• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part 1
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• pp.189-190
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• 2006

During cold compaction processes loose powder is pressed under tooling action in order to produce complex shaped engineering components. Here, the analysis of the plastic deformation of granular packings is of fundamental importance to the development of computer simulation models. Powders can be idealized by packing discrete particles, where each particle is a sphere meshed with finite elements. The pressing of a body centered cubic packing was compared with numerical prediction and experimental data. The global response was expressed in force-displacement curve, and the accuracy of the numerical models analyzed for high relative densities up to 0.95.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2002년도 학술발표회 논문집(II)
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• pp.1027-1033
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• 2002

The solute transport in a two-dimensional heterogeneous porous medium is numerically studied by using a random walk particle tracking (RWPT) method. Lognormally isotropic hydraulic conductivity fields are generated by using the turning band methods with mean zero and four different values of standard deviation. The numerical transport experiments are carried out to investigate the large time and spatial effects of the variable pore velocity field on solute plumes. The behavior of the solute plume through numerical simulations is presented in terms of longitudinal and transverse spatial moments: displacement of center-of-mass, plume spread variance and skewness coefficient. It was observed that the dispersive behavior of the solute plume is strongly affected by the degree of heterogeneity in the flow domain.

• International Journal of Naval Architecture and Ocean Engineering
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• 제1권1호
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• pp.20-28
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• 2009

In thus paper we validate a numerical model for wave-structure interaction by comparing numerical results with laboratory data. The numerical model is based on the Navier-Stokes (N-S) equations for an incompressible fluid. The N-S equations are solved by a two-step projection finite volume scheme and the free surface displacements are tracked by the volume of fluid (VOF) method The numerical model is used to simulate solitary waves and their interaction with a group of slender vertical piles. Numerical results are compared with the laboratory data and very good agreement is observed for the time history of free surface displacement, fluid particle velocity and wave force. The agreement for dynamic pressure on the cylinder is less satisfactory, which is primarily caused by instrument errors.

• Geomechanics and Engineering
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• 제35권2호
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• pp.195-208
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• 2023

The nodular diaphragm wall (NDW) is a novel type of foundation with favorable engineering characteristics, which has already been utilized in high-rise buildings and high-speed railways. Compared to traditional diaphragm walls, the NDW offers significantly improved vertical bearing capacity due to the presence of nodular parts while reducing construction time and excavation work. Despite its potential, research on the vertical bearing characteristics of NDW requires further study, and the investigation and visualization of its displacement pattern and failure mode are scant. Meanwhile, the measurement of the force component acting on the nodular parts remains challenging. In this paper, the vertical bearing characteristics of NDW are studied in detail through the indoor model test, and the displacement and failure mode of the foundation is analyzed using particle image velocimetry (PIV) technology. The principles and methods for monitoring the force acting on the nodular parts are described in detail. The research results show that the nodular part plays an essential role in the bearing capacity of the NDW, and its maximum load-bearing ratio can reach 30.92%. The existence of the bottom nodular part contributes more to the bearing capacity of the foundation compared to the middle nodular part, and the use of both middle and bottom nodular parts increases the bearing capacity of the foundation by about 9~12% compared to a single nodular part of the NDW. The increase in the number of nodular parts cannot produce a simple superposition effect on the resistance born by the nodular parts since the nodular parts have an insignificant influence on the exertion and distribution of the skin friction of NDW. The existence of the nodular part changes the displacement field of the soil around NDW and increases the displacement influence range of the foundation to a certain extent. For NDWs with three different nodal arrangements, the failure modes of the foundations appear to be local shear failures. Overall, this study provides valuable insights into the performance and behavior of NDWs, which will aid in their effective utilization and further research in the field.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10281-10287
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• 2015

Background: Development of a nanosized polymeric delivery system for erlotinib was the main objective of this research. Materials and Methods: Poly caprolactone-polyethylene glycol-polycaprolactone (PCEC) copolymers with different compositions were synthesized via ring opening polymerization. Formation of triblock copolymers was confirmed by HNMR as well as FT-IR. Erlotinib loaded nanoparticles were prepared by means of synthesized copolymers with solvent displacement method. Results: Physicochemical properties of obtained polymeric nanoparticles were dependent on composition of used copolymers. Size of particles was decreased with decreasing the PCL/PEG molar ratio in used copolymers. Encapsulation efficiency of prepared formulations was declined by decreasing their particle size. Drug release behavior from the prepared nanoparticles exhibited a sustained pattern without a burst release. From the release profiles, it can be found that erlotinib release rate from polymeric nanoparticles is decreased by increase of CL/PEG molar ratio of prepared block copolymers. Based on MTT assay results, cell growth inhibition of erlotinib has a dose and time dependent pattern. After 72 hours of exposure, the 50% inhibitory concentration (IC50) of erlotinib hydrochloride was appeared to be $14.8{\mu}M$. Conclusions: From the obtained results, it can be concluded that the prepared PCEC nanoparticles in this study might have the potential to be considered as delivery system for erlotinib.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2010년도 춘계학술대회 논문집
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• pp.640-649
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• 2010

Coarse granular materials such as gravel and crushed stone have been used as an important fill materials to large soil structure of railway, road, dam and so on. Although much studies for general soil materials have been carried out domestically, the studies for coarse materials were insufficient. Particularly, it is the level in which the study for dynamic properties(Elastic modulus and damping ratio) of coarse materials, applies the foreign country literature. This is due to the lack of large equipment for element test. But large soil structures made of coarse granular materials are generally important infrastructures. Therefore, the reliable design parameters for coarse materials should be obtained for safe and economic design, construction and maintenance. Triaxial test is the laboratory test method that is capable of controlling a confining pressure and boundary condition. In this project, we made a multi-purpose large triaxial testing system. This testing system is able to test coarse granular materials with maximum particle diameter of 100mm and support both the load control and displacement control. The load cell is installed inside of triaxial cell and the axial displacement is measured locally in order to control and measure more accurately in the small strain level. The verification test of this testing system was carried out with urethane verification specimens. So, from now on the useful information for coarse granular materials are expected to suggested by performing many tests with various material and condition.

• 폴리머
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• 제31권5호
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• pp.410-416
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• 2007

무유화제중합으로 제조된 폴리(메틸 메타크릴레이트) (PMMA) 시드 고분자 미립자에 가교단량체인 HDDA (1,6-hexanediol diacrylate), triEGDMA [tri(ethylene glycol) dimethacrylate] 또는 triEGDMA와 EGDMA (ethylene glycol dimethacrylate)의 혼합액을 흡수시키고, 이를 중합하여 단분산 가교고분자 미립자를 제조할 시 1) 흡수된 가교단량체와 시드 고분자 미립자의 중량비(흡수율) 변화, 2) 가교단량체의 변화, 3) 무전해 니켈도금 및 4) 무전해 (니켈/금)도금에 따른 단분산 가교고분자 미립자의 기계적 물성인 탄성복원율, 압축탄성률, 파괴강도 및 파괴변형률의 변화를 MCT(micro compression test)를 사용하여 측정하였다. 이번 연구를 통해 가교단량체의 흡수율 증가는 가교고분자 미립자의 파괴강도에만 큰 영향을 미쳤으나, 가교고분자 미립자의 무전해 도금은 도금분체의 탄성복원율 및 파괴강도는 감소시키나, 파괴변형률의 경우에는 거의 영향을 미치지 않으며, 압축탄성률의 경우는 $K_{10}$ 및 $K_{20}$는 크게 증가시키나, $K_{30}$ 이후에는 거의 영향을 미치지 못함을 알 수 있었다.

• 한국해안·해양공학회논문집
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• 제34권4호
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• pp.93-99
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• 2022

본 연구에서는 바닥 조파장치가 설치된 3차원 조파수조에서 재현된 규칙파에 대한 해석해를 유도하였다. 바닥 조파장치로 삼각형 형상, 사각형 형상 및 두 형상이 복합된 형상이 적용되었다. 선형파 이론과 움직이는 바닥에 대한 경계조건, 동역학적 및 운동학적 자유수면 경계조건을 이용하여 조파수조 내의 3차원 속도포텐셜을 유도하였다. 그리고, 이로부터 각 방향 성분의 유속과 자유수면변위에 대한 해석해를 구하였다. 유도된 해석해는 바닥 조파장치가 설치된 조파수조에서 규칙파의 전파 특성에 대해 물리적으로 타당한 결과를 보였다. 바닥 조파장치가 snake 형태로 움직이는 경우의 비스듬히 전파하는 파랑의 조파에 대해서도 해석해를 유도하였으며, 해석 결과는 이론적으로 예측한 결과와 일치하였다.

• 센서학회지
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• 제31권3호
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• pp.175-179
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• 2022

The physical properties of biomaterials are important for their isolation and separation from body fluids. In particular, the precise evaluation of the multi-physical properties of single biomolecules is essential in that the correlation between physical and biological properties of specific biomolecule. However, the majority of scientific equipment, can only determine specific-physical properties of single nanoparticles, making the evaluation of the multi-physical properties difficult. The improvement of analytical techniques for the evaluation of multi-physical properties is therefore required in various research fields. In this study, we developed a motion-tracking algorithm to evaluate the multi-physical properties of single-nanoparticles by analyzing their behavior. We observed the Brownian motion and electric-field-induced drift of fluorescent nanoparticles injected in a microfluidic chip with two electrodes using confocal microscopy. The proposed algorithm is able to determine the size of the nanoparticles by i) removing the background noise from images, ii) tracking the motion of nanoparticles using the circular-Hough transform, iii) extracting the mean squared displacement (MSD) of the tracked nanoparticles, and iv) applying the MSD to the Stokes-Einstein equation. We compared the evaluated size of the nanoparticles with the size measured by SEM. We also determined the zeta-potential and surface-charge density of the nanoparticles using the extracted electrophoretic velocity and the Helmholtz-Smoluchowski equation. The proposed motion-tracking algorithm could be employed in various fields related to biomaterial analysis, such as exosome analysis.

• Geomechanics and Engineering
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• 제34권5호
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• pp.577-595
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• 2023

A dynamic triaxial discrete element numerical model of lightweight soil was established using the discrete element method to study the microscopic mechanism of expanded polystyrene (EPS) particles in the soil under cyclic loading. The microscopic parameters of the discrete element model of the lightweight soil were calibrated depending on the dynamic triaxial test hysteresis curves. Based on the calibration results, the effects of the EPS particles volume ratio and amplitude on the contact force, displacement field, and velocity field of the lightweight soil under different accumulated strains were studied. The results showed that the hysteresis curves of lightweight soil exhibit nonlinearity, hysteresis, and strain accumulation. The strain accumulated in remolded soil is mainly tensile strain, and that in lightweight soil is mainly compressive strain. As the volume ratio of EPS particles increased, the contact force first increased and then decreased, and the displacement and velocity of the particles increased accordingly. With an increase in amplitude, the dynamic stress of the particle system increased, and the accumulation rate of the dynamic strain of the samples also increased. At 5% compressive strain, the contact force of the particles changed significantly and the number of particles deflected in the direction of velocity also increased considerably. These results indicated that the cemented structure of the lightweight soil began to fail at a compressive strain of 5%. Thus, a compressive strain of 5% is more reasonable than the dynamic strength failure standard of lightweight soil.