• 제목/요약/키워드: normal variant

검색결과 123건 처리시간 0.038초

Variant Identification in Platanus occidentalis L. Using SNP and ISSR Markers

  • Lee, Jin-Young;Han, Mu-Seok;Shin, Chang-Seob
    • Korean Journal of Plant Resources
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    • 제25권3호
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    • pp.308-316
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    • 2012
  • The purpose of this study was to identify the variant of Platanus occidentalis, whose bark looks white, also can be classified as P. occidentalis and to examine its genetic difference from the general P. occidentalis. For the variant identification of P. occidentalis, SNP and ISSR analysis were used in this study. Thirteen samples of P. occidentalis white variant were collected in Cheongju and 24 samples of normal P. occidentalis obtained in Cheongju, Pyongtaek, Ansan, Suwon, Osan and Jincheon area. ITS 1 and ITS 2 sequences of white variants were identical with those of P. occidentalis. We could not find any sequence difference between normal and white P. occidentalis. So we concluded that the white variant belongs to normal P. occidentalis even their bark is white and peeled easily. By ISSR test, 98 amplicons were acquired using 10 primers. P. occidentalis and white P. occidentalis showed different band patterns from the UBC #834. According to the result of Nei (1979)'s genetic distance analysis, the members of white P. occidentalis were grouped more tightly than the members of normal P. occidentalis. The UPGMA dendrogram shows that the variant and P. occidentalis divided widely into two groups. These results show that the phenotype of P. occidentalis white variant is caused by genetic factors rather than by environmental factors.

Manifestation of Transparent-Scaled Variant Type in Rhodeus notatus (떡납줄갱이(Rhodeus notatus)의 Transparent-Scaled Variant Type 출현 보고)

  • Park, Jae-Min;Cho, Seong-Jang;Sagong, Jin;Yu, Jeong-Nam
    • Korean Journal of Fisheries and Aquatic Sciences
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    • 제55권3호
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    • pp.338-344
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    • 2022
  • This study evaluated the external form of Rhodeus notatus TSV (transparent-scaled variant) type identified in Korea for the first time and compared it with that of the normal type. The TSV units newly found on Rhodeus notatus are iii10 of dorsal fin and anal fin iii10, which are similar to that in the normal type, considering the observing coefficient of each part's fins. The external form is, transparent enough to see the red gill filament in the operculum, the spiral digestive organ is observed opaquely, and numerous melanophores are stained at the upper part of abdomen. The coloration and scales are different between TSV type and normal type; however, there is no difference in the external form and meristic character.

Acute Alcohol Responses and Personality Traits by Aldehyde Dehydrogenase 2 Genotype Variances in Patients with Alcohol Dependence (알코올의존 환자의 Aldehyde Dehydrogenase 2 유전자 변이에 따른 음주 후 반응 및 성격특성)

  • Lee, Jong-Il;Lee, Jung-Sik;Cho, Sung Nam;Chai, Young-Gyu;Nam, Jung Hyun;Yang, Byung Hwan;Choi, Ihn-Geun;Kim, Seok Hyeon;Roh, Sungwon
    • Korean Journal of Biological Psychiatry
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    • 제12권2호
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    • pp.196-206
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    • 2005
  • Objectives:The purpose of this study is to evaluate the pathophysiology of alcoholics by investigating the differences in frequency of Aldehyde Dehydrogenase 2(ALDH2) genotypes and ALDH2 alleles between patients with alcohol dependence and controls, and the differences of drinking and personality traits in Korean male alcoholics with ALDH2 genotype variances. Methods:The authors selected 98 patients with alcohol dependence and 53 controls. Self-report questionnaires for acute reponses after alcohol ingestion, the AUI(Alcohol Use Inventory), and the NEO-PI-R(NEO Personality Inventory Revised) were given to all patients with alcohol dependence. ALDH2 genotypes were typed with MboII RFLP(Restriction Fragment Length Polymorphism) method in 53 controls and 98 patients with alcohol dependence. The authors divided alcoholic patients into two groups according to the presence of variant $ALDH2^2$ allele;normal ALDH2 alcoholics(N=87) and variant ALDH2 alcoholics(N=11). Results:1) The genotypic frequencies of subjects with $ALDH2^{1/1}$ were higher and those with $ALDH2^{1/2}$ and $ALDH2^{2/2}$ were lower in patients than in controls. 2) Alcohol dependence could be found in $ALDH2^{2/2}$ homozygote individuals. 3) Variant ALDH2 alcoholics had more family problems in the AUI than normal ALDH2 alcoholics. 4) Variant ALDH2 alcoholics experienced more flushing and cardiovascular responses after alcohol ingestion than normal ALDH2 alcoholics. 5) Variant ALDH2 alcoholics had less altruistic personality traits in the NEO-PI-R than normal ALDH2 alcoholics. 6) Variant ALDH2 alcoholics tended to have more tolerance to alcohol than normal ALDH2 alcoholics. Conclusion:Variant $ALDH2^2$ allele might play a protective role in the pathogenesis of alcohol dependence and there were several significant differences of drinking and personality traits in Korean male alcoholics with ALDH2 genotype variances.

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GROUND STATE SOLUTIONS OF NON-RESONANT COOPERATIVE ELLIPTIC SYSTEMS WITH SUPERLINEAR TERMS

  • Chen, Guanwei
    • Bulletin of the Korean Mathematical Society
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    • 제51권3호
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    • pp.789-801
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    • 2014
  • In this paper, we study the existence of ground state solutions for a class of non-resonant cooperative elliptic systems by a variant weak linking theorem. Here the classical Ambrosetti-Rabinowitz superquadratic condition is replaced by a general super quadratic condition.

DESMOPLASTIC VARIANT OF AMELOBLASTOMA (결체증식성 법랑모세포종)

  • Sohn Jeong-Ick;Kim Dong-Youn;Choi Karp-Shik
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • 제25권1호
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    • pp.151-157
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    • 1995
  • Desmoplastic variant of ameloblastoma is a new and unusual variant of ameloblastoma with extensive stromal desmoplastic proliferation. The authors experienced a case of desmoplastic variant of ameloblastoma with moderate-defined radiolucency on the right maxillary anterior area in 62-year-old female. As a result of careful analysis of clinical, radiological, histopathological examinations, we diagnosed it as desmoplastic variant of ameloblastoma, and the following results were obtained : 1. Main clinical symptoms were nontender bony swelling with normal intact overlying mucosa on the right maxillary anterior area. 2. Radiographically, moderate-defined, multilocular radiolucency on the right maxillary anterior area were shown, and severe cortical bony thinning and expansion to labial and palatal sides were also observed. And this lesion was shown to be extended to the right nasal cavity. 3. Histopathologically, follicle-like epithelial islands with densely abundant collagenous stroma were morphologically compressed.

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Rare Normal Variation Between Biceps Anchor and Superior Labrum - A Case Report - (상완 이두근 장두의 관절내 부착부위와 상부 관절와 순 간의 드문 변형 - 증례보고 -)

  • Kim, Yong-Ju;Jeong, Hoon;Ha, Jong-Kyoung;Lee, Kwan-Hee;Lee, Woo-Jin
    • Clinics in Shoulder and Elbow
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    • 제12권2호
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    • pp.245-249
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    • 2009
  • Purpose: Labral lesions and its anatomic variants have been studied by several authors in the last decade. Buford complex and sublabral recess are most common variants. Their recognition is important in order to distinguish them from superior and anterior labral tear. Materials and Methods: We report one case of a 19-year-old female who was mistaken SLAP lesion for normal variant and was treated with arthroscopic surgery. Results: The arthroscopic finding shows rare normal variant of biceps anchor and superior labrum. The biceps long head tendon was inserted at superior labrum and supraspinatus tendon area. This finding was mistaken to SLAP lesion. Conclusion: We report rare normal variant of biceps anchor and superior labrum that was observed during arthroscopic surgery for SLAP lesion.

TSTE: A Time-variant Stochastic Trust Evaluation Model in Social Networks

  • Li, Jingru;Yu, Li;Zhao, Jia;Luo, Chao;Zheng, Jun
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제11권6호
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    • pp.3273-3308
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    • 2017
  • Building appropriate trust evaluation models is an important research issue for security guarantee in social networks. Most of the existing works usually consider the trust values at the current time slot, and model trust as the stochastic variable. However, in fact, trust evolves over time, and trust is a stochastic process. In this paper, we propose a novel time-variant stochastic trust evaluation (TSTE) model, which models trust over time and captures trust evolution by a stochastic process. Based on the proposed model, we derive the time-variant bound of untrustworthy probability, which provides stochastic trust guarantee. On one hand, the time-variant trust level of each node can be measured by our model. Meanwhile, by tolerating nodes with relatively poor performance, our model can effectively improve the node resource utilization rate. Numerical simulations are conducted to verify the accuracy and consistency of the analytical bounds on distinguishing misbehaved nodes from normal ones. Moreover, simulation results on social network dataset show the tradeoff between trust level and resource utilization rate, and verify that the successful transmission rate can be improved by our model.

SLAP병변의 치료시 감별해야 할 상완 이두근 장두와 상부 관절와 순 간의 드문 변형 - 증례보고 -

  • Kim, Yong-Ju;Jeong, Hun;Ha, Jong-Gyeong;Lee, Gwan-Hui;Lee, U-Jin
    • 대한관절경학회:학술대회논문집
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    • 대한관절경학회 제21차 추계 학술대회
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    • pp.183-187
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    • 2009
  • Labral lesions and anatomic variants have been studied by several authors in the last decade. Buford complex and sublabral recess and foramen are most common variants. Their recognition is important in order to distinguish them from superior and anterior labral tear. We report rare normal variant of biceps anchor and superior labrum that was observed during arthroscopic surgery for SLAP lesion.

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Hemoglobin variant Found in Koreans (한국인(韓國人)을 대상(對象)으로 한 이상혈색소(異常血色素)의 변이형(變異型)에 관(關)한 연구(硏究))

  • Ro, Ihl-Hyeob
    • Journal of Nutrition and Health
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    • 제3권3호
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    • pp.161-166
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    • 1970
  • One male in the former group of 2110 Korean males of the Republic of Korea Army stationed Taegu. And two males and one female in the later group of 4590 Korean school children and university students in Seoul and Taejuon were found to have a slow hemoglobin in addition to normal hemoglobin A. In all four subjects the slow component migrated at a rate characteristic of the G hemoglobin. The overall incidence of the variant in the present group of Koreans was low: 4 in 6700 or 0.06 percent. It appears significant that no insistence of hemoglobin E were found among these Korean subjects. Hemoglobin E has been found among numerous ethnic groups of Southeast Asia and the variant most frequently appeared in Chinese subject. By Urea-Starch-Gel Electrophoresis in Alkaline PH and A.I. Chernoff method was demonstrated that another 3 cases of abnormal hemoglobin also were beta-chain variants. This was reconfirmed by Hybridization Experiment with canine hemoglobin. And the results of family test of 3 case of abnormal hemoglobin were heterozygous carrier.

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Role of MYH Polymorphisms in Sporadic Colorectal Cancer in China: A Case-control, Population-based Study

  • Yang, Liu;Huang, Xin-En;Xu, Lin;Zhou, Jian-Nong;Yu, Dong-Sheng;Zhou, Xin;Li, Dong-Zheng;Guan, Xin
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권11호
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    • pp.6403-6409
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    • 2013
  • Purpose: Biallelic germline variants of the 8-hydroxyguanine (8-OG) repair gene MYH have been associated with colorectal neoplasms that display somatic $G:C{\rightarrow}T:A$ transversions. However, the effect of single germline variants has not been widely studied, prompting the present investigation of monoallelic MYH variants and susceptibility to sporadic colorectal cancer (CRC) in a Chinese population. Patients and Methods: Between January 2006 and December 2012, 400 cases of sporadic CRC and 600 age- and sex-matched normal blood donors were screened randomly for 7 potentially pathogenic germline MYH exons using genetic testing technology. Variants of heterozygosity at the MYH locus were assessed in both sporadic cancer patients and healthy controls. Univariate and multivariate analyses were performed to determine risk factors for cancer onset. Results: Five monoallelic single nucleotide polymorphisms (SNPs) were identified in the 7 exon regions of MYH, which were detected in 75 (18.75%) of 400 CRC patients as well as 42 (7%) of 600 normal controls. The region of exon 1 proved to be a linked polymorphic region for the first time, a triple linked variant including exon 1-316 $G{\rightarrow}A$, exon 1-292 $G{\rightarrow}A$ and intron 1+11 $C{\rightarrow}T$, being identified in 13 CRC patients and 2 normal blood donors. A variant of base replacement, intron 10-2 $A{\rightarrow}G$, was identified in the exon 10 region in 21 cases and 7 controls, while a similar type of variant in the exon 13 region, intron 13+12 $C{\rightarrow}T$, was identified in 8 cases and 6 controls. Not the only but a newly missense variant in the present study, p. V463E (Exon 14+74 $T{\rightarrow}A$), was identified in exon 14 in 6 patients and 1 normal control. In exon 16, nt. 1678-80 del GTT with loss of heterozygosity (LOH) was identified in 27 CRC cases and 26 controls. There was no Y165C in exon 7 or G382D in exon 14, the hot-spot variants which have been reported most frequently in Caucasian studies. After univariate analysis and multivariate analysis, the linked variant in exon 1 region (p=0.002), intron 10-2 $A{\rightarrow}G$ (p=0.004) and p. V463E (p=0.036) in the MYH gene were selected as 3 independent risk factors for CRC. Conclusions: According to these results, the linked variant in Exon 1 region, Intron 10-2 $A{\rightarrow}G$ of base replacement and p. V463E of missense variant, the 3 heterozygosity variants of MYH gene in a Chinese population, may relate to the susceptibility to sporadic CRC. Lack of the hot-spot variants of Caucasians in the present study may due to the ethnic difference in MYH gene.