• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5075-5079
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• 2015

Background: Adverse effects of treatment prolongation beyond 8 weeks with radiotherapy for cervical cancer have been established. Clinical data also show that cisplatin increases the biologically effective dose of radiotherapy. However, there are no data on the effect of overall treatment time in patients with locally advanced cervical cancer treated with concomitant chemo-radiotherapy (CCRT) in an Indian population. The present study concerned the feasibility of concurrent chemotherapy and interspacing brachytherapy during the course of external radiotherapy to reduce the overall treatment time and compare the normal tissue toxicity and loco-regional control with a conventional schedule. Materials and Methods: Between January 2009 and March 2012 fifty patients registered in the Gynaecologic Oncology Clinic of Institute Rotary Cancer Hospital with locally advanced cervical cancer (FIGO stage IIB-IIIB) were enrolled. The patients were randomly allocated to treatment arms based on a computer generated random number. Arm I (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions, and weekly cisplatin $40mg/m^2$. High dose rate intra-cavitary brachytherapy (HDR-ICBT) was performed after one week of completion of external beam radiotherapy (EBRT). The prescribed dose for each session was 7Gy to point A for three insertions at one week intervals. Arm II (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions. Mention HDR-ICBT ICRT was performed after 40Gy and 7Gy was delivered to point A for three insertions (days 23, 30, 37) at one week intervals. Cisplatin $20mg/m^2/day$ was administered from D1-5 and D24-28. Overall treatment time was taken from first day of EBRT to last day of HDR brachytherapy. The overall loco-regional response rate (ORR) was determined at 3 and 6 months. Results: A total of 46 patients completed the planned treatment. The overall treatment times in arm I and arm II were $65{\pm}12$ and $48{\pm}4$ days, respectively (p=0.001). At three and six months of follow-up the ORR for arm I was 96% while that for arm II was 88%. No statistically significant difference was apparent between the two arms. The overall rate of grade ${\geq}3$ toxicity was numerically higher in arm I (n=7) than in arm II (n=4) though statistical significance was not reached. None of the predefined prognostic factors like age, performance status, baseline haemoglobin level, tumour size, lymph node involvement, stage or histopathological subtype showed any impact on outcome. Conclusions: In the setting of concurrent chemoradiotherapy a shorter treatment schedule of 48 days may be feasible by interspacing brachytherapy during external irradiation. The response rates and toxicities were comparable.

• 한국ITS학회 논문지
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• 제4권2호
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• pp.53-66
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• 2005

미시적 시뮬레이션 모델은 차량과 차량, 차량과 교통제어와의 개별차량 상호작용을 분석할 수 있어 교통공학 분야에 광범위하게 사용되고 있다. 미시 교통 시뮬레이션 모형을 이용하여 교통시스템을 분석 및 평가할 때 많은 고려요소가 있다. 이 요소들은 현장의 분석 대상지, 시뮬레이션 소프트웨어, 분석 시간, 평가 척도, 패러미터, OD 자료, 랜덤 넘버 등을 포함한다. 이러한 요소들이 미시적 시뮬레이션 결과에 어떠한 영향을 미치는지 평가하기 위해 CORSIM과 TRANSIMS 결과를 토대로 민감도 분석이 실시되었다. 휴스톤에 위치한 I-10과 US290, 샌안토니오에 위치한 I-37 고속도로가 분석에 이용되었다. 오전 첨두, 오후 첨두, 비첨두 시간이 분석되었고, 세 개의 OD 자료가 이용되었다. 분석결과 모델의 패러메터와 OD 자료가 가장 큰 영향을 주었다. 또한 분석대상지와 분석 시간에 따라 민감도가 달라졌다

• 한국자원식물학회지
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• 제14권3호
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• pp.235-240
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• 2001

Polyphenol 화합물이 다량 함유된 식물종의 유연관계 분석이나 형질전환 유전자 확인 등을 위해 PCR을 이용할 경우 다량의 재료로부터 신속 간편하게 분리한 DNA를 이용할 수 있는 조건을 설정 하였다. 폴리페놀 함량이 높은 포도, 사과, 복분자와 같은 과수류에서 간편법에 의해 추출된 DNA를 이용한 PCR 반응액에 2%의 BLOTTO를 첨가함으로서 DNA의 재현적 증폭이 가능하였다. 간편 추출 DNA를 이용한 PCR에서 의 BLOTTO효과는 primer, 품종, 식물종에 관계없이 일반적으로 발현되었다. 상추의 형질전환 유전자 검색을 위한 PCR에서 도 BLOTTO 효과가 확인되었다. 따라서 PCR 반응액에 2% BLOTTO를 첨가하면 간편 법 에 의해 추출된 polyphenol 화합물 고함유 식물종의 DNA를 이용하여서도 PCR에 의한 유전배경 및 특정 유전자의 대량 신속 분석이 가능할 것이다.

• 한국광학회지
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• 제14권4호
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• pp.383-391
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• 2003

개인의 신원정보 보호를 위하여 새로운 광 정보보호 시스템을 제안하였다. 개인 신원정보의 확인과 인증을 위하여 얼굴영상과 개인식별번호로 구성된 신원정보를 사용하였다. 영상 암호화는 4-f 광상관기의 입력과 푸리에영역에서 랜덤위상패턴을 사용하는 위상암호화 기술을 사용하였다. 그렇지만 암호화된 영상을 복원하는 과정에서 개인의 신원정보가 유출될 가능성이 있다. 이에 대처하기 위하여 신원확인 과정에서 영상을 복원하지 않고 암호화된 영상을 그대로 사용하였다. 암호화된 개인식별번호는 제안된 MMACE_p 필터를 사용하여 분류ㆍ인식하였고, 개인정보의 인증은 OWMF를 사용하여 얼굴영상의 상관치를 구하여 확인하였다. 제안된 MMACE_p 필터는 10개의 암호화된 숫자를 한꺼번에 인식할 수 있도록 4개의 MACE_p필터를 다중화하여 합성하였고, OWMF는 얼굴영상의 분리인식 능력과 SNR을 향상시킬 수 있도록 하였다. 컴퓨터 시뮤레이션을 통하여 제안된 정보보호기술이 개인신원정보 보호에 적용될 수 있음을 보였다.

• 한국조사연구학회지:조사연구
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• 제8권1호
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• pp.31-54
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• 2007

이 글은 2006 지방선거 시기의 여론조사의 경우를 중심으로 선거여론조사의 문제점과 개선방향을 살펴본 것이다. 여론조사방법의 문제점인 표집방법, 무응답자 분류방법 및 투표율 추정절차 등을 검토하였는데, 현재 사용되는 할당표집 및 그것의 보완방법으로 제시된 방안으로는 조사의 정확도 제고에 한계가 있다고 보고, 무선표집방안과 무선번호추출방안을 발전방안으로 제시했다. 또한 여론조사의 새로운 활용방식으로서 KBS에서 시도한 여론조사를 이용한 유권자 의제분석 과정도 살펴보았다. 이 글은 조사방법에 대한 새로운 발전이 필요하며, 이를 위해서는 표집을 비롯한 다양한 방법적인 개선과 함께 여론조사에 대한 비용산정 방식도 바뀔 필요가 있다고 보았다.

• 보건교육건강증진학회지
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• 제17권1호
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• pp.155-170
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• 2000

This study was aimed at preparing basic data required for establishment of a cancer screening program by examining the status of cancer screenings performed by women in a city and the factors that had an influence on cervical and breast cancers screening behavior of women. In order to find out the status of cervical and breast cancers screening and the factors having an influence on cervical and breast cancers screening behavior, 1,113 women were selected as study area and subjects by a random cluster sampling method, and the subjects were answered by questionnaires. The major results were as follows: 1. In the cases of the breast and the cervical cancers, 16.7% and 55.7% of the subjects turned out to have had one or more screenings respectively in their life-time. Also the rate of screening group of cervical and breast cancers was 16.7%, the rate of screening group of only cervical cancer was 38.9%, and the rate of non-screening group was 44.4%. 2. As to the screening pattern of cervical and breast cancer, there were significantly for age, income, occupation, married status, spouse, the factors associated with health promotion (doctor visiting, exercising), married age, number of children, and breast feeding(p〈0.05). 3. The factors associated with screening behaviors for cervical and breast cancers were age, income, occupation, married status, doctor visiting, exercising, married age, number of children, and breast feeding(p〈0.05). Based on the above-mentioned results obtained by this study, it was anticipated that this study may be playa vital role as basic data for the development and execution of cervical and breast cancers screening program for women in a community. And the analysis, done on the basis of the status of the cancer screening, of the influence factors on cervical and breast cancers screening behavior showed that for the development of a cancer screening program, the factors like age, social-economic class, married status, health promotion behavior, and reproductive characteristics should be considered.

• 약학회지
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• 제52권5호
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• pp.323-330
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• 2008

This study was conducted to investigate the actual conditions of vitamin supplement usage, the importance of their agents for health management, and the distribution of basic data for their correct consumption. For a period of one month 2003, the study was conducted based on questionnaires to the parents of students in both a middle school and a high school, and the personnel of K Company at random. The material used the survey sheets by setting up the previous investigation. The collected data analyzed the frequency and percentage of the following items: General demographic characteristics of consumers; the supplements taking; the reasons for taking them; the kinds of supplements taken; the media used for distributing data on their use; the potential use in the future, etc. According to the survey, the number of people who were taking supplements was higher than the number of people who weren’t taking them. Multi-vitamins were mostly consumed. The rate of supplements consume was high in people of a higher income bracket, had the time to exercise and to enjoy physical recreation. Most of the consumers who were taking the supplements said they did it to maintain their health and to recover from the fatigue. Those who weren’t taking them said they had enough vitamins from eating the appropriate food, and they were also concerned about the effectiveness of taking the supplements. The majority of useful information or advice for purchasing vitamins came from doctors, medical experts, relatives, and various media sources such as TV, newspapers, and magazines.

• 정보보호학회논문지
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• 제13권5호
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• pp.137-145
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• 2003

무선통신의 발달로 인해 사람들은 언제, 어디서나 서로 통화할 수 있는 시대에 살고 있다. 하지만, 이동통신의 개방성은 심각한 보안위협에 노출되며, 안전한 통신채널을 제공하기 위해 이동통신망에서 보안은 필수적이다. 이동통신망의 보안을 위해서 사용하는 가장 일반적인 방법중의 하나는 스트림 암호이다. 일반적으로, 이 스트림 암호는 LFSR (Linear Feedback Shift Reigster)을 주로 사용하여 구현된다. 본 고에서는 이동통신망의 스트림 암호의 비도를 향상시키기 위해서 블록 암호알고리즘에서 주로 사용하는 S박스의 변형된 메커니즘을 제안하며. 이 메커니즘은 랜덤성을 고려한 3개의 변형된 S박스 메커니즘이다. 일반적으로, S박스는 비선형 특성을 가진 함수로서 임의 데이터를 공격에 더 강하도록 만들어준다. 제안된 알고리즘의 랜덤성 테스트는 Ent 의사난수 테스트 프로그램을 사용하고, 실험결과 각각의 테스트에서 기존의 스트림 알고리즘보다 더 좋은 랜덤성과 serial correlation coefficient를 가진다는 것을 증명한다.

• 대한간호학회지
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• 제5권1호
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• pp.133-143
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• 1975

Most of mothers place their babies in either supine or prone position without change of position. Studies comparing supine and prone position of the newborn infants -have already been performed with the result that the prone position is relatively better than the supine position. However, one kind of position recommended to the mothers is not sufficient for the good rearing practice of children, because the same position placed for period long of time may bring out physical, mental tension and fatigue, and deformities of the skull and the thorax. For this reason nurses have to find out other position which has identical or more advantages than prone position so as to perform the position change for the babies. Main purpose of this study is to identify the differences of vital signs, the number of urination, defecation, diaper rash, crying and amount of feeding of the newborn infants with prone position or lateral position during the first three days of life. Sixty two newborn infants who were delivered at Seoul National University Hospital during the period from July 1 to September 5, 1974 were chosen as subjects for this study. The criteria for the choice of subjects were the babies born with vaginal delivery; body weight 2.5kg or over at birth; Apgar score Seven or over; and gestation period between thirty-eight months ana forty- two months. Of these subjects, by random sampling, thirty-one newborn infants were placed in the prone position and the other thirty-one in the lateral position. The results of this study reviewed in a statistical analysis of the t-test to obtain the following findings : 1. The heart rates of babies in the prone position were the mean heart rates of 135.03 and those in the lateral position 135.98 without any statistically significant difference. 2. There was no significant difference of respiration rate between two groups : a group in the prone position showed the mean respiration rates of 45,57 and the other in the lateral position 46.49. 3. There was no significant difference of body temperature between two groups: the mean body temperature of a group placed in the prone position was 98$^{\circ}$18'F(36$^{\circ}$77'C) and that of the other group 98$^{\circ}$20'F(36$^{\circ}$78'C). 4. One baby showed diaper rash only in a group of infants in the prone position. 5. The number of crying of the babies in the prone position were 23.70 and those in the lateral position 30.00 with a statistical difference at 5 percent level. 6, There was no difference of frequency of urination between two groups: the mean frequency of a group placed in tile prone position was 5.44 and that of the other group 5.06, 7. There was no significant difference of frequency of defecation between two groups : the mean frequency of a group placed in the prone position was 4.20 and that of tile other group 4.21, 8. There was no significant difference of feeding amount between two groups : the average amount of a group in the prone position showed 325.03 and that of the other group in the lateral position 291.51. All the above results mean that we may substitute tile lateral position for the Prone position or utilize both position for tile rearing practice of the babies.

• 한국정보과학회논문지:정보통신
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• 제31권5호
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• pp.490-500
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• 2004

모바일/무선 환경하에서 이음새없는(seamless) 이동성 관리 문제는 많은 연구의 대상이 되고 있다. 그러나 핸드오프 이후에 등록을 함으로써 사용중 끊김이 발생하거나, MN가 인접한 셀로 이동할 확률이 같다는 Random Work 모델을 사용함으로써 불필요한 네트워크 트래픽을 발생시키는 문제들이 있었다. 본 논문에서는 이러한 문제를 해결하여 이음새없는 이동성을 제공하는 방향성 사전등록 영역(DSRR) 구성 기법과 알고리즘을 제안한다. DSRR의 핵심은 핸드오프할 확률이 높은 인접 셀(AAAF)을 최소한으로 구성하여 사전 등록을 수행함으로써 끊김과 불필요 트래픽 발생을 방지하는 것이다. 이를 위해 셀 분할 스킴을 도입하였다. 셀을 영역적으로 분할(Regional Cell Division)하여 핸드오프 시기를 감지하였으며, 셀의 방향성 분할(Directional Cell Sectoring)로 계산된 방향벡터(DV: Direction Vector)를 적용하여 MN의 이동방향을 반영하였다. 결과적으로 본 논문에서 제안한 DSRR은 노드간 메시지 교환이 인트라도메인 내에서 처리되므로 끊김은 인터도메인 환경에서 처리되는 기존 연구들에 비해 현저히 줄었으며, 또한 핸드오프마다 발생하는 트래픽은 인접한 셀의 개수(n)만큼 발생하던 기존 연구에 비해 DSRR에서는 2번으로 감소하였다.