• 약학회지
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• 제14권3_4호
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• pp.45-50
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• 1970

Anti-infalmmatory action of p-methoxycinnamic acid (p-MCA) was investigated. p-MCA showed a significant decrease in carrageenin and acetic acid induced edema of the rat hind paw, and increased capillary permeability by anaphylaxis and chemical mediators of pontamine sky blue in the mouse peritoneal cavity. It, however, showed only weak inhibitory effect on cotton pellet-induced granuloma formation of the rat.

• 생약학회지
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• 제38권1호
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• pp.15-18
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• 2007

Scrophulariae Radix(Scrophulariaceae) is a perennial growing in all parts of korea, China and Asia. It has been used as a folk medicine in treating guttural diseases acting as an antiphlogistics, antipyretics and analgesics. In this report, to compare with Korea and China product, quantitative analysis of harpagoside and p-methoxy cinnamic acid(4-MCA) was performed by HPLC method. Using a Luna $C_{18}(2)$ column, we carried out quantitative analysis with 0.1% phosphoric acid in water and acetonitrile as gradient condition. Harpagoside and 4-MCA were detected at retention time of about 11.5 and 15.0 min, respectively. Contents of harpagoside and 4-MCA proved that Korean products were higher than China more than twice.