• 재활치료과학
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• 제10권2호
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• pp.37-51
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• 2021

목적 : 본 연구는 주로 침흘림을 보이는 뇌성마비 아동에게 비침습적인 치료적 중재와 침흘림 측정방법의 경향 분석 등에 대한 국외 문헌들을 중심으로 종합적으로 분석하고자 하였다. 연구방법 : 본 연구는 최근 15년 간(2005-2019) 국외 논문을 검색하여 총 265편의 논문이 검색되었다. 1차 제목 및 초록을 중심으로 44편의 논문이 선정되었고, 2차 원문 검색을 통해 10편의 논문이 최종적으로 선정되었다. 결과 : 선정된 논문의 PEDro Scale은 평균 6점으로 높은 편이었다. 전반적인 동향을 분석한 결과 연구대상자는 뇌성마비가 주를 이루었고, 행동수정에 비해 구강감각운동의 치료적 중재가 최근에 활발하게 연구되고 있었다. 행동수정과 구강감각운동 중재방법은 대상자의 나이, 인지수준, 대상자 수, 연구설계, 치료시간과 기간에서 차이가 있음을 확인하였다. 침흘림 측정방법은 빈도와 심각성을 동시에 확인하는 연구가 주를 이루는 것으로 나타났다. 결론 : 본 연구에서는 침흘림을 보이는 뇌성마비 아동에게 실시한 비침습적인 중재 중 대표적인 행동수정과 구강감각운동 중재에 대해서 분석하였고, 이러한 자료를 통해 행동수정과 구강감각운동치료를 통한 침흘림 프로그램 계획 시 적절한 치료적 중재방법을 선택하는데 도움이 될 수 있는 정보제공 및 근거를 마련하였다.

• 한국식품영양과학회지
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• 제43권1호
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• pp.55-59
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• 2014

치커리 화이바는 콜레스테롤 개선, 배변활동 원활, 식후혈당 상승억제의 기능성을 바탕으로 건강기능식품 기능성 원료로 사용되고 있다. 배변활동에 도움을 주는 치커리 화이바를 발효하여 변비개선 효능을 확인한 결과 실험기간 동안 식이 섭취량이 증가한 반면 체중이 유의적으로 감소하는 것으로 보아 비만예방에 효과가 있을 것으로 생각된다. 장 기능 개선효과를 확인하기 위해 소화관 이동률을 측정한 결과 대조군에 비해 양성 대조군 FWP(차전자피복합물), 실험군 CF(치커리 화이바), 실험군 FCF(치커리 화이바 발효물)에서 소화관 이동률이 증가하였고, 특히 실험군 FCF 1.62 mg/g (P<0.01)과 실험군 4.13 mg/g(P<0.05)의 경우 실험군 CF 동일 농도에 비해 소화관 이동률이 유의적으로 증가하였다. 또한 변비개선 효과를 확인하기 위해 대장 내 잔류하고 있는 변의 개수를 확인한 결과 변비를 유발시킨 loperamide 처리군은 대조군에 비해 대장 내에 변이 잔류하면서 배변활동이 제대로 이루어지지 않아 대장 내 변의 개수가 유의적으로 증가한 반면, 양성 대조군 FWP와 실험군 CF, 실험군 FCF에서 대장 내 변의 개수를 유의적으로 감소시켰고 특히 실험군 FCF 2.06 mg/g의 경우 실험군 CF 동일 농도에 비해 대장 내 변의 개수를 유의적으로 감소시켰다(P<0.01). 본 연구결과를 통해 치커리 화이바를 발효함으로써 배변활동 및 변비개선능이 비발효 치커리 화이바에 비하여 더욱 증진되는 것을 확인할 수 있었다. 따라서 발효된 치커리 화이바가 배변 및 변비 기능성을 증진시키는 소재로 활용될 수 있을 것으로 사료된다.

• 대한장애인치과학회지
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• 제12권2호
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• pp.55-65
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• 2016

The objective of this study was to estimate the proper amount of subsidy required to operating dental hospital or clinic for the disabled. Models for estimating operating profit of general dental hospital/clinic and opportunity cost of operating dental hospital/clinic for the disabled was formulated. Data were collected from various sources such as the annual reports of Purme Hospital, one of the running dental hospitals for the disabled, statistics from Healthcare Bigdata Hub, operated by Health Insurance Review & Assessment Service of Korean Government, and the deliberation data of non-reimbursable treatments in Seoul Dental Hospital for the Disabled. A dental hospital/clinic for the disabled was less profitable than a general dental hospital/clinic, of which the reason is that the chair time for the average patient is longer. However, It was false that a dental hospital/clinic for the disabled scored less average insurance fee for a treatment. Disabled patients had more frequent prosthodontic treatments, which had a high average insurance fee. There were some groups of treatments that could yield higher profitability in a dental hospital/clinic for the disabled; recall checks, and periodontal treatments.

• 구강회복응용과학지
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• 제36권4호
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• pp.203-210
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• 2020

현대사회는 4차 산업혁명 시대를 맞아 정보통신기술의 발달로 환자 개인 맞춤 의료서비스가 확대되고있다. 이러한 변화에 따라 질병의 진단, 환자 감시, 의사결정 지원에 디지털 의료기기가 활용되기 시작했으며 최근엔 장애나 질병예방, 관리 또는 치료하기 위한 목적의 소프트웨어 의료기기가 각광받고 있다. 본 종설은 현재 미국을 중심으로 활발하게 이뤄지고 있는 치료 목적의 소프트웨어에 대한 개념과 현황을 파악하고 앞으로 어떤 분야에서 적용될 수 있는지 알아보고자 한다. 또, 스마트 헬스케어와 관련된 국내 정책 동향을 파악해 다가올 의료계의 변화에 발맞춰 치과 임상에서 가능한 디지털기반 소프트웨어 의료기기의 적용에 대해 알아보고자 한다.

• 치위생과학회지
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• 제21권1호
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• pp.45-51
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• 2021

Background: Periodontal disease, also known as gum disease, is a major dental inflammatory disease with a very high prevalence; it is the main cause of tooth loss. Therefore, diagnostic biomarkers that can monitor gum inflammation are important for oral healthcare. Since the gingival crevicular fluid (GCF) adequately reflects changes in the periodontal environment, they have become a target for the development of effective diagnostic biomarkers for periodontitis. In the present study, the level of the target molecules suggested as diagnostic biomarkers for periodontitis were analyzed in GCF samples collected from healthy individuals and periodontitis patients. In addition, useful targets for the diagnosis of periodontitis were evaluated. Methods: GCF samples were collected from healthy individuals and periodontitis patients using absorbent paper points. SDS-PAGE and Coomassie staining were performed for protein analysis. The protein concentrations of GCF specimens were determined using the Bradford method. The levels of the target molecules appropriate for diagnosing periodontal disease were measured by ELISA, according to the manufacturer's protocol. Results: The protein concentration of GCF collected from periodontitis patients was 3.72 fold higher than that in an equal volume of GCF collected from healthy individuals. ELISA analysis showed that the level of interukin-6 (IL-6), IL-8, metalloproteinases 2 (MMP-2), MMP-9, tumor necrosis factor-alpha (TNF-α), azurocidin, and odontogenic ameloblast-associated protein (ODAM) were higher in the GCF samples from the periodontitis patients than in those from the healthy individuals. However, the level of IL-6 and TNF-α were relatively low (> 5 pg/ml). The prostaglandin E2 (PGE2) levels were not significantly different between the two GCF samples. Conclusion: These results indicate that IL-8, MMP-2, MMP-9, azurocidin, and ODAM are potentially useful diagnostic biomarkers for periodontitis; combining multiple biomarkers will improve the diagnostic accuracy of periodontitis.

• International Journal of Computer Science & Network Security
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• 제22권10호
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• pp.97-106
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• 2022

Objective. Nanotechnology is spreading among all areas of life, from everyday devices to medicine. The concept of nanotechnology argues that not only can new physical and chemical properties of materials be discovered, but also the new potential of nanostructures when reduced to the nanoscale. The growing interest in the application of nanomaterials in dentistry contributes to the proliferation of the range of nanomaterials used by specialists. The purpose of this review of information sources was to analyze the prospects for the use of nanomaterials in dentistry. Methods. We used the bibliographic semantic method of research, for which we analyzed electronic databases of primary literature sources Scopus, Web of Science, Research Gate, PubMed, MDPI, and MedLine. English-language scientific articles published after 2017 were taken into consideration. Results. According to the results of a search study among modern information primary sources, nanotechnology improves the preventive properties of oral care products, improves the structural-mechanical and aesthetic properties of composite mixtures for dentistry, overcomes the problems of the clinical application of dental implants. Despite the prospects of nanotechnology applications in medicine in general and dentistry in particular, the existing economic and technological problems require a thorough solution for further implementation of nanostructures. Scientific novelty. For the first time, the analysis of modern trends in the application of nanotechnology in dentistry is carried out and the peculiarities of materials are highlighted, the problems and prospects of nanostructures implementation in modern dental implantology are given, physical, chemical, mechanical, and antibacterial properties of nanomaterials are evaluated. The effect of nanomaterials on the microbial adhesion of the tooth or implant surface is described. Practical significance. The presented publication can become a scientific basis for the solution of urgent problems hindering the introduction of nanotechnology into dental practice. Conclusions. Thus, the use of nanostructures opens up great opportunities for the treatment of a wide range of diseases, not only of dental nature but also in medicine in general.

• 한국임상약학회지
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• 제33권1호
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• pp.8-21
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• 2023

Background: Gastrointestinal (GI) drugs are often co-prescribed with other medications to prevent GI complications. This study aimed to evaluate the prescribing pattern of potentially unnecessary GI drugs in patients with acute cystitis who were prescribed oral antibiotics and investigate the influencing factors affecting this. Methods: We identified female patients ≥20 years with acute cystitis who visited the outpatient clinic and were prescribed oral antibiotics between July and December by analyzing Health Insurance Review and Assessment Service (HIRA)-National Patients Sample (NPS)-2019 data. Patients with no prior history of GI disorders within 180 days prior to acute cystitis, excluding or including the date of diagnosis of acute cystitis, were selected (Group A and B). Multiple logistic regression analysis was performed to estimate the factors affecting the prescription of potentially unnecessary GI drugs. Results: A total of 1,544 in Group A and 552 patients in Group B were included for the final analysis. Potentially unnecessary GI drugs were prescribed in 1,176 patients in Group A (76.2%) and 231 patients in Group B (41.8%). Third generation cephalosporines and sulfonamides showed the lower odds ratio for prescribing GI drugs than penicillins. Prescribers from Urology clinics showed more than twice odds ratio for the prescription of GI drugs compared to prescribers from internal medicine clinics. Conclusion: The results of this study showed that potentially unnecessary GI drug prescriptions for patients with acute cystitis were high in South Korea. The positive risk factors affecting the prescription of unnecessary GIs were not patient-related factor but healthcare facility and prescriber-related factors.

• Genomics & Informatics
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• 제21권1호
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• pp.13.1-13.8
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• 2023

Importance of accurate molecular diagnosis and quantification of particular disease-related pathogenic microorganisms is highlighted as an introductory step to prevent and care for diseases. In this study, we designed a primer/probe set for quantitative real-time polymerase chain reaction (qRT-PCR) targeting rgpA gene, known as the specific virulence factor of periodontitis-related pathogenic bacteria 'Porphyromonas gingivalis', and evaluated its diagnostic efficiency by detecting and quantifying relative bacterial load of P. gingivalis within saliva samples collected from clinical subjects. As a result of qRT-PCR, we confirmed that relative bacterial load of P. gingivalis was detected and quantified within all samples of positive control and periodontitis groups. On the contrary, negative results were confirmed in both negative control and healthy groups. Additionally, as a result of comparison with next-generation sequencing (NGS)-based 16S metagenome profiling data, we confirmed relative bacterial load of P. gingivalis, which was not identified on bacterial classification table created through 16S microbiome analysis, in qRT-PCR results. It showed that an approach to quantifying specific microorganisms by applying qRT-PCR method could solve microbial misclassification issues at species level of an NGS-based 16S microbiome study. In this respect, we suggest that P. gingivalis-specific primer/probe set introduced in present study has efficient applicability in various oral healthcare industries, including periodontitis-related microbial molecular diagnosis field.

• Journal of Dental Anesthesia and Pain Medicine
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• 제23권5호
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• pp.273-280
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• 2023

Background: Intraoral local anesthesia is essential for delivering dental care; however, injection of this local anesthetic is perceived as the most painful and distressing agent for children, parents, and healthcare providers. Reducing pain as much as possible is essential to ensure smooth subsequent treatment procedures, especially in pediatric dentistry. In clinical practice, oral sucrose administration has been reported to decrease the pain during heel lance and cold pressor tests in neonates and children. This study aimed to determine whether the prior administration of a 30% sucrose solution reduced the pain related to inferior alveolar nerve block in children. Methods: A total of 42 healthy children aged 7-10 years requiring dental treatment of mandibular molars involving inferior alveolar nerve block were recruited. The participants' demographic details were recorded, height and weight were measured, and the anesthetic injection was delivered after receiving the respective intraoral sucrose solution and distilled water by the intervention (group 1) and control (group 2) group participants for 2 min. The subjective pain perceived during injection was measured using an animated emoji scale. The pain scores between the groups were compared using the Mann-Whitney U test. Results: The median pain score and range for the intervention and control groups were 4 (2 - 6) and 6 (4 - 8), respectively, and statistically significant differences (P < 0.001) were observed in the intervention group. Age, sex, height, and weight did not influence the analgesic effect of the sucrose solution. Conclusion: Oral administration of sucrose may relieve pain associated with inferior alveolar nerve block in children.

• 생명과학회지
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• 제31권3호
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• pp.330-337
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• 2021

본 연구에서는 천연물유래 구강건강 개선소재로써 노각나무의 이용 가능성을 알아보기 위해 노각나무 잎과 줄기를 에탄올에 추출한 다음 구강미생물에 대한 추출물의 항균활성을 조사하였다. 노각나무 잎과 줄기 추출물(1 mg/disc)은 구강미생물 중 P. gingivalis KCTC5352에 대해서만 항균활성을 나타내었으며 줄기보다는 잎 추출물의 항균활성이 우수하였다. 시판되고 있는 구강케어제품에 사용되고 있는 항균제와 노각나무 잎 추출물의 항균활성을 비교한 결과, P. gingivalis에 대한 노각나무 잎 추출물과 양성대조구로 사용한 triclosan의 항균활성은 유사하게 나타났으며. P. gingivalis에 대한 노각나무 잎 추출물의 MIC는 0.4 mg/ml이고 정균작용을 하였다. 노각나무 잎추출물이 0.2-2.0 mg/ml 농도로 처리된 배양액에서 P. gingivalis KCTC5352의 생물막 형성과 세균 생육은 추출물의 농도가 증가할수록 농도의존적으로 억제되는 경향을 보였다. 또한 노각나무 잎 추출물(1 mg/ml) 처리가 P. gingivalis의 생물막 형성에 미치는 영향을 주사전자현미경으로 관찰한 결과에 의하면 추출물을 처리하지 않은 대조구는 추출물 처리구에 비해 P. gingivalis가 군집을 이루며 모여 있었고 세포 주변에서 생물막이 관찰되었지만 추출물을 처리한 처리구의 세포 주변에서는 생물막을 관찰할 수 없었다. qRT-PCR을 이용하여 생물막 형성 초기 과정에서 치면 부착에 필수적인 섬모(fimbriae)관련 mRNA 발현 양상을 0조사한 결과, 노각나무 잎 추출물이 0.2-2.0 mg/ml의 농도로 처리된 배양액에서 fimA와 mfa1 유전자 발현은 추출물의 농도가 높아질수록 농도의존적으로 억제되는 것을 확인할 수 있었다. 이상의 결과를 종합하면 노각나무 잎 추출물은 치주질환 원인균인 P. gingivalis에 대한 항균 활성과 생물막 형성 억제능이 우수하기 때문에 천연물유래 구강건강 개선소재로써 이용 가능성이 높을 것으로 판단된다.