• 대한전기학회논문지:시스템및제어부문D
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• 제51권1호
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• pp.18-25
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• 2002

The software reliability is defined, and not only the relations between testing time and reliability, but also the relation between duration following failure fixing and reliability are studied in this paper. The release time making the testing cost to be minimum is determined through evaluating the cost for each condition. Also, the release time is determined depending on the conditions of the first reliability, considering the specified reliability. the optimum release time is determined by simultaneously studying two optimum release time issues that determine both the cost related time and the specified reliability related time. And, each condition and limitation are studied. The trend of the optimum time is also examined.

• Journal of Pharmaceutical Investigation
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• 제17권3호
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• pp.101-110
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• 1987

In order to reduce gastric irritation in the stomach of iron preparations, ferroglycine fumarate (FGF) granules coated with hydroxyethylcellulose was made by matrix granulator, and the constrained optimization method, employing the Lagrange equation, was successfully applied to the manufacturing process design of controlled release tablets. The effects of stearic acid and dried corn starch on tablet hardness, friability, dissolution rate $t_{50%}$ and tablet volume were found to be very significant. In rabbit test, pharmacokinetic parameters $(K_a,\;C_{max}\;and\;AUC^{0-12})$ and urinary excretion rate $(K_e)$ of the controlled release FGF tablets were higher than those of controlled release ferroglycine sulfate tablets which were manufactured in the same optimal conditions. Controlled release FGF tablets were more stable than controlled release ferroglycine sulfate tablets in accelerated storage conditions.

• Archives of Pharmacal Research
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• 제19권4호
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• pp.280-285
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• 1996

The sustained release dosage form which delivers melatonin (MT) in a circadian fashion over 8 h is of clinical value for those who have disordered circadian rhythms because of its short halflife. The purpose of this study was to evaluate the gelling properties and release characteristics of alginate beads varying multivalent cationic species $(Al^{+++}, \; Ba^{++}, \; Ca^{++}, \; Mg^{++}, \; Fe^{+++}, \; Zn^{++})$. The surface morphologies of Ca- and Ba-alginate beads were also studied using scanning electron microscope (SEM). MT, an indole amide pineal hormone was used as a model drug. The $Ca^{++}, \; Ba^{++}, \; Zn^{++}, \; Al^{++}\; and\; Fe^{+++}\; ions\; except\; Mg^{++}$ induced gelling of sodium alginate. The strength of multivalent cationic alginate beads was as follows: $Al^{+++}\llFe^{+++} the induced hydrogel beads were very fragile and less spherical. Fe-alginate beads were also fragile but stronger compared to Al-alginate beads. Ba-alginate beads had a similar gelling strength but was less spherical when compared to Ca-alginate beads. Zn-alginate beads were weaker than Ca- and Ba-alginate beads. Very crude and rough crystals of Ba- and Ca-alginate beads at higher magnifications were observed. However, the type and shape of rough crystals of Ba- and Ca-alginate beads were quite different. No significant differences in release profiles from MT-loaded multivalent cationic alginate beads were observed in the gastric fluid. Most drugs were continuously released upto 80% for 5 h, mainly governed by the passive diffusion without swelling and disintegrating the alginate beads. In the intestinal fluid, there was a significant difference iq the release profiles of MT-loaded multivalent cationic alginate beads. The release rate of Ca-alginate beads was faster when compared to other multivalent cationic alginate beads and was completed for 3 h. Ba-alginate beads had a very long lag time (7 h) and then rapidly released thereafter. MT was continuously released from Feand Zn-alginate beads with initial burstout release. It is assumed that the different release rofiles of multivalent cationic alginate beads resulted from forces of swelling and disintegration of alginate beads in addition to passive diffusion, depending on types of multivalent ions, gelling strength and drug solubility. It was estimated that 0.2M $CaCl_2$ concentration was optimal in terms of trapping efficiency of MT and gelling strength of Ca-alginate beads. In the gastric fluid, Ca-alginate beads gelled at 0.2 M $CaCl_2$ concentration had higher bead strength, resulting in the most retarded release when compared to other concentrations. In the intestinal fluid, the decreased release of Ca-alginate beads prepared at 0.2 M $CaCl_2$ concentration was also observed. However, release profiles of Ca-alginate beads were quite similar regardless of $CaCl_2$ concentration. Either too low or high $CaCl_2$ concentrations may not be useful for gelling and curing of alginate beads. Optimal $CaCl_2$ concentrations must be decided in terms of trapping efficiency and release and profiles of drug followed by curing time and gelling strength of alginate beads.

• Nuclear Engineering and Technology
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• 제36권1호
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• pp.36-46
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• 2004

The ISAAC fission product release calculation is based on detailed FPRAT models developed by Jaycor. For volatile fission product release calculations, either the Cubicciotti steam oxidation correlation or the NUREG-0772 correlation is used. In this study, evaluation is carried out for these volatile fission product release models. As a result, in the case of early release, the IDCOR model with an in-vessel Te release option shows the most conservative results and for the late release case, the NUREG-0772 model shows the most conservative results. Considering both early and late release, the IDCOR model with an in-vessel Te bound option is evaluated to show mitigated conservative results. In addition, a sensitivity study on detailed core nodalization is performed. In the study, 380 horizontal fuel channels in the Wolsong plant are nodalized into 12 (6 channels per loop, $3{\times}3$ Core Pass) representative channels and detailed by 16/20/24 channels. For reference accidents, LOAH and large LOCA are selected as representing high and low pressure sequences, respectively. According to the results, the original 12 channel approach with $3{\times}3$ core passes is evaluated to be sufficient as an optimal scheme.

• 대한정형도수물리치료학회지
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• 제27권2호
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• pp.87-92
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• 2021

Purpose: This study aimed to investigate the effects of myofascial release technique on pain threshold and hormonal changes in patients with adhesive capsulitis of the shoulder. Methods: Eight patients with adhesive capsulitis were treated with the myofascial release technique. Myofascial release is a form of manual therapy that involves the application of a low load, long duration stretch to the myofascial complex, intended to restore optimal length, decrease pain, and improve function. Blood tests and pressure pain threshold (PPT) examinations were performed on their first visit. On their second visit, the myofascial release technique was applied to the shoulder for 20 min. Then, blood tests and PPT were re-evaluated to determine the effects of the myofascial release technique on pain threshold and hormonal changes. Results: Pain threshold increased from 2.92 to 24.13 lb after treatment. Epinephrine decreased from .13 to .08 ng/mL whereas norepinephrine increased from .25 to .41ng/㎖ after treatment. Conclusion: Myofascial release technique in patients with adhesive capsulitis increased pain thresholds, norepinephrine and decreased epinephrine levels.

• 한국재료학회지
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• 제33권11호
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• pp.458-464
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• 2023

In order to develop catechin patches for skin regeneration at wound sites, patches with varying concentrations of catechin and chitosan were manufactured. An optimal composition ratio was determined by adjusting the drug release rate and amount, to maximize efficiency. The catechin used in this study was extracted from green tea leaves using a solvent/ultrasonication method, and its characteristics were confirmed through Fourier transform-infrared spectroscopy (FT-IR) and high-performance liquid chromatography (HPLC) analyses. Patches were prepared with different concentrations of catechin and chitosan, and various properties were analyzed using techniques such as FT-IR, water contact angle analysis, and UV-Vis spectroscopy. It was observed that as the chitosan concentration increased, the release of catechin slowed down or almost ceased. A patch manufactured with 1.5 mg/cm² of catechin at a 1 % chitosan concentration exhibited a high initial release rate over 24 h and demonstrated cellular biocompatibility. Consequently, these patches, with tailored release characteristics based on the concentrations of chitosan and catechin, hold promise for use as drug delivery systems in wound healing applications.

• 한국가스학회지
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• 제20권5호
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• pp.104-111
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• 2016

최근 화학물질을 사용하는 시설이 증가하면서 동시에 시설의 노후화, 기계적 결함, 인적오류 등으로 화학물질 누출사고 피해가 많아지고 있다. 특히, 산업단지는 군집 특성으로 인해 화학물질 누출사고 발생 시 인근 사업장으로 확산되어 큰 피해로 이어질 가능성이 크다. 이에 따라 화학물질을 취급하는 공정의 누출조건, 환경조건을 반영한 다양한 누출 시나리오를 토대로 빠른 감지와 대응을 위해 경계면의 센서배치 방안을 제시할 필요가 있다. 따라서 본 연구에서는 염소가스가 누출되는 경우에 대해 COMSOL를 사용하여 주요 매개변수의 적용으로 실질적인 사고 시나리오를 해석하였다. 그리고 사고 시나리오를 바탕으로, 센서의 감지 확률과 감지시간 등 각 항목마다 중요도를 부여하여 최적 위치가 산출되도록 목적함수를 선정하였다. 또한 예상치 못한 지역의 누출사고에 대해 최적화된 센서배치의 강건성 분석을 통해 본 방안의 타당성을 높였다. 결과적으로, 기존 방식보다 효과적으로 경계면의 센서배치 최적화 방법의 적용 가능성을 확인하였다. 이상의 결과로 부터 이동식 센서의 배치방법과 농도 데이터를 기반으로, 누출원의 역추적에 도움을 줄 수 있을 것으로 기대한다.

• 한국수자원학회논문집
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• 제56권12호
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• pp.969-980
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• 2023

2000년대 이후 우리나라에 도입된 앙상블 유량 예측은 수문 예측 현업에서 성과를 보였음에도 불구하고 수자원 시스템 관리에서는 적극적으로 활용되지 못하고 있다. 따라서 본 연구에서는 용수공급을 위한 수자원 관리 측면에서 앙상블 유량 예측의 효용성을 보이고자 댐 실무자들을 위한 간단한 가상 예제를 만들고, 이를 확장하며 실제 대한민국 다목적댐에 적용하였다. 가상 예제에서는 앙상블 유량 예측의 평균은 같지만 표준편차가 다를 때, 댐 운영 비용이 상이함을 확인하였다. 그리고 이를 대한민국 다목적댐에 적용하기 위해 동일한 평균을 가지지만 표준편차가 평균과 동일한 유형W와 표준편차가 평균의 10배인 유형 P를 가정하여 용량 대비 연유입량 비율에 따라 소양강댐(CIR = 1.345)과 충주댐(CIR = 0.563)에 표본 추계학적 동적계획법으로 최적방류량을 도출하였다. 그리고 도출된 최적방류량으로 2020년부 2022년까지 모의 운영을 진행하였다. 그 결과, 충주댐에서는 표준편차가 적은 유형W에서 상대적으로 공격적인 최적방류량이 도출되었고, 모의 운영 결과 또한 양호함을 보였다. 소양강댐에서도 최적방류량에서 충주댐과 같은 결과를 보였지만, 모의 운영에서는 유형W와 P의 차이가 없었다. 결과적으로 동일한 평균을 가지더라도 앙상블 유량 예측의 표준편차에 따라 다른 최적방류량과 모의 운영 결과가 도출되었고, 특히 용량 대비 연유입량이 작을수록 이러한 불확실성에 더욱 민감하게 반응함을 보였다. 본 내용을 바탕으로 현재 단일 대푯값만을 사용하여 댐 운영을 하는 수자원 관리에 개선을 기대한다.

• Journal of Information Technology Applications and Management
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• 제11권4호
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• pp.87-94
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• 2004

The software reliability growth model(SRGM) has been developed in order to estimate such reliability measures as remaining fault number, failure rate and reliability for the developing stage software. Almost of them assumed that the faults detected during testing were evetually removed. Namely, they have studied SRGM based on the assumption that the faults detected during testing were perfectly removed. The fault removing efficiency. however. IS imperfect and it is widely known as so in general. It is very difficult to remove detected fault perfectly because the fault detecting is not easy and new error may be introduced during debugging and correcting. Therefore, the fault detecting efficiency may influence the SRGM or cost of developing software. It is a very useful measure for the developing software. much helpful for the developer to evaluate the debugging efficiency, and, moreover, help to additional workloads necessary. Therefore. it is very important to evaluate the effect of imperfect dubugging in point of SRGM and cost. and may influence the optimal release time and operational budget. I extent and study the generally used reliability and cost models to the imperfect debugging range in this paper.

• 도시과학
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• 제7권1호
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• pp.55-61
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• 2018

Long bridges, such as suspension bridges and diagonal bridges, are complex phenomena that show different behaviors depending on the shape and rigidity of the cross sections, such as wind vibrations and liquid vibrations from earthquakes in liquid storage containers. This is called the lower skirt on the lower side of the bridge, and the installation of lower skirt is effective for release and vortex vibrations caused by rapid winds, and that increases the stability of the wind resistance of the bridge. Optimal shape and installation of the lower skirt is also essential to make maximum wind speed effect of the lower skirt. Therefore, this study proposes a numerical analysis method to control the vibration of a bridge by calculating the optimal installation angle of an optimal lower skirt according to the optimal control theory and this study evaluates the impact on the optimal control system by minimizing the dominance equation with an evaluation function,which is an indicator for evaluating the optimal control theory state.