• Journal of the Korean Society of Food Science and Nutrition
• /
• v.35 no.10
• /
• pp.1329-1335
• /
• 2006

LP-BM5 murine leukemia retrovirus induces the excessive oxidative stress and immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dysfunction. In the present study, the immune restoratory effect of antioxidant hormone dedydroepiandrosterone sulfate (DHEAS) was investigated in the primary splenocytes from LP-BM5 retrovirus-infected C57BL/6 mice. DHEAS significantly increased T and B cell response to mitogen and normalized the unbalanced production of Th1/Th2 type cytokines. In particular, both protein and mRNA expression of IL-4, IL-6, and $TNF-\alpha$ were down-regulated by DHEAS treatment whereas IL-2 and $IFN-\gamma$ level were increased. This result suggests that DHEAS directly or indirectly regulates the gene expression of Th1/Th2 type cytokines in transcription level. In addition, DHEAS treatment decreased the hepatic lipid peroxidation and preserved vitamin E level in liver cells. These results suggested that DHEAS could effectively prevent immune dysfunction by regulating cytokine secretion and preventing the oxidative stress in murine AIDS.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2016.05a
• /
• pp.326-327
• /
• 2016

A study on Ontology-based indoor positioning techniques using BLE Beacon. Recently BLE beacon has been widely used as a technique for measuring the indoor location. But it requires a filtering technique for the measurement of the correct position, and uses the most fixed beacon. It is not accurate that calculates the position information through the identification of the beacon signal. Therefore, filtering is important. So it takes a lot of time, position measurement and filtering. Thus, we is to measure the exact position at the indoor using a mobile beacon. The measured beacon signal is composed of an ontology for reuse in the same pattern. RSSI is measured the receiver is the distance of the beacon. And this value configure the location ontology to be normalized by the relationship analysis between the values. The ontology is a method for calculating the position information of the moving beacon. It may be detected fast and accurate indoor position information.

• Journal of the Korea Society of Computer and Information
• /
• v.16 no.11
• /
• pp.103-111
• /
• 2011

In this paper, we propose a Geometrical Centroid Contour Distance(GCCD) which is described by shape signature based on contour sequence. The proposed method uses geomertrical relation features instead of the absolute angle based features after it was normalized and aligned with dominant feature of the shape. Experimental result with MPEG-7 CE-Shape-1 Data Set reveals that our method has low time/spatial complexity and scale/rotation robustness than the other methods, showing that the precision of our method is more accurate than the conventional desctiptors. However, performance of the GCCD is limited with concave and complex shaped objects.

• The Journal of the Petrological Society of Korea
• /
• v.17 no.1
• /
• pp.44-50
• /
• 2008

A geochemical technique based on rare earth element geochemistry was used to clarity the source of the Asian dust (Yellow sand) in the Daejeon area. The Asian dusts were collected 4 times during 31th March- 2nd April and 25th May-27th May 2007. The Yellow sand shows PAAS (Post Archean Australian Shale)-normalized REE pattern of the flattened LREE and slightly depleted LREE without Eu anomaly, whereas the Daejeon soil has slightly enriched LREE and depleted HREE with negative Eu anomaly. Our results show that REE patterns of the Asian dust are LREE-flattened similar to those of the sediment from the south-eastern part of Ordos desert. This suggests that Asian dust in the Daejeon area might be derived from the south-eastern part of Ordos desert.

• Journal of Korean Medicine Rehabilitation
• /
• v.20 no.2
• /
• pp.175-181
• /
• 2010

Objectives : The purpose of this study is to investigate interaction and safety in administering herb-medicine with warfarin. Methods : For this study, we selected 19 patients who have been taking warfarin, from the ones that have been transferred from western hospital to oriental hospital. During their stay in the oriental hospital, we gave herb-medicine in addition to warfarin. Then we gathered informations and data on sex, age, main indications, and International Normalized Ratio(INR) values of selected patients through Electronic Medical Records(EMR) of Dong-Guk university hospital. Accordingly, we compiled all of the above data for a period of 10 days prior and 10 days post admission(western hospital period and oriental hospital period, respectively). Results and Conclusions : The statistical analysis of the data have revealed that there was no significant change of INR values after giving herb-medicine with warfarin(p=0.586). The result shows that administration of herb-medicine with warfarin is safe and has little drug interaction. However, this study was carried out on small sample size and the interaction with other drugs and various kinds of herb-medicine was not considered. Although we attained a restrictive result from this study, we are able to suggest the safety about co-administration of herb-medicine and warfarin.

• Journal of Digital Contents Society
• /
• v.19 no.2
• /
• pp.377-383
• /
• 2018

Internet of Things (IoT) is producing various data as the smart environment comes. The IoT data collection is used as important data to judge systems's status. Therefore, it is important to monitor the anomaly state of the sensor in real-time and to detect anomaly data. However, it is necessary to convert the IoT data into a normalized data structure for anomaly detection because of the variety of data structures and protocols. Thus, we can expect a good quality effect such as accurate analysis data quality and service quality. In this paper, we propose an anomaly detection system based on big data from collected sensor data. The proposed system is applied to ensure anomaly detection and keep data quality. In addition, we applied the machine learning model of support vector machine using anomaly detection based on time-series data. As a result, machine learning using preprocessed data was able to accurately detect and predict anomaly.

• Polymer(Korea)
• /
• v.37 no.4
• /
• pp.455-461
• /
• 2013

Mar behavior and visibility were investigated by applying a constant load to various gloss-coated urethane-acrylate surfaces. Using a area-contact scratch tip which can apply a relatively low stress level to the coated surfaces, the mar damages were generated on the surfaces. When evaluating the mar-induced damage by means of delta-gloss (${\Delta}G$) and delta-luminance (${\Delta}L$) with existing test methodologies, an increase in constant load on the same gloss-coated surface leads to an increase in ${\Delta}G$ and ${\Delta}L$. However, these are not suitable for evaluating and comparing the surface damages of different gloss-coated samples because of a disagreement between the measured values and the mar visibility. It is shown that new mar test assessment proposed in this work not only can be used to quantitatively evaluate the mar damage, but also accounts for the correlation that the increases of the normalized gloss and luminance on coated surfaces correspond with an increase in the mar visibility.

• YAKHAK HOEJI
• /
• v.43 no.5
• /
• pp.642-651
• /
• 1999

Nonsedating antihistamines do net cause sedation in therapeutic doses because these drugs hardly cross the blood-brain barrier. Since most of the peripheral side dffects of conventional antihistamines are related to their muscarinic receptor blocking action, the present study was performed to investigate whether nonsedating antihistamines interact with the muscarinic receptors and discriminate the muscarinic receptor subtypes in the rat cerebral microsomal fraction which containes both $M_1,{\;}M_2,{\;}M_3{\;}and{\;}M_4$ receptors. Five nonsedating antihistamines at high concentrations inhibited [$^3H$]QNB binding to the muscarinic receptor in a dose-dependent manner. The inhibition curves of these drugs except loratadine which showed positive cooperativity (nH=1.55) were steep (nH=1), indicating interaction with a single homogenous population of the binding sites. Astemizole, clemizole and mequitazine increased the $K_D$ value for [$^3H$]QNB without affecting the binding site concentrations, and this increase in the $K_D$ value resulted from the ability of these drugs to slow [$^3H$]QNB-receptor association. The Ki values of astemizole, clemizole and mequitazine for the inhibition for the inhibition of [$^3H$]QNB binding to muscarinic receptor were 0.58, 5.99 and $0.007{\;}{\mu}M$, respectively. However, loratadine and terfenadine inhibited noncompetitively [$^3H$]QNB binding with the normalized $IC_50$ value of about $2{\;}{\mu}M$. These results demonstrate that; 1) astemizole, clemizole and mequitazine interact directly with the muscarinic receptor at high concentrations; 2) muscarinic receptor blocking potency of these drugs varies widely among drugs; 3) these drugs do not discriminate between muscarinic receptor subtypes.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.18 no.6 s.121
• /
• pp.656-663
• /
• 2007

In this paper, when a E-polarized plane wave is incident on the grating consisting of tapered resistive strips, electromagnetic scattering is analyzed using the method of moments(MoM). The induced current density of each resistive strip in a grounded double dielectric layer is expected to blow up at both edges. To satisfy this, the induced surface current density is expanded in a series of Chebyshev polynomials of the second kind. The scattered electromagnetic fields are expanded in a series of Floquet mode functions. The boundary conditions are applied to obtain the unknown current coefficients. According to the variation of the involving parameters such as strip width and spacing and angle of the incident field, numerical simulations are performed by applying the Fourier-Galerkin moment method. The numerical results of the normalized reflected power for resistive strips case for several resistivities are obtained.

• The KIPS Transactions:PartD
• /
• v.8D no.6
• /
• pp.853-860
• /
• 2001

In the object-oriented software development, redesigning of classes and reorganizing of class hierarchy structures should be necessary to reduce many of the headaches of object-oriented software design and maintenance. To support this task, in this paper, we propose a theoretical foundation for class hierarchy reorganizations that is relatively complete, correct, formal and easy to understand and use. We introduce the flattened class hierarchy that characterizes the class hierarchy structures in object-oriented software evolution. And we also present an algorithm which transforms a given class hierarchy into the normalized form. The flattened class hierarchy helps us map the inheritance and aggregation paths in a class hierarchy to paths in an object hierarchy that is an instance of the class hierarchy. By applying the algorithm into a given class hierarchy, we can make a new, object-preserved, and flattened class hierarchy that is the cornerstone for reorganization of class hierarchy structure and plays an important role as a bridge on the incremental evolutionary changes and reuse of object-oriented software to reorganize class hierarchies.