• Genomics & Informatics
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• v.21 no.3
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• pp.37.1-37.11
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• 2023

Systemic lupus erythematosus (SLE) is an inflammatory-autoimmune disease with a complex multi-organ pathogenesis, and it is known to be associated with significant morbidity and mortality. Various genetic, immunological, endocrine, and environmental factors contribute to SLE. Genomic variants have been identified as potential contributors to SLE susceptibility across multiple continents. However, the specific pathogenic variants that drive SLE remain largely undefined. In this study, we sought to identify these pathogenic variants across various continents using genomic and bioinformatic-based methodologies. We found that the variants rs35677470, rs34536443, rs17849502, and rs13306575 are likely damaging in SLE. Furthermore, these four variants appear to affect the gene expression of NCF2, TYK2, and DNASE1L3 in whole blood tissue. Our findings suggest that these genomic variants warrant further research for validation in functional studies and clinical trials involving SLE patients. We conclude that the integration of genomic and bioinformatic-based databases could enhance our understanding of disease susceptibility, including that of SLE.

• Journal of the Korea Institute of Military Science and Technology
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• v.27 no.2
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• pp.203-212
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• 2024

This paper describes the establishment of defense systems test works architecture model for the efficient operation of an expanded test organization and the provision of standardized test services after the integration of proving grounds in ADD. The system engineering vee model is applied to the defense system test works to define the project management model and the unit-test management model. In order to establish the defense systems test works architecture model, the process flow of test works, artifacts by life cycle, and interrelations between regulations and test works are explained, and Integrated Test Information System for implementation of architecture model is discussed. Through the defense systems test works architecture model presented in this study, it will contribute to quickly responding to the test requirements of complex and diverse defense systems, efficiently managing projects, and providing standardized test services.

• Journal of the Korean Society of Industry Convergence
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• v.27 no.4_1
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• pp.769-780
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• 2024

For an organization to survive and prosper, it is essential to continuously develop innovative products by proactively anticipating consumers' implicit requirements. The Kano model has become more useful since Sireli et al. (2007) and Tontini (2007) introduced a simple equation for determining the importance of characteristics by using the concept of Kano's Potential Customer Satisfaction Coefficient (PCSC). However, although several studies have utilized the PCSC concept to determine the importance of characteristics, it is surprising that the two equations have been accepted without any validation process. This study aims to propose a modified equation using PCSC and to conduct a validity test of the proposed equation, demonstrating its superiority over the previously suggested two equations, The author analysed 26 Kano related articles (27 cases), and the correlation coefficients were compared with those obtained from direct rating importance, which served as a comparative criterion. The results indicate that the proposed equation is valid for assessing characteristic importance and demonstrates significantly higher correlation coefficients with the direct method than those suggested by Tontini (2007) and Siireli et al. (2007). The proposed method offers advantages in terms of accuracy and survey duration over traditional methods that directly ask for relative importance (e.g., AHP by Saaty (1980)). Furthermore, the integration of the Kano model with IPA or QFD could enhance the accuracy and efficiency of research in determining the importance of characteristics.

• Journal of Legislation Research
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• no.44
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• pp.241-281
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• 2013

First and foremost, a discussion concerning government structure has to be done in connection with the state form and the governmental form. For practical reasons, there is a need to balance the principle of legality and its exceptions under the Government Organization Act. To ensure the flexibility of government structure with respect to the principle of legality, the National Assembly should accept the government structure requested by the newly elected government. This mitigates the rigidity of the principle of the legality within the government organizations. However, excessive changes by each government could violate the principle of legality asked by Constitution. In this sense, arbitrary modification with respect to the government structure by the newly elected government is not desirable. The long term stability of the government organization is required in any case. Secondly, general administrative agencies, other than Executive Ministries, should not be established under the direct order of the President without the control of the Prime Minister. A hierarchy of the executive branch (President->Prime Minister-> Executive Ministries) is stipulated in the Constitution. Establishing a hierarchy of President -> executive institution should be considered unconstitutional. Therefore, only the Presidential Secretariat and institutions with special functions can be established in the Presidential Office. Establishing general administrative agencies in the Presidential Office for convenience purposes is against the spirit of the current Constitution. Consequently, only the office of staffs and special agencies can be placed in the presidential office. It is against the spirit of the current Constitution to found administrative agencies under the presidential office for convenience. Thirdly, the office of the Prime Minister should be the backbone of internal affairs. In that sense, the President, as the head of state, should focus on the big picture such as the direction of the State, while the Cabinet headed by the Prime Minister should be responsible for the daily affairs of the State. The cabinet surrounding the Prime Minister must control all the ordinary affairs of the State, while the President, as the head of the State, should focus on the big picture of blueprinting the aim of the State. Lastly, the Office of the Prime Minister and Executive Ministries are the two main bodies of the executive branch. It is important to reduce the confusion caused by repeated changes in the names of Executive Ministries, to restore the traditional names and authorities of these institutions, and to rehabilitate the legitimacy of the State. For the Korean democracy to take its roots, a systematic way of stabilizing a law-governed democratic country is needed. There is also the need not only to reform security and economic agencies, but also to rationally solve the integration of technique and policy, according to the changes of time.

• Journal of Distribution Science
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• v.10 no.2
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• pp.29-41
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• 2012

This paper undertakes a conceptual review of transaction cost to broaden the understanding of the transaction cost analysis (TCA) approach. More than 40 years have passed since Coase's fundamental insight that transaction, coordination, and contracting costs must be considered explicitly in explaining the extent of vertical integration. Coase (1937) forced economists to identify previously neglected constraints on the trading process to foster efficient intrafirm, rather than interfirm, transactions. The transaction cost approach to economic organization study regards transactions as the basic units of analysis and holds that understanding transaction cost economy is central to organizational study. The approach applies to determining efficient boundaries, as between firms and markets, and to internal transaction organization, including employment relations design. TCA, developed principally by Oliver Williamson (1975,1979,1981a) blends institutional economics, organizational theory, and contract law. Further progress in transaction costs research awaits the identification of critical dimensions in which transaction costs differ and an examination of the economizing properties of alternative institutional modes for organizing transactions. The crucial investment distinction is: To what degree are transaction-specific (non-marketable) expenses incurred? Unspecialized items pose few hazards, since buyers can turn toalternative sources, and suppliers can sell output intended for one order to other buyers. Non-marketability problems arise when specific parties' identities have important cost-bearing consequences. Transactions of this kind are labeled idiosyncratic. The summarized results of the review are as follows. First, firms' distribution decisions often prompt examination of the make-or-buy question: Should a marketing activity be performed within the organization by company employees or contracted to an external agent? Second, manufacturers introducing an industrial product to a foreign market face a difficult decision. Should the product be marketed primarily by captive agents (the company sales force and distribution division) or independent intermediaries (outside sales agents and distribution)? Third, the authors develop a theoretical extension to the basic transaction cost model by combining insights from various theories with the TCA approach. Fourth, other such extensions are likely required for the general model to be applied to different channel situations. It is naive to assume the basic model appliesacross markedly different channel contexts without modifications and extensions. Although this study contributes to scholastic research, it is limited by several factors. First, the theoretical perspective of TCA has attracted considerable recent interest in the area of marketing channels. The analysis aims to match the properties of efficient governance structures with the attributes of the transaction. Second, empirical evidence about TCA's basic propositions is sketchy. Apart from Anderson's (1985) study of the vertical integration of the selling function and John's (1984) study of opportunism by franchised dealers, virtually no marketing studies involving the constructs implicated in the analysis have been reported. We hope, therefore, that further research will clarify distinctions between the different aspects of specific assets. Another important line of future research is the integration of efficiency-oriented TCA with organizational approaches that emphasize specific assets' conceptual definition and industry structure. Finally, research of transaction costs, uncertainty, opportunism, and switching costs is critical to future study.

• Journal of the Korean earth science society
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• v.29 no.2
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• pp.163-174
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• 2008

In this study, we compared textbook knowledge organization with students' mental models to contribute to a more well-designed instruction scheme. The selected science content was the cause of moon phases. We investigated 9 textbooks and 25 third-year middle school students. Patterns and features in participants' mental models were identified through cross inter-rater data analysis by 9 researchers, including in service teachers and experts in science education. According to the results, observing and modeling are the main activities engaged in when dealing with moon phases. The activities consisted of such concepts as: lunar revolution, the sun's parallel rays, the illuminated half of moon, and the relative positions of the sun, moon, and earth. Each concept involved inquiry skills such as: creating and manipulating models, utilizing the relationship between time and space, and communicating. However, the most important skills which are required for authentic scientific inquiry, namely controlling variables and formulating hypotheses, were missing. We categorized students' mental models into three types: scientific models, mixed models, and alternative models. The knowledge structure of each of the models was also discussed in this paper. Consequently, it was found that, typically, students were not given enough opportunities to strengthen the connection among ideas.

• Journal of KIISE:Computing Practices and Letters
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• v.13 no.7
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• pp.520-533
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• 2007

The CRM(Customer Relationship Management) is the business strategy model for higher profits and competitive power of the enterprise in a new business environment. The large-scale customer response service technique uses internet, e-mail, SMS (Short Message Service), Telephony service, DM(Direct Mail) by customer channel point. Recently, business model diversify for new contract and retaining existing customer to the effort for a profitable model of business. This paper is based on Avaya PDS(Predictive Dialing System) model for CRM bond center. If the number of "available" agents are less than the number of inbound channels, then there may be real-time response problems in PDS system implemented. The Organization cannot afford to have many agents in available mode because of the high cost of manpower. This paper provides two contributions to the study. First, we present Call Object Management Mechanism of Customer Channel integration for reduce outbound consulting and reduce CallBack data in the PDS. Second, we design and implement the proposed system. Our simulation results show analysis of old model and proposed model. The proposed model can be efficiently used in Large-scale CRM.

• Journal of Korea Port Economic Association
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• v.29 no.2
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• pp.173-194
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• 2013

This paper aims at drawing policy schemes to establish marine clusters so as to enhance Korea's global port competitiveness and applying them to its national management for the advancement of national economy through policy suggestions. The research method is an integrated approach(IA) that comprises SWOT Method with strategic approaches, HFP Model enhanced by KJ Method and descriptive deductions. Strategic schemes established for the SPLC are followed by the group of geographical proximity, integration of ICT, expansion of the interchange of ICT & opportunities of ET, integration of ICT services with marine technologies, supply of integrated services in the SPLC and implementation of organizational policies. In order to make a specific implementation of strategic establishment schemes of the SPLC, we need to select a promotion entity. It is advised to establish the joint organization of the public sector and the private sector, which is considered most desirable. In practice, it is to be followed by promoting support schemes of the organizational policy on the level of national management. In order to reinforce this study, further compensative and proactive researches on the offshore sector with marine clusters are required in terms of the development of the high value added 'blue' ocean.

• Journal of the Korea Convergence Society
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• v.11 no.1
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• pp.237-246
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• 2020

The background of the research is the following: As a result of ultra-light flying device industry development, the utilization of drones and their efficiency have been increasing. However, problems regarding flight permission·approval procedure have not been improved, resulting in increased number of civil complaints. Thus, the purpose of this research is to minimize such civil petition according to the required standards of the two government organizations through enhancing the procedure for managing and employing the system. The research methods entail pinpointing the problems by analysing ultra-light flying device related literature review and by holding focus-interviews with field experts, thereby verifying and providing improved solutions. Under (MLIT) Ministry of Land, Infrastructure and Transport supervision and in accordance with aviation security law, the research provides various updated functions such as improved civil petition processing system's employment and management system, flight approval, integration of names, process, format regarding aviation photographing approval, tool buttons such as the 'Main' button in the system's homepage. This research has the following expected effects : Firstly in the law and regulations section, the clear distinction in the missions and roles of each organization enhances cooperations in tackling civil petition. Secondly the integration of civil petition process reduces time and improves efficiency. And lastly, the improvement of supplementary tools for the public is expected to minimize civil petitions. Future research needs to be conducted under the supervision of the Ministry of National Defense(MND). Factors such as systematic infrastructure for flight photography approval, related unit's reorganization following the defense reform 2.0, and guaranteed conditions for field security action units need to be ameliorated.

• Current Industrial and Technological Trends in Aerospace
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• v.6 no.1
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• pp.56-64
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• 2008

Although the EGSE (Electrical Ground Support Equipment) and MCS (Mission Control System) have many similar or even identical functions, the EGSE used for assembly, integration and validation phase and the MCS for the mission operations phase are normally developed separately and used by different groups of engineers. However, the common ground system for EGSE and MCS has developed and many space missions such as PROBA (PRoject for On-Board Autonomy), ROSETTA, MARS EXPRESS, CRYOSAT (Cryosphere Satellite), GOCE (Gravity field and steady state Ocean Circulation Explorer), and GALILEO have used or will use it to minimize risk, reduce cost and improve overall product quality. It is based on ECSS (European Cooperation for Space Standards) E70 which is the international standard for ground systems and operations published by ECSS E70 Working Group. The ECSS E70 contains the basic rules, principles and requirements applied to the engineering of the ground systems and the execution of mission operations. This paper introduces standardization policy, organization and standard documentation in ECSS. The overview of ECSS E70 such as status, purpose and contents is also described in this paper.