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An Experimental Study on the Heterotopic Canine Heart Transplantation: Pathologic Observation (동종 심장이식의 병리조직학적 연구)

  • 손광현;서경필;이영균
    • Journal of Chest Surgery
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    • v.2 no.2
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    • pp.155-166
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    • 1969
  • Heterotopic abdominal homograft of canine heart was carried out in 20 pairs of dogs. Of these 12 cases were subjected as a control and 8 were subjected to immunosuppressive group. The dosage of immunosuppressive agent was 5mg/kg/day of Imuran [Azathioprine] for 3 days preoperatively, 10mg/kg on operative day and 5mg/kg/day postoperatively. For reducing the metabolic demand, the donor heart was preserved in 4degree heparinized saline solution for approximately I4 minutes. In the most of the cases, transplantation was performed with the technique of end-to-side aorto-aortic anastomosis and end-to-side pulmonary artery-inferior vena cava anastomosis at the infrarenal portion. Five out of 20 grafted dogs were survived more than one day. The longest survived 18 days in the control group and survive more than 60 days in the treated group. The survival cases were 3 out of 8[37. 5%] in the group of dogs treated with lmuran and 2`out of 12 [16.6%] in the group of non-treated. A prominent gross findings of the grafted heart was a minimal to moderate degree of dilatation of the heart with or without thrombosis in the cardiac chambers and/or anastomotic site. The case number 10, 15, and 19 showed moderate hypertrophy in grossly. The microscopic findings were as follows; 1. There were early hypersensitive histologic reactions such as interstitial edema, cellular infiltrations and early degenerative changes in the myocardium in the cases of 3 hour survival. 2. In the cases of more than 6 hours survival, organizing thrombosis of myocardial vessels, vasculitis,myocardial necrosis and lymphocyte, plasma cell, round cell infiltrations were noted. In the cases of more than 12 hours survival, the degree of these histologic changes especially in the non-treated group were more intensified than in the treated. 3. In the cases which survived more than one day, so called homograft specific histologic changes were milder in the immunosuppressive group compared with the control. 4. All the host hearts showed no evidence of pathologic findings histologically. Among the homologous canine cardiac transplantation tissue reaction, was milder and suvival time longer in the group treated with immunosuppressive drug.

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Studies on the Components of Korean Panax Ginseng C.A. Mayer -Part. I On the Content of Starch, Size Frequency Distribution of Starch Granules, Amylose Content and Blue Value- (한국인삼 성분에 관한 연구 -제1보 전분함량, 전분의 입경분포, amylose함량 및 blue value에 대하여-)

  • Kim, Hai-Jung;Nam, Sung-Hi;Kim, Hyong-Soo;Lee, Suk-Kun
    • Korean Journal of Food Science and Technology
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    • v.9 no.1
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    • pp.19-23
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    • 1977
  • The variation of the amount of starch, size and shape of the starch granules, amylose content, and blue value of the starch in the Korean ginseng roots from one year old to five year old cultivated at Kumsan was studied. The results obtained were as follows; 1) The starch content of the ginseng root(dried) was increased with the age of the root; that is, 9.62% for one-year-old roots, 10.35% for two-year-old root, 15.50% for three-year-old root, 17.05% for four-year-old root, and 18.32% for five-year-old root. 2) The shape of the ginseng starch granules was round or short oval, and in the latter case the ratio of minor axis to major axis was 1 to 1.1. Diameter of the starch granules was in the range of $1.48\;{\mu}\;to\;8.14\;{\mu}$ and the most frequent granule size was $3\;{\mu}\;(32.1{\sim}35.7%)$. The number of big size starch granules was increased during the five years of growing, while, the number of small size granules was decreased. 3) The amylose content in the ginseng starch was varied with the age of the root, in the range of $53.6{\sim}70.5%$. 4. The blue value of the ginseng starch was in the range of 0.60 to 0.71.

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Idiopathic bone cavity: clinical and radiological features of 90 retrospective cases and surgical treatment

  • Ryu, Jihye;Nam, Inhye;Shin, Sang-Hun;Kim, Yong-Deok;Lee, Jae-Yeol
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.47 no.5
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    • pp.360-364
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    • 2021
  • Objectives: The purpose of this study was to evaluate the clinical and radiographic characteristics of idiopathic bone cavity (IBC) to determine the effect of surgical intervention on the process of healing. Materials and Methods: All cases diagnosed with IBC during the period of 2011 to 2020 at our Department of Oral and Maxillofacial Surgery were searched. Ninety cases were retrieved. The features evaluated were sex, age, contour of the lesion, number of teeth involved, site, history of trauma, and postoperative healing pattern. The significance of differences was assessed by Mann-Whitney U test and chi-square test. Results: The female:male ratio showed no predilection toward either sex (0.9:0.8). The mean age of the collected sample was 22.05±14.38 years, and the age ranged from 10 to 58 years. All cases presented in the mandible and showed well-circumscribed radiolucency. Margins were either scalloped or round in shape, and the size varied from one tooth to six teeth involvement. Seventy cases involved three or fewer roots. Three cases showed bilateral lesion. Four cases had a history of trauma at the area of the lesion. Fifty-one cases were followed for six months after surgery, and all showed increased bone density at the lesion. Conclusion: There is no definitive radiological or clinical feature of IBC. Considering the diversity of clinical and radiological features, such a diagnosis relies primarily on surgical findings of an empty bone cavity with no epithelial lining. Our data suggest that surgical intervention be the first choice of treatment as opposed to observation.

Current status of interprofessional education learning activities in wards provided by tertiary hospitals and secondary general hospitals and barriers

  • Kang, Joonsung;Sin, Hye Yeon
    • Korean Journal of Clinical Pharmacy
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    • v.32 no.2
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    • pp.106-115
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    • 2022
  • Background: The World Health Organization (WHO) has focused on the need for interprofessional education (IPE) to improve interprofessional collaboration competency and patient health outcomes. Accordingly, most European and North American medical colleges have established IPE for students. However, IPE learning activity in medical wards for the clinical experience of pharmacy students has not been fully reviewed in Korea. Therefore, this study aims to examine the current status of IPE learning activities in wards at tertiary and secondary hospitals in order to identify ways to improve the program. Methods: The official document of cooperation consists of six self-administered questions regarding IPE learning activities in wards. The preceptor's response in each hospital was evaluated. Results: Of the 22 hospitals, 9 tertiary hospitals and 12 secondary general hospitals responded. For the introductory pharmacy practice experience (IPPE), participating in intensive care (IC) was provided at one secondary general hospital (8.3%) and no tertiary hospital. Ward rounds with medical staff members were provided at two tertiary hospitals (22.2%) and one (8.3%) secondary general hospital. A major barrier to executing IPE was lack of rewards and incentives for the faculty and preceptors who participated in the program. Conclusion: In both tertiary hospitals and secondary general hospitals, pharmacy students have limited exposure to IPE learning activities in wards at hospital, and IPPE at most hospitals was carried out in pharmacy settings only. This study suggests that it is necessary for the hospitals to improve and support IPE learning activities in wards in order to improve learners' competency.

An Efficient Post-Quantum Signature Scheme Based on Multivariate-Quadratic Equations with Shorter Secret Keys (양자컴퓨터에 안전한 짧은 비밀키를 갖는 효율적인 다변수 이차식 기반 전자서명 알고리즘 설계)

  • Kyung-Ah Shim
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.33 no.2
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    • pp.211-222
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    • 2023
  • Multivariate quadratic equations (MQ)-based public-key cryptographic algorithms are one of promising post-quantumreplacements for currently used public-key cryptography. After selecting to NIST Post-Quantum Cryptography StandardizationRound 3 as one of digital signature finalists, Rainbow was cryptanalyzed by advanced algebraic attacks due to its multiple layered structure. The researches on MQ-based schemes are focusing on UOV with a single layer. In this paper, we propose a new MQ-signature scheme based on UOV using the combinations of the special structure of linear equations, spare polynomials and random polynomials to reduce the secret key size. Our scheme uses the block inversion method using half-sized blockmatrices to improve signing performance. We then provide security analysis, suggest secure parameters at three security levels and investigate their key sizes and signature sizes. Our scheme has the shortest signature length among post-quantumsignature schemes based on other hard problems and its secret key size is reduced by up to 97% compared to UOV.

A Freeze-fracture Study on the Odontoblast of Dental Pulp in the Rat Incisor (흰쥐 절치치수의 Odontoblast에 관한 Freeze-Fracture 연구)

  • Kim, Myung-Kook
    • Applied Microscopy
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    • v.16 no.2
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    • pp.1-13
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    • 1986
  • The purpose of this study was to investigate the morphology and intercellular junctions of the odontoblast of dental pulp in the rat incisor by means of the freeze fracture electron microscopy. Twenty male Sprague-Dawley rats weighing $150{\sim}200g$ were used. After being anesthetized by an intraperitoneal injection of 0.5 ml sodium pentobarbital per kg in body weight(60 mg/ml) the animals were perfused with 2.5% glutaraldehyde-2% paraformaldehyde fixative in 0.1 M cacodylate buffer, pH 7.2 through the ascending aorta for one hour. The incisors were carefully extracted from the jaws and demineralized by suspending them in 0.1 M EDTA in 3% glutaraldehyde (pH 7.2) for two weeks. After demineralization, the specimens were obtained from the portion divided into five equal parts. For freeze-fracture replication, demineralized tissues were infiltrated for several hours with 10%, 25% glycerol in 0.1M cacodylate buffer as a cryoprotectant and then frozen in liquid Freon 22 and stored in liquid nitrogen. Fracturing and replication were done in Balzers BAF 400D high-vacuum freeze-fracture apparatus at $-120^{\circ}C$ under routine $5X10^{-7}$ Torr vacuum. The tissue was immediately replicated with platinum unidirectionally at $45^{\circ}$ angle and reinforced with carbon at $90^{\circ}$ angle unidirectionally or by using a rotary stage. The replication process was monitored by a quartz-crystal device. The replicas were immersed in 100% methanol overnight. The tissue was then digested from the replica by clorox (laundry bleach), placed into 5% EDTA, and washed repeatedly with distilled water. The replicas were picked up on 0.3% formvar-coated 75 mesh grids and examined in the JEOL 100B electron microscope. The results were as follows; 1. Both in thin sections and freeze-fracture replicas, three types of intercellular junctions were recognizable in the plasma membrane of odontoblast: gap junction, tight junction and desmosome-like junction. 2. The nuclear pores were evenly distributed over the nuclear envelope. The pore complex formed a ring about 70 nm in diameter. 3. Gap junctions were found between odontoblasts as well as odontoblasts and neighbouring pulp cells (fibroblast, subodontoblastic cell process, nerve-like fibre). Gap junctions, which were round, ellipsoid and pear-shaped and 600 nm in diameter, were observed in the odontoblast. 4. Numerous round and ellipsoid gap junctions could be frequently seen on the plasma membranes in cell body and apical part of the odontoblasts. On the P face, the junctions were recognized as a cluster of closely packed particles, measuring about 9 nm in diameter, and on the E face, the junctions were recognized as a shallow grooves.

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A Design of PRESENT Crypto-Processor Supporting ECB/CBC/OFB/CTR Modes of Operation and Key Lengths of 80/128-bit (ECB/CBC/OFB/CTR 운영모드와 80/128-비트 키 길이를 지원하는 PRESENT 암호 프로세서 설계)

  • Kim, Ki-Bbeum;Cho, Wook-Lae;Shin, Kyung-Wook
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.20 no.6
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    • pp.1163-1170
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    • 2016
  • A hardware implementation of ultra-lightweight block cipher algorithm PRESENT which was specified as a standard for lightweight cryptography ISO/IEC 29192-2 is described. The PRESENT crypto-processor supports two key lengths of 80 and 128 bits, as well as four modes of operation including ECB, CBC, OFB, and CTR. The PRESENT crypto-processor has on-the-fly key scheduler with master key register, and it can process consecutive blocks of plaintext/ciphertext without reloading master key. In order to achieve a lightweight implementation, the key scheduler was optimized to share circuits for key lengths of 80 bits and 128 bits. The round block was designed with a data-path of 64 bits, so that one round transformation for encryption/decryption is processed in a clock cycle. The PRESENT crypto-processor was verified using Virtex5 FPGA device. The crypto-processor that was synthesized using a $0.18{\mu}m$ CMOS cell library has 8,100 gate equivalents(GE), and the estimated throughput is about 908 Mbps with a maximum operating clock frequency of 454 MHz.

A Study of Practical Strategies for Cooperative Rural Community Regeneration in Geochang (거창군 협업형 마을만들기 실천전략 연구)

  • Oh, Hyung-Eun
    • Journal of the Korean Institute of Landscape Architecture
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    • v.43 no.5
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    • pp.87-99
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    • 2015
  • Prior hardware-centered rural development projects implemented top-down rural community regeneration via the local government in accordance with central government agency policies. To improve this, software-centered projects have been promoted since 2000. With central agency-led rural development projects changing into local government-led ones, rural community regeneration has been built per village. Although rural community regeneration projects appear to have implemented a bottom-up development currently, the top-down development procedures being facilitated by the intervention of administrative institutions have not disappeared. In this regard, the purpose of this research thesis is to effectively perform bottom-up development methods that go one step further from the current process of rural community regeneration. As the research site, this thesis selected Geochang, which has difficulties in being steadily maintained and operated despite the development of various rural community regeneration projects. Subsequently, it determined the current status and substantial analysis of a project of the rural community regeneration in Geochang through 1:1 interviews with civil servants in charge of administration as well as conducted a prior study on rural resident awareness of rural community regeneration through a survey of village head members and in-depth interviews with rural residents. Based on these data, a 10 times-round table conference was held under the participation of pertinent civil servants, professionals and rural residents to select practical strategies for cooperative rural community regeneration in Geochang as five key areas: local food, culture & welfare, rural villages, community development, and urban and rural interchanges. In addition, it is considered that the project of building villages must be implemented by establishing steadfast administrative co-operation systems, strengthening rural residents' participation capacities and supporting professionals' systemic integrated operation and maintenance. By doing so, this research thesis sought to determine practical strategies in the cooperative rural community regeneration in Geochang. It is expected that bottom-up development rural community regeneration will be built and introduced in each rural community in the future.

Preparation of Powdered Dried Sea Mussel and Anchovy for Instant Soup (진주담치 및 마른멸치 분말수우프의 제조)

  • LEE Eung-Ho;HA Jae-Ho;CHA Yong-Jun;OH Kwang-Soo;KWON Chil-Sung
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.17 no.4
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    • pp.299-305
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    • 1984
  • As one trials to utilize sea mussel and anchovy effectively, powdered instant soups were prepared and then their quality stability were examined during storage. Powdered instant soup was made by adding $3\%$ sugar, $20\%$ table salt, $5\%$ monosodium glutamate, $0.2\%$ black pepper and garlic powder to the pulverized dried sea mussel or anchovy. Powdered instant soup products, powderd products, and dried round state sea mussel or anchovy were packed with air in laminated film bag (cellophane/polyester/aluminium foil/polyester: $20{\mu}m/15{\mu}m/7{\mu}m/20{\mu}m,\;13{\times}14cm$). The contents of amino-nitrogen and volatile basic nitrogen of these products were showed little significant variations and also water activity and color value (L, a, b) of these products were little changed during storage. Thiobarbituric acid value increased up to 30 days of storage and then decreased slightly. Comparing the quality of powdered-seasoned products with that of dried round state products, there were no significant differences in stability during storage. Judging from the experimental results, the quality of powdered instant soup of sea mussel and anchovy were stable for 100 days at room temperature($25{\pm}3^{\circ}C$).

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Overlay Multicast considering Fast Path Recovery (빠른 경로 복구를 고려한 오버레이 멀티캐스트)

  • Gu, Myeong-Mo;Kim, Bong-Gi
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.3
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    • pp.332-337
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    • 2016
  • The rapid reconstruction of a transfer path is caused by frequent secession of nodes in many applications using overlay multicast. For this, however, many studies have been proposed, but a study of fast path recovery is required. This paper proposes a new method for fast path recovery to improve the path reconstruction time and for stable path maintain caused by the sudden secession of the parent node on overlay multicast. The proposed method uses the virtual transfer path and the candidate parent node for the fast path recovery. All nodes exchange periodically the RTT (Round Trip Time) information between the other nodes of similar position itself and neighboring node. All nodes have a candidate parent node list, and each node stores the exchanged RTT information on the list. Each node constructs the virtual transfer path to reduce the recovery time after deciding a candidate parent node that is one of them by the RTT order. In this way, when the parent node is seceded, all nodes can recover the transfer path quickly using the virtual transfer path. The simulation result showed that the recovery time of the proposed method is an average 30% faster than the known method.