• Title/Summary/Keyword: optimal experimental design

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Development of Medium for Griseofulvin Production: Part II. Optimization of Medium Constituents Using Central Composite Design

  • Dasu, Venkata;Panda, V.T.;Chidambaram, M.
    • Journal of Microbiology and Biotechnology
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    • v.12 no.3
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    • pp.360-366
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    • 2002
  • Central composite experimental design was employed to determine the optimal concentration of medium constituents for griseofulvin production by Penicillium griseofulvum MTCC 1898 and Penicillium griseofulvum MTCC 2004. The optimal concentration of sucrose, $K_2HPO_4,\;NaNO_3,\;and\;FeSO_4{\cdot}7H_2O$ were found to be 48.08 g/1, 1.228 g/1 , 2.7 g/1, and 0.011 g/1, respectively, for Penicillium griseofulvum MTCC 1898, and for Penicillium griseofulvum MTCC 2004, 23.52 g/1, 43.67 g/1, and 0.0434 g/1 of glucose, lactose, and $MnSO_4{\cdot}H_2O$, respectively. The yield of griseofulvin under optimal composition of medium constituents increased by 1.26 and 1.38 times than prior to optimization, for Penicillium griseofulvum MTCC 1898 and Penicillium griseofulvutn MTCC 2004, respectively.

A Study of Optimal Mixture Fraction of Soil Bio-Filter for Removing NOX (질소산화물 제거를 위한 최적 토양 바이오 필터 혼합비 도출에 관한 연구)

  • Cho, Ki-Chul;Lee, Nae-Hyun
    • Journal of Environmental Science International
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    • v.16 no.11
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    • pp.1247-1255
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    • 2007
  • Soil biofiltration is an environmentally-sound technology for elimination of VOCs, odorous and $NO_X$ compounds from a low concentration, high volume waste gas streams because of its simplicity and cost-effectiveness. This study investigated the optimal mixture fraction of briquet ash, compost, soil and loess for $NO_X$ degradation. Extreme vertices design was used to examine the role of four components on $NO_X$ degradation. Under our experimental conditions, 74.5% of $NO_X$ degradation was observed, using a model mixture(25% briquet ash, 10% compost, 30% soil and 40% loess) containing 100 ppb of NO. It was shown that experimental design analysis could allow selecting optimal conditions in such biodegradation processes in this study.

The Arrangement of Heaters for Rubber Injection Molds using FEM and Optimal Design Method (유한요소법과 최적설계 기법을 이용한 고무 사출 금형 히터 배치)

  • Kim, Myung-Hun;Han, Jeong-Young;Choi, Eun-Ho;Bae, Won-Byong;Kang, Sung-Soo
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.20 no.1
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    • pp.34-39
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    • 2011
  • Temperature control of a rubber injection mold is important for the dimensional accuracy of product. The main objective of this paper is to optimize the arrangement of heaters by FEM and optimal design method. Firstly, 3-dimensional transient heat transfer analysis was carried out for a square specimen mold. Results of FE analysis are a good agreement with the experimental results, showing about 1.22~7.22% error in temperature distribution. Secondly, we suggested the optimal method about an arrangement of heaters of rubber injection mold by using the optimal design technique. Distances between heater's center and the contact surface of mold, distances between heater's center and symmetric surface were considered as design variables. And the variances between the temperatures of cavity surfaces and their average temperature were used as the objective functions. Applying the optimal solution, the temperature variation was improved about 52.9~88.1 % compared to the existing mold. As a result of sensitivity analysis for design variables, design variables parallel to the direction of the split plane in mold affect the largest on the surface temperature variation in mold cavity.

Development of Injection Tubes for Intelligent High-Efficiency Exhausted Injector (지능형 고효율 탈진 인젝터의 분사관 개발)

  • Jang, Sung-Cheol;Lee, Kyung-Jun;Lee, Jung-Won
    • Journal of the Korean Society of Industry Convergence
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    • v.20 no.1
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    • pp.74-80
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    • 2017
  • This study aimed to evaluate the validity of an exhausted injector design for filtration system and the performance characteristics thereof. The evaluation was intended through computational fluid dynamics(CFD) analysis based on computer simulation rather than through prototype fabrication and testing. Furthermore, the design of experiment was used to create an experimental design table by which the reaction characteristics of response factors were analyzed for design parameters. All experiments were substituted with computer simulations. Lastly, an optimal design model for the injection tubes was determined based on response surface method algorithms.

Composite Design Criteria : Model and Variance (복합실험기준의 설정: 모형과 분산구조)

  • 김영일
    • The Korean Journal of Applied Statistics
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    • v.13 no.2
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    • pp.393-405
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    • 2000
  • Box and Draper( 19(5) listed some properties of a design that should be considered in design selection. But it is impossible that one design criterion from optimal experimental design theory reflects many potential objectives of an experiment, because the theory was originally based on the underlying model and its strict assumption about the error structure. Therefore, when it is neces::;ary to implement multi-objective experimental design. it is common practice to balance out the several optimal design criteria so that each design criterion involved benefits in terms of its relative "high" efficiency. In this study, we proposed several composite design criteria taking the case of heteroscedastic model. WVhen the heteroscedasticity is present in the model. the well known equivalence theorem between 1)- and C-optimality no longer exists and furthermore their design characteristics are sometimes drastically different. We introduced three different design criteria for this purpose: constrained design, combined design, and minimax design criteria. While the first two methods do reflect the prior belief of experimenter, the last one does not take it into account. which is sometimes desirable. Also we extended this method to the case when there are uncertainties concerning the error structure in the model. A simple algorithm and concluslOn follow.On follow.

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Application of Taguchi Experimental Design for the Optimization of Effective Parameters on the Rapeseed Methyl Ester Production

  • Kim, Sun-Tae;Yim, Bong-Been;Park, Young-Taek
    • Environmental Engineering Research
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    • v.15 no.3
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    • pp.129-134
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    • 2010
  • The optimization of experimental parameters, such as catalyst type, catalyst concentration, molar ratio of alcohol to oil and reaction temperature, on the transesterification for the production of rapeseed methyl ester has been studied. The Taguchi approach (Taguchi method) was adopted as the experimental design methodology, which was adequate for understanding the effects of the control parameters and to optimize the experimental conditions from a limited number of experiments. The optimal experimental conditions obtained from this study were potassium hydroxide as the catalyst, at a concentration of 1.5 wt %, and a reaction temperature of $60^{\circ}C$. According to Taguchi method, the catalyst concentration played the most important role in the yield of rapeseed methyl ester. Finally, the yield of rapeseed methyl ester was improved to 96.7% with the by optimal conditions of the control parameters which were obtained by Taguchi method.

Optimization of Magnet Pole of BLDC Motor by Experimental Design Method

  • Kim, Jee-Hyun;Kwon, Young-Ahn
    • KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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    • v.3B no.2
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    • pp.84-89
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    • 2003
  • The finite element method (FEM) is typically used in the process of motor design. However, the FEM requires computation time, Therefore, decreasing the number of FEM simulations may also decrease the simulation cost. Several optimal design methods overcoming this problem have been recently studied. This paper investigates the optimal design of the magnet pole of a BLDC motor through reducing simulation cost. The optimization minimizes the magnet volume and limits the average and cogging torques to certain values. In this paper, the response surface methodology and Taguchi's table for reducing the number of FEM simulations are used to approximate two constraints. The optimization result shows that the presented strategy is satisfactorily performed.

Optimal Gator-filter Design for Multiple Texture Image Segmentation (다중 텍스쳐 영상 분할을 위한 최적 가버필터의 설계)

  • Lee, U-Beom;Kim, Uk-Hyeon
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.39 no.3
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    • pp.11-22
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    • 2002
  • The design of optimal filter yielding optimal texture feature separation is a most effective technique in many torture analyzing areas, such as perception of surface, object, shape and depth. But, most optimal filter design approaches are restricted to the issue of computational complexity and supervised problems. In this paper, Our proposed method yields new insight into the design of optimal Gabor filters for segmenting multiple texture images. The optimal frequency of Gator filter is turned to the optimal frequency of the distinct texture in frequency domain. In order to show the performance of the designed filters, we have attempted to build a various texture images. Our experimental results show that the performance of the system is very successful.

Optimal Parameter Design for Al/SiC Composites using Design of Experiments (실험계획법에 의한 Al/SiC 복합재료의 최적공정 설계)

  • Lee, K.J.;Kim, K.T.;Kim, Y.S.
    • Journal of Power System Engineering
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    • v.15 no.5
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    • pp.72-76
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    • 2011
  • In this work, the parameter optimization for thermal-sprayed Al/SiC composites have been designed by $L_9(3^4)$ orthogonal array and analysis of variance(ANOVA). Al/SiC composites were fabricated by flame spray process on steel substrate. The hardness of composites were measured using micro-vickers hardness tester, and these results were analyzed by ANOVA. The ANOVA results showed that the oxygen gas flow, powder feed rate and spray distance affect on the hardness of the Al/SiC composites. From the ANOVA results, the optimal combination of the flame spray parameters could be extracted. It was considered that experimental design using orthogonal array and ANOVA was efficient to determine optimal parameter of thermal-sprayed Al/SiC composites.

Development of 4 Types of Fuel Cell's Blower (연료전지 블로어 4기종 국산화 개발)

  • Tak, Bong-Yeol;Kim, Chan-Gyu;Lee, So-A;Jang, Chun-Man
    • 한국신재생에너지학회:학술대회논문집
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    • 2011.05a
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    • pp.91-91
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    • 2011
  • This paper describes development procedure of the four types of fuel cell's blowers: pressurized fuel blower, selective oxidation air blower, cathode air blower, and burner air blower. Diaphragm blowers having two heads are selected to maintain force balance when the rotating arms are moving by the driving motor. Dimensions of a diaphragm cavity is designed according to the optimal design procedure using numerical simulation and experimental measurement. Experimental apparatus is designed by considering the bower characteristics having low flow rate and high pressure. Test blower is operated by a diaphragm, which has suction and discharge port on the top of the blower. For analyzing the internal flow of the blower, three-dimensional Navier-Stokes analysis is introduced in the present study. Throughout the optimal design of the blowers, blower performance is enhanced by reducing the unbalance motion of the rotating arm and loss region in the diaphragm cavity.

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