• Title/Summary/Keyword: park-school

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PARK2 Induces Osteoclastogenesis through Activation of the NF-κB Pathway

  • Hong, Seo Jin;Jung, Suhan;Jang, Ji Sun;Mo, Shenzheng;Kwon, Jun-Oh;Kim, Min Kyung;Kim, Hong-Hee
    • Molecules and Cells
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    • v.45 no.10
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    • pp.749-760
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    • 2022

  • Osteoclast generation from monocyte/macrophage lineage precursor cells needs to be tightly regulated to maintain bone homeostasis and is frequently over-activated in inflammatory conditions. PARK2, a protein associated with Parkinson's disease, plays an important role in mitophagy via its ubiquitin ligase function. In this study, we investigated whether PARK2 is involved in osteoclastogenesis. PARK2 expression was found to be increased during the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. PARK2 gene silencing with siRNA significantly reduced osteoclastogenesis induced by RANKL, LPS (lipopolysaccharide), TNFα (tumor necrosis factor α), and IL-1β (interleukin-1β). On the other hand, overexpression of PARK2 promoted osteoclastogenesis. This regulation of osteoclastogenesis by PARK2 was mediated by IKK (inhibitory κB kinase) and NF-κB activation while MAPK (mitogen-activated protein kinases) activation was not involved. Additionally, administration of PARK2 siRNA significantly reduced osteoclastogenesis and bone loss in an in vivo model of inflammatory bone erosion. Taken together, this study establishes a novel role for PARK2 as a positive regulator in osteoclast differentiation and inflammatory bone destruction.

  • https://doi.org/10.14348/molcells.2022.0058 인용 PDF KSCI

The Impacts of Coeducation in High School on the College Scholastic Ability Test (고등학교의 남녀공학 여부가 대입수능에 미치는 영향)

  • Kim, Beomsoo;Kim, Ga-young
    • KDI Journal of Economic Policy
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    • v.37 no.sup
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    • pp.65-85
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    • 2015

  • Park et al. (2012) examined the impacts of coeducation in high school on the college scholastic ability test using random assignment in Seoul high schools. However, the student random assignment in Seoul within a school district was performed only within 30 min commutable areas using public transportation and Park et al. (2012) did not aware of this rule. This paper reexamines the question by matching nearest two single sex schools with a coeducation school within a school district. We found single sex school students achieve higher test score than that of coeducation school for both male and female. The magnitude of test score improvement for female is smaller than that of Park et al. (2012). However, the magnitude for male is bigger than that of Park et al. (2012).

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Two Unrecorded Wood Decay Fungi (Polyporales) in Dadohaehaesang National Park, Korea

  • Park, Myung Soo;Kim, Nam Kyu;Kim, Min-Ji;Park, Jae Young;Kim, Taeheon;Park, Jung-Won;Lim, Young Woon
    • The Korean Journal of Mycology
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    • v.46 no.1
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    • pp.43-50
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    • 2018

  • Dadohaehaesang National Park is a well-known habitat for a variety of indigenous animals and plants; however, there are no studies on the diversity of macrofungi. To undertake a basic survey of the macrofungi diversity in an unexploited area, we focused on surveying the macrofungi in Dadohaehaesang National Park, Korea, during 2017 and discovered two unrecorded species belonging to the order Polyporales. The two species were identified as Cinereomyces lindbladii and Steccherinum bourdotii based on a combination of morphological characteristics and sequence analysis of the internal transcribed spacer region. We provide macro- and micro-morphological descriptions for these two unrecorded species in Korea.

  • https://doi.org/10.4489/KJM.20180006 인용 PDF KSCI