• Title/Summary/Keyword: papilloma

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Immunohistochemical study on the expression of matrix metalloproteinase 2 and high-risk human papilloma virus in the malignant progression of papillomas

  • Lee, Ho-Jin;Kim, Jin-Wook
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.39 no.5
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    • pp.224-230
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    • 2013
  • Objectives: Papilloma frequently develops as a benign tumor of the head and neck area, but its potential for malignant transformation has yet to be studied. This study aims to provide basic information for papillomas using the immunohistochemical staining of matrix metalloproteinase 2 (MMP-2) and human papilloma virus (HPV) 16 and 18. Materials and Methods: To evaluate the malignant transformation of papillomas, the selected tissue samples were serially diagnosed with pre-cancerous papilloma (with epithelial dysplasia, pseudo-epitheliomatous hyperplasia) or malignant lesion (squamous cell carcinoma, SCC) after the first diagnosis (squamous papilloma, inverted papilloma). The selected tissues were stained with an antibody to MMP-2 and HPV 16-E7, HPV 18-L1. A statistical analysis was performed according to each transformation step. Results: The epithelial layer of papilloma and pre-cancerous papilloma lesions had a similar MMP-2 expression, but that of the malignant lesion had a significantly increased MMP-2 expression. HPV 16 and 18 infection rates were 28.6%, 33.3% and 63.6% in papillomas, pre-cancerous papilloma lesions, and SCC. Conclusions: A relatively high MMP-2 expression and HPV 16 or 18 infection of papillomas may be associated with early events in the multistep processes of malignant transformation of papillomas.

DIAGNOSTIC PROBLEM OF SQUAMOUS PAPILLOMA AND ORAL MUCOSA MALIGNANCY (구강내 악성병소와 유두종의 감별진단시 문제점)

  • Ryu, Dong-Mok;Choi, Byung-Jun;Kim, Yeo-Gab;Lee, Baek-Soo;Oh, Jung-Hwan
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.30 no.1
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    • pp.60-64
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    • 2004
  • Squamous papilloma is a benign proliferation of stratified squamous epithelium, resulting in a papillary or verruciform mass. Verrucous carcinoma is a differentiated variant of squamous cell carcinoma and may present diagnostic difficulties as it may be erroneously diagnosed as squamous papilloma. Squamous papilloma is similar to other oral mucosa malignancy in microscopic view. So, it is difficult to distinguish between squamous cell papilloma and other oral mucosa malignancy. Here are three patients. they were diagnosed as squamous papilloma initially, but the lesion was recurred. In recurred lesion, verrucous carcinoma or squamous cell carcinoma were found. So we report that recurred oral mucosa malignency(verrucous carcinoma or squamous cell carcinoma) which was diagnosed as squamous papilloma.

A Case of Paranasal Sinus Papilloma with Increased FDG Uptake (부비동 유두종에서의 FDG 섭취 증가를 보인 예)

  • An, Young-Sil;Park, Yong-Koo;Kim, Deog-Yoon
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.5
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    • pp.419-421
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    • 2008
  • The false-positive FDG uptakes on head and neck areas are common due to benign lesion, iatrogenic and physiologic changes. The Schneiderian papilloma is uncommon benign tumor arising from the mucosa of the paranasal sinuses and nasal cavity. The findings of paranasal papilloma on conventional modality such as CT and MRI are non-specific and they could be confused with inflammatory polyp or retention cyst. Despite of benign tumor, the papilloma usually shows locally aggressive growth with malignant potential, therefore the FDG can be actively accumulated in this lesion. We describe the case of 18F-FDG PET/CT finding in a 77-year-old woman who demonstrates oncocytic papilloma in maxillary sinus.

Bovine papillomavirus detection from bovine teats using immunohistochemistry and electronmicroscopy (면역조직화학염색 및 전자현미경검사를 이용한 소 유두로부터 소유두종바이러스 검출)

  • Bae, You-Chan;Yoon, Soon-Seek;Park, Jung-Won;Lee, Cheong-San;Jean, Yong-Hwa;Kang, Mun-Il
    • Korean Journal of Veterinary Research
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    • v.45 no.2
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    • pp.233-238
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    • 2005
  • We examined the teats of slaughtered cattles to investigate the prevalence of papilloma and to detect bovine papilloma virus (BPV) from those samples. Among 880 heads, 432 (49.0%) was Holstein and 448 (51.0%) was Korean native cattle. Grossly, out of 432 heads (Holstein), 263 (60.8%) had papilloma lesions on teats. However, out of 448 heads (Korean native cattle), only 33 (7.4%) had papilloma lesions on teats. Immunohistochemically, BPV antigen was detected in 35 heads (22.9%) of 153 (Holstein) which had papilloma lesions. But, in Korean native cattle, BPV antigen was detected in 1 head (3.8%) of 26. Electronmicroscopically, in Holstein papilloma cases, BPV particles was detected in 31 heads (39.2%) of 79. This study revealed that papilloma was very prevalent in holstein teats, Korea and the prevalence of papilloma in Holstein was 8 times higher than that of Korean native cattle. Moreover, it was needed to consider gross and histopathological lesions to confirm BPV infection on teats because the sensitivity of immunohistochemistry and electronmicroscopy was not high.

Glandular papilloma of the lung with malignant transformation

  • Sung, Woo Jung
    • Journal of Yeungnam Medical Science
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    • v.34 no.2
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    • pp.298-302
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    • 2017
  • Glandular papilloma of the lung is one of three histologic types of solitary endobronchial papillomas. It is known as an uncommon benign neoplasm. No malignant glandular papillomas have been reported. Herein, the first case of granular papilloma with malignant transformation is reported. A 74-year-old man with huge right lung mass extended upper and lower lobe was admitted to the hospital complaining of progressive cough and dyspnea. An open lung biopsy was performed. Microscopically, the tumor showed papillary growth pattern with thick fibrovascular cores. The stroma of the fibrovascular cores shown the infiltration of lymphoplasmacytic cells and proliferation of capillaries. The epithelial cells surrounding the papillary fronds were cilliated columnar cells with focal cellar atypia, and frequent mitoses. Suspicious pleural invasion foci were identified. The Ki-67 labeling index was about 24.3% and p53 labeling index was about 31.7%. Glandular papilloma is known as a benign neoplasm, which is lack of atypia and mitosis. In present case, there were several indications of malignant transformation, such as cellular atypia, frequent mitosis, architectural distortion, and pleural invasion. Pathologists must be aware that glandular papilloma can have a changes of malignant transformation. Further studies about disease behavior and molecular characteristics are needed.

Atypical Choroid Plexus Papilloma in an Adult

  • Lee, Sung-Ho;Park, Bong-Jin;Kim, Eui-Jong;Lim, Young-Jin
    • Journal of Korean Neurosurgical Society
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    • v.46 no.1
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    • pp.74-76
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    • 2009
  • We present an extremely rare case of the atypical choroid plexus papilloma in an adult which developed at the trigone of right lateral ventricle. A 62-year-old woman presented with the history of intermittent and gradually progressive headache and left side hemiparesis for 6 months. The brain magnetic resonance image showed highly enhanced and well demarcated mass at the trigone of lateral ventricle attached to the choroid plexus. Gross total resection was performed by transcortical approach via the middle temporal gyrus. The tumor was diagnosed as an atypical choroid plexus papilloma. She had no neurologic deficit after the surgery. We report a case of atypical choroid plexus papilloma in adult and introduce newly classified pathologic characteristics of this tumor.

Malignant Transformation of Laryngeal Papilloma (후두 유두종의 악성 변화)

  • Yoon Seok-Keun;Eun Sun-Jin;Nam Hae-Ju
    • Korean Journal of Head & Neck Oncology
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    • v.6 no.1
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    • pp.24-28
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    • 1990
  • It is well known that laryngeal papilloma has a tendency for malignant transformation, but the incidence was variable among many authors. The authors present a case of laryngeal cancer which was considered to be transformed from laryngeal papilloma after six years follow up, with serial pathological review of the specimen. Incidence of malignant transformation in our hospital is 2.5% of total laryngeal papilloma and it is the only case among 57 laryngeal cancer for 6 years duration. It must be stressed that long term follow up is recommanded in adult type laryngeal papilloma.

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Intraductal Papilloma of the Parotid Gland in a Child (소아의 이하선에 발생한 관내유두종)

  • Choi, Choong-Sik;Choi, Geon;Cho, Jae-Hoon;Kim, Dae-Hyung
    • Korean Journal of Bronchoesophagology
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    • v.5 no.2
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    • pp.127-129
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    • 1999
  • Intraductal papilloma is a rare benign tumor reported to be primarily in minor salivary gland. There were few reports in parotid gland. A case of a 5-year-old boy with a palpable mass in the left parotid gland, with a review of the literature pertaining to this unusual case. A supeficial parotidectomy was performed under impression of benign or congenital lesion. Histopathologic diagnosis of intraductal papilloma was made on the surgical specimen. Authors report a intraductal papilloma arising from the parotid gland in childhood.

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Mixed Squamous Cell and Glandular Papilloma of the Lung in a 64-Year-Old Woman

  • Yun, Ju Sik;Kim, Do Wan;Choi, Yoo Duk;Na, Kook Joo;Song, Sang Yun
    • Journal of Chest Surgery
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    • v.47 no.1
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    • pp.55-58
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    • 2014
  • Mixed squamous cell and glandular papilloma of the lung is an extremely rare benign epithelial tumor showing a mixture of squamous and glandular epithelium. Here, we report a case of mixed squamous cell and glandular papilloma that presented as a solitary nodule in the left lower lobe of a 64-year-old woman. Chest computed tomography demonstrated a lobulated mass in the basal segment of the left lower lobe. The patient underwent a lobectomy under the suspicion of lung malignancy. The histopathological diagnosis was mixed squamous cell and glandular papilloma.

A Case of the Laryngeal Papilloma Observed for the Past 13 Years (13년간 경과를 관찰한 후두유두종의 1예)

  • 이양선;박윤이;이인환
    • Proceedings of the KOR-BRONCHOESO Conference
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    • 1983.05a
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    • pp.5.2-5
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    • 1983
  • It is well known that laryngeal papilloma is histopathological benign, but clinically one of the most troublesome disease in otolaryngologic department, usually seen in child age. Since Cleesmann reported papilloma of the vocal cord, 1817 first, the etiology had not been known exactly. The symptoms in children are dyspnea, dysphonia due to recurrence, and papilloma in adult can change into neoplasm. The papilloma is thought as real neoplastic lesion and there is not effective treatment, using now repeated removal and combined therapy. This report is based on the typical findings and progress of one case of laryngeal papilloma observed for the past 13 years with repeated removal and topical application of 5-FU at our department. Authors have experienced this subject is interesting that the change of the tumor region during the course than to any new therapeutic methods employed, and so report with some reviews of the literatures.

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