• Archives of Pharmacal Research
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• v.26 no.4
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• pp.264-269
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• 2003

5-Aminosalicylic acid (5-ASA) is an active ingredient of therapeutic agents used for Crohn s disease and ulcerative colitis. Because it is absorbed rapidly and extensively in the upper intestine, delivery of the agent specifically to the colon is necessary. We selected taurine as a colon-specific promoiety and designed 5-aminosalicyltaurine (5-ASA-Tau) as a new colon-specific prodrug of 5-aminosalicylic acid (5-ASA). It was expected that introduction of taurine would restrict the absorption of the prodrug and show additive effect to the anti-inflammatory action of 5-ASA after hydrolysis. 5-ASA-Tau was prepared in good yield by a simple synthetic route. The apparent partition coefficient of 5-ASA-Tau in 1-octanol/pH 6.8 phosphate buffer or $CHCl_3$/pH 6.8 phosphate buffer was 0.10 or 0.18, respectively, at $37^{\circ}C$. To determine the chemical and biochemical stability in the upper intestinal environment, 5-ASA-Tau was incubated in pH 1.2 and 6.8 buffer solutions, and with the homogenates of tissue and contents of stomach or small intestine of rats at $37^{\circ}C$. 5-ASA was not detected from any of the incubation medium with no change in the concentration of 5-ASA-Tau. On incubation of 5-ASA-Tau with the cecal and colonic contents of rats, the fraction of the dose released as 5-ASA was 45% and 20%, respectively, in 8 h. Considering low partition coefficient and stability in the upper intestine, 5-ASA-Tau might be nonabsorbable and stable in the upper intestine. After oral administration, it would be delivered to the colon in intact form and release 5-ASA and taurine. These results suggested 5-ASA-Tau as a promising colon-specific prodrug of 5-ASA.

• School Mathematics
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• v.7 no.2
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• pp.123-137
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• 2005

Elementary combinatorial problem may be classified into three different combinatorial models(selection, distribution, partition). The main goal of this research is to determine the effect of type of combinatorial operation and implicit combinatorial model on problem difficulty. We also classified errors in the understanding combinatorial problem into error of order, repetition, permutation with repetition, confusing the type of object and cell, partition. The analysis of variance of answers from 339 students showed the influence of the implicit combinatorial model and types of combinatorial operations. As a result of clinical interviews, we particularly noticed that some students were not able to transfer the definition of combinatorial operation when changing the problem to a different combinatorial model. Moreover, we have analysed textbooks, and we have found that the exercises in these textbooks don't have various types of problems. Therefore when organizing the teaching , it is necessary to pose various types of problems and to emphasize the transition of combinatorial problem into the different models.

• Journal of Life Science
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• v.14 no.4
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• pp.567-572
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• 2004

This study was carried out to investigate the affects on antimicrobial and cytotoxicity of red cabbage (Brassica oleracea L.,BO). In the paper disc test, antimicrobial activity of BO fractions was increased in proportion to its concentration. Among the various solvent fractions of methanol extract (BOM) of BO, the ethylacetate partition layer (BOMEA) showed the strongest antimicrobial activity We also determined the cytotoxicity and Quinone Reductase induced effect of BO extract and fractions on human cancer cells. The cytotoxicity of BO fractions on HepG2, HeLa and MCF-7 cells was evaluated by MTT assay. The BOMEE and BOMEA showed strong cytotoxic effects on all cancer cell lines we used. The quinone reductase induced effect of BO fractions on HepG2 cells, the hexane partition layer (BOMH) at a dose of 200 $\mu{g}$/ml was 2.88 times more effective compared to the control values of 1.0.

• Journal of Pharmaceutical Investigation
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• v.29 no.4
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• pp.329-335
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• 1999

Clenbuterol, a selective ${\beta}_2-adrenergic$ receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic bronchitis and pulmonary emphysema. For the purpose of developing a transdermal preparation for clenbuterol, we attempted to select an optimal solvent system and permeation enhancer among fatty acids and fatty alcohols which are known to accelerate the penetration of various drugs in permeation experiments using hairless mouse skin and Franz diffusion cell. Apparent partition coefficient of clenbuterol was increased as pH of buffer solution was increased and solubility of clenbuterol was increased as the percent of propylene glycol(PG) in buffer solution(pH 10) was increased. Permeability of clenbuterol from different buffer(pH 10)/PG solvent mixtures was decreased as the percent of PG in pH 10 buffer solution was increased and among the various enhancers studied, lauryl alcohol was found to be the most effective enhancer, increasing the permeability of clenbuterol approximately 76-fold compared with control. Lauryl alcohol$(0{\sim}2%)$ enhanced the permeability of clenbuterol concentration-dependently. In this study, the optimal solvent system for the penetration of clenbuterol was found to be 50/50 buffer(pH 10)/PG solvent mixture containing 2% lauryl alcohol.

• The KIPS Transactions:PartA
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• v.13A no.3 s.100
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• pp.223-230
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• 2006

A MMORPG(Massively Multiplayer Online Role-Playing Game) is an online role-playing game in which a large number of players can interact with each other in the same world at the same time. Most of them require significant hardware requirements(e.g., servers and bandwidth), and dedicated support staff. Despite the efforts of developers, users often cite overpopulation, lag, and poor support as problems of games. In this paper, a dynamic load balancing method for MMORPGS is proposed. It tries to adapt to dynamic change of population by using dynamic map-partition method with VML(Virtual Map Layer) which consists of fields, sector groups, sectors, and cells. From the experimental results, our approach achieves about $23^{\sim}67%$ lower loads for each field server. By the modification to Virtual Area Layer, we can easily manage problems that come from changes of map data, resources' status, and users' behavior pattern.

• Journal of Microbiology and Biotechnology
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• v.7 no.5
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• pp.345-351
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• 1997

An aqueous/organic two-phase reaction system was applied to the production of catechol using immobilized resting cells of Pseudomonas putida CY 400. Water/ethyl ether system was used because of high partition coefficient of catechol and thus to reduce the product inhibition and degradation. Among the tested immobilization carriers, polyacrylamide gel gave the highest catechol productivity. The immobilization seemed to protect the cells against solvent toxicity. From the simulation of reaction conditions based on two-phase models, it was found that there was an optimum acetate concentration at fixed benzoate and cell concentrations for the catechol productivity. A lower phase volume ratio (lower fraction of organic phase) gave a higher productivity. However, the substrate conversion was low at low phase volume ratio.

• ETRI Journal
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• v.39 no.4
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• pp.546-557
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• 2017

In a long term evolution-advanced (LTE-A) system, the traffic overload of machine type communication devices is a challenge because too many devices attempt to access a base station (BS) simultaneously in a short period of time. We discuss the challenge of the gap between the theoretical maximum throughput and the actual throughput. A gap occurs when the BS cannot change the number of preambles for a random access channel (RACH) until multiple numbers of RACHs are completed. In addition, a preamble partition approach is proposed in this paper that uses two groups of preambles to reduce this gap. A performance evaluation shows that the proposed approach increases the average throughput. For 100,000 devices in a cell, the throughput is increased by 29.7% to 114.4% and 23.0% to 91.3% with uniform and Beta-distributed arrivals of devices, respectively.

• Journal of Microbiology and Biotechnology
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• v.13 no.6
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• pp.998-1000
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• 2003

This study was carried out to elucidate the mode of bacteriostatic property of xanthostatin (XS), a novel depsipeptide antibiotic with an N-acetylglycine side chain and selective antimicrobial activity against Xanthomonas spp. Two biotransformed XSs were isolated by the treatment of XS with the cell lysate of Xanthomonas campestris pv. citri, a solvent partition, preparative TLC, and HPLC. Structure determination of those two biotransformed XSs demonstrated deletion of the N-acetylglycine side chain. Noteworthily, they showed no antimicrobial activity against Xanthomonas spp. This result suggests that the N-acetylglycine side chain plays a critical role in the antimicrobial activity of XS, and that the bacteriostatic property of XS is due to susceptibility of the ester bond between the hexadepsipeptide nucleus and the N-acetylglycine side chain to hydrolytic enzyme(s) produced by Xanthomonas spp.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.165.2-165
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• 2001

A number of previous researches in evolutionary algorithm are based on the study of facets we observe in natural evolution. The individuals of species in natural evolution occupy their own niche that is a subdivision of the habitat. This means that two species with the similar requirements cannot live together in the same niche. This is known as the competitive exclusion principle, i.e., complete competitors cannot coexist. In this paper, a new evolutionary programming algorithm adopting this concept is presented. Similarly in the case of natural evolution , the algorithm Includes the concept of niche obtained by partitioning a search space and the competitive exclusion principle performed by migrating individuals. Cell partition and individual migration strategies are used to preserve search diversity as well as to speed up convergence of an ...

• Nuclear Engineering and Technology
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• v.47 no.5
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• pp.588-595
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• 2015

This study presents an effective method for additional recovery of residual actinides in liquid electrodes after the electrowinning process of pyroprocessing. The major distinctive feature of this method is a reactor with multiple reaction cells separated by partition walls in order to improve the recovery yield, thereby using the interelement difference in diffusion coefficients within the liquid electrode and controlling the selectivity and purity of element recovery. Through an example of numerical simulation of the diffusion scenarios of individual elements, we verified that the proposed method could effectively separate the actinides (U and Pu) and rare-earth elements contained in liquid cadmium. We performed a five-step consecutive recovery process using a simplified conceptual reaction cell and recovered 58% of the initial amount of actinides (U + Pu) in high purity (${\geq}99%$).