• Title/Summary/Keyword: optimal experimental design

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Production of Chiral Styrene Oxide by Microbial Enantioselective Hydrolysis Reaction (미생물 입체선택성 가수분해 반응을 이용한 광학활성 Styrene Oxide 생산)

  • 윤성준;이은열
    • KSBB Journal
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    • v.15 no.6
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    • pp.630-634
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    • 2000
  • Chiral epoxides are useful chiral synthons in organic synthesis, and various biological methods have been investigated for their production. In this work, the enantioselective resolution of racemic styrene oxide was investigated using Aspergillus niger sp. for the production of optically pure (S)-styrene oxide. The enantioselectivity and initial hydrolysis rates of the racemic substrate were highly dependent of the pH, temperature, and the volume ratio of cosolvent. Experimental sets of pH, temperature, and the volume ratio of cosolvent were investigated using a central composite experimental design, and reaction conditions were optimized by response surface analysis. The optimal conditions of pH, temperature, and the volume ratio of cosolvent were determined to be 7.78, $28.32^{\circ}C$, and 2.4%(v/v), respectively, and optically pure (S)-styrene oxide (>99% ee) was obtained at 35% yield using this microbial enantioselective hydrolysis reaction.

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Experimental Study and Process Optimization for Vibration-assisted Dry Micro-WEDM (진동을 이용한 건식 마이크로-WEDM 에 대한 실험적 연구 및 프로세스 최적화)

  • Hoang, Kien Trung;Yang, Seung-Han
    • Journal of the Korean Society for Precision Engineering
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    • v.31 no.3
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    • pp.215-222
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    • 2014
  • This paper presents an experimental study of a vibration-assisted dry micro-wire electrical discharge machining (${\mu}$-WEDM) utilized in high precision and micro-manufacturing area. The assisted vibration was applied to the workpiece using a piezoelectric actuator, and high pressure air was injected directly into the machining gap through a nozzle. Investigation experiments were performed to estimate the importance of input parameters and it was observed from experiment results that the width (kerf) of the cutting slot and the machining time were significantly affected by the air injection pressure and input energy. Moreover, it was also observed that there exists an optimal relationship between the machining time and input parameters including the air pressure and vibration frequency and amplitude. Central composite design based experiments were also carried out, and empirical models of the machining time and cutting slot kerf have been developed using the response surface methodology to analyze and optimize the process.

An Experimental Study on the Cooling Tower of Plume Prevention and Performance Improvements (냉각탑 백연방지의 성능 향상에 관한 실험적 연구)

  • JEONG, SOON YOUNG;LEE, BYEONG CHEON;KIM, SUNG
    • Journal of Hydrogen and New Energy
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    • v.30 no.6
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    • pp.578-584
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    • 2019
  • The occurrence of white plume in the cooling tower is phenomenon that the steam in the air through the cooling tower fan is condensed again by the cold ambient air to become saturated moist air. Accordingly, this can cause many problems like spoiling landscape around the cooling tower, odor of ambient air, falling accident by frozenness in the winter, and traffic accident, etc. This study was to install the heat exchanger in the inside of the cooling tower in order to prevent the white plume phenomenon in the cooling tower without affecting the performance of cooling tower. In addition, this study was to discharge the part of cooling water into the atmosphere through the recirculation of heat exchanger after creating dry air by heating the saturated moist air to the dew point temperature. At that time, this study was to conduct the experimental study in order to secure the optimal design data to prevent the white plume in the cooling tower because it checked the dry·moist temperature and relative humidity in the inside·outside of cooling tower on the moist air, and evaluated the performance of the heat exchanger.

Multi-response optimization for milling AISI 304 Stainless steel using GRA and DFA

  • Naresh, N.;Rajasekhar, K.
    • Advances in materials Research
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    • v.5 no.2
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    • pp.67-80
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    • 2016
  • The objective of the present work is to optimize process parameters namely, cutting speed, feed rate, and depth of cut in milling of AISI 304 stainless steel. In this work, experiments were carried out as per the Taguchi experimental design and an $L_{27}$ orthogonal array was used to study the influence of various combinations of process parameters on surface roughness (Ra) and material removal rate (MRR). As a dynamic approach, the multiple response optimization was carried out using grey relational analysis (GRA) and desirability function analysis (DFA) for simultaneous evaluation. These two methods are considered in optimization, as both are multiple criteria evaluation and not much complicated. The optimum process parameters found to be cutting speed at 63 m/min, feed rate at 600 mm/min, and depth of cut at 0.8 mm. Analysis of variance (ANOVA) was employed to classify the significant parameters affecting the responses. The results indicate that depth of cut is the most significant parameter affecting multiple response characteristics of GFRP composites followed by feed rate and cutting speed. The experimental results for the optimal setting show that there is considerable improvement in the process.

Experimental Parametric Study on the Rotordynamic Characteristics and Optimal Design of a Flexible Rotor Supported by a Slotted-Ring Electro-Rheological Squeeze Film Damper (슬롯 링 형상을 갖는 전기 유변 스퀴즈 필름 댐퍼로 지지된 연성 로터의 동특성 및 최적설계 파라미터 실험 연구)

  • 이용복;김창호;이남수;최동훈;정시영
    • Tribology and Lubricants
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    • v.16 no.3
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    • pp.157-165
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    • 2000
  • A discharge free Electro-Rheological Squeeze Film Damper (ER-SFD) with predetermined-clearances at leakage ends can inherently eliminate electric discharge problems while still supplying stable leakage control. Test results show that the damping force of the slotted-ring ER-SFD is mainly affected by electric voltage, oil supply pressure, position of the damper and ratio of effective surface area of slotted-rings. As the supply voltage is larger, the amplitudes of both slotted ER-SFD and rotor are decreased at first and second critical speeds. The influence of the oil supply pressure and the effective surface area ratio was shown mainly near the first critical speed. The effective surface area ratio of slotted-rings influences the reduction of flexible rotor vibration. As a result, experimental results confirm that the slotted-ring ER-SFD satisfactorily controls the flexible rotor vibration, while eliminates the inherent electric discharge problems in conventional ER-SFDs.

Effects of a Nurse Short-Message Service via Cellular Phones for People with Diabetes (휴대전화 문자 메시지를 이용한 당뇨 교육이 당뇨벙환자 혈당에 미치는 효과)

  • Kim, Hee-Seung;Park, Hea-Ja
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.13 no.2
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    • pp.235-241
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    • 2006
  • Purpose: The purpose of this study was to evaluate the effect of a six month web-based diabetic education on plasma glucose in people with diabetes. Method: A randomized design with control and experimental groups being assessed pre- and post-intervention was used. Seventeen patients were randomly assigned to a control group and 18 to an experimental group. Participants were requested to input the blood glucose level weekly to http://www.biodang.com by cellular phone or wire Internet for 6 months. The researcher sent optimal recommendations to each patient using the short message service (SMS) for cellular phone and wire Internet. Messages were sent weekly for 6 months. Results: Glycosylated hemoglobin ($HbA_1c$) decreased 1.5 percentage points at 3 months and 1.4 percentage points at 6 months compared with baseline in the intervention group. Patients in the intervention group had a decrease in 2 hours post meal glucose (2HPMG) of 94.3mg/dl at 3 months and 82.5mg/dl at 6 months compared with baseline. Conclusion: This web-based intervention using SMS for cellular phone improved HbAlc, and 2HPMG for six months in patients with type 2 diabetes.

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Substrate-integrated-waveguide cavity-backed circularly polarized antenna with enhanced bandwidth and gain

  • Shankaragouda M. Patil;Rajeshkumar Venkatesan
    • ETRI Journal
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    • v.46 no.3
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    • pp.404-412
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    • 2024
  • We propose a method for increasing the bandwidth of a substrate-integrated-waveguide (SIW) cavity-backed antenna with taper-based micro-strip SIW transition feeding. For radio transmission, a circular slot is etched on top of the SIW cavity. For optimal antenna design, the slot is etched slightly away from the cavity center to generate circularly polarized waves. Simulations show a wide axial ratio bandwidth of 7.860% between 11.02 GHz and 11.806 GHz. Experimental results confirm a similar wide axial ratio bandwidth of 4.9% between 10.8 GHz and 11.35 GHz. An SIW feed from an inductive window excites the radiating circular slot, resulting in a simulated wide impedance range of 1.548 GHz (10.338 GHz-11.886 GHz) and bandwidth of 13.93%. Experimental results show a wide impedance of 2.08 GHz (10.2 GHz-12.08 GHz) and bandwidth of 18.84%. The SIW cavity-backed antenna creates a unidirectional pattern, leading to gains of 6.61 dBi and 7.594 dBi in simulations and experiments, respectively. The proposed antenna was fabricated on a Rogers RT/Duroid 5880 substrate, and the reflection coefficient, radiation patterns, and gains were tested and compared using a computer simulator. The developed broadband antenna seems suitable for X-band applications.

A novel aerodynamic vibration and fuzzy numerical analysis

  • Timothy Chen;Yahui Meng;Ruei-Yuan Wang;ZY Chen
    • Wind and Structures
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    • v.38 no.3
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    • pp.161-170
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    • 2024
  • In recent years, there have been an increasing number of experimental studies showing the need to include robustness criteria in the design process to develop complex active control designs for practical implementation. The paper investigates the crosswind aerodynamic parameters after the blocking phase of a two-dimensional square cross-section structure by measuring the response in wind tunnel tests under light wind flow conditions. To improve the accuracy of the results, the interpolation of the experimental curves in the time domain and the analytical responses were numerically optimized to finalize the results. Due to this combined effect, the three aerodynamic parameters decrease with increasing wind speed and asymptotically affect the upper branch constants. This means that the aerodynamic parameters along the density distribution are minimal. Taylor series are utilized to describe the fuzzy nonlinear plant and derive the stability analysis using polynomial function for analyzing the aerodynamic parameters and numerical simulations. Due to it will yield intricate terms to ensure stability criterion, therefore we aim to avoid kinds issues by proposing a polynomial homogeneous framework and utilizing Euler's functions for homogeneous systems. Finally, we solve the problem of stabilization under the consideration by SOS (sum of squares) and assign its fuzzy controller based on the feasibility of demonstration of a nonlinear system as an example.

Rotor Position Sensorless Control of Optimal Lead Angle in Bifilar-Wound Hybrid Stepping Motor (복권형 하이브리드 스테핑 전동기의 회전차 위치 센서리스 최적 Lead Angle 제어)

  • Lee, Jong-Eon;Woo, Kwang-Joon
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.36S no.2
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    • pp.120-130
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    • 1999
  • In this paper, we show that the instantaneous phase current of the bifiler-wound hybrid stepping motor is dependent of lead angle and that the information of motor position is obtained from the instantaneous phase current at ${\pi}/2$ by the theoretical formular and its computer simulation results. From the facts, we design the microcontroller-based motor position sensorless controller of optimal lead angle, which generates the excitation pulses for the closed-loop drives. The controller is consist of microcontroller which has the function of A/D converter, programmable input/output timer, and the transfer table which has the values of optimal lead angle depending on motor velocity, and ROM which has the transfer table of the values of lead angle depending on velocity of motor and the values of instantaneous phase current at ${\pi}/2$. From the design of microcontroller-based controller, we minimize the external interface circuit and obtain flexibility by changing the contents of ROM transfer tables and the control software. We confirm that the designed controller drives the bifilar-wound hybrid stepping motor is the mode of optimal lead angle by comparing the instananeous phase current experimental results and computer simulation results.

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Determination of Optimal Dietary Sulfur Amino Acids Ratio Relative to Lysine for Growing Barrows and Gilts

  • Chang, W.H.;Kim, J.D.;Kim, S.W.;Xuan, Z.N.;Kim, Y.Y.;Paik, I.K.;Han, In K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.14 no.7
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    • pp.1003-1007
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    • 2001
  • This experiment was conducted to investigate the effects of dietary SAA (sulfur-containing amino acids) on growth performance, nutrient digestibility and blood urea nitrogen (BUN) content, and to determine the optimal SAA:lysine ratio for growing barrows and gilts. A total of 150 pigs (75 barrows and 75 gilts, Landrace${\times}$Yorkshire${\times}$Duroc) were assigned to 6 treatments with 5 replicates of 5 pigs per pen. All pigs were fed diets containing either 1.12 (for barrows) or 1.33% (for gilts) dietary lysine with increasing SAA levels (50, 55 and 60% of dietary lysine) in a $2{\times}3$ factorial design. Throughout the whole experimental period (15 to 54 kg body weight), there was no interaction between sexes and SAA:lysine ratios on ADG, ADFI and FCR. However, increasing the SAA:lysine ratio from 50 to 60% in a diet showed a trend to increase ADG and ADFI of barrows. None of differences in nutrient digestibilities except for calcium and phosphorus were observed and gilts showed higher digestibility of calcium and phosphorus (p<0.05). Among dietary SAA:lysine ratios, there were no differences in apparent nutrient digestibility. Mean values of the essential amino acids (EAA), non-essential amino acids (NEAA) and total amino acids (TAA) digestibilities were higher in gilts than barrows (p<0.01). However, no differences in mean value of EAA, NEAA and TAA digestibilities were observed among dietary SAA:lysine ratios. Between sexes and among SAA:lysine ratios, no significant difference in BUN concentration was observed. This study demonstrated that the optimal inclusion ratio of SAA:lysine was 55% and below 50% in barrows and gilts, respectively.