• Structural Engineering and Mechanics
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• v.74 no.6
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• pp.821-832
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• 2020

The fundamental period is an important parameter for seismic design and seismic risk assessment of building structures. In this paper, a simplified theoretical method to predict the fundamental period of masonry infilled reinforced concrete (RC) frame is developed based on the basic theory of engineering mechanics. The different configurations of the RC frame as well as masonry walls were taken into account in the developed method. The fundamental period of the infilled structure is calculated according to the integration of the lateral stiffness of the RC frame and masonry walls along the height. A correction coefficient is considered to control the error for the period estimation, and it is determined according to the multiple linear regression analysis. The corrected formula is verified by shaking table tests on two masonry infilled RC frame models, and the errors between the estimated and test period are 2.3% and 23.2%. Finally, a probability-based method is proposed for the corrected formula, and it allows the structural engineers to select an appropriate fundamental period with a certain safety redundancy. The proposed method can be quickly and flexibly used for prediction, and it can be hand-calculated and easily understood. Thus it would be a good choice in determining the fundamental period of RC frames infilled with masonry wall structures in engineering practice instead of the existing methods.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.11-13
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• 2013

Background: Esophagus cancer, the third most common gastrointestinal cancer overall, demonstrates high incidence in parts of Iran. The counties of Iran vary in size, shape and population size. The aim of this study was to account for spatial support with Area-to-Area (ATA) Poisson Kriging to increase precision of parameter estimates and yield correct variance and create maps of disease rates. Materials and Methods: This study involved application/ecology methodology, illustrated using esophagus cancer data recorded by the Ministry of Health and Medical Education (in the Non-infectious Diseases Management Center) of Iran. The analysis focused on the 336 counties over the years 2003-2007. ATA was used for estimating the parameters of the map with SpaceStat and ArcGIS9.3 software for analysing the data and drawing maps. Results: Northern counties of Iran have high risk estimation. The ATA Poisson Kriging approach yielded variance increase in large sparsely populated counties. So, central counties had the most prediction variance. Conclusions: The ATAPoisson kriging approach is recommended for estimating parameters of disease mapping since this method accounts for spatial support and patterns in irregular spatial areas. The results demonstrate that the counties in provinces Ardebil, Mazandaran and Kordestan have higher risk than other counties.

• Geophysics and Geophysical Exploration
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• v.9 no.1
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• pp.86-92
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• 2006

The full-waveform inversion algorithm using normalised seismic wavefields can avoid potential inversion errors due to source estimation required in conventional full-waveform inversion methods. In this paper, we have modified the inversion scheme to install a weighted smoothness constraint for better resolution, and to implement a staged approach using normalised wavefields in order of increasing frequency instead of inverting all frequency components simultaneously. The newly developed scheme is verified by using a simple two-dimensional fault model. One of the most significant improvements is based on introducing weights in model parameters, which can be derived from integrated sensitivities. The model-parameter weighting matrix is effective in selectively relaxing the smoothness constraint and in reducing artefacts in the reconstructed image. Simultaneous multiple-frequency inversion can almost be replicated by multiple single-frequency inversions. In particular, consecutively ordered single-frequency inversion, in which lower frequencies are used first, is useful for computation efficiency.

• Journal of the Korea Society of Computer and Information
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• v.3 no.2
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• pp.1-6
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• 1998

The evaluation of reliability is very important in the development process of software. There may be lack of trustfulness on the results that come from the analysis and evaluation of reliability of softwares which do not divide the test phases. At this point, this article studies how to evaluate the reliability dividing the test phases in order to settle the these problems. In doing so, I apply the fault data to be found in Unit Test, Integration Test, Validation Test and System Test to SRGM(Software Reliability Growth Model), Exponential SRGM, Delayed S-shaped SRGM and Inflection S-shaped SRGM. The result is that Inflection S-shaped is best suitable with Unit Test Delayed S-shaped is best suitable with Integration and Validation Test, and Exponential SRGM is best suitable with System test. In this respect, I can show that the results of this study on parameter estimation, difference square summation, number of fault remained is superior to the established methods.

• Korean Journal of Clinical Pharmacy
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• v.26 no.4
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• pp.312-317
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• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.

• Structural Engineering and Mechanics
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• v.57 no.4
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• pp.657-680
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• 2016

Reinforced concrete (RC) deep beams are structural members that predominantly fail in shear. Therefore, determining the shear strength of these types of beams is very important. The strut-and-tie method is commonly used to design deep beams, and this method has been adopted in many building codes (ACI318-14, Eurocode 2-2004, CSA A23.3-2004). In this study, the efficiency of artificial neural networks (ANNs) in predicting the shear strength of RC deep beams is investigated as a different approach to the strut-and-tie method. An ANN model was developed using experimental data for 214 normal and high-strength concrete deep beams from an existing literature database. Seven different input parameters affecting the shear strength of the RC deep beams were selected to create the ANN structure. Each parameter was arranged as an input vector and a corresponding output vector that includes the shear strength of the RC deep beam. The ANN model was trained and tested using a multi-layered back-propagation method. The most convenient ANN algorithm was determined as trainGDX. Additionally, the results in the existing literature and the accuracy of the strut-and-tie model in ACI318-14 in predicting the shear strength of the RC deep beams were investigated using the same test data. The study shows that the ANN model provides acceptable predictions of the ultimate shear strength of RC deep beams (maximum $R^2{\approx}0.97$). Additionally, the ANN model is shown to provide more accurate predictions of the shear capacity than all the other computed methods in this study. The ACI318-14-STM method was very conservative, as expected. Moreover, the study shows that the proposed ANN model predicts the shear strengths of RC deep beams better than does the strut-and-tie model approaches.

• Computers and Concrete
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• v.19 no.3
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• pp.275-282
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• 2017

The aim of this study is to build Machine Learning models to evaluate the effect of blast furnace slag (BFS) and waste tire rubber powder (WTRP) on the compressive strength of cement mortars. In order to develop these models, 12 different mixes with 288 specimens of the 2, 7, 28, and 90 days compressive strength experimental results of cement mortars containing BFS, WTRP and BFS+WTRP were used in training and testing by Random Forest, Ada Boost, SVM and Bayes classifier machine learning models, which implement standard cement tests. The machine learning models were trained with 288 data that acquired from experimental results. The models had four input parameters that cover the amount of Portland cement, BFS, WTRP and sample ages. Furthermore, it had one output parameter which is compressive strength of cement mortars. Experimental observations from compressive strength tests were compared with predictions of machine learning methods. In order to do predictive experimentation, we exploit R programming language and corresponding packages. During experimentation on the dataset, Random Forest, Ada Boost and SVM models have produced notable good outputs with higher coefficients of determination of R2, RMS and MAPE. Among the machine learning algorithms, Ada Boost presented the best R2, RMS and MAPE values, which are 0.9831, 5.2425 and 0.1105, respectively. As a result, in the model, the testing results indicated that experimental data can be estimated to a notable close extent by the model.

• Communications for Statistical Applications and Methods
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• v.18 no.1
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• pp.79-87
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• 2011

A spatial time series model was used for analyzing the method of spatial time series (not the ARIMA model that is popular for analyzing spatial time series) by using chicken pox data which is a highly contagious disease and grid data due to ARIMA not reflecting the spatial processes. Time series model contains a weighting matrix, because that spatial time series model influences the time variation as well as the spatial location. The weighting matrix reflects that the more geographically contiguous region has the higher spatial dependence. It is hypothesized that the weighting matrix gives neighboring areas the same influence in the study of the spatial time series model. Therefore, we try to present the conclusion with a weighting matrix in a way that gives the same weight to existing neighboring areas in the study of the suitability of the STARMA model, spatial time series model and STBL model, in the comparative study of the predictive power for statistical inference, and the results. Furthermore, through the Kalman-Filter method we try to show the superiority of the Kalman-Filter method through a parameter assumption and the processes of prediction.

• Industrial Engineering and Management Systems
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• v.12 no.3
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• pp.244-253
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• 2013

In industries, shipping is an important issue in improving the forecasting accuracy of sales. This paper introduces a hybrid method and plural methods are compared. Focusing the equation of exponential smoothing method (ESM) that is equivalent to (1, 1) order autoregressive-moving-average (ARMA) model equation, a new method of estimating the smoothing constant in ESM had been proposed previously by us which satisfies minimum variance of forecasting error. Generally, the smoothing constant is selected arbitrarily. However, this paper utilizes the above stated theoretical solution. Firstly, we make estimation of ARMA model parameter and then estimate the smoothing constant. Thus, theoretical solution is derived in a simple way and it may be utilized in various fields. Furthermore, combining the trend removing method with this method, we aim to improve forecasting accuracy. This method is executed in the following method. Trend removing by the combination of linear and 2nd order nonlinear function and 3rd order nonlinear function is executed to the original production data of two kinds of bread. Genetic algorithm is utilized to search the optimal weight for the weighting parameters of linear and nonlinear function. For comparison, the monthly trend is removed after that. Theoretical solution of smoothing constant of ESM is calculated for both of the monthly trend removing data and the non-monthly trend removing data. Then forecasting is executed on these data. The new method shows that it is useful for the time series that has various trend characteristics and has rather strong seasonal trend. The effectiveness of this method should be examined in various cases.

• Journal of Biosystems Engineering
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• v.39 no.3
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• pp.151-157
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• 2014

Purpose: In order to develop strategies to prevent farm-work accidents relating to agricultural machinery, influential factors were examined in this paper. The effects of these factors were quantified using logistic regression. Methods: Based on the results of a survey on farm-work accidents conducted by the National Academy of Agricultural Science, 21 tentative independent variables were selected. To apply these variables to regression, the presence of multicollinearity was examined by comparing correlation coefficients, checking the statistical significance of the coefficients in a simple linear regression model, and calculating the variance inflation factor. A logistic regression model and determination method of its goodness of fit was defined. Results: Among 21 independent variables, 13 variables were not collinear each other. The results of a logistic regression analysis using these variables showed that the model was significant and acceptable, with deviance of 714.053. Parameter estimation results showed that four variables (age, power tiller ownership, cognizance of the government's safety policy, and consciousness of safety) were significant. The logistic regression model predicted that the former two increased accident odds by 1.027 and 8.506 times, respectively, while the latter two decreased the odds by 0.243 and 0.545 times, respectively. Conclusions: Prevention strategies against factors causing an accident, such as the age of farmers and the use of a power tiller, are necessary. In addition, more efficient trainings to elevate the farmer's consciousness about safety must be provided.