• 대한본초학회지
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• 제24권2호
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• pp.57-65
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• 2009

Objectives : This study was aimed to developing Korean herbalogy of the plants belonging to Aspidiaceae in Korea. Methods : The herbological books and papers published at home and abroad were researched. The total list of Aspidiaceae was made and Medicinal plants in Aspidiaceae was classified. The medicinal properties, action and applications of medicinal plants were investigated. Results : 1. There are totaled to 17 genera and 130 species in Aspidiaceae in Korea and among them medicinal plants are 11 genera, 31 species, some 24% in total. 2. Athyrium genus is main kind enough that it has 32 species among 130 species in Aspidiaceae, and medicinal plants of Dryopteris is 4 species. 3. The rhizome is the main medicinal parts if medicinal plants in the Aspidiaceae, which is used in 24 species. 4. According to nature and flavor of medicinal plants in the Aspidiaceae, they were classified into cool 15 and cold 8 species ; bitter taste 19, and little bitter taste 15 in the order. 5. According to meridian propism of medicinal plants in the Aspidiaceae, they were classified into liver meridian 5 species, stomach meridian 3 species. 6. According to the properties and principal curative action, they were classified into drugs for clearing away heat 25 species, drugs for detoxification 22 species, drugs for promoting diuresis 16 species in the order. 7. The number of toxic species in the Aspidiaceae was examined to be 5 species. Conclusions : There are totaled to 17 genera and 130 species in Aspidiaceae in Korea and among them medicinal plants are 11 genera, 31 species, some 24% in total. They were classified into drugs for clearing away heat, drugs for detoxification, drugs for promoting diuresisr.

• Journal of Applied Biological Chemistry
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• 제43권1호
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• pp.54-58
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• 2000

Methanol extracts of 27 Brazilian plant samples and 10 oriental medicinal plant samples (27 families), using spectrophotometric and paper disc agar diffusion methods under anaerobic conditions, were tested in vitro for their growth-inhibiting activities against Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium adolescentis, Clostridium perfringens, and Bacteroides fragilis. The responses varied with bacterial strains, plant species, and tissues sampled. In a test with B. longum and B. bifidum(20 mg/disc), extracts of Acanthopanax sessilifolinus stem bark and Ampelozizyphus amazonicus leaves strongly inhibited the growth of B. longum, whereas other plant samples did not inhibit any intestinal bacteria tested. At 5 mg/disc, adding extracts of Aralia eleta, Euterpe oleracea, and Syzygium guineense to the media strongly inhibited the growth of C. perfringens and B. fragilis without growth inhibition of B. adolescentis, B. longum, and B. bifidum. Extracts of Jacaranda mimosifolia and Ulmus paraifolia significantly inhibited the growth of C. perfringens and B. fragilis as well as B. adolescentis. These results may be indications of at least one of the pharmacological actions of the five Brazilian plants but not oriental medicinal plants tested.

• 동의생리병리학회지
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• 제18권4호
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• pp.1078-1082
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• 2004

The purpose of this study was to investigate the possibility of medicinal plants application as an edible functional food resources. We carried out to develop a traditional functional beverage by using hot-water extraction of 4 medicinal plants(Polygonatun sibiricum, Ophiopogonis radix, Lycii fructus, Schizandriae fructus) and we examined the effects of drink on physiological function in aorta relaxation. Thus, the effect of developed beverage on phenylephrine induced contraction of isolated rat thoracic aorta. Contractile force was measured with force displacement transducer under 1.5g loading tension. Brix, pH and titratable acidity of developed drink were 9.5%, 3.3 and 0.22%. The approximate nutritional composition of beverage was carbohydrate, 5.98%, crude protein, 0.70%, crude fat, 0.20% and crude ash, 0.20%. Developed beverage contained K(4.00 ㎎%), Na(3.68 ㎎%), Ca(2.54 ㎎%), Mg(1.60 ㎎%) and Fe(0.29㎎%). The contraction forces by injection of phenylephrine in isolated thoracic aorta were significantly low in each experimental groups compared with control groups, These results that developed drink with medicinal plants can be used as a functional material to decrease aorta contraction.

• 생약학회지
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• 제30권2호
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• pp.211-215
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• 1999

This study was aimed to evaluate an agonistic activity to benzodiazepine receptor of several medicinal plants, which have been used as sedatives in oriental medicine. Methanol extracts of medicinal plants which were used in this study inhibited the binding of $[^3H]Ro15-1788$, a selective benzodiazepine receptor antagonist to benzodiazepine receptor of rat cortices. Inhibitory activity of Cyperus rotundus was observed to be the highest among the tested medicinal plants. Methanol extracts of Cyperus rotundus and Zizypus jujuba inhibited a $[^3H]flunitrazepam$, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. GABA significantly enhanced the inhibition of $[3H]flunitrazepam$ binding by Cyperus rotundus and Zizypus jujuba, and these positive GABA shifts supported the strong possibility of agonistic activity to benzodiazepine receptor. From these results, it may be concluded that the substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may be important components and contribute to the sedative property of these medicinal plants.

• 대한본초학회지
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• 제27권3호
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• pp.57-65
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• 2012

Objective : For the purpose of developing Korean herbology of the plants to Polyporaceae in Korea, the literatures of the successive generations have been thoroughly investigated to prepare this article. Methods : The examined herbological books and research paper which published domestically and abroad. Results : 1. Polyporacease plants (raised in Korea) are devided into 31 classes with 59 species. Among them, 26 species in 19 classes were found serviceable, which indicates 44 % of all Polyporacease plants. 2. Among those 59 species, $Coriolus$ $Phellinus$ $Trametes$ includes 5 species. $Ganoderma$, a medicinal plant, includes 3 species. 3. Dividing the serviceable plants of Polyporacease, the fruit body family had the largest number; 25. 4. Out of plants Polyporacease, neutral taste plants was 17 species and sweet taste was 14 species. 5. Only 8 species of Polyporaceae plants were found to enterd into the spleen and heart. 6. 11 species were found to prevent cancer, 7 species were found to dispel wind-dampness and Alleviate edem antittusive and antasth matic. 7. There were no toxic species in the Plyporaceae. Conclusion : There were totaled to 31 genera and 59 species in Polyporaceae in Korea and among them medicinal plants are 19genera, 26 species, some 44% in total.

• Plant Resources
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• 제6권3호
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• pp.205-210
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• 2003

Ginseng(Panax ginseng C.A. Meyer) is a perennial herbaceous plant which grows very slowly. It takes about 3 to 4 years from seeding to collecting the ripe seeds and the ginseng propagation is very difficult. and so, it is very difficult to breed ginseng plant. Ginseng tissue culture was started from at 1960, and ginseng commercial product by in vitro callus culture was saled, however upto now, regenerants were not planted to soil normally. Recently, plant genetic engineering to produce transgenic plants by introducing useful genes has been advanced greatly. In a present paper, transformation of ginseng plants was achieved by co-cultivation with Agrobacterium harboring the binary vector coding Proteinase-II gene, which confer resistant or tolerant to insect pests, The binary vector for transformation was constructed with disarmed Ti-plasmid and with double 35S promoter. The NPT II gene and introduced genes of the transgenic ginseng plants were successfully identified by the PCR. Especially the transgenic ginseng plants were regenerated using new techniques such as repetitive single somatic embryogenesis.

• Plant Biotechnology Reports
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• 제4권3호
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• pp.223-228
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• 2010

Schizonepeta tenuifolia (Korean name "Hyung- Gae") is an oriental medicinal plant that is widely used in Korea, China and Japan. S. tenuifolia (Hyung-Gae) has many pharmacological activities and is mostly used for many medicinal preparations. The dried aerial part (spikes and stems) of three oriental medicinal plants, S. tenuifolia (Hyung-Gae), Agastache rugosa (Kwhak-Hyang) and Elsholtzia ciliata (Hyang-Yoo) belonging to the same family, mint family Labiaceae, have such similar shape and smell that it is difficult to differentiate between them. The trnL-F regions of chloroplast DNA of the three medicinal plants were sequenced and used as targets in multiplex PCR reaction to identify S. tenuifolia. After alignment of trnL-F sequences of the authenticated plant samples, one single nucleotide polymorphism (SNP) specific to S. tenuifolia was found. Based on this SNP, a new primer was designed that specifically amplifies the trnL-F region of S. tenuifolia. The established multiplex-PCR was proven to be effective in the differentiation of commercial S. tenuifolia samples from A. rugosa and E. ciliata. This rapid and accurate molecular method is highly promising for use in the food industry.

• 대한한방내과학회지
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• 제17권1호
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• pp.204-209
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• 1996

Several medicinal Plants in Jeonbuk are screened for the contraction or relaxation to the acetylcholine and histamine induced contraction in the isolated rat and guinea pig's trachea smooth muscle. Contractions evoked by acetylcholine and histamine were inhibited by Flos Farfarae, Poria and Rhizoma alismatis, but contractions were increased Tuber Pinelliae, Herba Chelidonii, Fructus Qusqualis, Radix Asari, Semen Perillae, Folium Artemisiae and Fructus Schizamdrae increased the contractions evoked by acetylcholine and histamine. Radix Puerariae, Radix Osterici Koreani, Rhizoma Zingiberis siccatum, Radix Sanguisorbae, Rhizoma Atractylodis, Fructus gardeniae and Cortex Magnoliae did not effect the contractions evoked by acetylcholine and histamine.

• 한국약용작물학회지
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• 제11권4호
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• pp.264-267
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• 2003

Korean medicinal plants were screened for their inhibitory activity against HIV-1 protease. The inhibitory activity of protease was determined by incubating the extracts in reaction mixtures containing protease and substrate $His-Lys-Ala-Arg-Val-Leu-(p-NO_{2}-Phe)-Glu-Ala-Nle-Ser-NH_{2}$ to perform proteolytic cleavage reactions. In this study the twenty six extracts from medicinal plants were investigated. Of the extracts tested, the extracts from the stem of Morus alba. exhibited the strongest activity with inhibition of 81% at a concentration of $100{\mu}g/ml$. The extracts of the flower of Saxjfraga stolonifera, and stems of Euonymus japonica and Castanea crenata showed appreciable inhibitory activity (>50%) against HIV-1 protease at same concentration.

• KSBB Journal
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• 제22권3호
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• pp.139-145
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• 2007

암에 효능을 보이는 생리활성소재의 탐색원을 발굴하기 위한 방법의 하나로 동양의학 데이터베이스의 처방정보를 활용하였다. 신동의약보감에 포함되어 있는 170건의 암 처방 천연약재의 처방빈도와 처방분량을 분석하였다. 처방순위와 처방 분량에 따라 마련된 점수표 (score table)를 기준으로 총처방점수 (total prescription score)를 작성하였다. 선행연구 결과들을 조사한 결과 총처방점수가 높은 약재들을 소재로 한 관련 보고들이 많은 것으로 나타났다. 결과적으로 당귀, 황기, 감초, 반하, 백출, 진피, 인삼, 백작약, 대황, 천궁, 지모, 천남성, 오미자, 형개, 흑축, 방기, 복령, 오수유 등이 암에 효과가 있으며 이들 약재를 이용한 항암 소재의 탐색이 제안되었다.