• BMB Reports
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• v.47 no.3
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• pp.167-172
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• 2014

Reactivating the p53 pathway in tumors is an important strategy for anticancer therapy. In response to diverse cellular stresses, the tumor suppressor p53 mediates apoptosis in a transcription-independent and transcription-dependent manner. Although extensive studies have focused on the transcription-dependent apoptotic pathway of p53, the transcription-independent apoptotic pathway of p53 has only recently been discovered. Molecular interactions between p53 and Bcl-2 family proteins in the mitochondria play an essential role in the transcription-independent apoptosis of p53. This review describes the structural basis for the transcription-independent apoptotic pathway of p53 and discusses its potential application to anticancer therapy.

• Journal of the Korean Data and Information Science Society
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• v.19 no.3
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• pp.967-977
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• 2008

We consider densities of quotient Y/X and ratio X/(X+Y), and estimation of reliability P(Y

• Journal of the Korean Data and Information Science Society
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• v.18 no.3
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• pp.783-792
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• 2007

We consider estimation of reliability P(Y

• Journal of Korean Academy of Nursing
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• v.23 no.3
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• pp.397-416
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• 1993

This study identified the relationships between the hospital’s organizational pattern for nursing, the organizational characteristics perceived by nurses and their job satisfaction. The study subjects were a convenience sample of 383 staff nurses working at 10 general hospitals with more than 300 beds in Seoul. Hospitals included in the study were classified Into five organizational patterns, where nursing was organized as an independent but lower level, attached to the medical department, attached to a department supporting medicine, and various other organizational pattern. The data were collected from July 10 to August 15, 1992. The organizational characteristics as perceived by the staff nurses were measured by Park & Yoon’s Scale (1986) and job satisfaction was measured by Slavitt’s Scale (1978). The data were analyzed by percentage distribution, Pearson’s correlation, x$^2$-test, t-test, ANOVA, and ANCOVA The summarized results are as follows : 1. The proportion of independent and attached nursing organizational patterns was 35.1％ and 54.9％ respectively. 2. There were differences between four general characteristics of the nurses, age, experience, position and education level, and the five structural types of nursing organization(p〈.05). 3. 1) There were no relationship between the perceived organizational characteristics and general characteristics of the nurses but there was a differ once in job satisfaction according to education level of nurses in hopitals where nursing was an independent department(T=-2.24, p〈.05). 2) There were differences in the perceived organizational characteristics according to age group and experience of nurses (F=3.26, 5.41, p〈 , 05)and in job satisfaction according to the position of nurses in the independent but lower level organizational pattern (T=2.26, p〈.05). 3) There was a difference in the perceived organizational characteristics according to age group (F=3.19, p〈 .05) and in job satisfaction according to the experience of nurses where nursing was attached to the medical department (F=3.49, p〈.05). 4) There was a difference in the perceived organizational characteristics according to nursing unit (F=3.19, p〈 .05), but none between job satis-faction and general characteristics of nurses where nursing was attached to a departiment supporting medicine. 5) There were no relationships between the perceived organizational characteristics and job sat isfaction and general characteristics of nurses in the various other organizational patterns. 4. Nurses in hospitals where nursing is organizationed as an independent department perceived their organizatianal pattern more positively and had higher job satisfaction than nurses working in hospitals where nursing is part of another department. 5. There were differences between perceived organizational characteristics and job satisfaction according to the organizational patterns for nursing (F=13.52, 8.76, p=.0000). 6. There were correlations between the perceived organizational characteristics and job satisfaction of nurses working in two independent nursing departments (r=0.2180, 2351, p〈.05). In conclusion, the relationship between perceived organizational characteristics and job satisfaction was significantly correlated in the hospitals where the nursing department is independent. Perceived organizational characteristics and job satisfaction depended on whether the nursing department is independent from or attached to other departments in the hospital. For nurses job satisfaction the nursing department should be independent from other departments and at the highest level of organization in the hospital.

• Journal of the Chungcheong Mathematical Society
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• v.26 no.4
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• pp.743-748
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• 2013

The purpose of this note is to introduce interesting and useful properties differential-basis and p-basis in theorem 3.3. The result gives a existence differential basis of $S^P$ [$[{\Lambda}_1]$](S) which has a p-basis over $S^p$ ($S^p[{\Lambda}_1]$).

• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.360-360
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• 1998

C11, a chloride-containing VK3 analog, acts as a mediator of programmed cell death in SK-Hep-1 cell lines, but its molecular mechanisms linked to cell death are not understood. In this study, we investigated the expression of p21 gene and its relationship to apoptosis induced by C11. In SK -hep-1 cells, the addition of C11 resulted in time-dependent growth suppression and DNA fragmentation characteristics of apoptosis. p21 protein was induced during this process, while the protein level of p53 was not changed at the same condition. This apoptotic cell death with p21 induction was also observed in the Hep3B cells lacking functional p53 after treatment of C11. These results suggest that C11-induced apoptosis is associated with up-regulation of p21 protein in p53-independent pathway. Next, in order to confirm whether the p53-independent p21 induction is required for C11-induced apoptosis, we introduced the p21 gene into Hep3B. Overexpression of p21 did not affect the expression of the bcl-2 gene, but DNA fragmentation and PARa cleavage were significantly increased. These data indicate that p21 is involved in C11-induced apoptosis. Although Bcl-2 has been implicated to interfere with an essential signaling molecule involved in the apoptosis pathway, its molecular mechanism and target molecule are poorly understood. To determine the effects of bcl-2 overexpression on apoptosis and to investigate whether BcI-2 interfers with the p53-independent p21 pathway, we transfected the bcl-2 expression vector into SK - Hep-1 cels. Overexpression of Bcl-2 prevented C11-induced apoptosis. Taken together, C11-induced apoptosis is regulated by p52-independent p21 pathway and bcl-2 may inhibit functional activity of p21, therebe may inhibit the C11-induced apoptosis.ptosis.

• Journal of Nutrition and Health
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• v.38 no.2
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• pp.173-179
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• 2005

The study estimated employee satisfaction to apply TQM system to hospital foodservice management. A survey was mailed to foodservice employees of five general hospitals with more than 300 beds, three of them were independent and two of them were contract foodservice management. A total of 129 questionnaires were returned and analyzed for statistical analysis. Statistical analysis was completed using SPSS for chi-square test, t-test and Pearson's correlation. The results of this study showed that employees of contract foodservice presented higher scores than independent foodservice in interests, affection, importance of works. And achievement of work was significantly different between contract and independent foodservice employees (p < 0.05). The satisfaction of payment adequacy was lower for contract foodservice employees (p < 0.05). The employees of both contract and independent foodservice were satisfied with attitude of foodservice managers toward employee. Attitude scores of foodservice employees toward co-worker were higher in independent foodservice. Employees of independent foodservice showed higher scores for the attitude toward institution represented satisfaction. (Korean J Nutrition 38(2): 173～179, 2005)

• Bulletin of the Korean Mathematical Society
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• v.37 no.2
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• pp.255-263
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• 2000

Let ${X_{nk}}, u_n\; \leq \;k \leq \;u_n,\; n\; \geq\; 1}$ be an array of rowwise independent, but not necessarily identically distributed, random variables with $EX_{nk}$=0 for all k and n. In this paper, we povide a domination condition under which ${\sum^{u_n}}_=u_n\; S_{nk}/n^{1/p},\; 1\; \leq\; p\;<2$ converges completely to zero.

• Structural Engineering and Mechanics
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• v.54 no.6
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• pp.1201-1216
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• 2015

This paper presents the details of size independent fracture energy and bi-linear tension softening relation for nano modified high strength concrete. Nano silica in powder form has been used as partial replacement of cement by 2 wt%. Two popular methods, namely, simplified boundary effect method of Karihaloo et al. (2003) and RILEM (1985) fracture energy with P-${\delta}$ tail correction have been employed for estimation of size independent fracture energy for nano modified high strength concrete (compressive strength ranges from 55 MPa to 72 MPa). It is found that both the methods gave nearly same values, which is an additional evidence that either of them can be employed for determination of size independent fracture energy. Bi-linear tension softening relation corresponding to their size independent fracture energy has been constructed in an inverse manner based on the concept of non-linear hinge from the load-crack mouth opening plots of notched three-point bend beams.

• Journal of Families and Better Life
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• v.8 no.2
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• pp.31-47
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• 1990

The purpose of this paper is to investigate the relationship between the married people's conflict level and coping behavior, and find out how independent variables(male or female, age, level of education, family income, religion, types of marriage, types of family) have an effect on two dependent variables. The research problems as follows: 1) How independent variables influence on the level of conflict. 2) How independent variables influence on the coping behavior 3) How related the level of conflict and th coping behavior. Two instruments wee administrated to 302 married man and woman in Seoul, in June, 1990 The first instrument, 25 items questionnaire, made by investigator, was developed based upon Lee Sun and Moon Sung Sun. The second instrument, 20 item questionnaire, based upon filed , and modified to be appropriate to Korean Culture, Data was analyzed by frequency, percentage, mean, t-test, F-test and pearson r. The results are summarized as follows; 1) Most husbands and wives how the middle level of conflict 2) Among independent variables, male or female(p<.05), level of education (p<.05), types of family (p<.05), were variables to have influence on the level of conflict. 3) Husbands and wives's coping behavior are relatively middle level. 4) Among independent variables, types of marriage(p<.05) was variable to have influence on the coping behavior. 5) There were very low positive correlation (r=.15, p<.01) between the level of conflict and the negative coping behavior, and very low negative correlation(r=-.21, p<.001) between the level of conflict and the positive coping behavior. Form this results, more objective methods and research are needed to develop the style of conflict and the coping behavior.