• Radiation Oncology Journal
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• 제36권1호
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• pp.25-34
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• 2018

Purpose: This study aimed to evaluate the initial outcomes of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) in terms of tumor response and safety. Materials and Methods: HCC patients who were not indicated for standard curative local modalities and who were treated with PBT at Samsung Medical Center from January 2016 to February 2017 were enrolled. Toxicity was scored using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Tumor response was evaluated using modified Response Evaluation Criteria in Solid Tumors (mRECIST). Results: A total of 101 HCC patients treated with PBT were included. Patients were treated with an equivalent dose of $62-92GyE_{10}$. Liver function status was not significantly affected after PBT. Greater than 80% of patients had Child-Pugh class A and albumin-bilirubin (ALBI) grade 1 up to 3-months after PBT. Of 78 patients followed for three months after PBT, infield complete and partial responses were achieved in 54 (69.2%) and 14 (17.9%) patients, respectively. Conclusion: PBT treatment of HCC patients showed a favorable infield complete response rate of 69.2% with acceptable acute toxicity. An additional follow-up study of these patients will be conducted.

• Journal of Chest Surgery
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• 제6권2호
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• pp.131-142
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• 1973

Studies of cardiopulmonary function and acid-base balance were performed on 29 dogs during control period, during oligemic hypotension and following return of blood to the animals. Intravenous morphine and local anesthesia were used. Fifteen of the 29 animals survived the complete experiment. The 14 animals that failed to survive the experimental period died between 15 to 90 minutes after the onset of bleeding. The results were as follows. 1. The heart rate increased after the onset of bleeding and failed to return to control level following reinfusion. Stroke volume decreased markedly after bleeding and failed to recover after return of blood from the reservoir. Cardiac output also decreased during oligemic hypotension and was maintained at this level after re-infusion. Total peripheral resistance decreased significantly immediately after bleeding, however it increased soon over the pre-bleeding level. Central venous pressure decreased after the onset of bleeding and remained at lower level for the rest of the experimental period. Arterial blood pressure, clown to 40-45 mmHg by acute hemorrhage, was elevated near to control level. Left ventricular work decreased tremendously during oligemic hypotension and failed to return to control level with the re-infusion of blood. Hematocrit value showed no significant decrease after bleeding and increased after re-infusion. Hemoglobin decreased after the onset of bleeding and recovered to control value after re-infusion. 2. The respiratory rate fell rapidly after bleeding from 124 to 29 and remained at this lower level for the remainder of the experiment. The tidal volume increased after bleeding and was maintained at this level for the remainder of the experiment. The respiratory minute volume showed no significant changes throughout the experimental period. Oxygen consumption fell lightly in all animals during oligemic hypotension and returned to normal levels following re-infusion. Arterial oxygen content and arterial oxygen saturation decreased following bleeding and the values returned to normal levels after the return of blood from the reservoir The arterio-venous oxygen difference increased after the onset of bleeding. It failed to return to normal values following re-infusion. Arterial $Pco_2$ decreased in all animals after the beginning of the bleeding. Partial pressure of $Co_2$ continued to fall until re-infusion, after which the values returned toward normal. Animals became acidotic. The pH fell to lower level following bleeding. Lactic acid and lactate: pyruvate ratio also increased during same period. Arterial pH and lactic acid failed to return to control value and lactate: pyruvate ratio increased more after re-infusion. Sodium bicarbonate decreased after bleeding and returned to control value following re-infusion.

• Archives of Reconstructive Microsurgery
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• 제15권2호
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• pp.92-100
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• 2006

Radial forearm free flap (RFFF) has been established itself as a versatile and widely used method for reconstruction of the head and neck, although it is still criticized for high mortality of donor site. Delayed wound healing, cosmetic deformity, vascular compromise and potentially reduced wrist function have many plastic surgeons hesitate to adapt it as a first choice in micro-reconstruction. To overcome these drawbacks, some techniques for donor-site repair such as V-Y advancement with full thickness skin graft (FTSG), application of artificial dermis ($Terudermis^{(R)}$) or acellular dermal matrix ($AlloDerm^{(R)}$), and double-opposing rhomboid transposition flap have been reported. Authors performed 4 cases of RFFF in old-aged patients of the head and neck cancer from April 2005 to February 2006. We compared the outcomes of donor site of RFFF which were resurfaced with split thickness skin graft (STSG) only and STSG overlying an $AlloDerm^{(R)}$. Patients were all males ranging from 59 to 74 years old (mean, 67.5). Three of them had tongue cancers, and the other showed hypopharyngeal cancer. All cases were pathologically confirmed as squamous cell carcinomas. We included the deep fascia into the flap, so called subfascially elevated RFFF in three cases, and in the other one, we dissected the RFFF suprafascially leaving the fascia intact. The donor site of the suprafascially elevated RFFF was resurfaced with STSG only. Among three of subfascially elevated RFFFs, donor-sites were covered with thin STSG only in one case, and STSG overlying $AlloDerm^{(R)}$ in two cases. All RFFFs were survived completely without any complication. The donor site of the suprafascially elevated RFFF was taken well with STSG only. But, the partial graft loss exposing brachioradialis and flexor carpi radialis muscle was unavoidable in all the subfascially elevated RFFFs irregardless of $AlloDerm^{(R)}$ application. Considering that many patients of the head and neck cancer are in old ages, we believe the RFFF is still a useful and versatile choice for resurfacing the head and neck region after cancer ablation. Its reliability and functional characteristics could override its criticism for donor site in old-aged cancer patients.

• 정보처리학회논문지B
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• 제9B권3호
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• pp.359-368
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• 2002

본 논문에서는 매칭 에러 영상과 이동벡터를 이용한 효율적인 이동물체 외곽선 검출 알고리즘과 부분외곽선 정보를 이용한 이동물체 고속 추적 알고리즘을 제안하였다. 이동물체의 외곽선 검출은 watershed 알고리즘을 기반으로 확률분포함수를 적용하여 seed 영역을 생성하고 seed 영역을 확장하여 이동물체의 윤곽선을 검출한 다음 이동벡터를 이용하여 최종 외곽선을 추출한다. 외곽선 중 일부를 특징으로 하여 이동물체를 추적하는 알고리즘을 사용하였다. 이동물체 초기 특징 벡터는 이동물체의 외곽선 영역 중 상하좌우의 외곽선 일부분을 특징벡터로 정한다. 다음은 추적단계로 이전 프레임에서 얻은 특징벡터를 이용하여 현재 프레임에서 이동물체의 추적을 수행하였다. 실제영상에 대하여 제안된 알고리즘으로 이동물체추적 모의 실험을 수행한 결과 기존 능동 윤곽선 추적알고리즘은 물체 외곽선 전체를 추적하기 때문에 물체의 외곽선 길이에 따라 처리시간이 변화하지만 제안된 알고리즘은 이동물체의 외곽선 영역을 특징정보로 하여 추적하기 때문에 추적 연산이 간단하였다. 고속이동벡터를 추출 BMA 연산은 기존 알고리즘 보다 연산량이 약 39% 감소였고, 이동 물체 외곽선 검출 알고리즘은 과분할 문제점이 발생하지 않았으며, 상하 좌우 외곽선 정보를 이용하여 이동물체를 추적한 결과 추적오차는 특징벡터의 크기가 $(15\times{5)}$일 때 검색오차가 4 화소 이하로 양호하게 나타났다.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2004년도 대한지구물리학회.한국지구물리탐사학회 공동학술대회 초록집
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• pp.3-17
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• 2004

Space-borne Earth observation technique is one of the most cost effective and rapidly advancing Earth science research tools today and the potential field and micro-wave radar applications have been leading the discipline. The traditional optical imaging systems including the well known Landsat, NOAA - AVHRR, SPOT, and IKONOS have steadily improved spatial imaging resolution but increasing cloud covers have the major deterrent. The new Earth observation satellites ENVISAT (launched on March 1 2002, specifically for Earth environment observation), ALOS (planned for launching in 2004 - 2005 period and ALOS stands for Advanced Land Observation Satellite), and RADARSAT-II (planned for launching in 2005) all have synthetic aperture radar (SAR) onboard, which all have partial or fully polarimetric imaging capabilities. These new types of polarimetric imaging radars with repeat orbit interferometric capabilities are opening up completely new possibilities in Earth system science research, in addition to the radar altimeter and scatterometer. The main advantage of a SAR system is the all weather imaging capability without Sun light and the newly developed interferometric capabilities, utilizing the phase information in SAR data further extends the observation capabilities of directional surface covers and neotectonic surface displacements. In addition, if one can utilize the newly available multiple frequency polarimetric information, the new generation of space-borne SAR systems is the future research tool for Earth observation and global environmental change monitoring. The potential field strength decreases as a function of the inverse square of the distance between the source and the observation point and geophysicists have traditionally been reluctant to make the potential field observation from any space-borne platforms. However, there have recently been a number of potential field missions such as ASTRID-2, Orsted, CHAMP, GRACE, GOCE. Of course these satellite sensors are most effective for low spatial resolution applications. For similar objects, AMPERE and NPOESS are being planned by the United States and France. The Earth science disciplines which utilize space-borne platforms most are the astronomy and atmospheric science. However in this talk we will focus our discussion on the solid Earth and physical oceanographic applications. The geodynamic applications actively being investigated from various space-borne platforms geological mapping, earthquake and volcano .elated tectonic deformation, generation of p.ecise digital elevation model (DEM), development of multi-temporal differential cross-track SAR interferometry, sea surface wind measurement, tidal flat geomorphology, sea surface wave dynamics, internal waves and high latitude cryogenics including sea ice problems.

• Journal of Korean Neurosurgical Society
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• 제30권4호
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• pp.472-478
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• 2001

Objectives : The authors present a retrospective analysis of 100 consecutive adult patients harboring craniopharyngiomas who underwent microsurgical resection between 1981 and 1999 to assess the long-term outcome of surgical treatment and to determine the most optimal management strategy. Methods : The extent of surgical removal was divided into four categories ; GTR(gross total removal), RSTR(radical subtotal removal), STR(subtotal removal),and PR(partial removal). The median follow-up period was 50 months(4-198). CT scan and/or MR imaging and hormonal status were evaluated to the last follow-up. Results : Visual disturbance was the most common presentation, which was improved in 42 cases and aggravated in 19 cases following the operation. Hypopituitarism was detected in 56 patients preoperatively, 82 during the immediate postoperative period, and 76 at the last follow-up. Improvement of pituitary function was not observed in any of these patients. Twenty of 100 patients showed recurrence at the mean of 27 months(3 to 196). The median progression-free survival(PFS) time of all patients was 145 months and 5-year PFS rate was 74%. Five-year PFS rate of GTR or RSTR group(71%) was significantly higher than that of STR or PR group(30%)(p=0.01). Postoperative radiation therapy significantly prolonged the PFS from 94 months in non-radiation group to 182 months(p=0.002). However, there was no statistical difference in number of patients who required hormonal replacement therapy between radiation and non-radiation group. Conclusion : Visual disturbance can be improved by early diagnosis and surgical decompression. GTR or RSTR in selected patients is considered a proper surgical strategy. Post-operative radiation therapy for residual tumors must be considered, although the ideal timing of radiation therapy is to be determined.

• Journal of Korean Neurosurgical Society
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• 제46권5호
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• pp.479-483
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• 2009

Objective : A mouse model of spinal cord injury (SCI) could further increase our basic understanding of the mechanisms involved in injury and repair of the nervous system. The purpose of this study was to investigate whether methods used to produce and evaluate photochemical graded ischemic SCI in rats, could be successfully adapted to mice, in a reliable and reproducible manner. Methods : Thirty female imprinting control region mice (weighting 25-30 g, 8 weeks of age) were used in this study. Following intraperitoneal injection of Rose bengal, the translucent dorsal surface of the T8-T9 vertebral laminae of the mice were illuminated with a fiber optic bundle of a cold light source. The mice were divided into three groups; Group 1 (20 mg/kg Rose bengal, 5 minutes illumination), Group 2 (20 mg/kg Rose bengal, 10 minutes illumination), and Group 3 (40 mg/kg Rose bengal, 10 minutes illumination). The locomotor function, according to the Basso-Beattie-Bresnahan scale, was assessed at three days after the injury and then once per week for four weeks. The animals were sacrificed at 28 days after the injury, and the histopathology of the lesions was assessed. Results : The mice in group 1 had no hindlimb movement until seven days after the injury. Most mice had later recovery with movement in more than two joints at 28 days after injury. There was limited recovery of one joint, with only slight movement, for the mice in groups 2 and 3. The histopathology showed that the mice in group 1 had a cystic cavity involving the dorsal and partial involvement of the dorsolateral funiculi. A larger cavity, involving the dorsal, dorsolateral funiculi and the gray matter of the dorsal and ventral horns was found in group 2. In group 3, most of the spinal cord was destroyed and only a thin rim of tissue remained. Conclusion : The results of this study show that the photochemical graded ischemic SCI model. described in rats, can be successfully adapted to mice, in a reliable and reproducible manner. The functional deficits are correlated an increase in the irradiation time and, therefore, to the severity of the injury. The photothrombotic model of SCI, in mice with 20 mg/kg Rose bengal for 5 minutes illumination, provides an effective model that could be used in future research. This photochemical model can be used for investigating secondary responses associated with traumatic SCI.

• Journal of Chest Surgery
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• 제31권3호
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• pp.221-225
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• 1998

계명대학교 의과대학 흉부외과학교실에서는 1996년 2월부터 1997년 5월까지 승모판막폐쇄부전이 있는 18명의 환자에 대하여 승모판막재건술을 시행하였다. 환자의 남여비는 9:9였고, 연령분포는 19세에서 68세까지로 평균연령은 53세였다. 수술당시 환자의 임상소견은 NYHA 기능적 분류상 3 또는 4등급이 13례(81%)였다. 판막병변의 원인은 퇴행성이 12례, 류마치스성이 5례, 심내막염이 1례였다. Carpentier의 기능적 분류상 II형이 15례, III형이 2례, I형이 1례였다. 수술수기는 인조링을 사용한 경우가 16례, 후첨부의 사각절제가 15례, 건삭의 단축술이 5례, 전첨부의 삼각절제가 2례, 교련절개술이 2례, 후첨의 일부를 절제하여 전첨에 이전시킨례가 1례있었다. 수술수기는 대부분의 경우에서 위의 방법을 복합적으로 시술하였다. 수술사망례는 없었다. 술후 평균 외래추적관찰기간은 6.7개월(1-15개월)이었다. 외래 추적관찰중 1례가 사망하여 사망율은 5.6%였으며 사망원인은 저심박출증이었다. 사망한 환자는 술후 3개월째 발생된 심내막염으로 승모판막치환술을 받았던 례였다. 승모판막재건술후 환자의 NYHA 기능적 분류, 흉부X-선상 심흉곽 비, 심초음파검사상 전반적으로 호전된 소견을 보였다. 이상의 결과에서 승모판막재건술은 승모판막폐쇄부전이 있는 환자에게 적용할 수 있는 비교적 안전한 수술방법으로 사료되어진다.

• Journal of Biosystems Engineering
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• 제43권2호
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• pp.148-159
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• 2018

Purpose: Unmanned air vehicle (UAV) remote sensing was applied to test various vegetation indices and make prediction models of protein content of rice for monitoring grain quality and proper management practice. Methods: Image acquisition was carried out by using NIR (Green, Red, NIR), RGB and RE (Blue, Green, Red-edge) camera mounted on UAV. Sampling was done synchronously at the geo-referenced points and GPS locations were recorded. Paddy samples were air-dried to 15% moisture content, and then dehulled and milled to 92% milling yield and measured the protein content by near-infrared spectroscopy. Results: Artificial neural network showed the better performance with $R^2$ (coefficient of determination) of 0.740, NSE (Nash-Sutcliffe model efficiency coefficient) of 0.733 and RMSE (root mean square error) of 0.187% considering all 54 samples than the models developed by PR (polynomial regression), SLR (simple linear regression), and PLSR (partial least square regression). PLSR calibration models showed almost similar result with PR as 0.663 ($R^2$) and 0.169% (RMSE) for cloud-free samples and 0.491 ($R^2$) and 0.217% (RMSE) for cloud-shadowed samples. However, the validation models performed poorly. This study revealed that there is a highly significant correlation between NDVI (normalized difference vegetation index) and protein content in rice. For the cloud-free samples, the SLR models showed $R^2=0.553$ and RMSE = 0.210%, and for cloud-shadowed samples showed 0.479 as $R^2$ and 0.225% as RMSE respectively. Conclusion: There is a significant correlation between spectral bands and grain protein content. Artificial neural networks have the strong advantages to fit the nonlinear problem when a sigmoid activation function is used in the hidden layer. Quantitatively, the neural network model obtained a higher precision result with a mean absolute relative error (MARE) of 2.18% and root mean square error (RMSE) of 0.187%.

• 대한약리학회지
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• 제32권3호
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• pp.425-431
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• 1996

염증 질환의 원인이 되는 사람 중성구 elastases는 혈액에 존재하는 ${\alpha}_1-PI$나 ${\alpha}_2-macroglobulin$과 같은 단백질 분해효소 억제제에 의하여 조절되어진다. 그러나 특수한 병리적 상황에서 과다하게 분비되는 효소나 또는 단백질 분해효소 억제제의 비정상적 작용으로 말미암아 다양한 염증질환이 유발된다. 비스테로이드성 항염증제는 염증 질환을 치료하기 위하여 이미 임상에 적용 하고 있으며, prostaglandin 합성하는 효소인 cyclooxygenases의 활성도를 억제하는 것이 그 작용 기전으로 잘 알려져 왔다. 사람 중성구 elastase의 활성도는 naproxen, phenylbutazone, oxyphenbutazone 등에 의하여 억제되었으나, ibuprofen, ketoprofen, aspirin, salicylic acid, tolmetin 등에 의하여서는 억제되지 않았다. 또한 사람 중성구 elastase의 활성도는 EDTA, EGTA, tetracycline 등에 의하여서도 억제되었다. EDTA에 의하여 2가 이온 $Ca^{++}$나 $Zn^{++}$등을 elastase 분자로부터 일부 제거함으로 효소 활성도가 억제되었고 Raman spectra의 변화도 강하게 일어났으며, 금속이온 $Zn^{++}$를 새로 충진함으로 그 활성도는 원래대로 회복되고 Raman spectrum도 원래 상태와 유사한 상태로 회복되었다. 이런 현상은 chelator나 chelator-like agents가 효소분자안에 존재하는 $Zn^{++}$ 이온을 제거하거나 chelation함으로 활성 부위나 그 인접 부위의 4차원 구조의 변화를 일으켰음에 기인하며 특히 -C=O나 -COOH기의 관여에 의한 것으로 생각된다.