• The Journal of Pediatrics of Korean Medicine
• /
• v.22 no.2
• /
• pp.51-67
• /
• 2008

Objectives : The purpose of this study is to research the internet addiction and the Weak children. Methods : Total 400 of 5th and 6th grade JeonJu Elementary student children consisted with 203 men, 197 women were chosen for this study. They answered questionnaires of the internet addiction and the Weak children on June 12th, 2008. Results : 75% were general internet user, latent danger user group was 14.7%, high danger user group was 10.3%. The mean of the general weak children was the highest and then the group of children who had Heart, the Lung, the Liver, the Spleen, the Kidney problems were followed. These showed the relationships with living styles, especially eating patterns and parents' concerns about children's internet use. The more serious internet addiction was, the more the weaker children symptoms were answered significantly. The heart weak children symptoms were found in latent-high danger internet user group. Conclusions : In conclusion, the physical and psychological symptoms of the internet addiction children were resulted by the disturbance of Qi and the pathological change of internal organs.

• Journal of Acupuncture Research
• /
• v.19 no.2
• /
• pp.128-136
• /
• 2002

Objective : The purpose of this study was to evaluate water distribution differences of the right and left low limb in patients who had low back pain with sciatica or not. Methods : Water distribution differences of the right and left low limb by body composition(INBODY 2.0, Biospace, seoul, korea) were analysed in the views of groups(low back pain with and without sciatica) and duration of disease. Results : 1. In the case of low back pain patient, there was no significance in variance of water distribution of the right and left lower limbs regardless of suffering period, but significance difference in patients that have suffered low back pain with one side sciatica showed according to suffering period. 2. Within 2 weeks, there was no significant deflection between low back pain with and without sciatica in water distribution of the right and left lower limbs, More than 2 weeks significant deflection showed. Conclusion : Loss of lower limb's muscle that ensue in contracting a disease period was observed in Low Back Pain with Sciatica. The continuos studies about pathological change of lower limb in low back pain have to be perfomed.

• Herbal Formula Science
• /
• v.16 no.2
• /
• pp.163-169
• /
• 2008

The kidney toxicities of BDR-29 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with BDR-29, no mortality and gross pathological findings were shown for 13 weeks. There substantially was no change in body weight in all rats with treatment of BDR-29. The renal functional parameters including urinary volume, urine osmolality, electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were not exchanged in all rats treated with BDR-29. Taken together, these results suggest that BDR-29 has no toxicity on kidney in all male and female rats.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.29 no.3
• /
• pp.214-218
• /
• 2009

The occlusal force of the tooth leads to loss of tooth tissue owing to attrition and abrasion, and may cause abfraction and pathological change of the dentin. Thus, we developed finite element models, examined them by applying ordinary occlusal force, and analyzed the stress distribution. Specimens used were mandibular first premolars from 15 Korean males and 13 females and were made into finite element models from medical images that were obtained using a Micro-CT. We have found that the irregular feature of the tooth is not only useful to masticating and pronouncing as well known, but it is also suitable for protecting inner tissue by dispersing stress and delivering proper pressure to periodontal tissue to continue a physiological action. Also, image analysis could let us know the factor that is the cause of a disorder due to stress concentration in the cervical line. These results are expected to support the field of dental treatment planning, operating procedure and clinical trial, and the advance of technical expertise to develop implants and dentures.

• Journal of the Korean Society for Industrial and Applied Mathematics
• /
• v.18 no.2
• /
• pp.77-105
• /
• 2014

Medical imaging techniques have evolved to expand our ability to visualize new contrast information of electrical, optical, and mechanical properties of tissues in the human body using noninvasive measurement methods. In particular, electrical tissue property imaging techniques have received considerable attention for the last few decades since electrical properties of biological tissues and organs change with their physiological functions and pathological states. We can express the electrical tissue properties as the frequency-dependent admittivity, which can be measured in a macroscopic scale by assessing the relation between the time-harmonic electric field and current density. The main issue is to reconstruct spectroscopic admittivity images from 10 Hz to 1 MHz, for example, with reasonably high spatial and temporal resolutions. It requires a solution of a nonlinear inverse problem involving Maxwell's equations. To solve the inverse problem with practical significance, we need deep knowledge on its mathematical formulation of underlying physical phenomena, implementation of image reconstruction algorithms, and practical limitations associated with the measurement sensitivity, specificity, noise, and data acquisition time. This paper discusses a number of issues in electrical tissue property imaging modalities and their future directions.

• Bulletin of the Korean Chemical Society
• /
• v.33 no.1
• /
• pp.100-104
• /
• 2012

Thrombin is a serine protease that catalyzes the conversion of soluble fibrinogen to insoluble fibrin, and thus induces physiological and pathological blood coagulation. Therefore, it is important to detect thrombin in blood serum for purposes of diagnosis. To achieve this goal, it has been suggested that a 15-mer aptamer strongly binds with thrombin to form a G-quartet structure of the aptamer. Generally, 5'-end thiol-functionalized aptamer has been used as an anti-thrombin binder. Herein, we evaluate the possibility of utilizing a 3'-SH aptasensor for thrombin detection using SPR spectroscopy, and compare the enhancement of the electrochemical signal of the thrombin-aptamer bound on a porous gold substrate. Although the two aptamers have similar configurations, in SPR analysis, the 3'-SH aptamer was a effective aptasensor as well as 5'-SH aptamer. Results from electrochemical analysis showed that the porous gold substrate acted as a good substrate for an aptasensor and demonstrated 5-fold enhancement of current change, as compared to gold thin film.

• Korean Journal of Poultry Science
• /
• v.38 no.2
• /
• pp.145-154
• /
• 2011

By a series of positional cloning, we successfully narrowed down the AM candidate region to approximately 1.2 Mbp on GGA2q including 7 functional genes. Subsequently, we identified WWP1 gene as the most likely AM candidate by sequence comparison. The amino acid sequence around the candidate mutation was highly conserved among tetrapods, suggesting that WWP1 is the causative gene of chicken muscular dystrophy. Transfection of mutated WWP1 gene into $C_2C_{12}$ myoblasts disrupted muscle differentiation process. The abnormal muscle differentiation is a characteristic of chicken muscular dystrophy, so we could demonstrate a part of phenotype of the disease. Furthermore, western blotting revealed that accumulation of caveolin-3 protein is limited in damaged muscle of muscular dystrophic chicken, suggesting caveolin-3 may be associated with the pathological change of the disease. We could conclude that WWP1 gene is the responsible one for chicken muscular dystrophy from these results, but the mechanism leading the onset should be clarified in the future. The information will contribute to the study of chicken muscular dystrophy and the corresponding human dystrophies.

• Korean Journal of Veterinary Service
• /
• v.17 no.1
• /
• pp.67-80
• /
• 1994

8-10 week old ICR mice were infected intracerebrally and intraperitoneally with different encephalomyocarditis virus(K$_3$, $K_{11}$, ATT-VR 129) to observe histopathological and immunohistochemical change. Results obtained throuh the experiments were summarized as follows : 1. No differences in clinical signs by the virus strains and the inoculation routes were found. Mice infected with EMCV showed clinical signs after 3 days of inoculation. Main clinical signs were tremors, convulsions, circling movement, and uni or bilateral hindleg paralysis followed by death on the 3-8 days. In general, most of the infected animals died or recovered closely on the 8th day of postinoculation. 2. At necropsy, petechial and ecchymotic hemorrhages in lung were observed and no specific findings in other were observed. 3. In histopathological observation, neuroal cell degeneration perivascular mononucear cell in-filtration gliosis were appeared in central nervous system. Myocarditis with myocardial degeneration and necrosis, calcification were observed along with acinar cell necrosis of exocrine glands in pancreas, severe glomerulonephritis in kidney. Also, focal necrosis of hepatocytes and interstitial pneymonia hyperemia, hemorrhages in lungs were observed. 4. By immunohistochemical staining using ABCIT method, the positive cells were recognized in intracytoplasm of acinar cell in pancreas and intracytoplasm of neuronal cells in cerebrum.

• The Journal of Korean Medicine
• /
• v.37 no.4
• /
• pp.10-21
• /
• 2016

Objectives: This study was to investigate the anti-oxidative and anti-inflammatory effect of Psoralea corylifolia water extract (PE) on ulcerative colitis which was induced by dextran sulfate sodium (DSS) in mice. Methods: Ulcerative colitis was induced by DSS in male BALB/c mice. The mice were divided into 3 groups. The control group (Ctrl) was not induced ulcerative colitis. The pathological group (CE) was induced the colitis. The experimental group (PT) was administered PE after inducing the colitis. The effects of the PE on ulcerative colitis were evaluated by morphological change in the colon tissue and cells, substance P production, activity of tumor necrosis factor $(TNF)-{\alpha}$ and nuclear factor $(NF)-{\kappa}B$, cyclooxygenase (COX)-2 production, and anti-oxidative activity. Results: In the PT group, PE alleviated hemorrhagic erosion in colon mucosa and infiltration of inflammatory cells in lamina propria mucosae. In the colon of the PT group, COX-2 production was inhibited via regulating the activity of $TNF-{\alpha}$ and $NF-{\kappa}B$ p65. PE also had an anti-oxidative effect via activating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Conclusions: In this study, we found the utility of treatment with PE and the potential of developing a medicine for ulcerative colitis by applying our results. Further investigations for the anti-inflammatory mechanism of PE may be needed.

• PNF and Movement
• /
• v.6 no.3
• /
• pp.37-51
• /
• 2008

Purpose : This paper focuses on the emerging concept that adult central nervous system neurogenesis can be regulated by various physical activity, enriched environment, and pathological conditions. Neurogenesis-the production of new neuron-is an ongoing process that persists in the adult brain of mammalian, including humans. Result : The adult brain was thought be limited in its regenerative function. However, this concepts changed, recent evidence of neurogenesis in certain adult brain areas such as SVZ(subventricular zone) and SGZ(subgranular zone) in hippocampus, raised possibility for improved treatment for patient with stroke. Neural plasticity has an adaptive purpose, because an ability of the brain to change in response to peripheral stimulation, physical activity, experience, and injury. Conclusions : The major function of the neurogenesis in adult brain seems to be replacing the neuron that die regularly in discrete adult brain regions. These cells are capable of functionally integrating into neighboring neural cells, and reconnecting to the correct neural networks. This review suggest that various intervention, including physical activity, voluntary movement training, skilled forelimb reaching training, and enriched environment, induced neural cell production in certain adult brain, and associated with functional recovery after stroke.