• Korean Journal of Veterinary Research
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• v.41 no.1
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• pp.105-111
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• 2001

We performed this study to determine the effect of Jiegeng(Platycodon grandiflorum), Danggui(Angelica sinensis), Gancao(Glycyrrhiza glabla), Chaihu(Bupleurum falcatnosa), Shoudehuang(Rehmannia glutinosa), Huangqi(Satragalus membranaceus), Muxiang(Saussurea lappa), Yuanzhi(Polygala tenuifolia), Rensen(Panax ginseng) and Baishaoyao(Paeonia lactiflolia), as Oriental radices herbs, on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of ${\gamma}-radiation$. Jiegeng(p<0.005), Danggui(p<0.0005), Gancao(p<0.005), Chaihu(p<0.05), Muxiang(p<0.05), Rensen(p<0.005) and Baishaoyao(p<0.005) were effective in intestinal crypt survival. Danggui(p<0.05), Chaihu(p<0.05), Shoudehuang(p<0.05), Huangqi(p<0.05), Rensan(p<0.005) and Baishaoyao(p<0.05) increased the formation of endogenous spleen colony. The frequency of radiation induced apoptosis was also reduced by pretreatment with Chaihu(p<0.05), Muxiang(p<0.005), Yuanzhi(p<0.05), Rensan(p<0.05) and Baishaoyao(p<0.05). Although the mechanisms of this effect remain to be elucidated, these results indicated that Danggui, Chaihu, Muxiang, Rensan and Baishaiyao might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

• The Journal of Korean Medical History
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• v.22 no.2
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• pp.99-109
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• 2009

Jejung Sinpyeon (New Edition of Medical Prescriptions) is a medical book that was compiled in order to overcome the shortcomings of Donguibogam (Exemplar of Korean Medicine), to improve and offer prescriptions suitable for new diseases according to the changing times, and simply to publish new medical books. As a result of an analysis of Yakseongga of Jejung Sinpyeon (a book of medicine written by Kang Myeong-gil in 1799, the 23rd year of the reign of King Jeongjo of the Joseon Dynasty), it was found that a total of 303 lines had been quoted from Wan-bing-hui-chun of the Ming Dynasty of China] and Dongeui Susebowon and that 83 lines had been newly inserted by the author. Of the 303 lines, 296 were quoted from Dongeui Susebowon, and only seven from Wan-bing-hui-chun. This means that the author of Jejung Sinpyeon chiefly used Dongeui Susebowon as the source of Yakseongga quoted therein. 275 lines, or 76%, of a total of 386 lines of Yakseongga of Jejung Sinpyeon, have their Korean names marked. Medicinal herbs marked as Chinese herbs number 83 out of 386. Among the 83 herbs named, one belongs to the part newly inserted by the author, while the remaining 82 are quoted from Yakseongga. The foregoing suggests that the author expected that the knowledge could be used by people easily based on an effort to make it localized knowledge, although Yakseongga was compiled based on quotations from Chinese literature. Yakseongga of Jejung Sinpyeon has significant value as the country's first State-compiled book of medicine to contain Yakseongga.

• The Journal of Korean Medical History
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• v.22 no.2
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• pp.23-31
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• 2009

Jecheon is a place of Korean Medicine with many historical characters, medical tales and cultures. One of the most renowned characters is Lee Gong Gi(李公沂), a 扈聖功臣 (title given to the 86 people that escorted king Seonjo during the Japanese Invasion of Korea in 1592) at the level of Huh Jun(許浚) and famous royal physician of Joseon who served King Seonjo and reached the highest position of chief physician. He was recognized for his talent as a royal physician and was conferred with the title of 扈聖功臣 Rank 3 after attending on King Seonjo during the Japanese Invasion of Korea in 1592. Despite the fact that he was a renowned man of medicine, he didn't get as much attention as 許浚 or Yang Ye Soo(楊禮壽) because documents on his work had not been studied. In this study, the author was able to study Lee Gong Gi(李公沂) based on documents such as "朝鮮王朝實錄(True Record of the Joseon Dynasty)", "內醫院先生案(Naeeuiwonseonsengan)", "醫科先生案(Euigwaseonsengan)" and on "避難行錄(Pinanhengrok)" by Yakpo Jeongtak (1526~1605) who was a govemmental pharmacist at the time of Japanese Invasion of Korea in 1592. According to "內醫院先生案" and "醫科先生案", Lee Gong Gi's son Lee Young Nam followed his father's footsteps and became the chief royal pharmacist and 崇政大夫(one of the governmental titles of Joseon Dynasty). As for Jecheon's Korean medical traditions, many forms of medical tales and cultures are preserved such as the tales of Neokgogae, Mountain Ami's medical water cave, Otmaru and Seonsimgol. These tales are divided into various types of great doctors, medical herbs and devoted sons and have been passed down With the origin of traditional medicine still intact. Moreover, ancient documents and artifacts on Traditional Korean Medicine that reflect the area's medical culture have been discovered. Not only is Jecheon a place of medical culture but along with Jecheon Drug Market it also carries on the tradition of medical herbs production and possesses the largest new medical herbs market in Korea. In conclusion, Jecheon is a traditional place of Korean Medicine with many medical cultures and characters from a unique history.

• Journal of Society of Preventive Korean Medicine
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• v.16 no.2
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• pp.67-81
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• 2012

Objective : This study aimed to analyze the utilization of Korean Medicine clinics, and high-frequent diseases by sex, age, and region of outpatients and inpatients Methods : The data for this study were "Report on Usage Patterns of Korean Medicine Clinics" issued by the Ministry of Health and Welfare in 2008. Descriptive analysis and correspondence analysis were used to find the patterns of patient's utilization by sex, age and region Results : Diagnosis and examination methods mostly consisted of the pulse for diagnosis. Treatment methods consisted of acupuncture, medical herbs in package, and insurance extract powder. Fee for consultation was paid by Korean Medicine insurance. Usage increased when people's age was over 20 and climaxed among people who were in their 40s and 50s and decreased gradually afterwards. Also, there were differences between the sexes. There were differences in high-frequent diseases by regions, and in usage of Korean Medicine clinics according to sex and age. Conclusion : It was found that there were differences in usage and patterns of Korean Medicine Clinics according to sex, age, and region.

• Toxicological Research
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• v.21 no.1
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• pp.63-70
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• 2005

Gami-Honghwa-Tang (KH-19), a herbal prescription for reducing the side effect of radiotherapy, is composed of eight crude herbs such as Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Cnidii Rhizoma, Paeoniae Radix, Corni Fructus, Moutan Cortex Radicis, Lycii Fructus, Carthami Flos, and Glycyrrhizae Radix. In this study, marker substances in KH-19 were analyzed by high performance liquid chromatography-diode array detector (HPLC-DAD) and safety evaluation of standardized KH-19 was evaluated by good laboratory practices (GLP) guideline of Korea Food and Drug Administration. HPLC-DAD was employed to determine the quantities and the qualities of several marker substances such as 5-hydroxymethyl-2-furaldehyde (5-HMF), paeonol, loganin, paeoniflorin, glycyrrhizin, and decursin in the KH-19. In acute oral toxicity study on rat, transient inhibition of body weight was shown, but change in general symptom was not detected. No dead animal was observed up to 5,000 mg/kg in both male and female animals. In acute oral toxicity study on Beagle dog, transient vomiting, diarrhea, anorexia, and body weight reduction were observed, However, no dead animal was observed up to 2,000 mg/kg in both male and female animals.

• The Korea Journal of Herbology
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• v.25 no.4
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• pp.151-160
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• 2010

Objectives : The purpose of this research was to examine dietary therapy on the edema based on the literary findings, for clinical treatment and prevention of the edema. Methods : This Research was examined on histories, compositions, applications, and effects of dietetic treatment about 100 cases of dietary therapy of the edema from Chinese literatures. Results : 1. Various vegetables and animals including herbs, grains, vegetables, fruits, food and drink were used for the dietary therapy. 2. Methods of the preparation for use as therapeutics were decoction, pulvis, gruel, cake, tea, paste, gelatin and etc. 3. Frequently used materials were Cyprinus carpio Linnaeus, Cucumis sativus L. Coix lachrymajobi var. mayuen, Zea mays, Maydis Stigma, Citrullus vulgaris, Zingiber officinale, Cinnamomum cassia Blume, Allium scorodorpasum var. viviparum Regel, Camellia sinensis, Armeniacae amarum Semen, Phyllostachys bambusoides, Luffa cylindrica, Dioscorea batatas Decne, Panax ginseng, Brassica oleracea and Raphanus sativus. Conclusion : Though dietary therapy for the edema is not based on clinical or experimental data, but through experience. It is mostly based on Yin-Yang and five elements, visceral manifestation, channels and their collateral channels and Oriental herbal medicine theories. If we use them properly according to oriental medicine method, it will be effective on treating and preventing the edema.

• Journal of Korean Medical classics
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• v.26 no.2
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• pp.71-83
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• 2013

Objective : Printed in early Chosun dynasty Hyangyakjipseongbang quoted several medical books that were published at that time. Yuyaoyuanfang was printed in Yuan dynasty, China and imported to Chosun dynasty. However, Yuyaoyuanfang was vanished in history and another Yuyaoyuanfang, which is now-exist[Guisixinkan-Yuyaoyuanfang], was printed in Japan. In Hyangyakjipseongbang, Yuyaoyuanfang are mentioned 31 times but Yuyaoyuanfang quoteded in Hyangyakjipseongbang is quite different from Guisixinkan-Yuyaoyuanfang. Therefore, we had interests of those differences and tried to find out them in article. Method : We use the method of comparing quotations of Yuyaoyuanfang in Hyangyakjipseongbang with Guisixinkan-Yuyaoyuanfang. Result : 4 of 31 prescriptions of Yuyaoyuanfang quoteded in Hyangyakjipseongbang does not exist in Guisixinkan-Yuyaoyuanfang and several parts such as symtoms, herbs, taking methods of prescriptions are different from each other. Conclusion : Hyangyakjipseongbang prove the fact that Guisixinkan-Yuyaoyuanfang is not original form of Yuyaoyuanfang.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.4 no.1
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• pp.199-209
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• 1998

In order to find antiviral effect against Human immunodeficiency virus(HIV), Herpes simplex virus type I(HSV-1) and II(HSV-2) from herb medicines, publicated 29 paters on anti-viral effect of herbal medicines and a convenient virus-induced cytopathic effect (CEP) inhibition assay was introduced. The major virus on experiment are HIV, Hepatitis B virus and HSV-1,2. Those of other studies showed inhibition of infected virus DNA replication and screening test of herbal medicines. More than 15 extractions were prepared by pure water boiling from herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Cytotoxic concentration (CC) of the $H_2O$ extracts of Padoo against HIV was <4.0, Hyungbangpaedoksan against HIV was 9.3, Whangyonhaedoktang against HIV-1 and HSV-2 was 15.3. These are high level cytotoxic concentration compared with the contrast. But antiviral effect was unable to figure out for selective $index(SI)=CC_{50}/EC_{50}$. The other herbal medicines were unable to showed potent anti-HIV and anti-HSV activity. The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the direction of antiviral drug development that have less side effect and more excellent efficiency.

• The Korea Journal of Herbology
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• v.27 no.2
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• pp.17-24
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• 2012

Objective : For the purpose of investigating the herbal resources of Dokdo island, this study was designed. Method : For the first time, we searched the native plants of Dokdo island from research data. And we examined herbological books on the plants of Dokdo island. Result : The native herbaceous plants in Dokdo island were 27 family and 73 species, and the medicinal plants were 49 species among them. The woody plants in Dokdo island were 12 family and 13 species, and the medicinal plants were 10 species among them. The main medicinal parts of medicinal plants were the whole body of herbs, roots, and seeds in order. The herbal medicines with cold or cool nature were 45 species, they took the top nature of the herbal medicines. According to the properties and principal action of native herbal medicines in Dokdo island, the major parts were classified into drugs for clearing away heat, eliminating toxin, activating blood flow and removing blood stasis, urination, removing heat from the blood and stopping of bleeding. The number of native herbal medicines with small toxicity in Dokdo island were 7 species. Conclusion : For the purpose of preserving the native plants of Dokdo island, we should recognize not only medical benefits but also matters that demand special attention.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.1073-1079
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• 2009

The object of this study was to observe the protective effects of Yijin-tang-gamibang (YJGMB), Yijin-tang has been traditionally used as Korean medicine for treating various digestive diseases. The study showed that it is effective on reflux esophagitis induced by pylorus and forestomach ligation in rats. Three different dosages of Yijin-tang-gamibang extracts, 300, 150 and 75 mg/kg, were once orally administered 1 hour before pylorus ligation. 6 groups, each of 8 rats per group were used in the present study. The results were compared with Omeprazole, antioxidant and proton pump inhibitor, 30 mg/kg treated group. Yijin-tang-gamibang extracts 300 mg/kg were showed similar or slightly lower effects as compared with 30 mg/kg of omeprazole in the present study. Detail mechanism studies should be conduced in future with the efficacy tests of individual herbal composition of Yijin-tang-gamibang and the screening of the biological active compounds in herbs.