• Parasites, Hosts and Diseases
• /
• 제54권6호
• /
• pp.733-742
• /
• 2016

Acquaintance is scanty on primaquine (PQ) efficacy and Plasmodium vivax recurrence in Udupi district, Karnataka, India. We assessed the efficacy of 14 days PQ regimen (0.25 mg/kg/day) to prevent P. vivax recurrence. Microscopically, aparasitemic adults (${\geq}18years$) after acute vivax malaria on day 28 were re-enrolled into 15 months' long follow-up study. A peripheral blood smear examination was performed with participants at every 1-2 month interval. A nested PCR test was performed to confirm the mono-infection with P. vivax. Of 114 participants, 28 (24.6%) recurred subsequently. The median (IQR) duration of the first recurrence was 3.1 (2.2-5.8) months which ranged from 1.2 to 15.1 months, including initial 28 days. Participants with history of vivax malaria had significantly higher risk of recurrence, with hazard ratio (HR) (95% CI) of 2.62 (1.24-5.54) (P=0.012). Severity of disease (11.4%, 13/114) was not associated (P=1.00) with recurrence. Of 28 recurrence cases, the nPCR proved that P. vivax mono-infection recurrence rate was at least 72.7% (16/22) at first recurrence. In Udupi district, PQ dose of 0.25 mg/kg/day over 14 days seems inadequate to prevent recurrence in substantial proportion of vivax malaria. Patients with a history of vivax malaria are at high risk of recurrences.

• Journal of Nutrition and Health
• /
• 제54권1호
• /
• pp.104-115
• /
• 2021

Purpose: With increased time spent at home due to prolonged online classes, this study sought to determine how the coronavirus disease 2019 (COVID-19) pandemic has impacted the mukbang- and cookbang-watching patterns and dietary life of college students. Methods: All students majoring in food and nutrition (FN) at a college in Gyeonggi, Korea, participated in the survey in April 2019 (M/F = 36/106) and June 2020 (M/F -37/130) and data were analyzed using SPSS 26.0. Results: Compared to students responding in 2019, those in 2020 reported more frequently eating alone (p < 0.01) and cooking (p < 0.01), and evaluated their diets better regarding pleasant mealtimes atmosphere (p < 0.05), moderation in drinking (p < 0.05), and not consuming excessively delivery foods (p < 0.001), processed foods (p < 0.01), foods with animal fat (p < 0.01), salty foods (p < 0.01), and sweets (p < 0.01). Although the proportion of respondents who answered that they watched mukbang and cookbang at least occasionally did not change, greater proportions of respondents reported watching both genres frequently (p < 0.001, respectively) and spending less time/day in watching mukbang (p < 0.05) in 2020 vs. 2019. While they evaluated the effect of mukbang- and cookbang-watching on overall diet similarly, the proportion of respondents that reported feeling as though mukbang-watching prompted them to eat more of less-desirable foods decreased from 54.3% to 41.5% (p < 0.05). Diet improvement of participants due to COVID-19 resulted in that the association between frequent mukbang-watching and unhealthier dietary habits in 2019 was not shown in 2020. Conclusion: Our results suggest that the prolonged at-home stays due to COVID-19 might have improved many aspects of diet and decreased undesirable effect of frequent mukbang-watching in case of college students majoring in FN.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권5호
• /
• pp.2083-2087
• /
• 2014

Colorectal cancers remain to be a common cause of cancer-related death. Early-onset cases as well as those of various ethnic origins have aggressive clinical features, the basis of which requires further exploration. The aim of this work was to examine the expression patterns of $p15^{INK4b}$ and SMAD4 in colorectal carcinoma of different ethnic origins. Fifty-five sporadic colorectal carcinoma of Egyptian origin, 25 of which were early onset, and 54 cancers of Finnish origin were immunohistochemically stained with antibodies against $p15^{INK4b}$ and SMAD4 proteins. Data were compared to the methylation status of the $p15^{INK4b}$ gene promotor. $p15^{INK4b}$ was totally lost or deficient (lost in ${\geq}50%$ of tumor cell) in 47/55 (85%) tumors of Egyptian origin as compared to 6/50 (12%) tumors of Finnish origin (p=7e-15). In the Egyptian cases with $p15^{INK4b}$ loss and available $p15^{INK4b}$ promotor methylation status, 89% of cases which lost $p15^{INK4b}$ expression were associated with $p15^{INK4b}$ gene promotor hypermethylation. SMAD4 was lost or deficient in 25/54 (46%) tumors of Egyptian origin and 28/48 (58%) tumors of Finnish origin. 22/54 (41%) Egyptian tumors showed combined loss/deficiency of both $p15^{INK4b}$ and SMAD4, while $p15^{INK4b}$ was selectively lost/deficient with positive SMAD4 expression in 24/54 (44%) tumors. Loss of $p15^{INK4b}$ was associated with older age at presentation (>50 years) in the Egyptian tumors (p=0.04). These data show for the first time that $p15^{INK4b}$ loss of expression marks a subset of colorectal cancers and ethnic origin may play a role in this selection. In a substantial number of cases, the loss was independent of SMAD4 but rather associated with $p15^{INK4b}$ gene promotor hypermethylation and old age which could be related to different environmental exposures.

• 한국미생물·생명공학회지
• /
• 제26권6호
• /
• pp.507-514
• /
• 1998

국내 전통식품인 청국장으로부터 강력한 fibrinolytic activity를 갖는 K-54주를 분리, 동정한 결과 B. subtilis로 확인되었으며 이 균으로부터 강력한 갖는 효소를 정제하였다. 정제도는 약 66.9배 증가하였으며 약 10.1%의 수율을 보였다. B. subtilis K-54에서 분리한 fibrinolytic enzyme의 최적 활성 pH가 8-12사이였으며 50-75$^{\circ}C$사이에서 최적 활성을 보였다. 정제된 효소의 분자량은 약 29 kDa이었고, 등전점은 8.67로 나타났으며 Vmax값은 47.16%, Km값은 0.31(3.1 mg/$m\ell$)였다. N-말단 아미노산 서열 분석 결과 B. subtilis K-54주에서 정제한 fibrinolytic enzyme는 Ala-Gly-Ser-Val-Pro-Try-Gly-Ser이었으며 serine protease저해제인 PMSF에 강력한 활성 저해를 보여 serine protease계열의 효소임을 확인할 수 있었다.

• Korean Journal of Radiology
• /
• 제22권12호
• /
• pp.1996-2005
• /
• 2021

Objective: To investigate the multidetector computed tomography (MDCT) features of fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) with germline or somatic mutations, and compare them with those of papillary type II RCC (pRCC type II). Materials and Methods: A total of 24 patients (mean ± standard deviation, 40.4 ± 14.7 years) with pathologically confirmed FH-deficient RCC (15 with germline and 9 with somatic mutations) and 54 patients (58.6 ± 12.6 years) with pRCC type II were enrolled. The MDCT features were retrospectively reviewed and compared between the two entities and mutation subgroups, and were correlated with the clinicopathological findings. Results: All the lesions were unilateral and single. Compared with pRCC type II, FH-deficient RCC was more prevalent among younger patients (40.4 ± 14.7 vs. 58.6 ± 12.6, p < 0.001) and tended to be larger (8.1 ± 4.1 vs. 5.4 ± 3.2, p = 0.002). Cystic solid patterns were more common in FH-deficient RCC (20/24 vs. 16/54, p < 0.001), with 16 of the 20 (80.0%) cystic solid tumors having showed typical polycystic and thin smooth walls and/or septa, with an eccentric solid component. Lymph node (16/24 vs. 16/54, p = 0.003) and distant (11/24 vs. 3/54, p < 0.001) metastases were more frequent in FH-deficient RCC. FH-deficient RCC and pRCC type II showed similar attenuation in the unenhanced phase. The attenuation in the corticomedullary phase (CMP) (76.3% ± 25.0% vs. 60.2 ± 23.6, p = 0.008) and nephrographic phase (NP) (87.7 ± 20.5, vs. 71.2 ± 23.9, p = 0.004), absolute enhancement in CMP (39.0 ± 24.8 vs. 27.1 ± 22.7, p = 0.001) and NP (50.5 ± 20.5 vs. 38.2 ± 21.9, p = 0.001), and relative enhancement ratio to the renal cortex in CMP (0.35 ± 0.26 vs. 0.24 ± 0.19, p = 0.001) and NP (0.43 ± 0.24 vs. 0.29 ± 0.19, p < 0.001) were significantly higher in FH-deficient RCC. No significant difference was found between the FH germline and somatic mutation subgroups in any of the parameters. Conclusion: The MDCT features of FH-deficient RCC were different from those of pRCC type II, whereas there was no statistical difference between the germline and somatic mutation subgroups. A kidney mass with a cystic solid pattern and metastatic tendency, especially in young patients, should be considered for FH-deficient RCC.

• 한국산학기술학회논문지
• /
• 제18권2호
• /
• pp.277-286
• /
• 2017

본 연구는 간호사의 희망과 감사성향, 일터영성이 조직시민행동정도를 파악하고, 조직시민행동에 미치는 영향요인을 분석하여 바람직한 간호조직문화를 형성 및 증진시켜 간호조직의 효율적이고 경쟁력 있는 인적자원관리방안을 제시하고, 중재방안을 마련하는데 기초자료를 제공하고자 시도되었다. 서울 및 경기도 소재 종합병원 이상의 4개 병원에서 근무하는 간호사 147명을 대상으로 설문조사하였고, 수집된 자료는 SPSS 18.0 프로그램을 이용하여 t-test와 ANOVA, Person's correlation coefficients, multiple stepwise regression으로 분석하였다. 연구결과 간호사의 희망(${\gamma}=.22{\sim}.36$, p<.001), 감사성향(${\gamma}=.38$, p<.001), 일터영성(${\gamma}=.38{\sim}.54$, p<.001), 조직시민행동 간에는 정적 상관관계를 보였다. 또한, 일터영성(${\beta}=.54$, p<.001), 이직희망(${\beta}=.12$, p<.001), 희망(${\beta}=.09$, p<.001), 감사성향(${\beta}=.08$, p<.001)은 조직시민행동에 유의한 영향을 주었으며, 설명력은 41.6%이었다. 본 연구는 간호조직에서 아직 초기단계의 연구가 진행되고 있는 일터영성에 대한 기초이론을 체계화하였고, 간호사의 조직시민행동을 유발시키기 위해 간호사의 희망, 감사성향, 일터영성을 높일 수 있는 다양한 교육 프로그램과 지원 제도가 요구된다.

• Journal of Nutrition and Health
• /
• 제54권1호
• /
• pp.54-66
• /
• 2021

Purpose: Considering the various health benefits of vegetables, it is necessary to identify maternal correlates of vegetable preference and consumption in children for shaping desirable vegetable-related eating habits. This study aimed to investigate the maternal factors related to vegetable preferences and consumption in preschool-aged children. Methods: This is a cross-sectional study that surveyed 303 mother-child pairs (146 boys, 157 girls) to explore general characteristics, vegetable preferences, and cooked vegetable consumption in mothers and children using a questionnaire method. Maternal correlates of the child's vegetable preference and consumption were tested using a generalized linear model using SAS program. Results: Mothers' vegetable preferences and consumption were significantly higher than those in their children (p < 0.001). Mothers' vegetable preferences showed a significant positive correlation with the vegetable preferences of their children (mother-son, p < 0.001; mother-daughter, p < 0.001). Additionally, mothers' cooked vegetable consumption showed a significant positive correlation with the cooked vegetable consumption of children (mother-son, p < 0.001; mother-daughter, p < 0.001). Mothers' vegetable preferences and consumption respectively increased those of their children, in both boys and girls. Conclusion: Findings that mothers' vegetable preference and consumption correlates of children's vegetable preferences and consumption, indicate the importance of the mothers' role in increasing vegetable consumption in children. Mothers should be aware of the effects of their vegetable eating habits on their children's vegetable consumption and try to develop healthy eating habits. We suggest that the government or local communities provide nutrition education for mothers to adopt healthy eating habits and present information to educate their children on food and healthy dietary habits.

• Clinical and Experimental Pediatrics
• /
• 제59권2호
• /
• pp.54-58
• /
• 2016

Purpose: We evaluated the characteristics of patients with Kawasaki disease (KD) who presented with only fever and cervical lymphadenopathy on admission, and compared them with the characteristics of those who presented with typical features but no cervical lymphadenopathy. Methods: We enrolled 98 patients diagnosed with KD. Thirteen patients had only fever and cervical lymphadenopathy on the day of admission (group 1), 31 had typical features with cervical lymphadenopathy (group 2), and 54 had typical features without cervical lymphadenopathy (group 3). Results: The mean age ($4.3{\pm}2.1$ years) and duration of fever ($7.5{\pm}3.6$ days) before the first intravenous immunoglobulin (IVIG) administration were highest in group 1 (P=0.001). Moreover, this group showed higher white blood cell and neutrophil counts, and lower lymphocyte counts after the first IVIG administration as compared to the other groups (P =0.001, P =0.001, and P =0.003, respectively). Group 1 also had a longer duration of hospitalization and higher frequency of second-line treatment as compared to groups 2 and 3 (group 1 vs. group 2, P =0.000 and P =0.024; group 1 vs. group 3, P =0.000 and P =0.007). A coronary artery z score of >2.5 was frequently observed in group 1 than in group 3 (P = 0.008). Conclusion: KD should be suspected in children who are unresponsive to antibiotics and have prolonged fever and cervical lymphadenopathy, which indicates that KD is associated with the likelihood of requiring second-line treatment and risk of developing coronary artery dilatation.

• 한국어류학회지
• /
• 제12권1호
• /
• pp.14-19
• /
• 2000

한국산 가시고기 (Pungitius sinensis)와 잔가시고기 (P. kaibarae) 사이의 관계를 밝히기 위하여 18s 리보좀 DNA 두 단편의 염기서열을 분석하였다. G+C pair의 비율은 잔가시고기의 개체군에서 54.85~55.15%, 가시고기에서 52.76%로 나타났다. 잔가시고기 개체군들 사이의 염기치환수는 10~18개, 가시고기와 잔가시고기 사이의 염기치환수는 165개였다. 거리지수의 값은 잔가시고기의 개체군들 사이는 0.0118~0.0195, 가시고기와 잔가시고기 개체군 사이는 0.2136~0.2306으로 나타났다. 이를 개체군간 염기서열의 분석 결과는 잔가시고기와 가시고기가 종수준으로 분화한 것을 보여주었다.

• Kyungpook Mathematical Journal
• /
• 제54권2호
• /
• pp.173-188
• /
• 2014

In this paper, a new class of open sets, namely ${\gamma}^*$-pre-open sets was introduced and its basic properties were studied. Moreover a new type of topology ${\tau}_{{\gamma}p^*}$ was generated using ${\gamma}^*$-pre-open sets and characterized the resultant topological space (X, ${\tau}_{{\gamma}p^*}$) as ${\gamma}^*$-pre-$T_{\frac{1}{2}}$ space.