• The Korean Journal of Nuclear Medicine
• /
• v.35 no.4
• /
• pp.286-287
• /
• 2001

A 44 year-old male patient was undergoing diagnosis and therapy for acute myelogenous leukemia (AML, M2). On physical examination a thyroid mass was palpated in the left lower lobe. He had palpitation and intolerance to heat. Thyroid function tests revealed hyperthyroidism; T3: 150ng/dl (N:60-90), fT4: 2.26 ng/dl (N:0.70-1.80), TSH: 0.01 ulU/ml (N:0.25-5.00). Ultrasonography demonstrated a hypoechoic mass with scattered calcifications measuring 2.55 2.03 3.64 cm in size. F-18 FDG camera-based PET scan performed as a follow-up study of AML revealed a focal increased uptake in the left neck, where an autonomous nodule was detected on Tc-99m thyroid scan. After the diagnosis of toxic autonomous nodule, Goetz disease, he underwent surgical nodulectomy. Microscopically, the nodule contained follicular proliferation with degenerative change but without evidence of thyroid carcinoma. Focal uptake in autonomous thyroid nodules is due to increased glycolysis within the nodules.

• Nuclear Medicine and Molecular Imaging
• /
• v.43 no.4
• /
• pp.352-356
• /
• 2009

Intravascular large B-cell lymphoma (IVLBCL) is a subtype of diffuse large cell lymphoma, characterized by proliferation of lymphoid cells in the intravascular space of various organs without causing a mass effect. Although $^{18}$F-FDG PET is a powerful imaging tool in lymphoma, the usefulness of $^{18}$F-FDG PET in the assessment of IVLBCL is still controversial. $^{99m}$Tc-MIBI, a tumor imaging radiopharmaceutical with a different mechanism from that of $^{18}$F-FDG, has been reported to be also effective in lymphoma. However, there is nearly no report on the efficacy of $^{99m}$Tc-MIBI in the assessment of IVLBCL. We present one case of IVLBCL that showed $^{99m}$Tc-MIBI accumulation in the involved bone marrow as an incidental finding, which was discrepant from that of $^{18}$F-FDG PET.

• Nuclear Engineering and Technology
• /
• v.47 no.3
• /
• pp.315-322
• /
• 2015

The research carried out on thorium-based fuels indicates that these fuels can be considered as economic alternatives with improved physical properties and proliferation resistance issues. In the current study, neutronic assessment of $UO_2$ in comparison with two $(Th-^{233}U)O_2$, and $(Th-^{235}U)O_2$ thorium-based fuel loads in a heavy water research reactor has been proposed. The obtained computational data showed both thorium-based fuels caused less negative temperature reactivity coefficients for the modeled research reactor in comparison with $UO_2$ fuel loading. By contrast, $^{235}U$-containing thorium-based fuel and $^{235}U$-containing thorium-based fuel loadings in the thermal core did not drastically reduce the effective delayed neutron fractions and delayed neutron fractions compared to $UO_2$ fuel. A provided higher conversion factor and lower transuranic production in the research core fed by the thorium-based fuels make the fuel favorable in achieving higher cycle length and less dangerous and costly nuclear disposals.

• Nuclear Engineering and Technology
• /
• v.50 no.6
• /
• pp.923-928
• /
• 2018

We developed a compact gamma camera based on a modified uniformly redundant array coded aperture to investigate the position of a $UO_2$ pellet emitting characteristic X-rays (98.4 keV) and ${\gamma}-rays$ (185.7 keV). Experiments using an only-mask method and an antimask subtractive method were conducted, and the maximum-likelihood expectation maximization algorithm was used for image reconstruction. The images obtained via the antimask subtractive method were compared with those obtained using the only-mask method with regard to the signal-to-noise ratio. The reconstructed images of the antimask subtractive method were superior. The reconstructed images of the characteristic X-rays and the ${\gamma}-rays$ were combined with the obtained image using the optical camera. The combined images showed the precise position of the $UO_2$ pellet. According to the self-absorption ratios of the nuclear material and the minimum number of effective events for image reconstruction, we estimated the minimum detection time depending on the amount of nuclear material.

• Korean Journal of Plant Resources
• /
• v.29 no.3
• /
• pp.297-304
• /
• 2016

The seed of safflower (Carthamus tinctorius L) has been reported to suppress human cancer cell proliferation. However, the mechanisms by which safflower seed inhibits cancer cell proliferation have remained nuclear. In this study, the inhibitory effect of the safflower seed (SS) on the proliferation of human colorectal cancer cells and the potential mechanism of action were examined. SS inhibited markedly the proliferation of human colorectal cancer cells (HCT116, SW480, LoVo and HT-29). In addition, SS suppressed the proliferation of human breast cancer cells (MDA-MB-231 and MCF-7). SS treatment decreased cyclin D1 protein level in human colorectal cancer cells and breast cancer cells. But, SS-mediated downregulated mRNA level of cyclin D1 was not observed. Inhibition of proteasomal degradation by MG132 attenuated cyclin D1 downregulation by SS and the half-life of cyclin D1 was decreased in SS-treated cells. In addition, SS increased cyclin D1 phosphorylation at threonine-286 and a point mutation of threonine-286 to alanine attenuated SS-mediated cyclin D1 degradation. Inhibition of ERK1/2 by PD98059 suppressed cyclin D1 phosphorylation and downregulation of cyclin D1 by SS. In conclusion, SS has anti-proliferative activity by inducing cyclin D1 proteasomal degradation through ERK1/2-dependent threonine-286 phosphorylation of cyclin D1. These findings suggest that possibly its extract could be used for treating colorectal cancer.

• Natural Product Sciences
• /
• v.29 no.1
• /
• pp.31-37
• /
• 2023

In this study, we investigated the efficacy of Celtis choseniana Nakai (C. choseniana) as complementary herbal medicine to ameliorate androgenic alopecia (AGA). The effects of C. choseniana on AGA were evaluated using testosterone propionate-induced AGA mouse model and dihydrotestosterone-treated human hair follicle dermal papilla cells. In vivo, C. choseniana treatment deactivated androgen signaling by reducing the concentration of serum dihydrotestosterone level and expressions of 5α-reductase 2 and androgen receptor. Next, C. choseniana treatment increased the hair regrowth rate. Histological studies demonstrated that C. choseniana induced the anagen phase in testosterone propionate-induced AGA mouse model. Cellular proliferation was promoted by C. choseniana treatment via increasing the expression of proliferation factors, such as proliferating cell nuclear antigen and cyclin D1. Furthermore, C. choseniana treatment increased the expression of proteins related to the Wnt/β-catenin signaling pathway. In addition, dickkopf-1, a Wnt inhibitor, was downregulated with C. choseniana treatment. Likewise, C. choseniana treatment promoted cellular proliferation in vitro. This study demonstrated the inhibitory effect of C. choseniana on androgen-induced AGA. Moreover, C. choseniana induced activation of Wnt/β-catenin signaling, resulting in prolonged anagen and cellular proliferation. Therefore, we suggest that C. choseniana can be used as a therapeutic agent to alleviate AGA.

• Journal of the Korean Professional Engineers Association
• /
• v.42 no.3
• /
• pp.35-40
• /
• 2009

After the yield of North Korea conducted underground the first nuclear test in 2006, which was less than a kiloton, it launched a vehicle on this April 9 again, which is believed to be a Taepo-dong 2 missile, defying international warnings that the move would violate U.N. resolutions, from Musudan-ni, North Korea. Its development and proliferation of ballistic missile and nuclear bomb technology pose a threat to the northeast Asian region and to international peace and security. In the other launching the missile, a newspaper reported that "While the launch was dubbed a failure by the U.S., it was an improvement over the North Koreans' July 2006 test of the Taepodong-2, said Green of the Center for Strategic and International Studies. "It was definitely better than last time, but it's still not an operational system," Green said.

• Proceedings of the Korean Radioactive Waste Society Conference
• /
• 2003.11a
• /
• pp.172-179
• /
• 2003

Various type of tritium wastes can be produced from nuclear fuel cycle process satisfying non-proliferation, CANDU reactors, and nuclear industry. Activities of tritium processing in the world were surveyed to develope the processing technologies of tritium wastes. The tritium wastes were classified into gas phase, liquid phase, and organic phase. And the treatment techniques for the tritium wastes are analyzed. Development of tritium processing technologies is essential to finding public acceptance of radioactive wastes and forming a solid foundation to foster the growth of nuclear industry in Korea.

• Annual Conference of KIPS
• /
• 2020.05a
• /
• pp.188-190
• /
• 2020

최근 4차 산업혁명과 더불어 센서 네트워크와 같은 최신 무선통신 기술들의 기반시설 적용을 위한 연구들이 활발하게 이루어지고 있다. 원자력시설 또한, 보안 및 비상대응 시스템에 무선통신을 적용하기 위한 연구들이 진행되고 있으며, 미국과 UAE의 경우 이미 원자력시설에 무선통신을 적용하여 사용하고 있다. 그러나 무선통신의 경우, 물리적인 네트워크 접근 경로가 존재하지 않기 때문에 통신 경로에 대한 접근통제가 불가능하며 광범위한 지역에 네트워크를 설치하는 경우 중계 단말 수량의 증가로 인한 접근통제 취약점이 발생할 가능성이 있다. 이와 같은 무선통신의 특성 때문에 원자력시설의 필수디지털자산에 무선 네트워크를 적용 시 현재의 통신 경로 접근통제 등의 유선 통신을 기준으로 작성된 접근통제 규제기준으로는 무선통신에 대한 접근통제를 이행하기에는 부족함이 있다. 이에 본 논문에서는 무선 네트워크 접근통제를 위한 규제 기준 개선안을 제시한다.

• International Journal of Advanced Culture Technology
• /
• v.12 no.2
• /
• pp.309-317
• /
• 2024

The conflict between Iran and Israel has been a major source of instability and security threats in the Middle East. This study analyzes the historical background and modern aspects of the Israel-Iran conflict, examining its root causes, nuclear issues, proxy wars, cyber warfare, economic sanctions, and the role of the United States. The research employs qualitative methods, including literature review and case analysis, using various sources such as academic papers, government reports, and media articles. The findings suggest that the conflict is deeply rooted in historical, religious, and political factors, and has escalated since the 1979 Iranian Revolution. The study highlights the need for dialogue, negotiation, and international mediation to resolve the conflict and maintain regional stability. The Israel-Iran conflict also provides valuable lessons for addressing the North Korean nuclear issue, emphasizing the importance of dialogue, international cooperation, and confidence-building measures.