• Tuberculosis and Respiratory Diseases
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• 제43권4호
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• pp.637-644
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• 1996

만성 C형 간염환자에서 IFN으로 치료중에 발생된 간질성 폐렴은 매우 드물고 아직까지국내에는 보고된 바 없었다. 저자들은 만성 C형 간염환자가 IFN-${\alpha}$를 투여받던 중에 기침과 호흡곤란을 주소로 내원하여 간질성 폐렴으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Clinics in Shoulder and Elbow
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• 제23권1호
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• pp.3-10
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• 2020

Background: The aim of this study was to evaluate clinical experience with arthroscopic debridement for septic arthritis of the shoulder joint and to report on our patient outcomes. Methods: The retrospective analysis included 36 shoulders (male:female, 15:21), contributed by 35 patients (mean age, 63.8 years) treated by arthroscopy for septic arthritis of the shoulder between November 2003 and February 2016. The mean follow-up period was 14.3 months (range, 12-33 months). An additional posterolateral portal and a 70° arthroscope was used to access the posteroinferior glenohumeral (GH) joint and posteroinferior subacromial (SA) space, respectively. Irrigation was performed with a large volume of fluid (25.1±8.1 L). Multiple suction drains (average, 3.3 drains) were inserted into the GH joint and SA space and removed 8.9±4.3 days after surgery. Intravenous antibiotics were administered for 3.9±1.8 weeks after surgery, followed by oral antibiotic treatment for another 3.6±1.9 weeks. Results: Among the 36 shoulders, reoperation was required in two cases (5.6%). The average range of motion achieved was 150.0° for forward flexion and T9 for internal rotation. The mean simple shoulder test score was 7.9±3.6 points. Nineteen shoulders (52.8%) had acupuncture or injection history prior to the infection. Pathogens were identified in 15 shoulders, with Staphylococcus aureus being the most commonly identified pathogen (10/15). Both the GH joint and the SA space were involved in 21 shoulders, while 14 cases involved only the GH joint and one case involved only the SA space. Conclusions: Complete debridement using an additional posterolateral portal and 70° arthroscope, a large volume of irrigation with >20 L of saline, and multiple suction drains may reduce the reoperation rate.

• 치위생과학회지
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• 제3권1호
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• pp.1-4
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• 2003

본 고는 치위생 임상업무를 수행하는 과정에서 발생할 수 있는 외상성 치은 손상에 대처하기 위한 방법으로서 조직접착제의 활용 방안에 대해 검토하고자 하였다. 시아노아크릴레이트 조직접착제는 조직 표층의 열창을 기존 봉합법에 의하지 않고 화학물질에 의한 접착 방식으로 폐쇄하기 위한 용도로서 그 동안 구강외과나 치주수술 분야에서 그 응용이 모색되어 왔다. 치과위생사가 치석제거 및 치근활택술 등의 시술 과정에서 부적절하거나 과도한 기구조작에 의해 치은이나 구강점막에 열창이 초래될 수 있다. 이러한 상황에 발생하였을 경우, 조직접착제를 이용하여 열창을 폐쇄하면 매우 효과적이며 단순하고 편리하다. 조직접착제는 n-butyl-2-cyanoacrylate로 구성되어 있으며, 조직의 수분과 접촉하면 빠르게 중합되어 접착력을 나타낸다. 조직접착제를 이용한 치은열창의 처치는 그 심미적 결과가 양호하며, 추가적인 조직 손상이 없을 뿐 아니라 시술 방법이 간단하여 시간이 적게 소요된다. 또한 국소마취가 필요치 않으며, 창상 소독이나 봉합사 제거를 위해 환자가 다시 내원하지 않아도 되는 등의 여러 임상적 장점이 있다. 창상의 감염 방지나 지혈 작용 등에도 효과적이다. 조직접착제는 치위생 임상에서 발생할 수 있는 조직손상에 대한 처치법으로서 환자나 치과위생사 모두에게 유용하게 활용될 수 있다.

• Journal of Periodontal and Implant Science
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• 제37권1호
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• pp.91-102
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• 2007

The long term success of periodontal treatment is dependent upon the effectiveness of the main-tenance care program after active treatment. The purpose of this study was to evaluate whether nutraceutical containing PRF-K2 as natural product from plant and seaweed has beneficial effects on clinical parameters, gingival crevicular fluid (GCF) volume and GCF cytokine levels during main- tenance phase after periodontal treatment. Among the generally healthy and non-smoking. moderate to severe chronic periodontitis patients during maintenance phase in Department of Periodontics, Chonnam National University Hospital, twenty eight patients took nutraceutical containing PRF-K2 (Oscotec Inc. Cheonan, Korea) for 3 months as experimental group and sixteen patients received only maintenance care as control group. Clinical examination and GCF collection were performed at baseline, 1, 2 and 3 months of experiment. Total amounts and concentrations of GCF IL-1{\beta}, IL-1ra and $PGE_2$ were evaluated using ELISA kit. In probing pocket depth, experimental group showed the tendency of more reduction than control group after 3 months of experiment. Sulcus bleeding index (SBI) and GCF volume were significantly decreased in experimental group(p<0.05), whereas they were increased in control group. GCF IL-1{\beta} level tended to decrease in both experimental and control group and IL-1ra concentration tended to increase in experimental group and to decrease in control group. IL-1ra/IL-1{\beta} ratio tended to increase in experimental group and to decrease in control group during experimental period. GCF $PGE_2$ amount did not show any change in experimental group and tended to increase in control group. These results suggest that nutraceutical supplement which contain PRF-K2 could improve perio-dontal condition during maintenance phase after periodontal therapy.

• 대한소아치과학회지
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• 제28권1호
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• pp.146-153
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• 2001

콤포짓트 레진의 다양한 성분은 기계적 성질에 많은 영향을 미치고, 수복물 주위의 환경 또한 재료의 성질에 많은 영향을 줄 수 있다. 구강 내에서 수복된 콤포짓트 레진은 항상 수분에 노출되어 있고, 콤포짓트 레진의 매트릭스는 수분을 흡수할 수 있으므로, 그 결과 콤포짓트 레진은 팽창하게 된다. 또한 콤포짓트 레진의 수분 흡수가 표면강도와 마모저항의 저하와 관계된 다고 알려져 있는바 저자는 치과용 콤포짓트 레진의 수분 흡수에 따른 압축강도와 굴곡강도의 변화에 관하여 알아보고자 하였다. 재료는 1군을 Z-100(3M, U.S.A.), 2군을 Spectrum(Dentsply, U.S.A.), 3군을 Clearfil AP-X(Kuraray, Japan), 4군을 Pyramid(Bisco, U.S.A), 5군을 Heliomolar(Vivadent, Germany)로 나누어 7일, 30일, 60일, 120일간 증류수에 넣어 $37^{\circ}C$에서 보관한 후 Instron 6022(Instron, U.K.)를 이용하여 압축강도와 굴곡강도를 측정하여 다음과 같은 결과를 얻었다. 1. 7일, 30일, 60일, 120일로 기간이 증가함에 따라 모든 군에서 압축강도가 감소하였다(p<0.05). 2. 7일, 30일, 60일, 120일로 기간이 증가함에 따라 모든 군에서 굴곡강도가 감소하였다(p<0.05). 3. Hybrid type인 1, 2, 3군에 비해 matrix 비율이 높은 microfine type인 5군이 강도가 낮았다.

• 대한한방내과학회지
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• 제25권3호
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• pp.427-439
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• 2004

It has been reported that Bopheyangyoungjeon(BYJ) has an effect on deficiency asthma(喘虛) clinically. The aim of this study was to determine an appropriate dosage of BYJ to treat asthma. In order to study the effects of orally administered BYJ on allergic asthma, mice were pretreated with three oral doses of the herbal solution of BYJ before antigen sensitization. 2 days later Mice were actively sensitized with a subcutaneous injection of ovalbumin and 13 day later ovalbumin aerosols were used to provoke asthmatic reaction. Serum level of IgE, IL-4, WBC, RBC, HGB, cell numbers in bronchoalveolar lavage fluid(BALF), and in vitro isometric contractile responses of the isolated tracheal smooth muscle(TSM) to acetylcholine(ACh, 0.1-1000uM), KCl were measured. The results were as follows ; 1. Contractile responses of TSM to ACh significantly increased in C group at Ach 0.3, 1, 3, 10, 30, 100, 300, 1000uM(P<0.05, P<0.01) and increased in D at 0.1, 0.3, 3, 30, 30, 100, 300, 1000uM. 2. The sensitivity of TSM to Ach increased more in A, B group, but it was not significant. 3. The maximal contractile response of TSM to ACh decreased more significantly in C group(P<0.01) and D group(P<0.05) the control group. 4. The maximal contractile response of TSM to KCI decreased more significantly in B group and C group(P<0.001) than in the control group. 5. The counts of lymphocytes in BALF decreased more significantly in B group and D group(P<0.05) than in the control group. 6. The counts of macrophages in BALF decreased more significantly in B group, C(P<0.05) than in the control group. 8. Serum IgE level increased more significantly in B group and C group(P<0.05) than the control group. 9. The counts of WBC, RBC, HGB in blood increased more significantly in A group than the control group. The above results support a role for BYJ orally administered in treatment of deficiency allergic Asthma.

• 한국가스학회지
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• 제20권2호
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• pp.35-42
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• 2016

포름아미드(formamide)는 암모니아 냄새의 무색 액체로 흡입 시 자극성이 강하며, 급성독성 $LD_{50}$ 5,577 mg/kg(랫드), 표적장기(간장) 전신독성의 무유해영향농도(NOAEL)는 113 mg/kg/day) 및 생식독성물질(1B)로 작업환경 노출기준은 10 ppm이었다. 포름아마이드 취급사업장에 대한 작업환경 측정결과는 25개 시료 모두가 노출기준보다 매우 낮은 농도를 보였다. 그러나 작업강도, 국소배기장치의 가동 및 보호구(방독마스크)의 착용 여부 등 작업환경에 따라 노출농도가 변할 수 있어 가상 노출 시나리오별 노출량을 산출한 결과 노출량은 $5.16mg/m^3$, $1.72mg/m^3$, $0.43mg/m^3$으로 산출되었다. 이를 전신독성 및 생식독성의 유해성을 고려한 위험성을 평가한 결과 평균값은 0.02-0.58, 누적 90% 값은 0.02-0.66, 95% 값은 0.02-0.69로 모두 1보다 낮은 대체로 안전한 값으로 산출되었다. 단, 작업 상황에 따라 순간적 고농도에 노출될 위험도 있으며, 간독성 및 생식독성 물질이기에 건강장해 예방을 위해 노출되지 않도록 취급 시 주의가 요망된다.

• 대한치과보존학회:학술대회논문집
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• 대한치과보존학회 2001년도 추계학술대회(제116회) 및 13회 Workshop 제3회 한ㆍ일 치과보존학회 공동학술대회 초록집
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• pp.577-577
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• 2001

The lastest concepts in bonding are "total etch", in which both enamel and dentin are etched with an acid to remove the smear layers, and "wet dentin" in which the dentin is not blown dry but left moist before application of the bonding primer. Ideally, the application of a bonding agent to tooth structure should be insensitive to minor contamination from oral fluids. Clinically contaminations such as saliva, gingival fluid, blood and handpiece lubricant are often encountered by dentists during preparation of a restoration. The aim of this study was to evaluate the effect of contamination by hem-ostatic agents on shear bond strength of compomer restorations. One hundred and ten extracted human maxillary and mandibular molar teeth were collected. The teeth were cleaned from soft tissue remnant and debris and stored in physiologic solution until they were used. Small flat area on dentin of the buccal surface were wet ground serially with 400, 800 and 1200 abrasive paper on automatic polishing machine. The teeth were randomly divided into 11 groups. Each group was conditioned as follows: Group 1 : Dentin surface was not etched and not contaminated by hemostatic agents. Group2 : Dentin surface was not etched but was contaminated by Astringedent (Ultradent product Inc., Utah, U.S.A.). Group3 : Dentin surface was not etched but was contaminated by Bosmin (Jeil Phann, Korea.). Group4 : Dentin surface was not etched but was contaminated by Epri-dent (Epr Industries, NJ, U.S.A.). Group5: Dentin surface was etched and not contaminated by hemostatic agents. Group 6 : Dentin surface was etched and contaminated by Astringedent. Group7 : Dentin surface was etched and contaminated by Bosmin. Group8 : Dentin surface was etched and contaminated by Epri-dent. Group9 : Dentin surface was contaminated by Astringedent. The contaminated surface was rinsed by water and dried by compressed air. Group10 : Dentin surface was contaminated by Bosmin. The contaminated surface was rinsed by water aud dried by compresfed air. Group 11 : Dentin surface was contaminated by Epri-dent. The contaminated surface was rinsed by water and dried by compresfed air. After surface conditioning, F2000 was applicated on the conditoned dentin surface. The teeth were thermocycled in distilled water at $5^{\circ}C\;and\;55^{\circ}C$ for 1000 cycles. The samples were placed on the binder with the bonded compomer-dentin interface parallel to the lmife-edge shearing rod of the Universal testing machine(Zwick 020, Germany) running at a cross head speed of 1.0mmimin. There were no significant differences in shear bond strength between groups 1 and group 3 and 4, but group 2 showed significant decrease in shear bond strength compared with group 1. There were no significant differences in shear bond strength between group 5 and group 7 and 8, but group 6 showed significant decrease in shear bond strength compared with group 5. There were no significant differences in shear bond strength between group 5 and group 9, 10 and 11.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2002년도 추계국제학술대회
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• pp.168-168
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• 2002

To establish a test protocol for the rodent 20-day thyroid/pubertal assay, flutamide and diethylstilbestrol (DES) were administered to intact male Sprague-Dawley rats from postnatal day 33 for 20 days. Flutamide (1, 5, and 25 mg/kg/day) or DES (10, 20, and 40 ug/kg/day) was given once daily by oral gavage to immature male rats. Prepuce separation was significantly delayed in flutamide group and in DES group. One day after the last dose, the rats were killed and pituitary, thyroid, and reproductive organs were removed and weighed. Flutamide treatment resulted in a significant reduction in the weights of epididymides, ventral prostate, seminal vesicles plus coagulating glands and fluid (SVCGF), levator ani. bulbocarvenus muscles (LABC), Cowper's glands, and glans penis. The weight of adrenal glands decreased at % mg/kg/day, while testes and any other organ weights were unaffected. No microscopic changes were observed in the thyroid glands. Serum levels of testosterone wert significantly increased in the flutamide-treated groups and serum levels of estradiol were also increased. A significant reduction in the weights of testes, epididymides, ventral prostate, SVCGF, LABC, Cowpers glands, and glans penis of DES treated group. Serum testosterone and LH decreased significantly in DES group. Decrease of estradiol was observed, but not significant. These results indicate that flutamide and DES delay puberty in the male rat and its mode of action appears to be via altered secretion of steroids, which subsequently affect the development of the reproductive tract. (Supported by the grant from NITR/Korea FDA for Endocrine Disrupter Research.)

• Parasites, Hosts and Diseases
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• 제53권3호
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• pp.321-327
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• 2015

A 50-year-old male visited the outpatient clinic and complained of fever, poor oral intake, and weight loss. A chest X-ray demonstrated streaky and fibrotic lesions in both lungs, and chest CT revealed multifocal peribronchial patchy ground-glass opacities with septated cystic lesions in both lungs. Cell counts in the bronchoalveolar lavage fluid revealed lymphocyte-dominant leukocytosis, and further analysis of lymphocyte subsets showed a predominance of cytotoxic T cells and few T helper cells. Video-assisted wedge resection of the left upper lobe was performed, and the histologic examination was indicative of a Pneumocystis jirovecii infection. Trimethoprim-sulfamethoxazole (TMP-SMX) was orally administered for 3 weeks; however, the patient complained of cough, and the pneumonia was aggravated in the follow-up chest X-ray and chest CT. Molecular studies demonstrated mutations at codons 55 and 57 of the dihydropteroate synthase (DHPS) gene, which is associated with the resistance to TMP-SMX. Clindamycin-primaquine was subsequently administered for 3 weeks replacing the TMP-SMX. A follow-up chest X-ray showed that the pneumonia was resolving, and the cough was also alleviated. A positive result of HIV immunoassay and elevated titer of HCV RNA indicated HIV infection as an underlying condition. This case highlights the importance of careful monitoring of patients with P. jirovecii pneumonia (PCP) during the course of treatment, and the molecular study of DHPS mutations. Additionally, altering the anti-PCP drug utilized as treatment must be considered when infection with drug-resistant P. jirovecii is suspected. To the best of our knowledge, this is the first case of TMP-SMX-resistant PCP described in Korea.