• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1993년도 추계학술대회
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• pp.40-43
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• 1993

Electronic fetal monitoring system is an easier ar d usual method in various prenatal and labor period fetal surveilence methods currently in use. But there haven't been enough cases of using the central monitoring system despite the fact that the bedside fetal monitoring system have already been widely in use in Korea as an essential medical equipment item. We have developed more efficient central fetal monitoring system based on the personal computer with the visual maternal monotoring device using infrared camera which processes the signals from existing bedside fetal monitoring systems such as H/P's 8040 series. And we have performed the clinical application on 41 pregnant women and the results were satisfactory. In conclusion, more efficient and familial fetal monitoring is possible with our PC based central fetal monitoring system which provides the medical personnel with the view of a selected pregnant woman on the same screen where the electronic waveforms and data are displayed.

• Journal of Nutrition and Health
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• 제38권8호
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• pp.672-681
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• 2005

Metabolic syndrome (MS) was defined as condition in which the subjects have two or more abnormalities among obesity, hyperlipidemia, hypertension and hyperglycemia. To develop a nutritional education program for MS, this study was performed to compare the dietary habits and nutrients intake of complex symptoms of MS with obesity or hyper-glycemia. The participants in this study were 84 normal adults,62 MS with obesity, 33 MS with hyperglycemia and 54 MS with obesity and hyperglycemia (OB + HG). A dietary survey was conducted using 24-hour recall method. Total cholesterol level of MS with obesity group was significantly higher than other groups. WHR and systolic blood pressure showed no significant difference among MS with obesity, hyperglycemia and OB+HG groups. Dietary intakes of energy, Fe, Vit A, Vit $B_2$ and Ca were less than $75\%$ of 7th Korean RDA in the all groups. Especially, dietary intakes of Vit $B_2$, Vit A and Ca were less than $50\%$ of RDA in MS with hyperglycemia and OB+HG groups. The other nutrient intakes of each group were also below the RDA level except for P, Vit C. It appeared that most of the nutrient intakes in MS with hyperglycemia and OB + HG groups were significantly lower than normal group. In MS with obesity group, each consumption of sweet, organ meat and soup was higher than other groups. Each consumption of garlic and onion in MS with obesity, hyperglycemia and OB + HG groups was lower than normal group. Also, each consumption of soup in MS with hyperglycemia and OB + HG groups was higher than normal group. Indices of nutritional quality (INQ) for Ca, Vit A and Vit $B_2$ were below 1 in all the groups. Food composition group score of MS with hyperglycemia group was significantly lower than normal and MS with obesity groups. Our results indicated that nutritional education program for MS with obesity or hyperglycemia should include specific strategies to modify unsound dietary habits and inappropriate food intake for health.

• 한국식품영양과학회지
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• 제36권1호
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• pp.27-31
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• 2007

한약에서 사용하는 유황은 인체에서 열을 발생하는 물질로서 분류되어 있다. 차전자(車前子), 창출(蒼朮), 백복령, 천궁(川芎) 등은 비만을 치료하는 한약재로 이용되고 있다. 본 연구에서는 유황을 주성분으로 하고 차전자(車前子), 창출(蒼朮), 백복령, 천궁 등의 한약재를 혼합한 항비산을 제조하였다. 항비산을 10%(w/w) 함유한 식이를 C57BL/6J ob/ob mice에 12주 동안 투여하고 체중, 간 조직 및 혈액 지질 조성에 미치는 효과를 조사하였다. 유황이 주로 함유된 항비산을 섭취하는 동안 실험동물의 건강상태는 양호하였다. 항비산을 일반 식이와 병행 공급시 cellulose가 갖는 정도의 체중 감소 효과를 나타냈고, 혈중 총 콜레스테롤이 감소하여 혈중 지질 조성을 개선시키는 작용이 있었다. 또한 실험동물의 간 기능에는 독성을 나타내지 않았다. 따라서 항비산의 임상실험 및 지질 조성 개선 효과에 대한 기전연구가 필요하지만 항비산은 비만인의 체중감량 및 지질 조성 개선에 이용될 수 있을 것으로 사료된다.

• 대한한방부인과학회지
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• 제22권4호
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• pp.157-172
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• 2009

Purpose: The purpose of this study is to analyze the status of cooperative treatment of western-oriental medicine in post gynecological surgery. Methods: This study is conducted by investigating the hospitalized patient's medical chart and OCS dated from March 2008 to May 2009 in obstetrics and gynecology of oriental medicine department in Dong-Eui medical center. The total patient number was 58. Results: Out of 58 women, 74.1% complained abdominal pain and discomfort, 24.1% complained headache and dizziness, 22.4% complained lumbago, 22.4% complained lethargy and fatigue. There were 63.8% women in the age group between 41 to 50 and 20.7% women in the age group between 31 to 40. 53.4% women hospitalized for less than 7 days, 43.1% women hospitalized for 8 to 14 days. 53.4% had uterine myoma, 20.7% had more than two types of complex diseases and 19.0% had adenomyosis uterine. 60.3% had total hysterectomy and 27.6% had simple hysterectomy. 64.9% had abdominal surgery, 17.5% had laparoscope surgery and 15.8% had hysteroscope surgery. 62.8% of 43 women complained abdominal pain and discomfort, 78.6% of 14 women complained headache and dizziness, 46.2% of 13 women complained lumbago, 84.6% of 13 women complained lethargy and fatigue improved to VAS 0-3. Conclusion: The results has shown that it is necessary to have cooperative treatment of both western-oriental medicine for the effective treatment in managing post gynecological surgery. The further study in data collection and manual development is needed.

• 대한한의학회지
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• 제27권2호
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• pp.23-35
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• 2006

Objectives : This study examined the reliability of disease mechanism diagnosis, to evaluate items of questionnaires and inquire about the relationships between disease mechanisms and 'diagnosis program' questionnaires used for the objective diagnosis of Oriental medicine in the department of Oriental OB&GYN, Oriental Medical Hospital of Dongeui University. Method : We analyzed the results of questionnaires from 3504 outpatients of OB&GYN disease at the Oriental Medical Hospital of Dongeui University from April 2000 to April 2005. Results & Conclusions : 1. The research questionnaire had 188 questions, the summary questionnaire 137, and the diagnosis questionnaire 80. 2. The reliability of all questionnaires shows above 90% in deficiency of qi, deficiency of Yin, insufficiency of Yang coldness heat syndrome liver and spleen kidney in all, 8 case disease mechanisms. These are higher in the diagnosis questionnaires than in the research questionnaires and the summary questionnaires, except for kidney disease mechanism. 3. Cronbach a of the questionnaires decreased, especially blood deficiency, phlegm, heat syndrome, and insufficiency of Yang; these 4 case disease mechanisms were lower than 0.6. 4. For degree of correspondence of meeting points, both. the diagnosis and the summary questionnaires were above 80% with the exception of the 2 case disease mechanisms heart and blood deficiency. The meeting points of both the diagnosis and research questionnaires were above 80% in the to case disease mechanisms deficiency of qi blood stasis deficiency of Yim insufficiency of Yang damp dryness liver spleen kidney phlegm. 5. The change in the result values of questionnaires was a decreased level of deficiency of qi heat syndrome phlegm damp kidney and raised level of coldness heart disorder of qi dryness 6. The computation degree of disease mechanism in DSOM(r) D.1.1 was much lower on phlegm deficiency of qi heat syndrome disorder of blood, somewhat lower on insufficiency of Yang and higher on coldness than in the two different questionnaires.

• 대한본초학회지
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• 제26권1호
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• pp.65-74
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• 2011

Objectives : This study was undertaken to verify the modulation mechanism of Gyeongshingangjeehwan18 (GGEx18) in ob/ob male mice. Methods : Eight-week old mice (wild-type C57BL/6J and ob/ob) were used for all experiments. Wild-type C57BL/6J mice were used as lean control and obese ob/ob mice were randomly divided into 5 groups : obese control, GGEx15 (Ephedra sinica Stapf + Rheum palmatum L.), GGEx16 (Ephedra sinica Stapf + Laminaria japonica Aresch), GGEx17 (Rheum palmatum L. + Laminaria japonica Aresch), and GGEx18 (Ephedra sinica Stapf + Laminaria japonica Aresch + Rheum palmatum L.). After mice were treated with several kinds of GGEx for 11 weeks, the mRNA expression of peroxisome proliferator-activated receptor (PPAR) target genes and uncoupling protein (UCP) were measured. In addition, $PPAR{\alpha}$ and $PPAR{\beta}$ transactivation was examined in NMu2Li hepatocytes, C2C12 myocytes, and 3T3-L1 preadipocytes using transient transfection assays. Results : 1. Hepatic $PPAR{\alpha}$ target genes, such as ACOX and VLCAD mRNA levels were significantly increased by GGEx18 compared with obese controls. In skeletal muscle, LCAD mRNA expression was stimulated by GGEx16, GGEx17, and GGEx18, whereas MCAD mRNA expression by GGEx17 and GGEx18. $PPAR{\beta}$ target LPL mRNA levels were also increased by GGEx16, GGEx17, and GGEx18 in skeletal muscle, but adipose LPL mRNA levels were decreased. In addition, GGEx18 upregulated UCP mRNA expression in skeletal muslce. 2. $PPAR{\alpha}$ reporter gene expression was increased by GGEx18 in NMu2Li cells compared with vehicle. $PPAR{\alpha}$ and $PPAR{\beta}$ reporter activities were also increased by all GGEx treatments in C2C12 and 3T3-L1 cells. Conclusions : These results suggest that GGEx can act as $PPAR{\alpha}$ and $PPAR{\beta}$ activators, and that GGEx may regulate obesity by stimulating $PPAR{\alpha}$, $PPAR{\beta}$, and UCP activity. Of the 4 compositions, GGEx18 seems to be most effective in improving obesity and lipid disorders.

• 동의생리병리학회지
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• 제19권5호
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• pp.1146-1153
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• 2005

This study was investigated so that reliability of disease mechanism diagnosis would be examined, the estimation about disease mechanism item of Questionnaires and the relations of disease mechanism would be inquired about 'health diagnosis program' Questionnaires which were used for the object diagnosis of Oriental medicine in the department of Oriental OB&GY, Oriental Medical hospital of Dong-Eui University. We analyzed the results of Questionnaires for 3354 outpatients who had OB & GY disease in the Oriental Medical hospital of Dong-Eui University from April 2000 to March 2004. The diagnosis Questionnaires(after DSOM (r) S.1.1) was the figures 188, the health diagnosis Questionnaires (after DSOM (r) S.1.1) was the figures 137. phiegm deficiency of qi was used in DSOM (r) R.1.1 as it is. The reliability of DSOM (r) S.1.1 was usually higher than DSOM (r) R.1.1 in deficiency of qi blood stasis insufficiency of Yang heat syndrom damp, 5 case disease mechanism. The reliability of DSOM (r) S.1.1 was usually lower than DSOM (r) R.1.1 in blood deficiency stagnation of qi coldness damp dryness liver heart spleen kidney, 8 case disease mechanism. but the great difference wasn't seen, therefore both DSOM (r) S.1.1 and DSOM (r) R.1.1 had similar result. A meeting point both DSOM (r) S.1.1 and DSOM (r) R.1.1 was above 90% in liver spleen blood stasis blood deficiency, 4 case disease mechanism with the exception of phlegm deficiency of Yim nothing of fluctuations of question. A meeting point of coldness that was 82.47% was lowest, A meeting point of the rest disease mechanism was above 85%. The effect that contributed in producing disease mechanism result and in which pure question was over relevance calculation 0.9, insufficiency of Yang damp phlegm that contributed in producing disease mechanism result was lower comparatively in DSOM (r) R.1.1. But the effect that contributed in producing disease mechanism result and in which pure question was over relevance calculation 0.9 except spleen kidney phlegm in DSOM (r) S.1.1

• Molecular & Cellular Toxicology
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• 제4권4호
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• pp.318-322
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• 2008

Obesity is an increasing worldwide health problem that is strongly related to the imbalance of food intake and energy metabolism. It was well-known that several substances in the hypothalamus regulate food intake and energy metabolism. We planned an integrative study to elucidate the mechanism of the development of obesity. Firstly, to find candidate genes with the marvelous effect, the different expression in the hypothalamus between ob/ob and 48-h fasting mice was investigated by using DNA microarray technology. As a result, we found 3 genes [peroxisome proliferator activated receptor, gamma, coactivator 1 alpha (Ppargc1a), calmodulin 1 (Calm1), and complexin 2 (Cplx2)] showing the different hypothalamic expression between ob/ob and 48-h fasting mice. Secondly, a genetic approach on PPARGC1A gene was performed, because PPARGC1A acts as a transcriptional coactivator and a metabolic regulator. Two hundred forty three obese female patients with body mass index (BMI)${\geq}$25 and 285 control female subjects with BMI 18 to<23 were recruited according to the Classification of Korean Society for the Study of Obesity. Among the coding single nucleotide polymorphisms (cSNPs) of PPARGC1A, 2 missense SNPs (rs8192678, Gly482Ser; rs3736265, Thr612Met) and 1 synonymous SNP (rs3755863, Thr528Thr) were selected, and analyzed by PCR-RFLP and pyrosequencing. For the analysis of genetic data, chi-square ($X^2$) test and EH program were used. The rs8192678 was significantly associated with obese women (P<0.0006; odds ratio, 1.5327; 95% confidence interval, 1.2006-1.9568). Haplotypes also showed significant association with obese women ($X^2$=33.28, P<0.0008). These results suggest that PPARGC1A might be related to the development of obesity.

• Clinical and Experimental Reproductive Medicine
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• 제26권2호
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• pp.239-249
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• 1999

The role of amino acids in culture media for IVF-ET was examined in a total of 76 cycles. Patients received clomiphene citrate (CC) followed by hMG or GnRH-a combined with gonadotropins (FSH/hMG) for controlled ovarian hyperstimulation. Severe male (<$4{\times}10^6$ motile sperm) or age factor (>39 y) patients were excluded in this study. Pregnancy was classified as clinical if a gestational sac or fetal cardiac activity was seen on ultrasound. No significant differences were found in age, duration of infertility, follicle size, the level of $E_2$ on the day of hCG injection, the mean number of oocytes retrieved, total motile sperm count, fertilization rate and the mean number of embryos transferred between bHTF (without amino acids) and mHTF (with amino acids) groups. However, total ampules of gonadotropins were higher (p<0.01) in mHTF group than bHTF group. Significantly (p<0.05) more clinical pregnancies were recorded in mHTF group (13/30) compared with bHTF group (9/46). The multiple pregnancy rates were 11.1% in bHTF group and 7.7% in mHTF group. There were one ectopic pregnancy in mHTF group and one heterotopic pregnancy in bHTF group. Abortion rates were 22.2% in bHTF group and 7.7% in mHTF, respectively. The ongoing pregnancy or livebirth rate was significantly (p<0.05) higher in mHTF group (12/30) than bHTF group (7/46). These results suggest that the addition of amino acids in culture media is essential for culture of zygotes in vitro and adjustment of energy substrates in phosphate-free culture media appears to be beneficial for human IVF-ET procedure.

• Animal Bioscience
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• 제37권6호
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• pp.1110-1120
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• 2024

Objective: This study was conducted to evaluate the effect of offering (OSF) or not (NSF) supplemental feed at milking on temperament (TS), udder hygiene (UHS) and body condition (BCS) scores, and milk yield per milking (MYM), milk quality traits, and profitability of primiparous Anatolian buffalo cows at 90 days of lactation confined in closed-tied (CB) or semi-open free-stall (OB) barns. Methods: In Experiment I, 108 cows were selected to encompass four treatments (OBOSF, OB-NSF, CB-OSF, and CB-NSF) of 27 cows, considering barn type (OB and CB) and supplementary feed (OSF and NSF) at milking. In Experiment II, 60 OB cows were selected to encompass one of five groups of 12 cows each: i) no supplemental feed (CON), ii) commercial concentrate (CC), iii) CC + corn silage (CCS), iv) CCS + alfalfa hay (CSA), or v) CC + ryegrass silage (CRS) at milking. Results: The TS and UHS of the OB and OSF cows were lower (better) than those of the CB and NSF cows, respectively. The OSF increased milk protein, lactose, and solids-not-fat but decreased milk freezing point and electrical conductivity compared with the NSF. The MYM and milk fat of the OB-OSF cows were higher than those of the OB-NSF and CBNSF cows. The TS and UHS of the cows negatively correlated with MYM and some milk chemicals (fat, protein, and solids-not-fat), but BCS correlated positively. The TS and milk electrical conductivity of the CCS, CSA, and CRS cows were lower than those of the CON and CC cows, but BCS, MYM, and milk fat were higher. Partial budget analysis identified a higher net profit for supplemental feed-offered groups (OB-OSF, CCS, CSA, and CRS). Conclusion: Offering roughage with concentrates at milking for indoor primiparous buffalo cows is more conducive to well-being, milk yield, milk quality, and economy.