• Clinical and Experimental Pediatrics
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• v.60 no.6
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• pp.189-195
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• 2017

Purpose: The purpose of this study was to investigate the effects of lamotrigine for the treatment of attention-deficit hyperactivity disorder (ADHD) symptoms in children with epilepsy. Methods: Pediatric patients newly diagnosed with epilepsy (n=90 [61 boys and 29 girls]; mean age, $9.1{\pm}3.4years$) were enrolled. All patients were evaluated with the Korean ADHD rating scale (K-ARS)-IV before treatment with lamotrigine and after doses had been administered. The mean interval of ADHD testing was approximately 12.3 months. The initial dosage of lamotrigine was 1 mg/kg/day (maximum 25 mg/day for the first 2 weeks), and increased by 1 mg/kg every 2 weeks until titrated up to 7 mg/kg/day (or maximum 200 mg/day). Results: The mean ADHD test score of the 90 subjects was $17.0{\pm}1.8$ at baseline. It was slightly reduced to $15.6{\pm}1.7$ after lamotrigine monotherapy (P>0.01). Prior to treatment, a total of 31 patients (34.4%) met the diagnostic criteria for ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision, Of these 31 patients, 27 (87.1%) had significantly improved ADHD scores with lamotrigine monotherapy ($28.0{\pm}1.6$ reduced to $18.1{\pm}2.6$, P<0.001). Among these 27 patients, 25 (92.6%) showed normalized electroencephalogram (EEG) and 26 (96.3%) achieved total freedom from seizures within 12 months of the initiation of lamotrigine monotherapy. Conclusion: The results from our study show that lamotrigine had a positive effect in pediatric epilepsy patients by reducing ADHD symptoms, preventing seizures, and normalizing EEG. However, further research is required to determine whether lamotrigine is efficacious against ADHD symptoms independent of its effects on epileptic seizures.

• The Journal of Internal Korean Medicine
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• v.25 no.4
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• pp.105-116
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• 2004

Objective : In this study, we used the aged bilateral common carotid artery occlusion (BCAO) rats were used to measure the effect of Bupleuri Radix (Si-Ho) on the brain ischemic injury, because aging is an important factor in storke, Method : The brian ischemic injury was induced by temporary closing of carotids on both sides in a low blood pressure state. Bupleuri Radix (Si-Ho) was orally administered in 18-month-old BCAO rats. Result : The Ischemic Damaged Hippocampus and HSP expression were analyzed by the immunohistochemical staining and the result were as follows: 1. The low numbers of pyramid cells in the hippocampus CA1 area for the ischemically injured experimental group rose to numbers simillar to those of the control group. 2. The thin neuronal cell layer in the hippocampus CA1 area for the ischemically injured experimental group returned to thickness simillar to those of the control group. 3. The normalized optical density of HSP70 expression was suppressed in CA2, DG and CA1 expression was significantly suppressed in the experimental group compared to the control group. Conclusion : These results suggested that Bupleuri Radix (Si-Ho) has a neuroprotective effect by reducing neural cell injury in the initial ischemic state.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.2
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• pp.77-107
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• 2018

Objectives : In present study, therefore, possible beneficial pharmacological activities of standard potato protein extracts (SPE) were observed on the mild diabetic obese mice. Methods : After end of 12 weeks of continuous oral administrations of three different dosages of SPE 400, 200 and 100 mg/kg, or metformin 250 mg/kg, analyzed the hepatoprotective, hypolipidemic, hypoglycemic, nephroprotective and anti-obesity effects, separately. In addition, liver antioxidant defense systems were additionally measured with lipid metabolism-related genes expressions and hepatic glucose-regulating enzyme activities for action mechanism. Results : All of diabetes and related complications including obesity were significantly inhibited by treatment of SPE 400, 200 and 100 mg/kg, dose-dependently, and they also dramatically normalized the hepatic lipid peroxidation and depletion of liver endogenous antioxidant defense system, the changes of the hepatic glucose-regulating enzyme activities, also changes of the lipid metabolism-related genes expressions including hepatic $AMPK{\alpha}1$ and $AMPK{\alpha}2$ mRNA expressions, dose-dependently. Especially, SPE 200 mg/kg constantly showed favorable inhibitory activities against type II diabetes and related complications as comparable to those of metformin 250 mg/kg in HFD mice, respectively. Conclusions : The present work demonstrated that SPE 400, 200 and 100 mg/kg showed favorable anti-diabetic and related complications including obesity refinement activities in HFD mice, through AMPK upregulation mediated hepatic glucose enzyme activity and lipid metabolism-related genes expression, antioxidant defense system and pancreatic lipid digestion enzyme modulatory activities.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.34 no.4
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• pp.431-441
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• 2016

Since the use of UAV (Unmanned Aerial Vehicle) is convenient for the acquisition of data on broad or inaccessible regions, it is nowadays used to establish spatial information for various fields, such as the environment, ecosystem, forest, or for military purposes. In this study, the process of estimating FVC (Fractional Vegetation Cover), based on multi-spectral UAV, to overcome the limitations of conventional methods is suggested. Hence, we propose that the FVC map is generated by using multi-spectral imaging. First, two types of result classifications were obtained based on RF (Random Forest) using RGB images and NDVI (Normalized Difference Vegetation Index) with RGB images. Then, the result map was reclassified into vegetation and non-vegetation. Finally, an FVC map-based RF were generated by using pixel calculation and FVC map-based GI (Gutman and Ignatov) model were indirectly made by fixed parameters. The method of adding NDVI shows a relatively higher accuracy compared to that of adding only RGB, and in particular, the GI model shows a lower RMSE (Root Mean Square Error) with 0.182 than RF. In this regard, the availability of the GI model which uses only the values of NDVI is higher than that of RF whose accuracy varies according to the results of classification. Our results showed that the GI mode ensures the quality of the FVC if the NDVI maintained at a uniform level. This can be easily achieved by using a UAV, which can provide vegetation data to improve the estimation of FVC.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.10 no.1
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• pp.98-103
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• 2007

An 8-year-old boy presented with abdominal pain and poor oral intake for two months. Serum amylase and lipase levels were elevated. CT of the abdomen and chest X-ray showed two pseudocysts at the pancreatic uncinate process, pancreatitis with a parenchymal defect, a large amount of ascites, and a right pleural effusion. MR cholangiography and endoscopic retrograde cholangiopanreaticography revealed a pancreatic duct disruption. The patient was successfully treated with a chest tube placement and percutaneous drainage. After surgery, his general condition improved; the serum level of amylase normalized and the pleural effusion resolved. Pancreatic injuries are rare in pediatric blunt trauma; however, diagnostic difficulty is common with isolated blunt trauma. Therefore, a high index of suspicion should follow such an injury. We report the case of an 8-year-old boy with pancreas transection, ductal disruption, ascites, and pleural effusion who was successfully treated.

• Molecules and Cells
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• v.26 no.3
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• pp.250-257
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• 2008

Microsatellites or simple sequence repeats (SSR) are widely distributed in eukaryotic genomes and are informative genetic markers. Despite many advantages of SSR markers such as a high degree of allelic polymorphisms, co-dominant inheritance, multi-allelism, and genome-wide coverage in various plant species, they also have shortcomings such as low polymorphic rates between genetically close lines, especially in Capsicum annuum. We developed an alternative technique to SSR by normalizing and alternating anchored primers in random amplified microsatellite polymorphisms (RAMP). This technique, designated reverse random amplified microsatellite polymorphism (rRAMP), allows the detection of nucleotide variation in the 3' region flanking an SSR using normalized anchored and random primer combinations. The reproducibility and frequency of polymorphic loci in rRAMP was vigorously enhanced by translocation of the 5' anchor of repeat sequences to the 3' end position and selective use of moderate arbitrary primers. In our study, the PCR banding pattern of rRAMP was highly dependent on the frequency of repeat motifs and primer combinations with random primers. Linkage analysis showed that rRAMP markers were well scattered on an intra-specific pepper map. Based on these results, we suggest that this technique is useful for studying genetic diversity, molecular fingerprinting, and rapidly constructing molecular maps for diverse plant species.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.11
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• pp.5381-5399
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• 2016

Currently, the quantize-and-forward (QF) scheme with high order modulation and quantization has rather high complexity and it is thus impractical, especially in multiple relay cooperative communications. To overcome these deficiencies, an improved low complex QF scheme is proposed by the combination of the low order binary phase shift keying (BPSK) modulation and the 1-bit and 2-bit quantization, respectively. In this scheme, the relay selection is optimized by the best relay position for best bit-error-rate (BER) performance, where the relays are located closely to the destination node. In addition, an optimal power allocation is also suggested on a total power constraint. Finally, the BER and the achievable rate of the low order 1-bit, 2-bit and 3-bit QF schemes are simulated and analyzed. Simulation results indicate that the 3-bit QF scheme has about 1.8~5 dB, 4.5~7.5 dB and 1~2.5 dB performance gains than those of the decode-and-forward (DF), the 1-bit and 2-bit QF schemes, at BER of $10^{-2}$, respectively. For the 2-bit QF, the scheme of the normalized Source-Relay (S-R) distance with 0.9 has about 5dB, 7.5dB, 9dB and 15dB gains than those of the distance with 0.7, 0.5, 0.3 and 0.1, respectively, at BER of $10^{-3}$. In addition, the proposed optimal power allocation saves about 2.5dB much more relay power on an average than that of the fixed power allocation. Therefore, the proposed QF scheme can obtain excellent features, such as good BER performance, low complexity and high power efficiency, which make it much pragmatic in the future cooperative communications.

• Journal of the Korean Society of Safety
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• v.21 no.2 s.74
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• pp.15-21
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• 2006

The railroad bogie's components experience repeated loading during service. Especially, oil damper bush has been fatigue fractured on the plane between rubber and steel stem during service, and which results in inferior of performance of the bogie. In this study, in order to offer a proper maintenance method of the bush, bubber bush used for the oil damper was fatigue tested and its damage fraction during service was estimated. Also, FEM analysis on the bush was conducted. When 1400, 1200, and 1000kgf of repeated loads were applied to the oil damper bush, final damage fraction exhibited 63.7%, 50% and 40%. From the results of FEM analysis, deformation energy density was found to be $0.5452kgf/mm^{2}$ at an applied load of 1400kgf and the location with maximum value coincided with the fractured location of the bush. Finally, it will be desirable to adopt the normalized damage fraction rather than absolute damage fraction in estimating remaining service lifetime of the bush.

• Transactions of the Korean Society of Automotive Engineers
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• v.16 no.5
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• pp.49-59
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• 2008

The effects of design parameters on the pellet transport rate in the ejector system which is widely used in the production processes of automotive parts were investigated experimentally. The primary nozzle geometry, the area ratio (R) of nozzle exit cross-sectional area to mixing chamber cross-sectional area and the distance (S) from primary nozzle exit to mixing chamber entrance were considered as the design parameters. The area ratios of the primary nozzle were varied from R=0.10 to R=0.25, 0.30, 0.40 and 0.55. The primary nozzle was positioned at the non-dimensional distance (S/D) of 1.30, 1.87, 2.44, 3.00 and 3.75, normalized using the mixing chamber diameter (D). The design parameters were determined to run with high efficiency by measuring the pellets transport rate. The geometry and the area ratio (R) of the primary nozzle had an effect on the pellet transport rate of the ejector system, and the area ratio of R=0.3 was carefully selected after taking the minimum fluidization velocity and transport rate of applied pellets into account. The higher pellet transport rate with the variation of the distance (S/D) was observed at S/D of 2.44.

• Journal of Ginseng Research
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• v.41 no.2
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• pp.159-168
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• 2017

Background: Radiotherapy is one of the most important modalities in cancer treatment; however, normal tissue damage is a serious concern. Drug development for the protection or reduction of normal tissue damage is therefore a clinical issue. Herein, we evaluated the protective properties of Panax ginseng Meyer and its corresponding mechanisms. Methods: C56BL/6 mice were orally pretreated with P. ginseng water extract (PGE; 25 mg/kg, 50 mg/kg, or 100 mg/kg) or intraperitoneally injected melatonin (20 mg/kg) for 4 d consecutively, then exposed to 15-Gy X-ray radiation 1 h after the last administration. After 10 d of irradiation, the biological properties of hematoxicity, fat accumulation, histopathology, oxidative stress, antioxidant activity, pro-inflammatory cytokines, and apoptosis signals were examined in the hepatic tissue. Results: The irradiation markedly induced myelosuppression as determined by hematological analysis of the peripheral blood. Steatohepatitis was induced by X-ray irradiations, whereas pretreatment with PGE significantly attenuated it. Oxidative stress was drastically increased, whereas antioxidant components were depleted by irradiation. Irradiation also notably increased serum liver enzymes and hepatic protein levels of pro-inflammatory cytokines. Those alterations were markedly normalized by pretreatment with PGE. The degree of irradiation-induced hepatic tissue apoptosis was also attenuated by pretreatment with PGE, which was evidenced by a terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick-end labeling assay, western blotting, and gene expressions analysis, particularly of apoptotic molecules. Conclusion: We suggest that PGE could be applicable for use against radiation-induced liver injury, and its corresponding mechanisms involve the modulation of oxidative stress, inflammatory reactions, and apoptosis.