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Fabrication of an ultra-fine ginsenoside particle atomizer for drug delivery through respiratory tract (호흡기를 통한 약액 전달을 위한 진세노사이드 초미세입자 분무장치 제작)

  • Byung Chul Lee;Jin Soo Park;Woong Mo Yang
    • Journal of Convergence Korean Medicine
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    • v.2 no.1
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    • pp.5-12
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    • 2021
  • Objectives: The purpose of this study is to fabricate an ultra-fine ginsenoside particle atomizer that can provide a new treatment method by delivering ginsenoside components that have a therapeutic effect on respiratory diseases directly to the lungs. Methods: We fabricated the AAO vibrating mesh by using the micromachining process. The starting substrate of an AAO wafer has a 350nm pore diameter with 50㎛ thickness. A photomask having several 5㎛ opening holes with a 100㎛ pitch was used to separate each nanopore nozzle. The photoresist structure was optimized to pattern the nozzle area during the lift-off process precisely. The commercial vibrating mesh was removed from OMRON's NE-U100 product, and the fabricated AAO vibrating mesh was installed. A diluted sample of 20mL with 30% red ginseng concentrate was prepared to atomize from the device. Results: As a result of liquid chromatography analysis before spraying the ginsenoside solution, ginsenoside components such as 20S-Rg3, 20R-Rg3, and Rg5 were detected. After spraying through the AAO vibrating mesh, ginsenosides of the same component could be detected. Conclusion: A nutrient solution containing ginsenosides was successfully sprayed through the AAO vibrating mesh with 350 nm selective pores. In particular, during the atomizing experiment of ginsenoside drug solution having excellent efficacy in respiratory diseases, it was confirmed that atomizing through the AAO vibrating mesh while maintaining most of the active ingredients was carried out.

The effect of oral care program for the elderly women of the Visiting oral health care (방문구강보건사업 여성노인 대상자의 구강관리프로그램 효과)

  • Lee, Yun-Hui;Lee, Sung-Kook
    • Journal of Korean society of Dental Hygiene
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    • v.12 no.2
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    • pp.365-377
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    • 2012
  • Objectives : This research was conducted to determine the effect of the Visiting Oral Health Care Program by examining the oral health of the elderly women, who are the beneficiaries of this Visiting Oral Care Program. Methods : This research was conducted from November of 2011 to February of 2012, in Chilgok-gun in the Kyeongbuk Province, South Korea. One hundred and twenty five (125) elderly women among the beneficiaries of the Visiting Oral Care Program within the area were randomly selected for the research. The research subjects would regularly visit the area senior citizen center, and they were divided into two groups, with 64 of them belonging to a control group, and the rest (61 people) belonged to a intervention group. The research subjects were examined for their dental health condition, and we investigated the effect of the Visiting Oral Care Program through this research. Results : 1. When they were asked about how many times they wash their dentures, the majority of the control group, 57.4% of them answered that they do it "once" a day. The majority of the intervention group answered "more than 3 times", with 35.2% of group mentioning that they wash their dentures more than 3 times a day(p<.001). 2. When the research subjects were asked to scale their overall quality of life before and after the Visiting Oral Care Program, the control group had rated 49.3 before the Service and 56.8 after the Service (p<.01), and scores for the individual factors to determine the overall quality of life has significantly improved as well (p<.01, p<.01, p<.01, p<.01, p<.01, p<.01, p<.01). 3. The oral hygiene condition after the Visiting Oral Care Program has shown improvement as well. The control group scored 64.2 for the severity of the symptoms of dental plaque before the dental care, and scored 46.8 after the dental care (p<0.1). The control group was diagnosed for the symptoms of coated tongue, and the severity of the symptoms were scaled as 3.7 before the Program and 2.0 after the Program (p<.01). Furthermore, the overall functionality of the oral cavity was improved as well. The control group showed 1.0 time increase in repetitive voluntary swallowing test (p<0.1), increased amount of sublingual saliva from 0.8mm to 1.4mm, and from 1.6mm to 2.0mm in dorsum linguae(p<0.1). Also, the control group showed an improvement in mouth opening as well, increased from 3.9 to 4.0cm after the oral care program (p<.05). When compared the result with the examination after the Visiting Oral Care Program, the two groups showed a significant difference with the control group showing a significant improvement compared to the intervention group(p<.01, p<.01, p<.01, p<.01, p<.05). 4. The correlation between the dental hygiene condition and the functionality of oral was made for the result of examining the beneficiaries for Visiting Oral Care Program. The amount of saliva showed a negative correlation with the severity of dental plaque (p<.05), and a positive correlation with the repetitive voluntary swallowing count (p<0.1). Also, mouth opening showed a positive correlation with repetitive voluntary swallowing count (p<.05). Conclusions : After the Visiting Orall Care Program, the beneficiaries of the program experienced improvement in their quality of life related to oral health, overall oral hygiene and functionality of oral.

An Analysis of the Quantitative Changes of Elements on Golf Courses - With Special Reference to the Membership Golf Courses in Capital Area, Korea - (한국 골프 코스 구성 요소의 정량적 변화 분석 - 수도권 회원제 골프장을 대상으로 -)

  • Rho, Joon-Taek;Cho, Se-Hwan
    • Journal of the Korean Institute of Landscape Architecture
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    • v.40 no.6
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    • pp.112-126
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    • 2012
  • The theme is to analyze the time-series changes of design elements on golf courses and golf country club and its factors influencing to the changes with regard to 81-membership country club located in the Capital Area of Seoul, created in the periods from 1964 until 2011. The research methods is to analyze the time-series changes of environmental factors influencing to the changes of the elements on the golf course by book review, and to compare and speculate the results of the analysis on the environmental factors with the time-series changes on the golf course elements of statistical analysis as like regression analysis. The research results were as follows. The first, the environmental factors influencing to the change of golf course elements were analyzed as the five elements of the golf-related policies and regulations, the economy, the numbers of golfers, PGA and KPGA golf tournaments, the golf instruments. The second, the type and scale of the location of the golf course were showing trends of transformation from flat ground to mountainous one and from small scale to large one. The third, it was analyzed that he golf course elements as like the sizes, length, numbers of golf course elements as like fairway, green, bunker, teeing ground and pond were influenced by the law and regulation, the increase of amateur golfers, the promotion of techniques of golfers, the increase of the chance of foreign course designer's involvement to domestic market through the opening of PGA and KPGA tournaments etc. The fourth, the promotion of golf instruments and the flying distance were the factors influencing to the numbers of bunker, the lengths of holes. The fifth, it was revealed that the trends of increase of sizes of ponds influenced by enacting environmenal friendly laws and regulations, considering of landscaping, reflecting of design trends followed by the opening of PGA tournaments. Finally, it was proposed that the further research would be introduced with regard to the qualitative analysis onto the changes and influential factors of golf course design.

1910's Tap-gol Park Construction Process through Design Document Interpretation (설계도서를 중심으로 본 1910년대 탑골공원의 성립과정)

  • Kim, Hai-Gyoung;Kim, Young-Soo;Yun, Hye-Jin
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.31 no.2
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    • pp.103-117
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    • 2013
  • This research analyzed the spatial components and establishment of the Tap-gol Park according to the plans between 1897 to 1916 when the discussions on the construction of the park began and it was accomplished as an urban park. The results are as follows. The establishment of Tap-gol Park can be divided by three period. Firstly, Tap-gol Park was owned by the royal family from 1987 to 1904. The discussions on construction of Tap-gol Park as a first urban park of Gyeongseong(京城) in 1897, and the private houses were tear down in order to secure land for the park in 1899. Gates and fences surrounding of Tap-gol Park were organized and it was opened in 1902 based on park plane of turtle - shaped. The octagonal pavilion for 'Lee-Wang-Jik musical band(李王職音樂隊)' was relocated in the southwestern part of the park in 1903. Secondly, Tap-gol Park was used actively by the public between 1910 to 1913, because it was opened for individuals. Also The boundary of Park were changed by surrounding facilities and recreational facilities and benefits was complemented for users. Tap-gol park was opened at nighttime in August 1913. Tap-gol Park was used as a place of amusement park. Thirdly, commercial facilities were made as the park facility between 1914 to 1916. The purpose of 'Kkikdajeom(喫茶店)' was similar to the one of modern cafes. It was built as a typical Japanese tea-house with a small pond having an island and a bridge constructed inside. With the increase of usage of Tap-gol Park as a recreational area by the citizens in 1916, the pavilion as a rest area and toilet as amenities were supplemented. Superintendent's office was equipped too. Simple chairs made from the wooden logs were installed around greenhouse, concert hall, the Wongaksa Buddhist temple(圓覺寺址十層石塔), and the flower garden was fenced round. After the relocation of Yongsan music band to Tap-gol Park, the existing concert hall was demolished. The shape of the park which was seen from the pictures of the magazines of 1920s were achieved as early as 1916. The importance of this research includes the basis to revise the errors of the preexistence researches and value of historical material of the design plan reference of the park which was accomplished during the Japanese colonial era. Also this research is to study on the spatial components of the modern landscape architecture and parks.

Dynamic Characteristics for the Model of Horn Fish Hemiramphus Sajor Surface Pair Trawl Gear (학공치 표층예망어구 모형의 운동특성)

  • 김석종
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.37 no.4
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    • pp.285-295
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    • 2001
  • This study describes the analysis on the dynamic characteristics of model as a fundamental studies for the horn fish Hemiramphus sajor surface pair trawl gear. The model experiments were carried out in a flume tank by using model net for the horn fish surface par trawl gear. The model net was made to the scale of 1/40 by scaling down two surfce par trawl boats of 6.67 and 9.98 ton used for sea experiment in the coast of Jeju Island. Dimensions of the model net were 1.2m for stretch length of net, 1.3m for float line, 1.0m for sinker line, 2.5g for floats, and 0.86g for sinkers. Experiments were conducted in the observation channel of a flume tank with experimental equipments used to change the distance between paired boats and towing velocity. Motion of model net during towing was recorded by two sets of digital camera which were placed in the top and side of the model net. The leading coordinate of net height and net mouth width was captured by the photograph analysis system. Through the experiment, we obtained the following results: 1. The relationship between the net hight(Nh) and towing velocity(Vt) during towing was found to be Nh=(2.39Db-$^{0.62})Vt^{0.56}$ and the relationship between the net mouth width (Nw) and towing velocity during towing was Nw=(0.96Db^{0.62})Vt^{0.11}$, where Db is the distance between paired boats. 2. The relationship between the net tension(Nt) and towing velocity during towing was found to be Nt=106.94Vt+1.43 and the model net becomes parallel to the water surface at the towing velocity larger than 1.5 Knot. 3. The relationship between the net opening area(Na) and towing velocity during towing was found to be Na=(2.28Db0.37)Vt.-0.45, and the relationship between the filtering volume(Fv) and towing velocity during towing was Fv=(69.9Db$^{0.37})Vt^{0.55}$. The net opening area and filtering volume reach maximum value at the distance of 25m between paired boats.

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Direct bonding of Si(100)/Si$_3$N$_4$∥Si (100) wafers using fast linear annealing method (선형열처리를 이용한 Si(100)/Si$_3$N$_4$∥Si (100) 기판쌍의 직접접합)

  • Lee, Young-Min;Song, Oh-Song;Lee, Sang-Hyun
    • Korean Journal of Materials Research
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    • v.11 no.5
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    • pp.427-430
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    • 2001
  • We prepared 10cm-diameter Si(100)/500 $\AA$-Si$_3$N$_4$/Si(100) wafer Pairs adopting 500 $\AA$ -thick Si$_3$N$_4$layer as insulating layer between single crystal Si wafers. Si3N, is superior to conventional SiO$_2$ in insulating. We premated a p-type(100) Si wafer and 500 $\AA$ -thick LPCVD Si$_3$N$_4$∥Si (100) wafer in a class 100 clean room. The cremated wafers are separated in two groups. One group is treated to have hydrophobic surface and the other to have hydrophilic. We employed a FLA(fast linear annealing) bonder to enhance the bond strength of cremated wafers at the scan velocity of 0.1mm/sec with varying the heat input at the range of 400~1125W. We measured bonded area using a infrared camera and bonding strength by the razor blade crack opening method. We used high resolution transmission electron microscopy(HRTEM) to probe cross sectional view of bonded wafers. The bonded area of two groups was about 75%. The bonding strength of samples which have hydrophobic surface increased with heat input up to 1577mJ/$m^2$ However, bonding strength of samples which have hydrophilic surface was above 2000mJ/$m^2$regardless of heat input. The HRTEM results showed that the hydrophilic samples have about 25 $\AA$ -thick SiO layer between Si and Si$_3$N$_4$/Si and that maybe lead to increase of bonding strength.

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An Interpretation of a Social Implication on the Transition of the Urban Park in Daegu (대구 도시공원의 변천에 나타난 사회적 의미 해석)

  • Lee, Jung-Youn;Jung, Tae-Yeol
    • Journal of the Korean Institute of Landscape Architecture
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    • v.41 no.3
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    • pp.72-82
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    • 2013
  • This study was done for analyzing processes on the planning and opening of chronological urban parks in Daegu City since the 1960s, and for interpreting the social meaning on changes of the urban parks with regards to historical circumstances during that period. In the 1960s, urban parks, which were recognized as one of urban planning facilities, were only designated for creating rather than created, although nationally several laws including urban planning act and park act were newly legislated. Rapid urbanization and increasing population in the 1970s led to create many urban parks. However, the policy for increasing parks had been not successful because of the lack of enough funds. In the 1980s, multi-purpose urban parks including stable area as well as active facilities were created for getting several attractions to urban residents. During this period, urban parks were recognized on an aesthetic perspective through vegetating plans on the city-beautiful movement for hosting consecutive international games. The citizen participation in urban parks and the increasing concern about urban environment were started in the 1990s, and the people living in an urban area were interested in the quantitative expansion and qualified renovation of the urban parks as well. Finally, modernistic urban parks were first introduced in the late period of Chosun Dynasty, however their substantial introduction was done in the 1960s. Through this study, the concept of an urban park as a public resting place for citizen in Daegu was thought to be mostly established in the 1990s as we have investigated on the social meaning derived from the periodical changes of urban parks.

The LOS Analysis of Railway Station Facilities Based on Design Hourly Factor and Simulation (설계시간계수 및 Simulation 기반 철도역사 이용시설 LOS 분석)

  • Oh, Tae-ho;Lee, Seon-ha;Cheon, Choon-keun;Kim, Eun-ji;Yu, Byung-young
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.15 no.3
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    • pp.105-117
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    • 2016
  • Recently the passenger of railway satisfaction levels are lowered. the reason why the railway station was built without considering the increased passenger due to diversification(transfer, shopping, and etc.) of the domestic railway station infrastructure. Especially, in case of KTX Gwangju-Songjeong Station, the number of its passenger has been increased about more than three times since its opening in 2015, so that there are much inconvenience generated in the station congested with passengers. his study aims to excute using Pedestrian simulation and Design Hourly Factor concepts of Highway Engineering, in order to designing the optimum area through the passenger demand forecast for each station. For this analysis was divided into the second stage. Frist, the railway passenger was calculated by using the methodology of Design Hourly Factor that is used during road design in the aspect of traffic engineering. Second, we tried to analyze the level of service in each railway station facility through the pedestrian simulation. Analytical results show that utilizing pedestrian simulation provides verification for calculation of LOS of each railway station facility. Therefore, In the future when designing railway station of facilities will be possible to suggest the facilities area based on LOS.

Using a Borehole Stability Device for Hydraulic Testing in Unconsolidated Alluvium (공벽 유지장치를 이용한 미고결 충적층의 수리특성 평가)

  • Won, Kyoung-Sik;Kim, Chunsoo;Chae, Soo-Yong;Shin, Dong-Min
    • The Journal of Engineering Geology
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    • v.26 no.1
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    • pp.15-22
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    • 2016
  • Hydraulic falling head and slug tests were carried out in an alluvium aquifer using a borehole stability device. The hydraulic testing had proved difficult in alluvial formations of sands and gravels due to borehole collapse and unstable borehole walls within the test section. This study aims to improve the hydraulic test results by using a borehole stability device. The device can minimize the collapse of borehole walls, and the use of a filter with a constant opening ratio improves the calculations per unit area of the test section. Permeability obtained from the falling head test without a borehole stability device was 8.82 × 10−5m/sec. When the borehole stability device was installed in the same test section the measured permeability increased to 4.00 × 10−4m/sec, which is 4.5 times that obtained without the borehole device. The relatively low permeability obtained using the conventional test method is attributed to the presence of a fine-grained slime generated during drilling and a reduction of the test area in the test interval due to a gradual collapse of the borehole walls. This study considers how the use of a borehole stability device to prevent borehole collapse can influence the results of hydraulic tests in alluvial formations. It is expected that the results can be used as a basis for improving the reliability and applicability of hydraulic tests performed in alluvial aquifers.

The Analysis of e-Learning Gap among Regions in the Context of Adult Learning (성인 인적자원개발 영역에서의 지역 간 교육격차 및 e-Learning 인식 수준 연구)

  • Cho, Jae-Jeong;Lee, Sook-Young
    • Journal of Digital Contents Society
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    • v.11 no.2
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    • pp.265-276
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    • 2010
  • The purpose of this study was to investigate the Korean Local Government's recognition on the educational gap among regions in the filed of adult learning including vocational education and life long-learning. The study also tried to figure out the local government's recognition and infrastructure of e-Learning which is suggested as one of the solutions on the regional gap of educational opportunities and quality. This study took 12 HRD(Human Resources Development) centers funded and operated by the Korean Local Governments except Seoul and Kyong-Gi classified by the metropolitan areas in Korea. As a result, firstly it was found that the local governments had perception on the difference and gap of educational opportunities and quality among regions in the area of adult education. Especially, the perception was relatively more serious on quality than quantity. Secondly, the result showed the large gap among regions on the area of opening educational and training programs, the quality of teachers and tutors, the effectiveness and outcomes of educational programs. Thirdly, they perceived more serious educational gap on face-to-face classes rather than e-Learning in the context of educational methodology. It also revealed that the local governments had relatively better foundations on physical systems than other infrastructures and resources such as human-ware, culture-ware and soft-ware(contents, programs etc.). It was recommended to consider these findings in developing and implementing future educational policies to solve the problem of regional gap on education.