• 한방재활의학과학회지
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• 제31권4호
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• pp.129-143
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• 2021

Objectives This study was aimed to evaluate clinical practice guidelines (CPGs) of traffic injuries, which has already been developed at domestic or outside of country, and to explore the Korean medical treatments included in the CPGs. Methods Twelve electronic databases (PubMed, Cochrane library, China National Knowledge Infrastructure [CNKI {Chinese Academic Journals, CAJ}], Research Information Sharing Service [RISS], Oriental Medicine Advanced Searching Integrated System [OASIS], KoreaMed, Korean Medical Guideline Information [KoMGI), National Guideline Clearinghouse [AHRQ], Core Outcome Measures in Effectiveness Trials Initiative Website [COMET], Turning Research into Practice [TRIP], The National Institute for Health and Care Excellence [NICE], and Medical Research Information Center [MedRIC]) up to July 2021 were searched. Only systematically developed CPGs for traffic injuries were selected and appraised. The appraisal was conducted by using Appraisal of Guidelines for Research & Evaluation (AGREE) II tool. Results Six CPGs were included and evaluated. All CPGs were appraised as highly recommended because they exceeded 60% in more than 4 among 6 domains of AGREE II, including domain of 'rigor of development', and 30% in the rest. Recommendations related to Korean medicine treatments such as on manual therapy related to Chuna were given in 6 CPGs, 4 for acupuncture, 1 for Qigong and 1 for Taping. Conclusions The 6 CPGs were developed up to now through a systematic development methodology and there were many recommendations for Korean medical treatments related to manual (Chuna) treatment, acupuncture and Qigong. However, the evidence for the side effects and risk factors of Korean medical treatments was scantly reflected in CPGs. Therefore, it is considered that balanced CPG with benefits and risks should be developed, covering Korean medical diagnosis, treatment and prognosis.

• 대한본초학회지
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• 제36권3호
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• pp.15-24
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• 2021

Objectives : The Glycyrrhiza new varieties, WONGAM and SINWONGAM, were developed through interspecific cross between Glycyrrhiza glabra and Glycyrrhiza uralensis by the National Institute of Horticultural and Herbal Science, Rural Development Administration in Korea. This in vitro study was undertaken to compare the antioxidant and cytotoxic effects between Glycyrrhiza new varieties (WONGAM and SINWONGAM) and official compendia (Glycyrrhiza glabra and Glycyrrhiza uralensis). Methods : Antioxidant activity was determined by DPPH (1,1-diphenyl-2-picrylhy drazyl), ABTS (2,2-azino-bis (3-rthylbenz-thiazoline-6-sulfonic acid)) diammonium salt, Nitrite radical scavenging assay, and Reducing Power assay. Cytotoxicity was determined by MTT assay and cell morphology was observed by an inverted microscope. Results : The DPPH, ABTS, Nitrite radical scavenging activities and reducing power of Glycyrrhiza glabra, Glycyrrhiza uralensis, WONGAM, and SINWONGAM were evaluated at different concentrations (0, 10, 50, 100, 500, 1000 ㎍/㎖). Glycyrrhiza glabra, Glycyrrhiza uralensis, WONGAM, and SINWONGAM showed similar dose-dependent increase in antioxidant activities. The cytotoxic effects with increasing doses of Glycyrrhiza new varieties and official compendia did not differ in HCT116, HT29, A549, MDA-MB231, PC3, ACHN, and HeLa cells. However, significant difference in cytotoxicity were observed in AGS, MCF7 and Hep3B cells by Glycyrrhiza glabra, Glycyrrhiza uralensis, WONGAM, and SINWONGAM. Conclusions : These results showed that Glycyrrhiza new varieties and official compendia acts as a potent antioxidant. Also, the finding that equivalent cytotoxic potency was observed in a cell dependent manner. Our study suggests that Glycyrrhiza new varieties may offer a wide-variety of health benefits.

• 한국산업보건학회지
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• 제31권4호
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• pp.427-439
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• 2021

Objectives: This study aims to investigate differences in microbial contamination according to the duration and environment of mask wearing. Methods: Forty-five participants were recruited from workers in an offices, multi-purpose facilities, and a schools. After wearing of KF94 mask for two. four, and six hours, the microorganisms adsorbed on the outer and inner layers of the mask were inoculated on BAP(Blood Agar Plate), Chocolate agar, and SDA plates. The bacterial count (CFUs: colony-forming units) cultured in each plate was measured and analyzed for changes in filtration efficiency. Results: The microbial contamination of masks worn in classrooms, offices, and multi-purpose facilities showed a significant difference depending on the environment (p<0.000). The measured CFUs increased significantly according to the time wearing the mask. The difference between the inner and outer layers of the mask was also significant (p<0.05). However, there was no statistical difference in the filtration efficiency of the masks by duration time (p=0.515). Conclusions: Masks worn by workers in the offices, multi-purpose facilities, and schools showed an increase of microbial contamination with the amount of time wearing the mask. The results indicate that the masks used in daily life may have adverse health effects if they are worn for a long time or reused over several days without the realizing that the masks can be contaminated with biological hazards. Guidelines on the safe threshold time for mask use should be established through further research.

• 생명과학회지
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• 제31권7호
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• pp.631-640
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• 2021

Houttuynia cordata Thunberg는 전통의학에서 다양한 약리학적 작용에 대해 연구되어 왔다. 본 연구에서, 거세 및 테스토스테론 프로피오네이트(TP) 주입에 의해 유도된 양성 전립선 비대증(BPH) 모델에 대한 Houttuynia cordata 에탄올 추출물(HCE)의 영향을 조사했다. 총 30마리의 쥐를 6개의 그룹으로 나누었다. 한 그룹은 정상 대조군으로 사용되었고 다른 그룹은 거세 후 14일 동안 복강내 TP를 주입하여 BPH를 유도하였다. 양성 대조군은 BPH 모델에 매일 피나스테라이드(5 mg/kg)를 투여했다. 피나스테라이드 대신 HCE (0.5, 1, 2mg/kg)를 투여한 군은 실험 군으로서 대조군과 비교하였다. 체중 100 g 기준으로 전립선 무게에 대한 통계적 유의성은 없었다. ELISA 검사로 5-α 환원효소 및 디하이드록시 테스토스테론(DHT) 농도를 측정하였으며, 모든 실험군에서 유의미한 감소가 있었다. 5-α 환원효소의 경우 HCE (0.5 mg/kg) 군이 가장 낮았고, DHT는 HCE (2 mg/kg) 군에서 가장 낮은 수치를 보였다. 전립선에 대한 조직병리학적 관찰에서 대조군과 HCE (2 mg/kg) 투여 군은 정상 세포 형태를 보였고 세포팽창이 없었다. 그러나 음성 대조군과 HCE (1 mg/kg) 군에서는 세포가 부풀어 오르고 세포 사이의 간격이 좁아졌다. 특히 HCE (0.5 mg/kg) 군에서는 일부 세포가 터지는 현상이 나타났다. 따라서 2 mg/kg 이상의 HCE를 투여하는 것이 BPH의 보호 효과에 적합할 것이다.

• 수면정신생리
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• 제25권2호
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• pp.82-91
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• 2018

목 적 : 본 연구는 전 수면 주기 동안 수면단계에 따른 전체 뇌 영역과 수면 관련 뇌 영역들의 뇌기능 연결망의 변화를 살펴보기 위해 동기화된 뇌파(EEG)-자기기능공명영상(fMRI)를 전 수면 주기 동안 측정하고 신호처리 기법을 사용함으로 수면 단계에 따른 뇌 연결망의 탐구가 가능함을 살펴 보기 위해 수행되었다. 방 법 : 정상 성인 피험자 5인을 대상으로 6~7시간의 수면동안 MRI 기계 안에서 안전도, 심전도, 근전도와 EEG-fMRI를 측정하였고 EEG에 발생한 MRI 자장 변화 잡음과 심박관련 잡음을 제거하였다. fMRI에서는 피험자의 움직임에 의해 발생하는 영상 왜곡을 보정하는 부분볼륨활용기법을 제안하여 사용하였다. 잡음이 제거된 수면중 fMRI에 독립성분분석기법을 적용하여 뇌 전체를 68 영역으로 구획하여 수면 연구에 적합한 뇌 구획 지도를 만들고 이를 바탕으로 각 구획들간의 연결성을 계산하였다. 수면관련 뇌심부 영역을 선택하여 연결망 분석을 수행하였다. 결 과 : 뇌파를 비롯한 수면 생리적 신호들은 잡음 제거의 방법을 이용하게 되면 수면단계설정에 문제가 없으며 수면 단계별 뇌 연결망 연구가 가능함을 보여 주었다. 뇌연결망 분석에서 수면 관련 뇌심부 연결망은 렘과 비렘수면에 따라 다른 특성이 나타나는데 비렘수면에서 전반적으로 높은 연결성을 보였다. 대뇌를 포함한 전체 뇌 연결망의 경우 각성에 비해서 수면 중에 뇌 연결성이 떨어지는 양상을 보였다(Kolmogorov-Smirnov 검정 ; p < 0.05, Bonferroni corrected). 결 론 : 본 연구를 통해서 장시간 수면 EEG-fMRI 측정과 수면단계설정이 가능하고 신호처리 기법을 통해서 보정하게 되면 뇌기능 연결망을 이용한 전체 수면 뇌 연구가 가능함을 시사한다.

• 대한예방한의학회지
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• 제22권3호
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• pp.1-10
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• 2018

Backgrounds : In 2017, National Health Insurance implemented the pilot insuring project for Chuna manual therapy(CMT). 65 Korean Medicine(KM) hospitals and clinics were selected in the project to monitor the provision of insured CMT. Objectives : This study aimed to evaluate the effectiveness of CMT for low back pain provided in the real world setting. Methods : Patients with low back pain who agreed to participated in the study were enrolled and requested to complete questionnaires. Patients who received CMT regardless of receiving other KM therapies were classified to Chuna group, and patient who received KM therapies without CMT to KM group. Pain(pain-VAS) and back function(KODI, Oswestry disability index-Korean version), quality of life were assessed at baseline, 4 weeks, and 8 weeks. Additionally, patients who received CMT twice and more, and who's pain-VAS 20 and over were included, and patients who used pain injection were excluded in the analysis. Results : Of 371 patients who completed all questionnaire (mean age=42.6years, SD=12.45; 61% female), 96 were excluded, 170 were in Chuna group, and 105 were in KM group. Proportions of patients who had low back pain for more than twelve weeks in the Chuna group and KM group were 57.7% and 24.8%, respectively. Pain and back function were significantly improved on 4weeks and 8weeks in both groups, but there was no difference between two groups. For the patients in the sub-acute and chronic stage(>=12 weeks), change of total KODI scores in the Chuna group was higher than KM group(p=0.013) at 4weeks. Conclusions : CMT with other KM therapies can improve back function in the sub-acute and chronic patients. For insurance policy decision, economic evaluation of CMT is needed.

• 한방안이비인후피부과학회지
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• 제32권3호
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• pp.151-163
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• 2019

Objectives : The purpose of this study is to investigate the use of herbal medicine for the treatment of atopic dermatitis in cases and to find the general tendency of herbal medicine treatment and to establish the primary treatment direction of Atopic dermatitis. Methods : In the domestic databases, Oriental medicine Advanced Searching Integrated System(OASIS), Korean Traditional Knowledge Portal(KTKP), National Discovery for Science Leader(NDSL), Research Information Sharing Service(RISS), we selected among the papers published in the last 20 years using search terms related to "Atopic dermatitis & Cases". Reports based on Sasang constitutional medicine and Six meridian pattern identification were excluded and a total of 21 papers were finally selected. Results : 113 herbal medicines were retrieved from 21 papers. The most commonly used herbs are Scutellariae Radix(黃芩), Rehmanniae Radix(地黃), and Glycyrrhizae Radix et Rhizoma(甘草). Atractylodis Rhizoma(蒼朮), Akebiae Caulis(木通), Smilacis Rhizoma(土茯?), Paeoniae Radix(芍藥) used mostly when Oozing exists, Trichosanthis Radix (瓜蔞), Asparagi Radix(天門冬), Persicae Semen(桃仁), Carthami Flos(紅花) used mostly when Dryness, Lichenification, and Pigmentation exist. The average score of SCORAD index was improved after Herbal medicine treatment. Conclusion : Through this study, we could find out the tendency of herbal medicine to treat Atopic dermatitis along with Symptoms.

• 사물인터넷융복합논문지
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• 제8권6호
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• pp.27-33
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• 2022

수면은 건강한 삶을 사는데 필수적 요인이나 많은 현대인들이 수면상태의 불편함을 호소하고 있다. 이러한 사람들을 위해 수면상태를 간단하게 평가하고 관리할 수 있는 수단의 필요성이 높아지면서 검사자의 모니터링 없이 집에서 수면 상태를 검사 할 수 있는 기기들이 개발되고 있다. 본 사용성 평가의 대상인 스마트 수면 안대는 잠을 잘 때 생체신호 모니터링을 제공하여 수면 상태를 스스로 편리하게 측정하고 관리할 수 있도록 해준다. 스마트 수면 안대의 사용성과 안전성을 평가하여 발생할 수 있는 사용오류에 관한 잠재적인 요인을 찾아내어 방지하고 본 제품의 사용감과 안전성을 발전시켜 해당 기기의 보급과 개발을 위한 지침을 제시하고자 하였다. 수면안대 시제품을 형성평가를 시행한 결과, 전원 켜기, 결과 확인이 어렵다는 의견과 수면 안대 착용감이 좋지 않다는 의견이 있었고 수면안대 크기과 무게에 대해 연령별로 다른 의견이 제시되었다.

• 대한한방부인과학회지
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• 제34권1호
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• pp.1-14
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• 2021

Objectives: We studied for the adjustment of the patterns of 'The Diagnostic Tool for Climacteric and Postmenopausal Syndrome Pattern Identification (hereinafter CaPSPI)' (studyI) and the correlation between CaPSPI and Korean medicine doctors' diagnosis which was carried out without knowing the results of CaPSPI (studyII). Methods: The studyI followed the previous study method in 2018 (2018-3). The studyII was conducted from June 1, 2019 to July 10, 2020 with ◯◯ University Korean Medicine Hospital IRB's approval (2019-4). Doctors' diagnosis was conducted face-to-face with the subjects. Doctors' diagnosis was carried out based on the Kupperman's questionnaire, 'Diagnosis System of Oriental Medicine (hereinafter DSOM)' and four examinations (四診) records. The diagnosis was marked with 0 for 'no', 1 for 'somewhat', 2 for 'yes' and 3 for 'very yes'. The correlation between CaPSPI and the mean of doctors diagnostic scores were investigated statistically. Results: The studyI showed that heart-heat (心火) pattern was added. The Factor loading coefficient for heart-heat was 0.551 to 0.789, and the Cronbach's coefficient was 0.896. The studyII showed that the diagnosis (Kappa statistic) of two doctors showed statistically significant concordance (all eight patterns), with correlation of them were 0.3 or higher. And the correlation between the CaPSPI score and the mean of doctors' diagnostic score showed a statistically significant correlation, with liver qi depression (肝鬱) being the highest at 0.552 and dual deficiency of the heart-spleen (心脾兩虛) being the lowest at 0.301. Conclusions: Since the diagnosis results of CaPSPI showed a significant correlation with the diagnosis of Korean traditional medicine experts, it was believed that the CaPSPI results can be trusted and used for clinical purposes.

• 대한한방내과학회지
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• 제43권1호
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• pp.1-21
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• 2022

Purpose: The standard tool for the pattern identification is used for identifying patterns in patients using a questionnaire. The purpose of this study is to reorganize the standard tool for the pattern identification of gastroesophageal reflux disease (GERD) developed in 2017 and to analyze the reliability and validity of the standard tool for pattern identification by applying it to GERD patients. Methods: To reorganize the standard tool for the pattern identification of GERD developed in the previous study, we searched the literature in the main databases, OASIS (Oriental Medicine Advanced Searching Integrated System) and CNKI (China National Knowledge Infrastructure). We added the search results to the data used in the previous study and went through the reorganizing courses, such as evaluating the validity of the translation, the Delphi technique, and a small survey. After reorganization, the patients who visited the Kyunghee University Korean Medicine Center for GERD symptoms were provided the questionnaire, including the reorganized standard tool for pattern identification. We analyzed the survey results to evaluate their reliability and validity. Results: Fifty patients completed the questionnaire. Reliability analysis results showed a pattern identification match rate of 86%, Cronbach's α coefficient of 0.834, and intraclass correlation coefficient of 0.907. The Mann - Whitney U test and logistic regression were implemented to check the relations between the survey questions and pattern identification results; the Pearson correlation, compared with other scales, showed a moderate score. Conclusion: We reorganized the standard tool for the pattern identification of GERD to be updated on current issues and so that it is easily used. The analysis results of the questionnaire showed that the reorganized standard tool had high reliability and moderate validity.