• The Korean Journal of Physiology and Pharmacology
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• v.10 no.2
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• pp.71-77
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• 2006

The goal of this study was to analyze the effects of genistein, a widely used tyrosine kinase inhibitor, on cloned Shaw-type $K^+$ currents, Kv3.1 which were stably expressed in Chinese hamster ovary (CHO) cells, using the whole-cell configuration of patch-clamp techniques. In whole-cell recordings, genistein at external concentrations from 10 to $100{\mu}M$ accelerated the rate of inactivation of Kv3.1 currents, thereby concentration-dependently reducing the current at the end of depolarizing pulse with an $IC_{50}$ value of $15.71{\pm}0.67{\mu}M$ and a Hill coefficient of $3.28{\pm}0.35$ (n=5). The time constant of activation at a 300 ms depolarizing test pulses from -80 mV to +40 mV was $1.01{\pm}0.04$ ms and $0.90{\pm}0.05$ ms (n=9) under control conditions and in the presence of $20{\mu}M$ genistein, respectively, indicating that the activation kinetics was not significantly modified by genistein. Genistein $(20{\mu}M)$ slowed the deactivation of the tail current elicited upon repolarization to -40 mV, thus inducing a crossover phenomenon. These results suggest that drug unbinding is required before Kv3.1 channels can close. Genistein-induced block was voltage-dependent, increasing in the voltage range $(-20\'mV{\sim}0\'mV)$ for channel opening, suggesting an open channel interaction. Genistein $(20{\mu}M)$ produced use-dependent block of Kv3.1 at a stimulation frequency of 1 Hz. The voltage dependence of steady-state inactivation of Kv3.1 was not changed by $20{\mu}M$ genistein. Our results indicate that genistein blocks directly Kv3.1 currents in concentration-, voltage-, time-dependent manners and the action of genistein on Kv3.1 is independent of tyrosine kinase inhibition.

• Archives of Plastic Surgery
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• v.38 no.4
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• pp.516-518
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• 2011

Purpose: The prevalence of antibiotic-resistant Streptococcus pneumoniae meningitis has increased worldwide. There are some reports about postoperative antibiotic-resistant Streptococcus pneumoniae infection after craniofacial surgery, but, there is no report in Korea. We present a report on the treatment of postoperative multidrug-resistant Streptococcus pneumoniae (MRSP) meningitis and sepsis after craniofacial surgery based on our experience. Methods: The patient was a 7-year-old boy with Crouzon's disease who was treated by fronto-orbital bar advancement. Intraoperatively, frontal sinus opening was seen during osteotomy which was covered with forehead galeopericranial flap. MRSP meningitis was diagnosed after the surgery, he was treated with intravenous vancomycin, meropenem, and levofloxacin. Results: The patient was treated successfully after 3 weeks of intravenous antibiotics treatment. During the 8 month follow-up period, there was no neurologic sequelae. Conclusion: Postoperative infection after craniofacial surgery is an important phenomenon that needs immediate recognition. Prevention, early diagnosis, and treatment immediate after onset are important as countermeasures against postoperative drug-resistant bacterial infection. To prevent adverse outcome and reoperation, proper antibiotics treatment should be performed.

• Fire Science and Engineering
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• v.29 no.1
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• pp.53-59
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• 2015

Water hammering created by an unsteady flow in pipeline systems can cause excessive change in pressure, vibration, and noise. So, water hammer analysis is very important for limiting the damage caused to pipeline, pump and valve systems by operation conditions. On the other hand, water hammer arrester has been manufactured and used in order to minimize the damage caused by water hammering phenomenon in domestic, and it has been produced and installed as the low cost-oriented because of being no separate standard in the meanwhile. Therefore, our research team investigated about the standardization of water hammer arrester performance through the various methods, such as test methods for verification of one pipe, assuming the occurrence of water hammer in a water-based fire extinguishing system, separated for opening impact pressure and shut off impact pressure and for a branch pipe in order to make guideline for water hammer arrester performance. And finally, verified the performance of the water hammer pressure as the simple mechanical way using the U-shaped pipe and a test weight, so KFI standards for the water hammer arrester could be established.

• Earthquakes and Structures
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• v.16 no.3
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• pp.265-277
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• 2019

Framed masonry wall structures represent a typical high-rise structural system that are also seismically vulnerable. During ground motions, they are excited in both in-plane and out-of-plane terms. The interaction between the frame and the infill during ground motion is a highly investigated phenomenon in the field of seismic engineering. This paper presents a numerical investigation of two distinct static out-of-plane loading methods for framed masonry wall models. The first and most common method is uniformly loaded infill. The load is generally induced by the airbag. The other method is similar to in-plane push-over method, involves loading of the frame directly, not the infill. Consequently, different openings with the same areas and various placements were examined. The numerical model is based on calibrated in-plane bare frame models and on calibrated wall models subjected to OoP bending. Both methods produced widely divergent results in terms of load bearing capabilities, failure modes, damage states etc. Summarily, uniform load on the panel causes more damage to the infill than to the frame; openings do influence structures behavior; three hinged arching action is developed; and greater resistance and deformations are obtained in comparison to the frame loading method. Loading the frame causes the infill to bear significantly greater damage than the infill; infill and openings only influence the behavior after reaching the peak load; infill does not influence initial stiffness; models with opening fail at same inter-storey drift ratio as the bare frame model.

• Journal of the Society of Naval Architects of Korea
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• v.56 no.4
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• pp.361-372
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• 2019

The flow pattern of air layers and skin-friction drag reduction by air injection are investigated to find the suitable multiphase flow model using unstructured finite-volume CFD solver for the Reynolds-averaged Navier-Stokes equations. In the present computations, two different multiphase flow modeling approaches, such as the Volume of Fluid (VOF) and the Eulerian Multi-Phase (EMP), are adopted to investigate their performances in resolving the two-phase flow pattern and in estimating the frictional drag reduction. First of all, the formation pattern of air layers generated by air injection through a circular opening on the bottom of a flat plate are investigated. These results are then compared with those of MMkiharju's experimental results. Subsequently, the quantitative ratios of skin-friction drag reduction including the behavior of air layers, within turbulent boundary layers in large scale and at high Reynolds number conditions, are investigated under the same conditions as the model test that has been conducted in the US Navy's William B. Morgan Large Cavitation Channel (LCC). From these results, it is found that both VOF and EMP models have similar capability and accuracy in capturing the topology of ventilated air cavities so called'air pockets and branches'. However, EMP model is more favorable in predicting quantitatively the percentage of frictional drag reduction by air injection.

• International Journal of Naval Architecture and Ocean Engineering
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• v.13 no.1
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• pp.554-565
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• 2021

Air bubble entrainment is a phenomenon that can significantly reduce the efficiency of liquid motion in piping systems. In the present study, the bubble formation mechanism in a globe valve with 90% water fraction flow is explained by visualization study and pressure oscillation analysis. The shadowgraph imaging technique is applied to illustrate the unsteady flow inside the transparent valve. This helps to study the effect of bubbles induced by the globe valve on pressure distribution and valve flow coefficient. International Society of Automation (ISA) recommends locations for measuring pressure drop of the valve to determine its flow coefficient. This paper presents the comparison of the pressures at different locations along with the upstream and the downstream of the valve with the values at recommended positions by the ISA standard. The results show that in partially filled pipe flow, the discrepancies in pressure between different measurement locations in the valve downstream are significant at valve openings less than 30%. The aerated flow induces the oscillation in pressure and flow rate, which leads to the fluctuation in the flow coefficient of the valve. The flow coefficients have a linear relationship with the Reynolds number. For the same increase of Reynolds number, the flow coefficients grow faster with larger valve openings and level off at the opening of 50%.

• International Journal of Computer Science & Network Security
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• v.22 no.8
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• pp.385-391
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• 2022

The relevance of the published study lies in the fact that since the introduction of the first Global Distribution System, new information and communication technologies have constantly been changing the tourism industry. In the context of a current digital environment, travel agencies can't avoid participating in digital transformation processes aimed at rethinking operational models, skills, and organisational structures in the regions. This publication aims to present and provide a critical overview of digitalisation processes in tourism development in the regions of the Russian Federation, as well as to reflect on the challenges to the widespread digitalisation processes in the regional tourism sector. The subject of research is digitalisation processes, as they radically transform the modern tourism industry, in the regions as well. The pragmatic research paradigm was considered the most appropriate for the study of tourism digitalisation processes in the regions, as it does not require the selection of a specific theoretical basis for data collection. The pragmatic approach forms an alternative to classical theoretical approaches and serves as a particular type of grounded theory, combining both inductive and deductive methods. No software was used for the inductive part of the analysis. The deductive part was conducted using the qualitative data analysis software Nvivo 11. Given the wide diversity of interested parties in the regional tourism digital area, a stratified purposive sampling method was preferred due to its ability to adequately represent the full picture of the phenomenon under study. The selection and stratum criteria were chosen to maximise the representation of different perspectives in the regional tourism digital area. The novelty of the study is due to the digitalisation processes, with an implication of new needs, while opening up promising opportunities for more productive tourism business in the regions of the Russian Federation. Currently, e-tourism in the Russian Federation has become a subject of lively debate among scholars and practitioners. However, the involvement of advanced digitalisation technologies in the field of information processes in the regions of the Russian Federation is of a very sporadic character.

• Journal of Korean Tunnelling and Underground Space Association
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• v.12 no.1
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• pp.15-29
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• 2010

Spalling is a kind of instability phenomenon of surrounding rock around underground openings subjected to high in-situ stress according to the development of extension fractures. Three kinds of spalling criteria have been presented so far; however, all spalling criteria have the range of values so that the fuzziness and vagueness of spalling criterion cannot be avoided. In this study, a new fuzzy probability model is proposed to predict the probability of spalling in a systematic way by using fuzzy probability theory. Many of the underground opening projects worldwide are evaluated with the proposed method. Prediction results expressed as the spalling probability agree well with the in-situ observations. In particular, a new fuzzy probability model considering all three evaluation indices of spalling by adopting weighting factors based on relative reliability among three evaluation indices is able to resolve erroneous prediction of spalling by choosing only one prediction method. Moreover, the more reasonable value of spalling probability could have been obtained by adopting the modified damage index to the newly proposed fuzzy probability model.

• Korean Journal of Culture and Social Issue
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• v.9 no.1
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• pp.81-114
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• 2003

This study examines the basis and change of delinquent behavior among Korean adolescents. Theoretical framework was developed and qualitative analysis of delinquency behavior was examined. In order to understand the basis and change of juvenile delinquency, the influence of family environment, school environment and individual factors were investigated through cross-sectional and longitudinal studies. The results of the findings can be summarized into the following six main points: 1) two subcultures of adolescent functioning could be ascertained, 2) the decrease in social support and increase in moral disengagement were directly related to a rise in juvenile delinquency, 3) family disintegration contributed to juvenile delinquency, 4) peer influence help to raise juvenile delinquency, 5) schools were unable to give hope to those students who were not doing well in school and were ineffective in dealing with juvenile delinquents, and 6) the phenomenon of juvenile delinquency points to the importance of opening up the closed school system and closed society, allowing individual diversity and skills to be recognized.

• Journal of Digital Convergence
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• v.14 no.5
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• pp.85-93
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• 2016

Convergent education is essential to develop consilient thinking skills, ability to recreate information and knowledge, and problem-solving skills which are demanded in society of convergent knowledge. Accordingly, this study is going to develop a convergent class model of augmented reality and art based on consilient knowledge. Teaching model is designed based on the ADDIE model, which was operated by opening a real class in order to verify the validity. The result showed a high satisfaction of learners showed the ability to adapt to the major areas associated with the cultivation of learners. Characteristics of augmented reality medium were found to enable learners to analyze a new phenomenon and to fuse the necessary knowledge by inducing them to actively interact by the their intention in learning. Therefore, it is possible to cultivate creative and convergent persons of ability equipped with more flexible and creative thinking ability and discernment through deepened education for recognizing and understanding convergent cases between art and scientific technology. There is a study on the validation and the convergence of different subjects in terms of a variety of aspects, left behind of this study.