• The Korean Journal of Physiology and Pharmacology
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• v.19 no.6
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• pp.515-522
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• 2015

Notch signaling is a key regulator of neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-2 (Mib2) is an essential positive regulator of the Notch pathway, which acts in the Notch signal-sending cells. Therefore, genetic deletion of Mib2 in the mouse brain might help understand Notch signaling-mediated cell-cell interactions between neurons and their physiological function. Here we show that deletion of Mib2 in the mouse brain results in impaired hippocampal spatial memory and contextual fear memory. Accordingly, we found impaired hippocampal synaptic plasticity in Mib2 knock-out (KO) mice; however, basal synaptic transmission did not change at the Schaffer collateral-CA1 synapses. Using western blot analysis, we found that the level of cleaved Notch1 was lower in Mib2 KO mice than in wild type (WT) littermates after mild foot shock. Taken together, these data suggest that Mib2 plays a critical role in synaptic plasticity and spatial memory through the Notch signaling pathway.

• Development and Reproduction
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• v.16 no.4
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• pp.371-378
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• 2012

Notch signaling plays fundamental roles in various animal development. It has been suggested that Hr-Notch, a Notch homologue in the ascidian Halocynthia roretzi, is involved in the formation of peripheral neurons by suppressing the neural fates and promoting the epidermal differentiation. However, roles of Notch signaling remain controversial in the formation of nervous system in ascidian embryos. To precisely investigate functions of Notch signaling, we have isolated and characterized Hr-Numb, a Numb homologue which is a negative regulator of Notch signaling, in H. roretzi. Maternal expression of Hr-Numb mRNAs was detected in egg cytoplasm and the transcripts were inherited by the animal blastomeres. Its zygotic expression became evident by the early neurula stage and the transcripts were detected in dorsal neural precursor cells. Suppression of Hr-Numb function by an antisense morpholino oligonucleotide resulted in larvae with defect in brain vesicle and palps formation. Similar results have been obtained by overexpression of the constitutively activated Hr-Notch forms. Therefore, these results suggest that Hr-Numb is involved in Notch signaling during ascidian embryogenesis.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2005.11a
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• pp.205-210
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• 2005

In this paper, a planar half-circle shape ultra-wideband(UWB) antenna fed by CPW is designed, fabricated and measured for UWB communications. Within the UWB band(3.1 GHz $\sim$ 10.6 GHz), 5.15 GHz $\sim$ 5.825 GHz frequency band is used by IEEE 802.lla WLAN applications. It may be necessary to notch out this band to avoid interference with IEEE 802.lla WLAN. Therefore, we have proposed three kinds of UWB antennas having a notch function, such as a rectangular slot, a hat-shaped slot, a circle-shaped slot. The notch frequency of the proposed antenna can be adjusted by controlling the slot length or slot width. From the measured results, the proposed antennas show a good gain flatness except the IEEE 802.lla WLAN frequency band and have a reasonable agreement with simulated results.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.12 no.12
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• pp.935-942
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• 2002

When designing fluid mounts, design parameters can be varied in order to obtain a desired notch frequency and notch depth. The notch frequency is a function of the mount parameters and is typically selected by the designer to occur at the vibration disturbance frequency. Since the process of choosing these parameters can involve some trial and error, it seems to be a great application for obtaining optimal performance of the mount. Many combinations of parameters are possible to give us the desired notch frequency, but the question is which combination provides the lowest depth. Therefore. an automatic optimal technique is needed to optimize the performance of the fluid mount. In this study. the enhanced genetic algorithm (EGA) is applied to minimizing transmissibility of a fluid mount at the desired notch frequency, and at the notch and resonant frequencies. The EGA is modified genetic algorithm to search global and local optimal solutions of multi-modal function optimization. Furthermore. to reduce the searching time as compare to conventional genetic algorithm and Increase the precision of the solutions, the modified simplex method is combined with the algorithm. The results show that the performance of the optimized mount by using the hybrid algorithm is better than that of the conventional fluid mount.

• Journal of electromagnetic engineering and science
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• v.10 no.1
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• pp.39-44
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• 2010

In this paper, a compact wideband antenna with a band-notch function is proposed. It operates over the UWB band with a band-stop characteristic. To increase the impedance bandwidth, a ring-shaped radiator is used. By attaching a circular stub to the ring-shaped radiator, the band-notch performance is obtained. The proposed antenna operates over a frequency range from 2.7 GHz to 11 GHz to satisfy the 10-dB return-loss requirement and provides band-stop performance in the frequency band from 5.15 GHz to 6.1 GHz. Experimental results reveal that the proposed antenna exhibits good radiation performance and is suitable for UWB applications.

• Biomolecules & Therapeutics
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• v.28 no.1
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• pp.45-57
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• 2020

In the neurovascular unit, the neuronal and vascular systems communicate with each other. O₂ and nutrients, reaching endothelial cells (ECs) through the blood stream, spread into neighboring cells, such as neural stem cells, and neurons. The proper function of neural circuits in adults requires sufficient O₂ and glucose for their metabolic demands through angiogenesis. In a central nervous system (CNS) injury, such as glioma, Parkinson's disease, and Alzheimer's disease, damaged ECs can contribute to tissue hypoxia and to the consequent disruption of neuronal functions and accelerated neurodegeneration. This review discusses the current evidence regarding the contribution of oxygen deprivation to CNS injury, with an emphasis on hypoxia-inducible factor (HIF)-mediated pathways and Notch signaling. Additionally, it focuses on adult neurological functions and angiogenesis, as well as pathological conditions in the CNS. Furthermore, the functional interplay between HIFs and Notch is demonstrated in pathophysiological conditions.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.4 no.2
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• pp.46-53
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• 1995

In this study, Wear of a ceramic cutting tool for hardened STD11 steel was investigated. Under the finish machining condition. DOC notch wear of a ceramic cutting tool was mostly occurred earlier than flank and crater wear were proceeded. The relations of DOC notch wear, which was characteristically produced at the beginning of cutting. to cutting speed, feed, depth of cut, and nose radius of a ceramic cutting tool were examined. Effective approach angle, which is a function of cutting conditions, and boundary area were suggested, and then the influence of those was investigated, The following conclusions were obtained: (1)as cutting speed was increasing. DOC notch wear was decreasing (2) the cutting condition that magnitude of slendermess ratio was made small, was favorable for DOC notch wear, (3) as depth of cut was smaller, the influence of feed on DOC notch wear was also smaller, (4) DOC notch wear was mainly influenced by effective approach angle, but by boundary area in the range of low feed.

• Journal of the Korean Solar Energy Society
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• v.39 no.2
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• pp.81-92
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• 2019

When Photovoltaic inverter is connected to grid and used as PVPCS (Photovoltaic Power Conditioning System), 120 Hz AC ripple occurs at the dc-link capacitor voltage. This AC ripple reduces the efficiency of PVPCS and shortens the lifetime of the capacitor. In this paper, we design a notch filter to remove AC ripple. As a result, the AC voltage ripple was removed from the dc link and the THD of the PVPCS output current with the notch filter was lowered. This notch filter is determined by the damping coefficient, the bandwidth coefficient, and the switching frequency. Among these, the switching frequency determines the switching loss and the size of the LC filter, and the PVPCS with the high switching frequency has a greater efficiency loss due to the switching loss than the efficiency improvement by the notch filter. Therefore, it is important to set the optimum switching frequency in the PVPCS with the notch filter applied. In this paper, THD and switching loss of PVPCS output current with notch filter are calculated through simulation, and cost function to calculate optimum switching frequency through data is proposed.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.1
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• pp.176-183
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• 2010

This paper presents some practical design issues that should be carefully considered when a notch filter is included in a linear feedback controller. A notch filter is generally used to compensate the effects of resonant modes that may result in poor performance. It is very common that the practical engineers prefer to add such a notch filter after having previously designed a feedback controller without the filter. It is known that the resulting performance by this approach is not seriously different from when a feedback controller is designed for a plant previously compensated by a notch filter. However, we will point out that there are some cases where both approaches have different performances. In order to show this, a low-order controller design using the partial model matching method has been applied to a linear time invariant (L Tn model. The results suggest that there is a tendency to achieve much better time responses in terms of reducing the overshoot and shortening the settling time, and in the frequency domain characteristics such as the sensitivity function and the stability margins when the design of a feedback controller after including a notch filter is carried out.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.6
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• pp.959-965
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• 2008

This paper presents a novel method for cogging torque reduction of interior type permanent magnet motor. For calculation position and width of notch, energy formulation and cogging torque function in air gap are analyzed by analytical method(space harmonics method) and numerical method. The optimal shape of notchs is decided by using finite element method. The validity of the proposed method is confirmed with experiments.