• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2635-2638
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• 2012

Background: Many studies have investigated the association between glutathione S-transferase T 1 (GSTT1) null genotype and risk of prostate cancer, but the impact of GSTT1 null genotype in Asians is still unclear owing to inconsistencies across results. Thie present meta-analysis aimed to quantify the strength of the association between GSTT1 null genotype and risk of prostate cancer. Methods: We searched the PubMed, Embase and Wangfang databases for studies of associations between the GSTT1 null genotype and risk of prostate cancer in Asians and estimated summary odds ratio (OR) with their 95% confidence interval (95% CI). Results: A total of 11 case-control studies with 3,118 subjects were included in this meta-analysis, which showed the GSTT1 null genotype to be significantly associated with increased risk of prostate cancer in Asians (random-effects OR = 1.49, 95% CI 1.15-1.92, P = 0.002), also after adjustment for heterogeneity (fixed-effects OR = 1.45, 95% CI 1.23-1.70, P < 0.001). No evidence of publication bias was observed. Conclusions: This meta-analysis of available data suggested the GSTT1 null genotype does contribute to increased risk of prostate cancer in Asians.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.87-89
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• 2013

Glutathione S-transferases (GSTs) constitute a multigene family of multifunctional phase II metabolic enzymes. GSTT1, an important member of this group has a wide range of substrates including carcinogens. Total homozygous deletion or null genotype resulting in total lack of enzyme activity exists in populations for this enzyme. Since the null genotype may contribute to lower detoxification of carcinogens, this genotype is expected to increase cancer risk. The frequency of the GSTT1 null genotype is known to vary significantly among populations. However, little is known about its distribution in the hilly Kumaun region of northern India. Therefore, in this study, we determined the prevalence of the GSTT1 null polymorphism in the Kumaun popilation by conducting duplex PCR in 365 voluntary healthy individuals. The GSTT1 null genotype was detected in 18.4% of the individuals. Since GSTs play significant role in xenobiotic metabolism, the present data on GSTT1 genotype distribution should contribute in understanding genetic association with cancer risk in this understudied population.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6263-6267
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• 2012

Background: Glutathione-S-transferase (GST) is an important phase II xenobiotic compound metabolizing enzyme family, involved in tolerance to a particular drug or susceptibility to a diseasec. This study focused the GSTM1 and T1 null allele frequency in the Gujarat population with a comparison across other Inter- and Intra-Indian ethnic groups to predict variation in the possible susceptible status. Methods: DNA was isolated by a salting out method and GSTM1 and T1 homozygous null genotypes were detected by multiplex polymerase chain reaction in 504 unrelated individuals. The genotype distribution of null alleles was compared with Indian and non Indian ethnics reported earlier in the literature using Fisher's test. Results: The frequencies of the homozygous null genotypes of GSTM1 and GSTT1 were 20% (95%CI 16.7-23.9) and 35.5% (95%CI 31.4-39.9) respectively. GSTM1 null frequency did not deviate from most other Indian ethnic groups but differed from the majority of those of non Indian ethnicity studied. The frequency of homozygous null type of GSTT1 was significantly higher and deviated from all Indian groups and a few of non Indian ethnicity. Conclusions: Gujarat ethnicity, possibly the most susceptible for GSTT1 dependent drug disposition and diseases regarding effects of pollution. Further, the results have implications for GSTT1 dependent drugs used for treatment, a serious problem which needs to be solved by physicians and clinical researchers.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3109-3112
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• 2012

Background: Many studies have focused on possible associations between the glutathione S-transferase M 1 (GSTM1) null genotype and risk of renal cell carcinoma (RCC), but the impact remains unclear owing to obvious inconsistencies among the findings. The present study aimed to quantify the strength of any association in a meta-analysis. Methods: We searched the PubMed, Embase and CBM databases for studies concerning the association between the GSTM1 null genotype and risk of RCC. We estimated the summary odds ratio (OR) with its 95% confidence intervals (95% CI) to assess the association. Results: The meta-analysis showed the GSTM1 null genotype was not associated with risk of RCC overall (OR = 1.04, 95% CI 0.92-1.18, P = 0.501). For Caucasians, the GSTM1 null genotype was also not associated with risk of RCC (OR=1.02, 95% CI 0.90-1.16, P = 0.761). The cumulative meta-analyses showed a trend of no obvious association between GSTM1 null genotype and risk of RCC as information accumulated. Sensitivity analyses by omitting those studies also did not materially alter the overall combined ORs. No evidence of publication bias was observed. Conclusion: Meta-analyses of available data show that the GSTM1 null genotype is not significantly associated with risk of renal cell carcinoma.

• Communications of the Korean Mathematical Society
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• v.29 no.2
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• pp.295-310
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• 2014

This paper provides a study of lightlike submanifolds of a generalized Robertson-Walker (GRW) space-time. In particular, we investigate lightlike submanifolds with curvature invariance, parallel second fundamental forms, totally umbilical second fundamental forms, null sectional curvatures and null Ricci curvatures, respectively.

• Bulletin of the Korean Mathematical Society
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• v.49 no.4
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• pp.863-874
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• 2012

We provide a study of lightlike hypersurfaces of a generalized Robertson-Walker (GRW) space-time. In particular, we investigate lightlike hypersurfaces with curvature invariance, parallel second fundamental forms, totally umbilical second fundamental forms, null sectional curvatures and null Ricci curvatures, respectively.

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.32.4-32
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• 2002

We consider inertial navigation system (INS) sensor redundancy and propose a method which uses singular value decomposition to detect and isolate faults when even two sensors have faults simultaneously. When redundant sensor configuration is given, such as symmetric configuration in INS, the range space and null space of configuration matrix are determined. We use null space of configuration matrix and define 21 reference fault vectors which include 6 one-fault vectors and 15 two-fault vectors. Measurements are projected into null space of measurement matrix and compared with 21 normalized reference fault vectors, which determines fault detection and isolation.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 1991.10a
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• pp.115-118
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• 1991

In this paper we derived the asymptotic distribution of the MUSIC null-spectrum, from which an exact expression of the asymptotic variance of the MUSIC null-spectrum can be obtained. From this result in addition an explicit expression of the normalized standard deviation (NSD) has been derived and it is shown that the NSD is affected by the number of sensors and the number of signals.

• Korean Journal of Mathematics
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• v.29 no.2
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• pp.267-269
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• 2021

A finitely generated torsion module M for ℤ_p[[T, T₂, ⋯ , T_d]] is pseudo-null if M/TM is pseudo-null over ℤ_p[[T₂, ⋯ , T_d]]. This result is used as a tool to prove the generalized Greenberg's conjecture in certain cases. The converse may not be true. In this paper, we give examples of pseudo-null Iwasawa modules whose reduction are not pseudo-null.

• Journal of KIISE:Software and Applications
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• v.32 no.7
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• pp.683-692
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• 2005

Java specification states that all accesses to an object must be checked at runtime if object refers to null. Since Java is an object-oriented language, object accesses are frequent enough to make null pointer checks affect the performance significantly. In order to reduce the performance degradation, there have been attempts to remove redundant null pointer checks. For example, in a Java environment where a just-in-time (JIT) compiler is used, the JIT compiler removes redundant null pointer check code via code analysis. This paper proposes a technique to remove additional null pointer check code that could not be removed by previous JIT compilation techniques, via early null pointer check using an architectural feature called predication. Generally, null point check code consists of two instructions: a compare and a branch. Our idea is moving the compare instruction that is usually located just before an use of an object, to the point right after the object is defined so that the total number of compare instructions is reduced. This results in reduction of dynamic and static compare instructions by 3.21$\%$ and 1.98$\%$. respectively, in SPECjvm98 bechmarks, compared to the code that has already been optimized by previous null pointer check elimination techniques. Its performance impact on an Itanium machine is an improvement of 0.32$\%$.