• Journal of Pharmacopuncture
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• v.27 no.2
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• pp.101-109
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• 2024

Objectives: Dyslipidemia has currently become a major health challenge that still opens for safer and more effective modes of treatment. The plant Pandanus amaryllifolius Roxb. (pandan) has been indicated to contain active ingredients that interfere with the pathological pathway of dyslipidemia. The aim of the study was to test the effects of pandan leaves ethanol extract on lipid and proinflammatory profiles in a rat dyslipidemic model. Methods: Dyslipidemia was induced by administration of high-fat feed for 8 weeks. Treatments (vehicle, the reference drug simvastatin at 1.8 mg/kg, and extract at 200, 300 or 600 mg/kg) were given for 4 weeks following the completion of induction. Results: Significant post-treatment decreases in total cholesterol, low density lipoprotein (LDL), and triglyceride levels in groups receiving all doses of extract and simvastatin were observed. Similar results were also found in regards to proinflammatory cytokines levels. Pandan extracts significantly lowered the concentrations of IL-6, TNF-α, and NFκB p65. Characterization of metabolite contents of the extract confirmed the presence of the previously suggested active alkaloids pandamarilactonine-A and B. Conclusion: Taken together, results of the present study implied the ameliorating effects of pandan leaves ethanol extract in dyslipidemic condition which is potential for opening an avenue in combating this essential component of metabolic disorder.

• Journal of the Korean Society for Precision Engineering
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• v.12 no.5
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• pp.88-97
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• 1995

The leaf spring is used in the suspension of most buses and trucks due to its compactness, which reduces the shock-force and the vibration from the road, and increases passenger comfortability and carlife. Of the various kinds of leaf springs, the leaf spring without eyes can be found easily in the heavy duty truck, and has different characteristics to the leaf spring with eyes in the case of large free camber. Because of radius change, the leaf without eyes slips on the supports, which makes the deflection. The difference is due to this deflection. In this paper, we show the general method of characteristic analysis, for example, Pandan method, can be no more applicable to these springs. Thus considering the geometry deflection by slip, we have developed the equation of the characteristic of the leaf spring without eyes and prove the effectiveness of this equation by experiment. From the result, at large camber the slip deflection is large and as camber smaller, this is smaller. At the camber behind some value, the effect of slip no longer influence to the characteristic of leaf springs.