• Journal of Genetic Medicine
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• v.5 no.1
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• pp.21-25
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• 2008

Purpose : In recent years, many countries have adopted newborn screening programs that use tandem mass spectrometry (MS/MS) to screen and the number of diseases screened has also increased. We began screening for inherited metabolic disorders using MS/MS in April, 2001. Our goal was to determine the overall prevalence of metabolic disorders and to assess the effectiveness of newborn screening by MS/MS in Korea. Methods : From April, 2001 to December, 2007, we screened newborns and high risk groups using MS/MS. Acylcarnitines and amino acids were extracted and butylated and were introduced into the inlet of MS/MS. Confirmatory testing including a repeat newborn screening, and urine organic acid and plasma amino acid analysis were performed on a case-by-case basis. Results : The total number of screened subjects 284,933 which comprised 251,799 neonates and 33,134 high risk subjects. The recall rate was 0.4% (1158 tests) and true positive cases were 117 (0.04%). Confirmed metabolic disorders (newborn/high risk group) were as follows; 78 (25/53) amino acid disorders, 27 (16/11) organic acid disorders, and 12 (5/7) fatty acid oxidation disorders. The estimated prevalence of inherited metabolic diseases in newborns was 1:5,000 and that in the total group was 1:2,000. Conclusion : Newborn screening by MS/MS improved the detection of many inherited metabolic disorders. We therefore propose that all newborns be screened by a MS/MS national program and followed-up using a systemic organization strategy.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6779-6782
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• 2015

Background: Chemoradiotherapy is an important treatment modality for lung cancers. The aim of this study was to investigate alterations in, as well as the interrelationship between, lung function and quality of life of patients receiving chemoradiotherapy due to locally advanced non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) limited to the thorax. Materials and Methods: The study included patients receiving definitive chemoradiotherapy for lung carcinoma. The respiratory function of the patients was assessed by measuring forced expiratory volume in 1 s per unit (FEV1) and forced expiratory volume in 1s per unit of vital capacity (FEV1/VC) before, in the middle of and after treatment. During the study, EORTC QLQ C30 and LC13 questionnaires developed by the Committee of the European Organization for Research and Treatment of Cancer (EORTC) were employed to evaluate the quality of life on the same day as respiratory function tests (RFT). Findings: The study included 23 patients in total: 19 (82.6%) diagnosed with NSCLC and 4 (17.4%) with SCLC. The average percentage FEV1 was $55.6{\pm}21.8%$ in the pre-treatment period, $56.2{\pm}19.2%$ in the middle of treatment and $60.4{\pm}22%$ at the end of treatment. The improvement in functional scores, symptom scores and general health scores during treatment was not statistically significant (P= 0.568, P= 0.734, P= 0.680, P=0.757 respectively). Conclusions: Although this study showed an improvement in respiratory function and quality of life of patients during treatment with thoracic chemoradiotherapy, no statistically significant results were obtained. While evaluating the effectiveness of treatments for lung carcinoma, the effects of treatment on respiratory function and quality of life should be considered.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.47 no.1
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• pp.80-91
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• 2010

As the volume of image data increases dramatically, its good organization of image data is crucial for efficient image retrieval. Clustering is a typical way of organizing image data. However, traditional clustering methods have a difficulty of requiring a user to provide the number of clusters as a parameter before clustering. In this paper, we discuss an approach for clustering image data that does not require the parameter. Basically, the proposed approach is based on Cross-Association that finds a structure or patterns hidden in data using the relationship between individual objects. In order to apply Cross-Association to clustering of image data, we convert the image data into a graph first. Then, we perform Cross-Association on the graph thus obtained and interpret the results in the clustering perspective. We also propose the method of hierarchical clustering and the method of outlier detection based on Cross-Association. By performing a series of experiments, we verify the effectiveness of the proposed approach. Finally, we discuss the finding of a good value of k used in k-nearest neighbor search and also compare the clustering results with symmetric and asymmetric ways used in building a graph.

• Korean Journal of Environment and Ecology
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• v.29 no.5
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• pp.803-813
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• 2015

This study was intended to investigate recognition of the general public on water pollution and nonpoint pollution, and to promote participation of the common people in prevention and management of nonpoint pollution by investigating the necessity and participation in the education for reducing the nonpoint pollution. To this end, this study conducted questionnaire on 1,000 male and female adults over 20 years of age nationwide who are registered in Onpanel. The questionnaire was comprised of recognition on water pollution, preventive activity for nonpoint pollution, countermeasures for preventing nonpoint pollution, necessity of national education for reducing the nonpoint pollution, recognition of promotion and campaign participation, and revitalization of organization for reducing the nonpoint pollution. As a result of the questionnaire investigation, interest in water pollution of respondents was high, and specially, interest in the nonpoint pollution was higher when age, academic level, and income were higher that effectiveness of promotion and education on the source of nonpoint pollution is expected to be increased. Respondents recognized the effect of education on reducing the nonpoint pollution positively when they had higher interest, information, education and experience related to the reduction activity of nonpoint pollution. Therefore, formation of sympathy of the public is positively necessary for the nonpoint pollution management, and provision of civil activity program that increases information on the nonpoint pollution, education, and participation in reduction activity and easy promotion with high information communicability should be conducted continuously.

• Journal of Internet Computing and Services
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• v.14 no.4
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• pp.63-72
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• 2013

Business Process Intelligence (BPI) is one of the emerging technologies in the knowledge discovery and analysis area. BPI deals with a series of techniques from discovering knowledge to analyzing the discovered knowledge in BPM-supported organizations. By means of the BPI technology, we are able to provide the full functionality of control, monitoring, prediction, and optimization of process-supported organizational knowledge. Particularly, we focus on the focal organizational knowledge, which is so-called the BPM activity-performer affiliation networking knowledge that represents the affiliated relationships between performers and activities in enacting a specific business process model. That is, in this paper we devise a statistical analysis method to be applied to the BPM activity-performer affiliation networking knowledge, and dubbed it the activity-performer correspondence analysis method. The devised method consists of a series of pipelined phases from the generation of a bipartite matrix to the visualization of the analysis result, and through the method we are eventually able to analyze the degree of correspondences between a group of performers and a group of activities involved in a business process model or a package of business process models. Conclusively, we strongly expect the effectiveness and efficiency of the human resources allotments, and the improvement of the correlational degree between business activities and performers, in planning and designing business process models and packages for the BPM-supported organization, through the activity-performer correspondence analysis method.

• Korean Security Journal
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• no.38
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• pp.163-189
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• 2014

This research is carried out to offer suggestions for improving the work efficiency and quality of private security officers and developing the private security industry; it examines the relationship between the training of private security officers that affects task efficiency as well as the ultimate outcome of an organization's work and job satisfaction while confirming the mediation effect of job consciousness. A self-administration survey method is employed and the questionnaires filled out by 180 related personnel at a private security firm located in Seoul, South Korea are analyzed for the following results. The training satisfaction variable shows a statistically significant effect on the job consciousness of private security officers, meaning that the trainees that are satisfied with the training they receive are also more dedicated to carrying out their tasks dutifully compared to those who are not content with the training. The research results stated above confirm the findings of the past studies which assert that training satisfaction factor affects job satisfaction and job consciousness has a statistically significant impact on job satisfaction and acts as a mediator between training and job satisfaction. With the results acquired, the author suggests the training providers and instructors prepare an educational service that can suit the needs of the trainees and promote job consciousness through increased training satisfaction. Lastly, with the basis on the results from this study, further research should be conducted to examine other various explanatory factors that might affect job satisfaction.

• 대한공업교육학회지
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• v.36 no.1
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• pp.47-73
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• 2011

The purpose of the study was to examine cooperative education between industry and school recognized by tentatively called managers of cooperative education, teachers in charge of cooperative education between industry and school, in vocational high school in Incheon Area. In order to accomplish the study purpose, the study conducted a research through questionnaire and examined their recognition for cooperative education between industry and school focusing on curriculum (purpose and content), operational system including supporting system (establishment and operational level) and educational type (process, effectiveness, problems and reinforcing measures). The study conducted a survey using Likert 5 score scale and analyzed the survey results using technical statistics such as frequency, average, standard deviation, etc. From the comprehensive results from the survey, it was found that although outcomes from industry-school cooperation are relatively high, participation is insufficient and intermediating organizations connecting concerned parties and mediating them are not enough because recognition and will of interested parties of industry-school cooperation are not sufficient. In addition, policies, legal and systematical and financial infrastructure for activation and efficiency of industry-school cooperation are not established perfectly, therefore, there are a lot of things to be improvement in operation. In particular, it was observed that establishment of internal organization and infrastructure for the number of workers in vocational training organizations are decisively inadequate.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.4
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• pp.113-131
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• 2015

Decision effectiveness depends on type of knowledge within team members generated by decision making process. Thus, organization in accordance with teams' experience and capability ultimately achieve their desired outcome. However, previous research has not addressed a mediating role between different knowledge type in decision making and product competitive advantages(pioneering advantage and product quality superiority). Based on the knowledge-based view, we model how different knowledge characteristics in decision making affect to acquire each of knowledge in decision making effectively and then to apply acquired knowledge in decision making. Anchored in a source-position-performance (SPP) framework (Day and Wensley's, 1988), we shed light on the effects of three knowledge characteristics dimensions in decision making process on knowledge management competences in decision making for a new product project. We also examine the relationship between two dimensions of NPD knowledge management competences, and product competitive advantages which consist of market pioneering advantage and product quality superiority. To test the relationships, the empirical analyses are conducted using a sample of team managers who participated in NPD projects. This study suggest that managers should increase their acquirability and applicability of knowledge by integrating complexity of diverse and new knowledge, developing codifiability of well-documented knowledge, and creating the sharing common knowledge among NPD team members. Thus, they are able to outrun major competitors in terms of pioneering advantage and product quality superiority perspective.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3139-3145
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• 2016

Cancer is the leading cause of morbidity and mortality worldwide, characterized by irregular cell growth. Cytotoxicity or killing tumor cells that divide rapidly is the basic function of chemotherapeutic drugs. However, these agents can damage normal dividing cells, leading to adverse effects in the body. In view of great advances in cancer therapy, which are increasingly reported each year, we quantitatively and qualitatively evaluated the papers published between 1981 and December 2015, with a closer look at the highly cited papers (HCPs), for a better understanding of literature related to cytotoxicity in cancer therapy. Online documents in the Web of Science (WOS) database were analyzed based on the publication year, the number of times they were cited, research area, source, language, document type, countries, organization-enhanced and funding agencies. A total of 3,473 publications relevant to the target key words were found in the WOS database over 35 years and 86% of them (n=2,993) were published between 2000-2015. These papers had been cited 54,330 times without self-citation from 1981 to 2015. Of the 3,473 publications, 17 (3,557citations) were the most frequently cited ones between 2005 and 2015. The topmost HCP was about generating a comprehensive preclinical database (CCLE) with 825 (23.2%) citations. One third of the remaining HCPs had focused on drug discovery through improving conventional therapeutic agents such as metformin and ginseng. Another 33% of the HCPs concerned engineered nanoparticles (NPs) such as polyamidoamine (PAMAM) dendritic polymers, PTX/SPIO-loaded PLGAs and cell-derived NPs to increase drug effectiveness and decrease drug toxicity in cancer therapy. The remaining HCPs reported novel factors such as miR-205, Nrf2 and p27 suggesting their interference with development of cancer in targeted cancer therapy. In conclusion, analysis of 35-year publications and HCPs on cytotoxicity in cancer in the present report provides opportunities for a better understanding the extent of topics published and may help future research in this area.

• The Journal of the Korea Contents Association
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• v.13 no.2
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• pp.400-411
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• 2013

OCB(organizational citizenship behavior) is a employee behavior that goes above and beyond the call of duty, that is discretionary and not explicitly recognized by the employing organization's formal reward system, and that contributes to organizational effectiveness. In a word, OCB has great potential as a organizational slack. As such, researchers have been showing great interest in the antecedents of OCB, and as a result, now we can meet so many antecedents of OCB from individual level variables to group or organizational level variables that are said to be important in explaining OCB. Additionally each of these variables is known to have its own sound logic and statistically significant effect on OCB. However the results of these studies are so fragmented that researchers have a great difficulty in drawing some meaningful or coherent conclusions. In this context, we try to applicate Q-methodology to find more coherent way of explaining the motives of OCB, and briefly speaking, we find four types of the motives of OCB, that is norm-based, instrumentality-based, trait-based, and avoidance-based type. Among these the last avoidance-based type is especially interesting, because we can't find any remarks on this type in the previous studies. The paper ends with suggestions for future research directions. We expect that these suggestions could be a foundation on which more developed and coherent OCB theories stand. We don't see this approach supplanting earlier efforts; rather we believe this can offer more detailed explanation in addition to those provided by other approaches.