls in questions about avarice and pathological symptoms.