• Clinical and Experimental Pediatrics
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• v.56 no.4
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• pp.151-158
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• 2013

Purpose: We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-${\alpha}$, PPAR-${\gamma}$, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge, and the effect of rosiglitazone, a PPAR-${\gamma}$ agonist. Methods: We developed 6 mice models: OVA-challenged lean mice with and without rosiglitazone; obese mice with and without rosiglitazone; and OVA-challenged obese mice with and without rosiglitazone. We performed real-time polymerase chain reaction for leptin, leptin receptor, adiponectin, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-${\alpha}$, transforming growth factor (TGF)-${\beta}$, PPAR-${\alpha}$ and PPAR-${\gamma}$ from the lung tissue and determined the cell counts and cytokine levels in the bronchoalveolar lavage fluid. Results: Mice with OVA challenge showed airway hyperresponsiveness. The lung mRNA levels of PPAR${\alpha}$ and PPAR-${\gamma}$ increased significantly in obese mice with OVA challenge compared to that in other types of mice and decreased after rosiglitazone administeration. Leptin and leptin receptor expression increased in obese mice with and without OVA challenge and decreased following rosiglitazone treatment. Adiponectin mRNA level increased in lean mice with OVA challenge. Lung VEGF, TNF-${\alpha}$, and TGF-${\beta}$ mRNA levels increased in obese mice with and without OVA challenge compared to that in the control mice. However, rosiglitazone reduced only TGF-${\beta}$ expression in obese mice, and even augmented VEGF expression in all types of mice. Rosiglitazone treatment did not reduce airway responsiveness, but increased neutrophils and macrophages in the bronchoalveolar lavage fluid. Conclusion: PPAR-${\alpha}$ and PPAR-${\gamma}$ expressions were upregulated in the lung tissue of OVA-challenged obese mice however, rosiglitazone treatment did not downregulate airway inflammation in these mice.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1411-1418
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• 2005

Obesity is not classed in general psychiatry disease. But, psychoneurotic factor has been known to be a risk factor of obesity. In order to evaluate and understand the psychoneurotic state on obese patient, this study used Minnesota Multiphasic Personality Inventory(MMPI). Total patients were classified into 3 or 5 clusters. MMPI scores were compared according to education, BMI and Sasang Constitution. Multiple regression analysis were used for psychological factor on obese patients by age, height, weight, education, percent body fat, fat distribution, BMI. Based on this study, it was no significantly difference by education level, BMI, sasang(四象) constitution except L profile according to BMI. These result is different from our general recognition of the psychoneurotic state on obese patient. Therefore, the bigger sample study is needed.

• Korean Journal of Health Education and Promotion
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• v.18 no.3
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• pp.117-131
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• 2001

This study was attempted to develope a highly reliable and valid tool which is useful to assess the Korean obese adolescents' stress and coping method. The data were collected from the total of 600 obese students from middle and high schools in Pusan. The author used a convenience sampling method. The data collection was done from March 2 to July 11, 1999. The analysis of the data was done with SPSS Win(10.0) for descriptive statistics and factor analysis. The preliminary tool was composed of 72 items(stress items: 34, coping method items: 38) with the five point Likert scale. Item analysis and inter consistency were calculated for reliability and validity through pre-test. The preliminary tool was analyzed for reliability and validity. Finally, the tool was of 65 items(stress items: 33, coping method items: 32). The results were as follows: 1. Cronbach Coefficient Alpha for the 33 items of stress was .9485 and the 32 items of coping method was .8534. 2. The factor analysis was done in order to confirm construction and the items were extracted Oblimin rotation and Maximum likelihood extraction method. 3. The factor analysis showed 6 factors in stress and 10 factors in coping method. These 6 factors of stress explained 62.4％ and 10 factors of coping method explained 57.4％. 4. Six factor of stress lable were 〈outward appearance〉, 〈boyfriend/ girlfriend〉, 〈occur an outbreak of disease〉, 〈mutual relation of family〉, 〈an obese figure〉, 〈be a burden on exercise〉. 5. Ten factor of coping method lable were 〈be concerned about another affairs〉, 〈recreation activities〉, 〈self-violence〉, 〈relaxation〉, 〈hobby activities〉, 〈avoid a situation〉, 〈communication〉, 〈music〉, 〈negative behavior〉, 〈positive thinking〉. The results of using this scale in a study will contribute to design an appropriate school health management of obese students, and also it will contribute to the development of nursing research.

• Fashion & Textile Research Journal
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• v.2 no.4
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• pp.300-307
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• 2000

The purpose of this study was to classify and analyze the body type of obese boys who are school year for 9 to 11 years. A total of 49 body measurements were collected for this study including both direct and indirect measurements (33 variables from the direct anthropometric data, 16 variables from the indirect anthropometric data). Data from anthropometric measurement were analyzed using descriptive, factor and cluster analysis. The obese boys investigated in this project were in the category of average height 146.31 cm, weight 52.17 kg. The values for the study were compared to values from the National Anthropometric Survey of Korea. As the result of factor analysis for the classification of body type, 6 factors were extracted from all items. The first was transverse size of upper body, also, the second was its longitudinal size. The third was thicknesses of front and back at side views. The fourth was shoulder shape. The fifth was upper body angle factor. The sixth was upper body length. The body form was classified with cluster analysis, using factor score. The shape of the body was classified in 3 types.

• Korean Journal of Community Nutrition
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• v.8 no.4
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• pp.477-484
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• 2003

This study was conducted to investigate nutrient intakes and obesity-related factors of obese children by interviewing the subjects aged from 11 to 13 in Daegu. The collected data were consisted of items on general characteristics, dietary behavior, nutrition knowledge and daily nutrient intakes of subjects. The subjects were classified into obese and non-obese control groups according to their relative weights. Frequency of skipping breakfast and eating rate of obese group were significantly higher than those of control group. There was no significant difference between obese and control group in the nutrition knowledge score. Except vitamins $B_1$, $B_2$ and iron, the average daily intakes of other nutrients in obese were greater than control group. The most contributing factor to BMI turned out to be cholesterol intake. After the nutrition education targeting obese children, their nutrition knowledge scores improved, but the dietary behavior score was not significantly changed. Therefore, childhood obesity may be prevented by continuous education programs including the behavior modification of obese children. (Korean J Community Nutrition 8(4) : 477-484, 2003)

• Journal of the Ergonomics Society of Korea
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• v.26 no.4
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• pp.103-111
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• 2007

The purpose of this study is to categorize and analyze the body shape of obese Korean men that are needed for industrial design. Using the anthropometric data that were surveyed through the 5^th Size Korea project, this study was conducted in four steps mostly through the multivariate statistical analysis. In the first step, Broca, BMI, WHR indices are used to define obesity and select obese men from Korean adults and teens. After 34 human anthropometric variables are supposed to be related to obesity were extracted through an expect survey. In the second step, a factor analysis was executed for those human anthropometric variables. Through this analysis, we obtained the human body factors that are related to the representation of obesity. Then the third step, we used a cluster analysis from the result of the factor analysis. And ANOVA analysis was also conducted to obtain the critical obese human anthropometric variables. In the final step, we found the characteristics of the body types of obese men according to clusters and ages. The body types of obese men classified in the study are expected to be applied to product design for clothing, furniture, automobile packaging, etc.

• The Research Journal of the Costume Culture
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• v.19 no.6
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• pp.1150-1162
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• 2011

Considering the fact that the fit for men's clothes is important for the sizing system modern ready-made pants, an analysis of obese middle-aged men is required at this period of time to determine the appropriate fit for obese men. The following research focused on 635 middle-aged obese men who had a BMI index of at least 25 and a waist circumference from the belly-button level of 34 inches or more. This research deals with the articles of circumference, thickness and other major physical changes that happen during the 30s, 40s, and 50s. According to the analysis of these body measurement articles with specific regard to age, men's height and the height of their waist seemed to decrease as their age increased. This demonstrates that as these men grow older, the waist and stomach slowly curved into a circular and flat body type due to their obesity. In this study, the first factor figure was the height and leg length. The second factor figure was the waist form. The third factor figure was the center thigh circumference. The fourth and fifth factor figures were the hip length and shape. Lastly, the sixth factor figure was the calf circumference. These 6 factor figures construct 80.57% of the volume explanation and showed 3 patterns through a cluster analysis that showed different patterns of obesity forms for waist circumferences in key figure 1, waist and thigh circumferences in key figure 2, and waist and buttocks circumferences. Therefore, it was worthwhile to consider the circumferences of the waist, buttocks and thigh according to the body type category to enhance the drafting of well-fitting pants.

• Biomedical Science Letters
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• v.24 no.4
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• pp.341-348
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• 2018

The polyherbal drug Gyeongshingangjeehwan 18 (GGEx18) from Rheum palmatum L. (Polygonaceae), Laminaria japonica Aresch (Laminariaceae), and Ephedra sinica Stapf (Ephedraceae) has traditionally been used as an antiobesity drug in Korean local clinics. This study investigates the effects of GGEx18 on pancreatic fibroinflammation in high-fat diet (HFD)-fed obese C57BL/6J mice and the molecular mechanism involved in this process. After HFD-fed obese C57BL/6J mice were treated with GGEx18 (125, 250, and 500 mg/kg) for 12 weeks, variables and determinants of obesity, pancreatic inflammation, and fibrosis were measured using histology, immunohistochemistry, and real-time polymerase chain reaction. Administration of GGEx18 at 500 mg/kg/day to obese mice decreased body weight gain, mesenteric adipose tissue mass, and adipocyte size. GGEx18 treatment not only reduced mast cells and CD68-immunoreactive cells, but also decreased collagen levels and ${\alpha}$-smooth muscle actin-positive cells in the pancreas of HFD-fed mice. Concomitantly, GGEx18 decreased the expression of genes for inflammation (i.e., CD68 and tumor necrosis factor ${\alpha}$) and fibrosis (i.e., collagen ${\alpha}1$ and transforming growth factor ${\beta}$) in the pancreas of obese mice. These results suggest that GGEx18 may inhibit visceral obesity and related pancreatic fibroinflammation in HFD-fed obese mice.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.15 no.1
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• pp.44-51
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• 2012

Purpose: Tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) polymorphism has been suggested to play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) in obese adults, and known to be a mediator of insulin resistance. In this study, we evaluated the role of TNF-${\alpha}$ promoter polymorphisms and insulin resistance in the development of NAFLD in obese children. Methods: A total of 111 obese children (M:F=74:37; mean age, $11.1{\pm}2.0$ yrs) were included. The children were divided into 3 groups: controls (group I, n=61), children with simple steatosis (group II, n=17), and children with non-alcoholic steatohepatitis (group III, n=33). Serum TNF-${\alpha}$ levels, homeostasis model assessment of insulin resistance (HOMA-IR), and TNF-${\alpha}$ -308 and -238 polymorphisms were evaluated. Results: There were no differences in TNF-${\alpha}$ polymorphism at the -308 or the -238 loci between group I and group II + III ($p$=0.134 and $p$=0.133). The medians of HOMA-IR were significantly different between group I and group II + III ($p$=0.001), with significant difference between group II and group III ($p$=0.007). No difference was observed in the HOMA-IR among the genotypes at the -308 locus ($p$=0.061) or the -238 locus ($p$=0.207) in obese children. Conclusion: TNF-${\alpha}$ promoter polymorphisms at the -308 and -238 loci were not significantly associated with the development of NAFLD in children; nevertheless, insulin resistance remains a likely essential factor in the pathogenesis of NAFLD in obese children, especially in the progression to NASH.

• Journal of Korean Academy of Nursing
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• v.31 no.6
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• pp.1034-1043
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• 2001

To determine the frequency of past and present obesity among patients with NIDDM and to identify the differences of body fat, blood pressure and C-peptide/glucose ratio according to obese diabetic patients (BMI$\geq$25 kg/$m^2$) and nonobese (BMI<25 kg/$m^2$). Also the final factor is to observe the anthrometric change patterns in the study. Method: The weight at 20 years-old, previous maximal body weight, and acute weight loss were queried. Current height, body weight, BMI, waist & hip circumferences, waist-hip ratio, skinfold thicknesses, blood pressure, fasting blood glucose, and fasting C-peptide were measured in one hundred sixty-seven NIDDM patients. The differences of the parameters ccording to obese and nonobese, and three anthropometric change patterns were analyzed. Result: Results were as follows: 1. 66.5 % of the NIDDM patients had a history of past obesity as assessed by their maximum weight, while only 33.2% of them were currently obese (p's < 0.001). 2. The waist & hip circumferences, skinfold thicknesses, systolic, diastolic & mean arterial blood pressure in obese patients were greater than those of nonobese patients (all p's < 0.001). 3. The waist and the hip circumferences, and skinfold thicknesses (subscapula & triceps) were highest among the obese-obese group. WHR and abdominal skinfold thickness in the obese-obese and obese-nonobese groups were higher than those in the nonobese- nonobese group. Systolic & diastolic and mean arterial blood pressures in the obese-obese group were higher than those of obese-nonobese and nonobese-nonobese groups(all p's < 0.005). 4. The abdominal and subscapular skinfold thicknesses in female diabetic patients were greater than those of male patients (all p's <0.0001). Conclusion: Although most Korean NIDDM patients were previously obese, many of them were not obese during the course of the study. Greater central and upper body adiposicity and higher blood pressure was shown in obese diabetic patients. Also, greater central and upper body adiposicity was demonstrated in female diabetic patients.