• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1339-1344
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• 2014

Aims: Alterations in mitochondrial DNA (mtDNA) have been implicated in carcinogenesis and tumor progression. We here evaluated the diagnostic and prognostic potential of mtDNA as a biomarker for breast cancer. Methods: Using multiplex real-time polymerase chain reaction, nuclear DNA (nDNA) and mtDNA levels in serum, buffy coat, tumor, and tumor-adjacent tissue samples from 50 breast cancer patients were determined and assessed for associations with clinicopathological features. To evaluate mtDNA as a biomarker for distinguishing between the four sample types, we created receiver operating characteristic (ROC) curves. Results: The mtDNA levels in buffy coat were significantly lower than in other sample types. Relative to tumor-adjacent tissue, reduced levels of mtDNA were identified in buffy coat and tumor tissue but not in serum. According to ROC curve analysis, mtDNA levels could be used to distinguish between buffy coat and tumor-adjacent tissue samples with good sensitivity (77%) and specificity (83%). Moreover, mtDNA levels in serum and tumor tissue were positively associated with cancer TMN stage. Conclusions: The mtDNA levels in blood samples may represent a promising, non-invasive biomarker in breast cancer patients. Additional, large-scale validation studies are required to establish the potential use of mtDNA levels in the early diagnosis and monitoring of breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3355-3360
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• 2015

Background: Zinc transporters have been considered as essential regulators in many cancers; however, their mechanisms remain unknown, especially in gliomas. Isocitrate dehydrogenase 1(IDH1) mutation is crucial to glioma. This study aimed to investigate whether zinc transporters are correlated with glioma grade and IDH1 mutation status. Materials and Methods: IDH1 mutation status and mRNA expression of four zinc transporters (ZIP4, ZIP9, ZIP11, and ZnT9) were determined by subjecting a panel of 74 glioma tissue samples to quantitative real-time PCR and pyrosequencing. The correlations between the expression levels of these zinc transporter genes and the grade of glioma, as well as IDH1 mutation status, were investigated. Results: Among the four zinc transporter genes, high ZIP4 expression and low ZIP11 expression were significantly associated with higher grade (grades III and IV) tumors compared with lower grade (grades I and II) counterparts (p<0.0001). However, only ZIP11 exhibited weak correlation with IDH1 mutation status (p=0.045). Samples with mutations in IDH1 displayed higher ZIP11 expression than those without IDH1 mutations. Conclusions: This finding indicated that zinc transporters may interact with IDH1 mutation by direct modulation or action in some shared pathways or genes to promote the development of glioma. Zinc transporters may play an important role in glioma. ZIP4 and ZIP11 are promising molecular diagnostic markers and novel therapeutic targets. Nevertheless, the detailed biological function of zinc transporters and the mechanism of the potential interaction between ZIP11 and IDH1 mutation in gliomagenesis should be further investigated.

• Journal of the Korean Institute of Navigation
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• v.14 no.2
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• pp.33-59
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• 1990

In cold season, the developed extratropical cyclones and associated cold fronts, and NW winter monsoon are encountered very frequently in the North Pacific, especially in the northwest part of it. The two sea areas, namely, the northwest part of North Pacific, especially the eastern area far off Japan east coast, and Burmuda Triangle in the North Atlantic are generally known as two of the most dangerous areas in the world because of high incidence of sea casualties. Even large ocean going vessels were sunk frequently due to strong winds and very high seas caused by NW monsoon or developed cyclones during the winter months. The purpose of this paper is to analyse the real state of heavy weather and high sea phenomena on the vesscls at sea, thus helping mariners operate in such conditions.

• Journal of the Korean Institute of Navigation
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• v.11 no.1
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• pp.107-144
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• 1987

In cold season, ice accretion on ship, drift ice, NW winter monsoon, developed extratropical cyclones and associated cold fronts, in warm season, tropical cyclones and dense sea fogs, are encountered very frequently in the North Pacific, especially in the northwest part of it. The two areas, namely, the northwest part of the North Pacific and Burmuda Triangle in the North Atlantic are generally known as most dangerous areas in the world because its high incidence of sea cascualities. In recent years, the small fisherboats operating in the northern seas were frequently sunk in a group as they encountered ice accretion or drift ice. And ocean going vessels were also sunk frequently due to strong winds and very high seas in winter monsoon or developed cyclones and cold fronts. The purpose of this paper is to analyze the real state of heavy weather conditions such as ice accretion on ship drift, ice, typhoons and sea fogs, and also to analyse the effect of these heavy weather phenomena on the vessels at sea, thus helping mariners operate in such heavy weather conditions.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.32 no.3
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• pp.249-256
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• 1996

The saury stick - held dip net fishery of Korea in the Northwest Pacific Ocean began in 1985 with 3 vessels. Since then the fishery has grown so rapidly year by year that the number of vessels increased to 34 and the catch to 40 thousands Mff in 1993. In the present study, the monthly situation and the movement of the fishing ground for the pacific saury in the Northwest Pacific were investigated and the monthly optimum fIshing tempertures were estimated, from the relationship between the catch and the sea surface temperature. In the beginning of the fishing season, June to August, the fIshing ground is formed in the very wide range, mainly in the northward area of the front meandering, as the parcific saury migrate northward. In the main season, September to November, the ground is formed in the southward area of the front, off the east coast of Japan. Andd then, the fishing season ends in December with the ground coming near to the east coast of Japan. The monthly optimum fishing tempertures showed 11~$13^{\circ}C.$ in June to July, 13-$17^{\circ}C.$ in August to November, and 15~ $17^{\circ}C.$ in December in general. The profIles of water temperature were much different in accordance by net casting position in the fishing ground, regardless of season. So, the MLD and CPUE was analyzed to find out the relation between the water temperature and the catch. Then, it is found that the CPUE shows over 0.7Mtr/haul as the MLD 40~70m.40~70m.

• ALGAE
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• v.33 no.1
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• pp.109-125
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• 2018

Turkish towel (Chondracanthus exasperatus), Pacific dulse (Palmaria mollis, also known as Red ribbon seaweed), and sea lettuce (Ulva spp.) were cultivated in a land-based intensive culture system at the Manchester Research Station, USA from August 2013 to September 2014. Macroalgae were grown in tumble-aerated tanks, harvested bimonthly for seasonal growth calculations, and analyzed for protein, lipid, ash, and amino acid content. Growth rate of all three species exhibited a similar pattern, with the highest specific growth rates occurring during the summer months (Turkish towel: 7.8%, Pacific dulse: 8.2%, and sea lettuce: 6.2%). Growth of all three species was lowest around winter solstice; with negative growth only observed in sea lettuce. On a dry weight basis significant differences in protein content existed between the three species with highest values for sea lettuce ($29.5{\pm}1.4%$). Lipid content varied between species (0.95-2.78%) with significantly higher lipid observed in sea lettuce (0.58-4.82%). No significant differences were detected on a seasonal basis among each species. Essential amino acids accounted for $43{\pm}0.9$ to $47{\pm}1.2%$ of total amino acids with Turkish towel having the highest value. Turkish towel had a significantly higher taurine level ($0.82{\pm}0.27$) than the other macroalgae. The levels of persistent organic pollutants and heavy metals were low. The estimated annual product of the three species ranged from 50- to $70-mt\;dry\;weight\;ha^{-1}\;y^{-1}$, significantly higher than conventional crops. Land-based culture of these species can produce year-round harvest, consistent product quality, and low contaminant levels.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.7 no.1
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• pp.28-38
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• 1971

There has been established bilateral and multilateral agreements of fisheries in the North Pacific, such as, the Agreements of International North Pacific Fisheries Commission, of Japan-Soviet Fisheries Commission for the Northwest Pacific and of the Furseal and King Crab. The auther reviewed these agreements and discussed about the growth of the International Fisheries Agreements in the future. This paper concerns with the present status of demersal resources which are important in commercial fisheries and caught in the North Pacific.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2015.10a
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• pp.229-230
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• 2015

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2713-2717
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• 2015

Background: Possible associations between the single nucleotide polymorphism (SNP) rs8034191 in the aminoglycosidephosphotransferase domain containing 1 (AGPHD1) gene and lung cancer risk have been studied by many researchers but the results have been contradictory. Materials and Methods: A computerized search for publications on rs8034191 and lung cancer risk was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between rs8034191 and lung cancer risk with 13 selected case-control studies. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed. Results: A significant association between rs8034191 and lung cancer susceptibility was found using the dominant genetic model (OR=1.344, 95% CI: 1.285-1.406), the additive genetic model (OR=1.613, 95% CI: 1.503-1.730), and the recessive genetic model (OR=1.408, 95% CI: 1.319-1.503). Moreover, an increased lung cancer risk was found with all genetic models after stratification of ethnicity. Conclusions: The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer. Further functional studies of this polymorphism and lung cancer risk are warranted.

• Journal of the korean society of oceanography
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• v.35 no.2
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• pp.98-108
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• 2000

A geochemical study on a hemipelagic core sediment taken from the northwest Pacific Ocean (eastern edge of the Shikoku Basin) was conducted to use of excess barium (Ba(ex)) for evaluate the paleoceano-graphic changes. Also, the excursion of sedimentary Ba(ex) was compared with those of biogenic opal, carbonate and organic carbon content in the sediment during the last glacial and interglacial periods. The calculated Ba(ex) derived from the major and minor element shows a distinctive glacial-interglacial variations, and the mass accumulation rate (MAR) of Ba(ex) shows coincident variations with the MARs of biogenic fractions. Especially, strong positive correlation (r$^2$=0.85) between the MAR of Ba(ex) and the MAR of biogenic carbonate is recognized. Based on the strong positive correlation(r$^2$=0.85) between the MAR of Ba(ex) and the MAR of carbonate content, we estimated the degree of carbonate dissolution rate during the glacial and interglacial periods. Assuming the proportional variation and the refractory nature of barium exist between two factors, the variation of index Ca/Ba ratio in sediment indicates the degree of carbonate dissolution. Sedimentary Ca/Ba ratios index clearly show a striking fluctuation between the glacial and interglacial periods with higher positive correlation during glacial and lower correlation during interglacial. This fact indicates enhanced carbonate dissolution during interglacial period. Thus, the sedimentary Ca/Ba ratio in sedimentary records can be used as one of the useful tools for estimation of the relative degree of carbonate dissolution. The excursion of Ba(ex) and the sedimentary Ca/Ba ratio follows the typical pacific carbonate dissolution type(enhanced dissolution during interglacial and reduced dissolution during glacial time) as suggested by previous work (e.g., Wu et al., 1990). Variation in sedimentary Ca/Ba ratio thus strongly supports that glacial-interglacial fluctuation in carbonate dissolution has been prevailed in the northwest Pacific Ocean.