• 동의생리병리학회지
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• 제20권4호
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• pp.1014-1020
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• 2006

This study was intended to examine the effects of electroacupuncture(EA) and therapeutic exercise on the improvement of exercise function, BNDF, and HSP70 protein expression in an ischemic stroke model induced by MCA occlusion. Experiments were conducted for 1, 3 days, 1, 8 weeks respectively. Group I was a group of EA and therapeutic exercise; Group II was a group of therapeutic exercise; Group III was a group of EA; Group IV was a sham group of EA; Group V was a control group; and Group VI was a sham group without ischemic stroke. In each group, neurologic motor behavior test, histologic observations, BDNF, and HSP70 expression were observed and analyzed. The following results were obtained. The results of behavior test suggest that 8 weeks after ischemic stroke was induced, Group I improved in degeneration and inflammation of muscle fiber and decreased in destruction of nerve cells and cerebral infarction, indicating a similar state of muscle fiber and brain to Group VI. In immunohistochemical observations, Group I showed increase in BDNF and decrease in HSP70. Based on these results, EA and therapeutic exercise may improve muscle atrophy and change in BDNF and HSP70 expression of ischemic stroke rats and contribute to the improvement of exercise function.

• 사상체질의학회지
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• 제20권3호
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• pp.70-81
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• 2008

1. Objective Recently we have known 'First Impression' is the major factor to check the review point for the classification of sasangin. And we want to find out the objected data contribute to dignosis of female sasang constitution using Sasangins Face. 2. Methods We analysed the datum collected by multi-center researchers in 2007-2008. And this study analysed the datum of the measurement of the face by 3D-AFRA (3-Dimensional Automatic Face Recognition Apparatus) and the items of impression by SDQ. We used chi-square test to define the relationship between the item and sasang constitutions. We used independent samples t - test with classifying measuring variables of the face. 3. Results and Conclusion We put out specific female sasangin's constitutional measuring variables of face. The measuring variables of count is Taeyangin 30point, Soyangin 15point, Taeumin 32point, Soeumin 21point. There is the need to accumulate more accurate pictures about sasangin's external shape.

• 한방안이비인후피부과학회지
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• 제15권2호
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• pp.210-219
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• 2002

Background and Objectives The diagnosis of allergic rhinitis includes detailed clinical history, physical examination and the use of either in vivo or vitro tests for relevant allergens. Skin test has been used the most commonly. Recently MAST CLA is used for determination of serum spcecific IgE, This study attempted to find out the distribution of Sasang Constitution and to compare the MAST CLA with skin tests in allergic rhinitis patients. Methods Skin tests, MAST CLA and Sasang Constitution study were performed for 35 allergic rhinitis patients who visited Kyunghee Oriental Medical Center from Sept. 2001 to Nov. 2001. Results 1. The ratio between male and female was 1:1.5. the peak age was the thirties(42.9$\%$) 2. 45.7$\%$ of patients had family history of allergic diseases and allergic rhinitis was the most common. 3. 51.4$\%$ of patients lived in A.P.T. and in preference of cool and warm, 54.3$\%$ of patients prefered both of cool and warm. 4. Among 24 cases who were consulted to dept. of Sasang, 45.8$\%$ was Taeumin. 5. 65.7$\%$ of patients reacted positive to skin test and the common offending allergen was D. pteronyssinus(82.6$\%$). 6. 25.7$\%$ of patients reacted positive to MAST CLA and the common offending allergen was D. farinae(88.9$\%$). 7. Among 22 cases who was performed skin test and MAST CLA the sensivity and specificity of MAST CLA was 27.4$\%$ and 94.9$\%$. There was significant correlations between MAST CLA and skin test(p=0.005, r=0.574, 1, spearman correlation coefficienct).

• 한방안이비인후피부과학회지
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• 제24권2호
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• pp.68-78
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• 2011

Objective : The purpose of this clinical research was to investigate the effects of herbal cosmetics containing Momordica charntia L. extracts on the anti-wrinkle and whitening effects. Methods : A total of 25 subjects who visited Daegu Hanny Oriental Medical Center from November 1st, 2010 to December 31th, 2010 were included in this study. In this study, we observed change of R1, R2, R3, R4, R5 for using products, change of average melanin content and pigmental area, analysis results of subjective wrinkle improvement, Analysis results of subjective whitening improvement. Statistical analysis was performed by using paired t-test and wilcoxon signed ranks test. Statistical significance was achieved if the probability was less than 5%(p<0.05) Results : Statistically, herbal cosmetics containing Momordica charntia L. extracts showed siginificant effect on change of R1, R2, R3, R4, R5 for using products, change of average melanin content and pigmental area, analysis results of subjective wrinkle improvement, Analysis results of subjective whitening improvement(p<0.05). And satisfaction after using herbal cosmetics was near good. Conclusions : Considering the above results, we have concluded that herbal cosmetics containing Momordica charntia L. extracts have the remarkable effects on the anti-wrinkle and whitening effects.

• 동의생리병리학회지
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• 제32권6호
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• pp.411-417
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• 2018

Last year, the elderly population aged 65 years and over exceeded 14.2 percent of the total population, and Korea has entered the ageing society. At the same time, social interest in improving the health level and quality of life in the elderly has also increased. In particular, pain is one of the most common diseases experienced by middle-aged and elderly people and is one of the factors that closely affect the quality of life. The purpose of this study was to analyze the factors affecting the pain level and pain region of Korean medicine users and the use of Korean medicine in the Korean middle aged and elderly using the 6th Korean Longitudinal Study of Ageing (KLoSA) panel. As a result, the main influencing factors of Korean medical care were subjective factors such as gender, subjective health status, and education level. In particular, half of the middle-aged and elderly who used Korean medicine experienced back and knee pain, and generally complained of low level of pain. This study suggests the need for research and development of Korean medicine that can control and relieve the pain of the middle-aged and elderly.

• Biomolecules & Therapeutics
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• 제27권1호
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• pp.107-116
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• 2019

The global obesity epidemic and associated metabolic diseases require alternative biological targets for new therapeutic strategies. In this study, we show that a phytochemical sulfuretin suppressed adipocyte differentiation of preadipocytes and administration of sulfuretin to high fat diet-fed obese mice prevented obesity and increased insulin sensitivity. These effects were associated with a suppressed expression of inflammatory markers, induced expression of adiponectin, and increased levels of phosphorylated ERK and AKT. To elucidate the molecular mechanism of sulfuretin in adipocytes, we performed microarray analysis and identified activating transcription factor 3 (Atf3) as a sulfuretin-responsive gene. Sulfuretin elevated Atf3 mRNA and protein levels in white adipose tissue and adipocytes. Consistently, deficiency of Atf3 promoted lipid accumulation and the expression of adipocyte markers. Sulfuretin's but not resveratrol's anti-adipogenic effects were diminished in Atf3 deficient cells, indicating that Atf3 is an essential factor in the effects of sulfuretin. These results highlight the usefulness of sulfuretin as a new anti-obesity intervention for the prevention of obesity and its associated metabolic diseases.

• 한방재활의학과학회지
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• 제31권4호
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• pp.1-11
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• 2021

Objectives Hwanggeumjakyak-tang (HJT) has traditionally been used to treat gastrointestinal inflammatory diseases; however, its protective effects against neuronal inflammation are still undiscovered. Methods We investigated the anti-neuroinflammatory effects of HJT water extract on lipopolysaccharide (LPS)-stimulated BV2 mouse microglia cells. BV2 cells were treated with LPS (1 ㎍/mL) 1 hour prior to the addition of HJT. We measured cell viability using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and nitrite production using the Griess assay. We performed a reverse transcription-polymerase chain reaction assay to measure messenger RNA expression of inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. Western blot analysis was performed to determine protein expression of mitogen-activated protein kinases (MAPKs) and inhibitor of nuclear factor kappa B (NF-κB)α. Results HJT inhibited excessive nitrite release in LPS-stimulated BV2 cells and also significantly inhibited inflammatory cytokines such as IL-1β, IL-6, and TNF-α in LPS-stimulated BV2 cells. Moreover, HJT significantly suppressed LPS-induced MAPK and NF-κB activation and inhibited the elevation of IL-1β, IL-6, and TNF-α in the brain of LPS-injected mice. Conclusions Our study highlights the anti-neuroinflammatory effects of HJT via MAPK and NF-κB deactivation.

• 대한본초학회지
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• 제34권1호
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• pp.33-42
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• 2019

Objectives : This study aimed to be used as basic data for obtaining excellent quality of Salvia miltiorrhiza (SM) root. Methods : SM cultivated in Anhui Bozou, Henan, Shandong, Henan Wenxian, Zhejiang, Hebei, Liaoning, Shanxi, Shaanxi Shangluo, Sichuan Zhongjiang, Sichuan Minyang and Jiangsu in China were gathered and its internal morphology and physicochemical patterns were analyzed. Results : Cross-section of sang plants according to cultivated regions in China showed that cork layers consisted of cells with four to six layers, cortex width was wide, and phloem was semilunar-shaped. Although there are forms layers, yet boundary was vague. It was observed that eight to ten vascular bundles were arranged in wooden parts in all directions and as a single line of vascular was distributed nearby form layers as it nears to the center. Tanshinon IIA identified a spot in the same location with standard product near by Rf 0.9 in the test identifying TLC of SM according to cultivated areas in China. The largest amount was 0.535% identified in Shandong and the lowest amount of 0.05% in Hebei. Salvianolic acid B identified a spot in the same location with standard product near by Rf 0.7 in the test identifying TLC of SM according to cultivated areas in China. The largest amount was 2.72% identified in Liaoning and the lowest amount of 0.825% in Jiangsu. Conclusions : The results are assumed to be used as basic data for obtaining excellent quality of SM oriental medical hers and distinguishing authentic or fake herbs.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 추계학술대회
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• pp.167-169
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• 2021

충청남도 도서지역에 주민들이 정기적으로 이용할 수 있는 공공의료시설은 보건진료소 14개, 건강생활지원센터 1개, 병원선 1척이 전부이며, 이러한 시설과 장비로는 중증외상, 뇌혈관·심혈관 질환 등의 응급환자 발생 시 효과적으로 대응할 수 없다. 가장 신속한 응급환자 이송 수단은 단국대학교병원(천안시 소재)에 배치된 닥터헬기를 이용하는 것이다. 그러나 배치된 닥터헬기는 1대 뿐이고, 야간에는 운항을 할 수 없으며, 충청남도 전 지역을 담당하므로 다수 환자 발생 시에는 신속한 이송에 한계가 있다. 따라서 4차 산업의 한 분야인 도심 항공 모빌리티(UAM) 산업과 도서지역 응급환자 이송체계의 문제점을 보완하는 '충남형 닥터UAM 개발'의 필요성을 검토하고자 한다.

• 동의생리병리학회지
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• 제24권5호
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• pp.727-736
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• 2010

This study is about researching mechanistic pattern identification of disease for DongEuiBoGam NaeGyungPyen by analysing with pattern identification of modern Traditional Korean medical patholgy as more logical, systematic and standardized theory. Disease pattern mechanisms of uterine, urine and excrements parts of DongEuiBoGam NaeGyun gPyen in NaeGyungPyen of DongEuiBoGam are these. Menstrual irregularities in DongEuiBoGam can be classified flui d-humor depletion, blood deficiency, qi deficiency, qi stagnation, qi stagnation complicated by heat, blood stasis, blood deficiency complicated by heat, syndrome of heat entering blood chamber, syndrome of cold entering blood chamber. The disease pattern of abdominal pain after menstruation in DongEuiBoGam is blood deficiency complicated by heat, and a dysmenorrhea represents blood stasis with heat, fluid-humor deficiency. Advanced menstruation represent dual heat of the qi and blood, delayed menstruation is blood deficiency. The disease pattern of inhibited urination in DongEuiBoGam can be classified deficiency heat pattern of kidney yin deficiency(yin deficiency with effulgent fire), kidney qi deficiency, yin deficiency with yang hyperactivity, fluid-humor depletion, spleen-stomach dual deficiency, and excess he at pattern of bladder excess heat. The disease pattern of urinary incontinence in DongEuiBoGam can be classified deficiency pattern of kidney-bladder qi deficiency, consumptive disease, lung qi deficiency, kidney yin deficiency(yin deficiency with effulgent fire), kidney yang deficiency and excess pattern of lower energizer blood amassment, bladder excess heat. And most of them are deficiency from deficiency-excess Pattern Identification. The disease pattern of diarrhea in DongEuiBoGam can be classified deficiency pattern of qi deficiency, qi fall, spleen yang deficiency, kidney yang deficiency and so on and excess pattern of wind-cold-summerheat-dampness-fire, phlegm-fluid retention, dietary irregularities, qi movement stagnation. And most of them are deficiency from deficiency-excess Pattern Identification. Like these, this study identify pattern of disease in DongEuiBoGam by mechanism of disease theory.