• 제목/요약/키워드: pathogenic infection

검색결과 485건 처리시간 0.03초

A Study on Application of Radix Asari Main Blended Prescription From Dongeubogam (동의보감(東醫寶鑑) 중(中) 세신(細辛)이 주약(主藥)으로 배오(配伍)된 방제(方劑)의 활용(活用)에 대한 고찰(考察))

  • Jeon Ho-Cheol;Rho Euy-Joon;Kim Hyung-Rul;Yun Young-Gab
    • Herbal Formula Science
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    • 제12권2호
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    • pp.57-76
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    • 2004
  • This report describes the remedial fields, symptoms, pathology, dosage, prescriptional constitution of 69 studies related to the use of Radix Asari main blended prescriptions from Dongeubogam. The following conclusions were reached through investigations on the prescriptions that use Radix Asari as a key ingredient. Radix Asari blended prescriptions are utilized for 14 therapeutic purposes, for example, in symptoms of tooth, eye, paralysis, ear-nose, skin infection and carbuncle. In particular, 14.49% of the prescriptions appear in the chapter of tooth, and 10.14% of those appear in the chapter of eye. Prescriptions that utilize Radix Asari as the main ingredient are used in the treatment of dental disease, othalmology, nose and ear disease, throat disease, common cold, dermothology, paralysis, musculoskeletal disease, disease of the head, asthma, genital disease, the injury of the cuts and they are also used for treating 50 different types of diseases. Radix Asari is used in Six pathogenic factors such as wind, wind-cold, wind-heat, wind-dampness heat, wind-dampness, dampness, paralysis, cold-chill, cold, dryness, in visceral pathogenic factors such as stomach, kidney, liver-kidney, liver and in chi-blood pathogenic factors such as chi-blood deficiency, chi-blood stagnation and in extravasated blood pathogenic factors such as impact injury, an injury such as cuts, blood accumulation as well as weakness-cold and parasites. The actual amount of Radix Asari blended has ranged at a wide variety of amounts from 2.5pun(about 0.94gram) to 3don(about 11.25gram). 26.09% of the prescriptions used 1don(about 3.75gram). The function of Radix Asari is to calm down, to get the consciousness back, to bore through, to warm up the meridians and to run it smoothly, to discharge of phlegm from the combination of drugs and prescriptions.

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Host-Induced gene silencing of fungal pathogenic genes confer resistance to fungal pathogen, Magnaporthe Oryzae in rice

  • Jin, Byung Jun;Chun, Hyun Jin;Kim, Min Chul
    • Proceedings of the Korean Society of Crop Science Conference
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    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
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    • pp.134-134
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    • 2017
  • Recently, host-induced gene silencing (HIGS) system has been successfully applied into development of resistant crops against insects, fungal and viral pathogens. To test HIGS-mediated resistance in rice against rice blast fungus, Magnaporthe oryzae, we first tested possibility of movement of small non-coding RNA from rice cells to rice blast fungus. The rice blast fungus expressing GFP transgene were inoculated to transgenic rice plants ectopically expressing dsRNAi construct targeting fungal GFP gene. Expression of dsRNAi construct for GFP gene in transgenic plants significantly suppressed GFP expression in infected fungal cells indicating that small RNAs generated in plant cells can move into infected fungal cells and efficiently suppress the expression of fungal GFP gene. Consistent with these results, expression of dsRNAi constructs against 3 fungal pathogenic genes of M. oryzae in transgenic rice specifically and efficiently suppressed not only the expression of fungal pathogenic genes, but also fungal infection. The conidia of M. oryzae applied on leaf sheath of transgenic rice expressing dsRNAs against 3 fungal pathogenic genes showed abnormal development of primary hyphae and malfunction of appressorium, which is consistent with the phenotypes of corresponding fungal knock-out mutants. Taken these results together, here, we suggest a novel strategy for development of antifungal crops by means of HIGS system.

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The Magas1 Gene is Involved in Pathogenesis by Affecting Penetration in Metarhizium acridum

  • Cao, Yueqing;Zhu, Xiangxian;Jiao, Run;Xia, Yuxian
    • Journal of Microbiology and Biotechnology
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    • 제22권7호
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    • pp.889-893
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    • 2012
  • Appressorium is a specialized infection structure of filamentous pathogenic fungi and plays an important role in establishing a pathogenic relationship with the host. The Egh16/Egh16H family members are involved in appressorium formation and pathogenesis in pathogenic filamentous fungi. In this study, a homolog of Egh16H, Magas1, was identified from an entomopathogenic fungus, Metarhizium acridum. The Magas1 protein shared a number of conserved motifs with other Egh16/Egh16H family members and specifically expressed during the appressorium development period. Magas1-EGFP fusion expression showed that Magas1 protein was not localized inside the cell. Deletion of the Magas1 gene had no impact on vegetative growth, conidiation and appressorium formation, but resulted in a decreased mortality of host insect when topically inoculated. However, the mortality was not significant between the Magas1 deletion mutant and wild-type treatment when the cuticle was bypassed by injecting conidia directly into the hemocoel. Our results suggested that Magas1 may influence virulence by affecting the penetration of the insects' cuticle.

Antiviral Effects of Titanium Dioxide Photocatalyst Treated Films against Highly Pathogenic Avian Influenza (고병원성 조류인플루엔자(H5N1)에 대한 이산화티타늄 광촉매 처리 필름의 항바이러스성 연구)

  • Lee, Sang-Do;Park, Hyun
    • Journal of the Korea Convergence Society
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    • 제12권4호
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    • pp.201-206
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    • 2021
  • Damage to the highly pathogenic avian influenza virus(H5N1) continues to increase, but there is a lack of antiviral research. In this study, we analyze antiviral properties on H5N1 by coating Cu/TiO2 photocatalyst on polyethylene films. The specimen was manufactured a photocatalyst master batch and coated both sides of the 3-layer polyethylene fabric at 280℃ from the extrusion coating machine. The results showed a 99.9% decrease in the Staphylococcus aureus and Escherichia coli. In particular, H5N1 type highly pathogenic avian influenza viruses, which is capable of human infection, has been found to decrease 99.9% within five minutes of contact with Cu/TiO2 films. Antibacterial effects of films coated with photocatalyst are known, but this study also confirmed the antiviral effects.

Evaluation on Immunogenicity and Safety of Avian Influenza Isolate(ADL0401) as a Candidate for the Killed Vaccine against tow-Pathogenic Avian Influenza (약병원성 조류인플루엔자 사독백신개발을 위한 후보주(ADL0401)의 면역 원성 및 안전성 평가)

  • Lee J. S.;Ha D. H.;Kim J. E.;Ha B. D.;Mo I. P.
    • Korean Journal of Poultry Science
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    • 제32권2호
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    • pp.113-123
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    • 2005
  • Avian influenza (AI) virus (AIV) is distributed worldwide and it has been isolated from various species of wild and domestic birds. AI transfers with high speed and shows diverse pathogenicity syndroms. In Korea, several low Pathogenic AIV, H9N2, have been isolated from the commercial farms with severe decrease of egg production and mortality resulted in severe economic loss since 1996. Therefore, it has been requested to develop AI vaccines to prevent clinical signs and economic losses from the field infection of AIV. To develop a killed vaccine that efficiently prevents low pathogenic AIV (H9N2), evaluation on the pathogenicity and selection of an inactivator for H9N2 is taking place and is being tested safety and immunogenicity of vaccine produced. Based on the pathogenicity test and viral reisolation test, the ADL0401 isolate is the characteristic low pathogenic AIVs and has fairly similar biologic functions compared with MS96 which is the official low pathogenic AIV (H9N2) and one of the predominant AIV isolated from poultry farms in Korea. In antigenicity tests, the ADL0401 and MS96 virus have no significant antigenic difference. In inactivation tests, the ADL0401 isolates can be easily inactivated with $0.1\%$ Formalin at $37^{\circ}C$ within 1 hour with a little decrease of HA titer. The vaccine developed in the present report has no harmful effect on bird and forms good immune capability. Therefore, the isolates, ADL0401 can be used for a killed vaccine which can reduce the clinical signs and viral shedding in the birds infected with H9N2 low pathogenic AIVs.

Oral Candidiasis (임상가를 위한 특집 2 - 구강 캔디다증)

  • Kim, Ok-Joon
    • The Journal of the Korean dental association
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    • 제48권5호
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    • pp.355-364
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    • 2010
  • The frequency of mucosal and cutaneous fungal infection is increasing worldwide, which is due to the increase of immunocompromised patients. Candida albicans are the principal species associated with human oral mycosis and are known to be the most virulent among pathogenic Candida spp. In this review, oral candidiasis were classified and oral mucosal manifestations of candidiasis were filed. And its diagnosis and management would be reviewed briefly.

Studies on the bacterial stem-dry-rot of pinus rigida mill (가칭 리기다소나무 거부병)

  • 이구영
    • Korean Journal of Microbiology
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    • 제1권1호
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    • pp.45-47
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    • 1963
  • 1. A Kind of Bacillus, which was seemed to be pathogenic, was isolated from Pinus rigida planting. 2. The bacillus were grown well on the Agar-Bacto-Beef media (pH 7.4) at $30^{\circ}C$. C for 24 hours. 3. The soil infection for the one year old seedling was the best inoculating method in this experiment. 4. Almost of all characteristics were simillar between isolated and reisolated bacillus. 5. The author should like to call temporarily the name of this bacterial disease Stem-rot of pinus rigida Mill.

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A literatual studies on the ajangpung(鵝掌風). (鵝掌風에 關한 文獻的 考察)

  • Jang, Gi-young;Roh, Sek-seon
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • 제11권1호
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    • pp.141-161
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    • 1998
  • In the literatual studies on the ajangpung(鵝掌風), the results were as follows. Ajangpung(鵝掌風) is called 'Jangsimpung(掌心風)', is concerned with 'Tinea Manus(手癬)' in western medicine. The pathogenic factors of Ajangpung were stomach-heat & blood dryness, wind-cold-wetness evil, or contact infection etc. The treatments of Ajangpung were used external treatments for dispelling wind-evil & cooling blood, dispelling wetness-evil & parasiticidal therapy. In the frequency of prescription, the most numerous prescription was Yibansan(二礬散) and the next were Yungigo(潤肌膏), Gupungjihwanghwan(祛風地黃丸) etc.

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An Overview of Research Trends in Antibacterial Coatings on Titanium Implants (임상가를 위한 특집 3 - 티타늄 임플란트의 항균코팅 동향)

  • Kim, Woo-Hyun;Kim, Kyoung-Nam
    • The Journal of the Korean dental association
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    • 제48권2호
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    • pp.113-118
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    • 2010
  • Titanium and titanium alloys are the most common materials used for dental and biomedical implants, owing to their biocompatibility and favourable mechanical properties. However infection of the region surrounding a dental implant by pathogenic microorganisms is a significant factor in implant failure. Prevention and control of microbial colonization of implant surfaces is considerable interest to the biomedical community. One important strategy is to render the implant surface antibacterial by impeding the formation of biofilm. A number of approaches have been proposed for this purpose. Therefore, we reviewed the researches of antibacterial coatings on titanium implants in this articles.