• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.16 no.1
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• pp.42-48
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• 2020

The effect of improving the tensile and J-R fracture toughness properties of SA508 Gr.1a on the LBB margin for the main steam pipe is investigated. The material properties and microstructure images of the existing main steam piping material SA106 Gr.C used in domestic nuclear power plants and the newly selected material SA508 Gr.1a were compared. For each material, LBB margins were calculated and compared through finite element analysis and crack instability evaluation. The LBB margin of the improved SA508 Gr.1a is found to be greatly improved compared to that of the existing SA106 Gr.C and SA508 Gr.1a. This is because of the increased material's strength and J-R fracture toughness compared to the previous materials. In order to analyze the effect of physical property change on the LBB margin, the sensitivity of each LBB margin according to the variation of tensile strength and J-R fracture toughness was analyzed. The effect of the change in tensile strength was found to be greater than that of the change in fracture toughness. Therefore, an increase in strength significantly influenced the improvement of the LBB margin of the improved SA508 Gr.1a.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.11
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• pp.4641-4645
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• 2015

The present investigation was designed to assess the anticancer activity of six different leaf extracts (ethyl acetate, methanol, chloroform, petroleum ether, n-butanol, and water soluble) of Abelia triflora on A-549 human lung adenocarcinoma epithelial cells. A-549 cells were exposed to $10-1000{\mu}g/ml$ concentrations of the leaf extracts of A. triflorafor 24 h and then percentage cell viability was assessed by 3-(4,5-dimethylthiazol-2yl)-2,5-biphenyl tetrazolium bromide (MTT) assay. The results showed that leaf extracts of A. triflora significantly reduced the viability of A-549 cells in a concentration-dependent manner. Decrease was recorded as 31% with ethyl acetate, 36% with methanol, 46% with chloroform, 54% with petroleum ether, 62% with n-butanol, and 63% with water soluble extracts at $1000{\mu}g/ml$ each. Among the various plant extracts, ethyl acetate extract showed the highest decrease in the percentage cell viability, followed by methanol, chloroform, petroleum ether, n-butanol, and water soluble extracts. Our results demonstrated preliminary screening of anticancer activity of different soluble extracts of A. triflora extracts against A-549 cells, which can be further used for the development of a potential therapeutic anticancer agents.

• The Journal of Korean Association of Computer Education
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• v.3 no.2
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• pp.67-75
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• 2000

Due to the advantages of Internet, many teachers use Internet as an educational tool and due to the computerized works in schools, the usages of the Internet increase. However, because of the openness of the Internet, the sensitive data of an organization are exposed to outsiders and the Internet-based working has some problems such as the corruptions of instructional data or on-line assessment results. The need for protecting a school network from outsiders increases but the school networks with firewalls rarely exist. In this paper, in order to solve the security problem of a school network, we construct a hybrid firewall for school networks. In addition, we implement a graphical user interface for teachers to set up the access control rules of a hybrid firewall easily. The interface also provides the facilities such as log analysis, a real-time monitor for network traffics, and the statistic on traffics.

• Biomolecules & Therapeutics
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• v.24 no.2
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• pp.147-155
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• 2016

Chaetominine is a quinazoline alkaloid originating from the endophytic fungus Aspergillus fumigatus CY018. In this study, we showed evidence that chaetominine has cytotoxic and apoptotic effects on human leukemia K562 cells and investigated the pathway involved in chaetominine-induced apoptosis in detail. Chaetominine inhibited K562 cell growth, with an $IC_{50}$ value of 35 nM, but showed little inhibitory effect on the growth of human peripheral blood mononuclear cells. The high apoptosis rates, morphological apoptotic features, and DNA fragmentation caused by chaetominine indicated that the cytotoxicity was partially caused by its pro-apoptotic effect. Under chaetominine treatment, the Bax/Bcl-2 ratio was upregulated (from 0.3 to 8), which was followed by a decrease in mitochondrial membrane potential, release of cytochrome c from mitochondria into the cytosol, and stimulation of Apaf-1. Furthermore, activation of caspase-9 and caspase-3, which are the main executers of the apoptotic process, was observed. These results demonstrated that chaetominine induced cell apoptosis via the mitochondrial pathway. Chaetominine inhibited K562 cell growth and induced apoptotic cell death through the intrinsic pathway, which suggests that chaetominine might be a promising therapeutic for leukemia.

• Journal of the Society of Naval Architects of Korea
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• v.51 no.3
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• pp.246-253
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• 2014

Liquid natural gas is stored and transported inside cargo tank which is made of specially designed cryogenic materials such as 9% Ni steel, Al5083-O alloy and SUS304 and so on. The materials have to keep excellent ductile characteristics under the cryogenic environment, down to -163oC, in order to avoid the catastrophic sudden brittle fracture during the operation condition. High manganese steel is considered to be the promising alternative material that can replace the commonly used materials mentioned above owing to its cost effectiveness. In line with this industrial need, the mechanical properties of the high manganese steel under both room and cryogenic environment were investigated in this study focused on its tensile and fatigue behavior. In terms of the tensile strength, the ultimate tensile strength of the base material of the high manganese steel was comparable to the existing cryogenic materials, but it turned out to be undermatched one when welding is involved in. The fatigue strength of the high manganese steel under room temperature was as good as other cryogenic materials, but under cryogenic environment, slightly less than others though better than Al 5083-O alloy.

• Safety and Health at Work
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• v.2 no.3
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• pp.236-242
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• 2011

Objectives: To determine the feasibility of predicting static and dynamic peak back-compressive forces based on (1) static back compressive force values at the lift origin and destination and (2) lifting speed. Methods: Ten male subjects performed symmetric mid-sagittal floor-to-shoulder, floor-to-waist, and waist-to-shoulder lifts at three different speeds (slow, medium, and fast), and with two different loads (light and heavy). Two-dimensional kinematics and kinetics were captured. Linear regression analyses were used to develop prediction equations, the amount of predictability, and significance for static and dynamic peak back-compressive forces based on a static origin and destination average (SODA) backcompressive force. Results: Static and dynamic peak back-compressive forces were highly predicted by the SODA, with R2 values ranging from 0.830 to 0.947. Slopes were significantly different between slow and fast lifting speeds (p < 0.05) for the dynamic peak prediction equations. The slope of the regression line for static prediction was significantly greater than one with a significant positive intercept value. Conclusion: SODA under-predict both static and dynamic peak back-compressive force values. Peak values are highly predictable and could be readily determined using back-compressive force assessments at the origin and destination of a lifting task. This could be valuable for enhancing job design and analysis in the workplace and for large-scale studies where a full analysis of each lifting task is not feasible.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.623-627
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• 2005

Abnormal thyroid cell proliferation has a very important role in hypothyroidism. Thyroid stimulating hormone (TSH) stimulates proliferation and maintains differentiated function in thyroid follicular cells. A functioning rat thyroid cell line (FRTL) was used to study the effect of Gamgung-tang (GGT, Glycyrrhizae Radix, black beans, Angelicae Radix and Cnidii Rhizoma) on proliferation and cAMP accumulation of thyrocytes. Proliferation of cell was assessed by DNA synthesis and incorporation of $[^3H]thymidine$ into DNA. The concentration of cAMP was measured simultaneously with growth assessment. Extract of GGT ($0.15{\sim}0.9\;mg/ml$ increased DNA synthesis in a dose-dependent manner. GGT at 0.6 (p<0.05) and 0.9 mg/ml (p<0.01) significantly increased $[^3H]thymidine$ incorporation. A comparable effect was observed with TSH. GGT also enhanced cAMP accumulation. These results indicate that GGT increases the proliferation of thyrocytes and may be considered a promising agent for the treatment of autoimmune thyroid disease.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.11 no.6
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• pp.16-21
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• 2012

Magnesium alloy has been focussed as lightweight material owing to its high strength even though low density with aluminum alloy, titanium alloy and plastic material. Friction stir welding technique was performed by rotating and plunging a shouldered tool with a small diameter pin into the joint line between two butted plates and useful to join magnesium alloy. In this paper, the experiments of friction stir welding were done to investigate the joint characteristics of AZ31 magnesium alloy. For its evaluation, the orthogonal array method$(L_{27}(3^{13}))$ was applied with four factors of pin diameter, shoulder diameter, travel speed and rotation speed of tool and also three levels of each factor. Nine tools were worked through shoulder diameter of 9, 12, 15mm and pin root diameter of 3, 4, 5mm. In addition tensile tests were excuted for the assessment of mechanical properties for joint conditions. From the results, pin diameter, shoulder diameter, and rotating speed of tool influenced on the tensile strength meaningful, but welding speed did not influence on that by the variance analysis. Beside of that, optimum condition of tensile strength was estimated as following ; shoulder diameter:15mm, welding speed:200mm/min, rotating speed:200rpm.

• Journal of Electrical Engineering and Technology
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• v.9 no.3
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• pp.991-996
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• 2014

Power frequency magnetic field is still a critical problem for new construction of overhead power transmission lines in Korea because most people have been concerned about possibly carcinogenic effects of it. Although reference level of power frequency(60Hz) magnetic field has been set to 200uT in ICNIRP guidelines published in 2010, Korean government has no intention of adjusting 83.3uT specified by law in 2006 to this new reference level in consideration of people's concerns for the time being. Regardless of the current regulated magnetic field value, electric utility company has been trying to reduce magnetic field in the residential area in the vicinity of overhead power transmission lines to take into account of public concerns on the long-term effect of magnetic fields. In an effort to reduce magnetic field, engineering side has made considerable efforts to develop passive loop based, cost-effective mitigation technique of power frequency magnetic field more than ten years. In order to verify developed power frequency magnetic field mitigation technique based on passive loop, a horizontal type of passive loop was designed and installed for commercially operating 154kV overhead power transmission line for the first time in Korea. The measurement results before and after the installation of passive loop showed that magnetic field could be reduced to about 20%. The electrical environmental effects such as AN, RI and TVI were assessed before and after the installation of passive loop and these values were complied with the requirements specified by electric utility. It has been confirmed from the field test results that passive loop could be commercially and cost-effectively utilized to mitigate power frequency magnetic field.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.2
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• pp.1426-1433
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• 2015

CCTV-applied monitoring is an effective measure to suppress potential crimes and record objective relationship; however, there is no methodology that can quantitatively compare and assess the afore-mentioned effects. Thus, this study intended to construct the methodology and analysis application that can measure the changes in the space-corresponding performance of CCTVs depending on installation measures by using 3-dimenstional virtual simulation technology. For analysis, the raster-based Isovist theory was 3-dimensionally expanded and the amount of incident sight line to each point was accumulated. At the same time, the amount of overlapped monitoring in the CCTV cameras that were connected to each measurement node was accumulated for cross-analysis. By applying the examples and analyzing the results, it was possible to construct an analysis application in use of collision detection model and quantify the changes of monitoring performance depending on positioning alternative of the cameras. Moreover, it enabled intuitive review and supplementation by reproducing visible shadow areas in a graph.