• Maxillofacial Plastic and Reconstructive Surgery
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• v.33 no.6
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• pp.549-558
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• 2011

The latissimus dorsi myocutaneous flap (LDMF) was initially described at the turn of the century by Tansini et al, and latissimus dorsi myocutaneous free flap (LDMFF) was also first described for the coverage of a chronically infected scalp by Maxwell et al. As a pedicled flap, LDMF has been often used for breast reconstruction and for soft tissue replacement near the shoulder and the lower reaches of the head and neck. LDMFF is a flat and broad soft tissue flap with large-caliber thoracodorsal vessels for microvascular anastomosis. A skin paddle of the LDMFF can be more than $20{\times}40$ cm, so very large defects in the oral cavity and outer facial region can be covered by this LDMFF. Other advantages include consistent vascular anatomy, acceptable donor site morbidity and the ability to perform simultaneous flap harvest with tumor resection. For a better understanding of LDMFF as a routine reconstructive procedure in large defects of the oral cavity and facial legion, anatomical findings must be learned and memorized by young doctors during the special curriculum periods for the Korean national board of oral and maxillofacial surgery. This review article discusses the anatomical basis of LDMFF with Korean language.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.10
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• pp.1265-1271
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• 2011

In this study, the safety of a rack structure was evaluated through seismic analysis considering fluid-structure interactions using a finite-element model. The rack structure was immersed under water, so it was influenced by the water. The fluid-structure interaction can be specified in terms of the hydrodynamic effect, which is defined as the added mass per unit length. Modal analysis and seismic analysis using the Floor Response Spectrum (FRS) were carried out under Operating Basis Earthquake (OBE) and Safe Shutdown Earthquake (SSE) conditions. The analytical maximum displacements of the rack structure were 0.29 and 0.36 mm under OBE and SSE conditions, respectively. The maximum stresses were 17.9 MPa under OBE conditions and 19.6 MPa under SSE conditions; these results corresponded to 23 % and 14% of the yield strength of the applied material, respectively.

• Applied Chemistry for Engineering
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• v.7 no.1
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• pp.18-25
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• 1996

Power input in stirred vessel is especially important in the design of mixers, as well as the evaluation of mixing processes. A type of baffles in mechanically agitated vessels and power employed are major factors that determine the stirring efficiency in a large scale, multi-step processes. In the present study, power input in the totally baffled agitated vesseles was compared systematically in connection with several previous studies and adequate power input correlation was found to be : $Np_{(pitch)}=({\theta}/90^{\circ})Np_{(90^{\circ})}$ Power number correlation was dependent upon the distance of among the impeller in the agitated vesseles, as follows : $$Np=7.09(n_p)^{0.7}(\frac{b_(double)}{d})(\frac{H}{D})^{0.18}$$, $${n_p}^{0.7}(\frac{b_{(double)}}d)$$<2 $$Np=8.73\{(n_p)^{0.7}(\frac{b_{(double)}}{d})\}^{0.7}(\frac{H}{D})^{0.18}$$, $${n_p}^{0.7}(\frac{b_{(double)}}d)$$>2.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.4137-4140
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• 2012

The authors present five cases of combined oral mucosa-mandible defects reconstructed with the vascularized internal oblique-iliac crest myoosseous free flap. This technique has many advantages compared to other conventional methods such as the radial flap, scapula flap, and fibula flap. Vascularized iliac crest flaps provide sufficient high-quality bone suitable for reconstructing segmental madibular defects. Although fibular flaps allow longer donor bone tissue to be harvested, the iliac crest can provide an esthetic shape for mandibular body reconstruction and also provides sufficient bone height for dental implants. Conventional vascularized iliac crest myoosseous flaps have excessive soft tissue bulk for reconstruction of intraoral soft tissue defects. The modification discussed in the present article can reduce soft tissue volume, resulting in better functional reconstruction of the oral mucosa. Another advantage is that complete replacement of the oral mucosa is observed in as early as one month post-operation. The final mucosal texture is much better than that obtained with other skin paddle flaps, which is especially beneficial for the placement of dental implant prostheses. Donor site morbidity looks to be similar to, if not less than that observed for other modalities in terms of function and esthetics. For combined oral mucosa-mandible defects, the vascularized internal oblique-iliac crest myoosseous free flap shows good results with respect to hard and soft tissue reconstruction.

• Archives of Plastic Surgery
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• v.45 no.4
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• pp.340-344
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• 2018

Background In performing extended latissimus dorsi (ELD) flap procedures, a skin paddle design on the bra line helps reduce visible scarring. This improves the patient's satisfaction with the outcome. However, such a design leads to a longer operation time and increased fatigue of the surgeon due to the narrow operative field. In this study, the authors propose a method that elongates the axillary incision line posteriorly by 1.5 cm from the lateral border of the latissimus dorsi muscle. We examined whether this method could shorten the operation time and compared the incidence of complications between patients who underwent this novel procedure and patients who underwent the traditional procedure. Methods In this study of patients who underwent ELD flap procedures for immediate breast reconstruction, 89 underwent surgery with the elongated axillary incision and 45 underwent surgery without the elongated incision. The total operation time and complications were retrospectively examined based on the patients' medical records, and we examined whether there was any statistically significant difference in the total operation time. Results In the experimental group with the elongated axillary incision, the operation time ranged from 125 to 255 minutes (median, 175 minutes). In contrast, in the control group without the elongated axillary incision, the operation time ranged from 142 and 340 minutes (median, 205 minutes). The operation time was statistically significantly different between the two groups, and no significant complications were observed in the experimental group. Conclusions Elongation of the axillary incision alone may shorten the operation time of the ELD flap procedure without causing additional complications.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.680-685
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• 2006

This paper describes the aeroelastic stability test of the small-scaled 'Next-Generation Blade(NRSB)' with NRSH (Next-Generation Hub System) and HCTH hingeless hub system in hover and forward flight conditions. Excitation tests of rotor system installed in GSRTS(General Small-scale Rotor Test System) at KARI(Korea Aerospace Research Institute) were tarried out to get lead-lag damping ratio of blades with flexures as hub flexure. MBA(Moving Block Analysis) technique was used for the estimation of lead-lag damping ratio. First, NRSB-1F blades with HCTH hub system, Then NRSB-1F with NRSH hub system were tested. Second, NRSB-2F blades with NRSH hub system were tested. Tests were done on the ground and in the wind tunnel according to the test conditions of hover and forward flight, respectively. Non-rotating natural frequencies, non-rotating damping ratios and rotating natural frequencies were showed similar level fir each cases. Estimated damping ratios of NRSB-1F, NRSB-2F with HCTH and NRSH were above 0.5%, and damping ratio increased by collective pitch angle increasement. Furthermore damping ratios of NRSB-2F were higher than damping ratios of NRSB-1F in high pitch angle. It was confirmed that the blade design for noise reduction would give observable improvement in aeroelastic stability compared to paddle blade and NRSB-1F design.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.2
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• pp.98-105
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• 2005

This paper presents the result of the aeroelastic stability test of the small-scaled hingeless hub system with composite paddle blades in hover and forward flight conditions. Excitation tests of hingeless hub system installed in GSRTS(General Small-scale Rotor Test System) at KARI(Korea Aerospace Research Institute) were carried out to get lead-lag damping ratio of blades with flexures as hub flexure. MBA(Moving Block Analysis) technique was used for the estimation of lead-lag damping ratio. First, blades with metal flexures, then with composite flexures of the same dynamic properties of rotor system as metal one were tested. Tests were done on the ground and in the wind tunnel according to the test conditions of hover and forward flight, respectively. Composite flexures were found to have better damping characteristics over metal ones in the non-rotating vibration test, and it was confirmed that the use of composite flexures would give observable improvement in aeroelastic stability compared to metal ones in all test conditions.

• Journal of Pharmaceutical Investigation
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• v.24 no.2
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• pp.57-65
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• 1994

To increase the dissolution rate of practically insoluble biphenyl dimethyl dicarboxylate (DDB), various solid dispersions were prepared with water soluble carriers, such as povidone (PVP K-30), poloxamer 407, sodium deoxycholate (SDC) and polyethylene glycol (PEG) 6000, at drug to carrier ratios of 1:3, 1:5 and 1:10 (w/w) by solvent or fusion method. Dissolution test was performed by the paddle method. The dissolution rate of DDB tablets (25 mg) on market was found to be very low (11.44, 9.02 and 6.42% at pH 1.2, 4.0 and 6.5 after 120 min, respectively). However, dissolution rates of DDB from various solid dispersions were very fast and reached supersaturation within 10 min. DDB-PEG 6000 solid dispersion appeared to be better in enhancing the in vitro dissolution rate than others. Furthermore, the incorporation of DDB and phosphatidylcholine (PC) into ${\beta}-cyclodextrin$ at ratios of 1:2:20, 1:5:20 and 1:10:20 resulted in a 4.9-, 11.2- and 19.6-fold increase in DDB dissolution after 120 min as compared with the pure drug, respectively. This might be attributed to the formation of lipid vesicles which entrapped a certain concentration of DDB during dissolution. On the other hand, the permeation of DDB through rabbit duodenal mucosa was examined using some enhancers such as SDC, sod. glycocholate (SGC) and glycyrrhizic acid ammonium salt (GAA). Only trace amounts of DDB were found to permeate through deuodenal mucosa in the absence of enhancer. SDC was found to markedly decrease the permeation flux of DDB, however, SGC and GAA (5 mM) enhanced the flux of DDB 1.6 and 2.4 times higher as compared with no additive, respectively.

• Journal of Pharmaceutical Investigation
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• v.30 no.1
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• pp.27-32
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• 2000

Various release test methods have been applied for the evaluation of nicotine release in vitro from commercial patches. However, whether and how the release data reflect the permeation of nicotine across the skin, is not fully elucidated. To predict in vivo bioavailability from in vitro release tests, correlation between in vitro release and in vitro skin permeation was assessed in the present study. Release of nicotine from three commercial patches was measured for 24 hours under nine experimental conditions which were classified depending on the apparatus (i.e., paddle over disk, cylinder and reciprocating holder) and dissolution media (i.e., phosphate buffer pH 7.4, water and the 1 % phosphoric acid pH 1.5). In vitro permeation of nicotine from the patches across the human cadaver skin was also measured using a diffusion cell. The release of nicotine was better explained by the Higuchi's equation rather than by the first order rate equation. Correlation between the release rate and the in vitro skin permeation differed among the patches. However, in general, the cylinder method, in which water is used as a dissolution medium, showed the highest correlation among the nine release test conditions.

• Journal of Pharmaceutical Investigation
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• v.34 no.3
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• pp.185-192
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• 2004

The objective of this study was to evaluate the effects of surfactant type and concentration upon dissolution rates of carbamazepine from an immediate-release tablet. The dissolution media used in this study were aqueous solutions containing 0.1-2% sodium lauryl sulfate, cetyltrimethylammonium bromide, or polysorbate 80. The solubility of carbamazepine in the dissolution media was determined at first. A dissolution study was then conducted by using the USP dissolution apparatus II (paddle method) with an agitation rate of 75 rpm. Aliquots of the dissolution media were taken at predetermined time intervals, and the amount of carbamazepine dissolved was measured spectrophotometrically at 285 nm. The dissolution data obtained were fitted into a biphasic exponential equation with four parameters. Excellent correlations were observed between the experimental data and the theoretical ones predicted by the equation. This equation permitted the calculation of $T_{50%}$ (the time required for dissolving 50% of carbamazepine) under various experimental conditions. Differentiation of the equation also led to the attainment of dissolution rates at dissolution time points. The addition of a surfactant to an aqueous solution led to increasing the solubility of carbamazepine by 3- to 12-folds, depending upon its type and concentration. This event also resulted in enhancing the magnitude of a sink condition during the dissolution study. As a result, the dissolution rate of carbamazepine was affected by the aqueous surfactant concentration in a proportional manner. Subsequently, $T_{50%}$ values declined rapidly, as the surfactant concentration increased. Such effects were observed in decreasing order of sodium lauryl sulfate, cetyltirmethylammonium bromide, and polysorbate 80. These results clearly demonstrated that it was possible to tailor a dissolution rate and $T_{50%}$ of carbamazepine by manipulating the type and concentration of a surfactant. Relevant information would be beneficial to setting up dissolution specifications for poorly water-soluble drug products.