• Journal of Veterinary Clinics
• /
• v.34 no.5
• /
• pp.318-324
• /
• 2017

The objective of this study was to establish kinematic reference ranges for the femorotibial (FT) joint and the patellofemoral (PF) joint in healthy small-breed dogs by measuring 3D kinematics at the walk. Single-plane fluoroscopy was used to image the stifle joints of five healthy beagle dogs while the dogs were walking. 3D bone models of the femur, patella, and tibia were reconstructed by computed tomography scanning of the beagle dogs' hind limbs. The shape-matching technique was used to measure kinematic data from the fluoroscopic images and the 3D bone models. The cranial translation of the tibia during walking was inversely proportional to the FT joint flexion. There were significant correlations between the patellar motion and the tibial motion. The FT joint flexion had a strong correlation with the patellar proximodistal translation and flexion. Additionally, the tibial mediolateral translation had a strong correlation with the patellar shift and tilt. In this study, normal in vivo 3D FT joint and PF joint kinematics were demonstrated, and the average kinematic parameters were determined in walking beagle dogs.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.21
• /
• pp.9217-9223
• /
• 2014

Background: Today, leukemia is one of the biggest problems worldwide. The Wilms' tumor gene (WT1) and the vascular endothelial growth factor (VEGF) gene are highly expressed in patients with various cancers. This study concerned the relationship between expression of WT1 and VEGF in patients with acute leukemia. Materials and Methods: We evaluated expression of WT1 mRNA and VEGF mRNA using real-time quantitative RT-PCR in the peripheral blood (PB) of 8 newly diagnosed AML and 4 newly diagnosed ALL patients, serially monitored for 2 months. A further 12 normal PB samples served as controls. Results: In the patient group, in comparison with the normal ranges, WT1 and VEGF gene expression was increased, the average values for the expression of these two genes being $0.2852{\pm}0.11$ and $0.2029{\pm}0.018$, respectively. While was no significant relevance between the two genes pre-treatment, a positive link between the two genes in 75% of patients with AML was noted during the procedure of chemotherapy, whereas in 75% of patients with ALL an antiparallel association was observed. Conclusions: Leukemia is associated with production of WT1, which may affect the expression of VEGF.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.20 no.1
• /
• pp.88-99
• /
• 1996

The explicit scheme for finite element analysis of sheet metal forming problems has been widely used for providing practical solutions since it improves the convergency problem, memory size and computational time especially for the case of complicated geometry and large element number. The explicit schemes in general use are based on the elastic-plastic modeling of material requiring large computataion time. In the present work, a basic formulation for rigid-plastic explicit finite element analysis of plain strain sheet metal forming problems has been proposed. The effect of some basic parameters involved in the dynamic analysis has been studied in detail. Thus, the effective ranges of parameters have been proposed for numerical simultion by the rigid-plastic explicit finite element method. A direct trial-and-error method is introduced to treat contact and friction. In computation, sheet material is assumed to possess normal anisotropy and rigid-plastic workhardening characteristics. In order to show the validity and effectiveness of the proposed explicit scheme, computations are carried out for cylindrical punch stretching and the computational results are compared with those by the implicit scheme as well as with a commercial code. The proposed rigid-plastic exlicit finite element method can be used as a robust and efficient computational method for analysis of sheet metal forming.

• Journal of the Korean Society for Precision Engineering
• /
• v.27 no.2
• /
• pp.145-152
• /
• 2010

Gait phase detection is important for evaluating the recovery of gait ability in patients with paralysis, and for determining the stimulation timing in FES walking. In this study, three different motion sensors(tilt sensor, gyrosensor and accelerometer) were used to detect gait events(heel strike, HS; toe off, TO) and they were compared one another to determine the most applicable sensor for gait phase detection. Motion sensors were attached on the shank and heel of subjects. Gait phases determined by the characteristics of each sensor's signal were compared with those from FVA. Gait phase detections using three different motion sensors were valid, since they all have reliabilities more than 95%, when compared with FVA. HS and TO were determined by both FVA and motion sensor signals, and the accuracy of detecting HS and TO with motion sensors were assessed by the time differences between FVA and motion sensors. Results show of that the tilt sensor and the gyrosensor could detect gait phase more accurately in normal subjects. Vertical acceleration from the accelerometer could detect HS most accurately in hemiplegic patient group A. The gyrosensor could detect HS and TO most accurately in hemiplegic patient group A and B. Valid error ranges of HS and TO were determined by 3.9 % and 13.6 % in normal subjects, respectively. The detection of TO from all sensor signals was valid in both patient group A and B. However, the vertical acceleration detected HS validly in patient group A and the gyrosensor detected HS validly in patient group B. We could determine the most applicable motion sensors to detect gait phases in hemiplegic patients. However, since hemiplegic patients have much different gait patterns one another, further experimental studies using various simple motion sensors would be required to determine gait events in pathologic gaits.

• Journal of Korean Neurosurgical Society
• /
• v.49 no.5
• /
• pp.262-266
• /
• 2011

Objective : The endocrine dysfunction after the operation for suprasellar arachnoid cysts is not rare. The careful operation to prevent structures can prevent this complication, but it is not enough and effective to prevent it. Authors present technical surgical considerations to prevent this complication with a review of our suprasellar arachnoid cyst patients who had postoperative endocrine dysfunction. Methods : From January 2002 to December 2009, eight patients who had suprasellar arachnoid cysts with visual impairment underwent surgery. The mean age was 57.1 years (range, 33-77). Preoperatively, their endocrine function was clinically normal, and laboratory hormonal levels were within normal ranges. Cyst fenestration was performed by craniotomy (n=6) or by a neuro-endoscopic procedure (n=2), and, simultaneously, along with a cyst wall biopsy. Results : The surgery was uneventful in all eight patients, and there were no neurological morbidities. However, in four patients, endocrine dysfunction occurred postoperatively. We compared these four patients (group A) to the other 4 patients without endocrine dysfunction (group B) with intraoperative findings and with the histopathological findings of the cyst wall biopsy. The group A patients had more abundant vasculature on the cystic wall than the group B patients according to both the intraoperative findings and the histopathological findings. Conclusion : When performing a surgical cyst wall fenestration, surgeons should try to minimize the destruction of the cystic wall vasculature and not to make the fenestration at a site that contains many vascular striae.

• Journal of Veterinary Clinics
• /
• v.22 no.2
• /
• pp.119-124
• /
• 2005

This study was performed to validate the procedure of transarterial embolization of the renal artery (TAE-RA) and sclerotherapy of renal pelvis using iohexol-ethanol solution in dogs with unilateral experimental hydronephrosis. Experimental hydronephrosis was induced by unilateral ureter ligation for 20 days in five Beagle dogs. Renal artery embolization with iohexol-ethanol solution was performed using selective catheterization technique in the hydronephrotic kidney and sclerotherapy was done by injection of the iohexol-ethanol solution through percutaneously placed pig-tail catheter. EKG, $SpO_2$ body temperature, pulse, and respiratory rate were within normal ranges during procedures. Average pure ethanol dose for renal artery embolization was $1.1\pm0.3ml/kg$. Renal artery embolization was confirmed by the detection of no blood flow signal at the interlobar and arcuate artery using color Doppler ultrasonography. There were no dogs expired after TAE-RA and sclerotherapy and no side effects associated with regurgitation of iohexol-ethanol solution. The value of BUN, creatinine, ALT, AST, Ca, P in five dogs were within normal range during the experiment period. Ultrasonographically, the mean longitudinal and transverse length and the depth of the embolized kidney significantly decreased at 28 days after TAE-RA. We may conclude that TAE-RA and sclerotherapy with iohexol-ethanol solution is an effective methods for the treatment of unilateral hydronephrosis in dogs.

• Korean Journal of Veterinary Research
• /
• v.25 no.2
• /
• pp.133-144
• /
• 1985

The changes of acid-base status in vitro of the venous blood for 24 hours in ten Korean native goat were investigated. The acid-base parameters were measured within ten minutes after collection of the blood, and every hour during the first six hours and finally after twenty four hours of storage. Blood samples were stored at two different temperatures ($0-4^{\circ}C$ and $21-24^{\circ}C$). Twelve goats were induced acute acid-base disturbances by intravenous infusion of either hydrochloric acid or sodium bicarbonate and inhalated with $CO_2$ gas mixture (20% $CO_2$, 80% $O_2$) or hyperventilation were performed by means of respirator. The results were as follows; 1. Blood samples could be stored during the first two hours in ice water ($0-4^{\circ}C$) and one hour at room temperature without significant changes in pH. The magnitudes of changes were similar to those of cow, and lower than those of men and dogs. 2. The mean values of acid-base parameters in normal goat were arterial pH, 7.40; $P_{CO_2}$, 35.4mmHg; $HCO_3{^-}$, 21.8mEq/L. 3. Both the base excess and the bicarbonate showed high correlation (r=0.99) during the metabolic disturbance and were represented as $B.E.=1.38\;HCO^-{_3}-29.7$. 4. The slope of blood buffer curve obtained from the in vivo experiment was 16.3mEq/L/pH. 5. The magnitudes of changes in hydrogen ion concentration per unit change of $P_{CO_2}$ were 0.8nM/mmHg in hypercapnia and 1.0nM/mmHg in hypocapnia. 6. The ranges of acid-base parameters in normal goat urine were pH, 6.0-8.1; $P_{CO_2}$, 42-61mmHg; $HCO_3{^-}$, 2-110mEq/L. The concentration of potassium was higher (60-200mEq/L), and that of sodium was lower (8-70mEq/L) than those of human urine.

• Tuberculosis and Respiratory Diseases
• /
• v.50 no.5
• /
• pp.615-623
• /
• 2001

Background : Pneumoconiosis is a parenchymal lung disease that results from the accumulation of coal dust in the lungs and the consequent tissue reaction. To evaluate the role of various personal factors in pneumoconiosis and the significance of some serologic markers for assessing the disease activity related to pneumoconiosis, the Rheumatoid Factor(RF), ${\alpha}_1$-AT, C-Reactive Protein(CRP), ceruloplasmin and fibrinogen levels were measured. Method : All the patients were males, 45-76 years old, and the mean duration of coal dust exposure was 23.2 years. 51 patients were classified as having Simple Pneumoconiosis (SP), 59 had Progressive Massive Fibrosis (PMF). Fifty eight men with ages ranging from 26-70 years were used as normal controls. The serum RF and CRP were titrated using an Autochemistry analyzer (HITACHI 7150 : Japan) and the ${\alpha}_1$-AT and ceruloplasmin levels were measured using a Nephelometer (Behring Nephelometer : Germany) and the fibrinogen levels were estimated by using an Autoanalyzer for hematologic coagulation. Result : There was a higher RF level in the SP, and PMF groups than in the control groups but there was no statistical difference. The CRP, ${\alpha}_1$-AT, and ceruloplasmin levels were also higher in the SP, and PMF groups. However, the fibrinogen concentration was within the normal ranges in both the SP and PMF groups. Conclusion : The CWP (Ed note : Define CWP) patients had significantly higher CRP, ${\alpha}_1$-AT, and ceruloplasmin levels compared to the control group. It is believed that these serologic changes could be used as a marker of the disease activity.

• The KIPS Transactions:PartC
• /
• v.10C no.7
• /
• pp.857-866
• /
• 2003

For detecting an intrusion based on the anomaly of a user's activities, previous works are concentrated on statistical techniques in order to analyze an audit data set. However. since they mainly analyze the average behavior of a user's activities, some anomalies can be detected inaccurately. In this paper, a new clustering algorithm for modeling the normal pattern of a user's activities is proposed. Since clustering can identify an arbitrary number of dense ranges in an analysis domain, it can eliminate the inaccuracy caused by statistical analysis. Also, clustering can be used to model common knowledge occurring frequently in a set of transactions. Consequently, the common activities of a user can be found more accurately. The common knowledge is represented by the occurrence frequency of similar data objects by the unit of a transaction as veil as the common repetitive ratio of similar data objects in each transaction. Furthermore, the proposed method also addresses how to maintain identified common knowledge as a concise profile. As a result, the profile can be used to detect any anomalous behavior In an online transaction.

• Fashion & Textile Research Journal
• /
• v.12 no.4
• /
• pp.487-493
• /
• 2010

The objectives of this study were to investigate the progress of obesity in women from childhood to adulthood and to analyze the characteristics of obese figures through comparing their body proportions to normal-weight people, to provide a basic reference for development of new size categories and improved pattern grading. Body measurement was made on 6,704 women age between 7-39 in Sizekorea 2004 database. The age range was divided into three groups: children(7-12), teenagers(13-18) and adults(19-39). The result of research into the characteristics of body proportions of obese figures and the classification of different figure groups of obese people are as follows: The ratio between width and circumference for each part of the body was investigated according to body weight which was grouped into three different weights of low, normal and obese body weights. And the result demonstrated that in all the ranges of age, the obese groups had the lowest ratio between width and circumference, having a thick body shape. And according to the result of comparing the ratio of the circumference of each body part divided by the waist circumference, the obese group also showed a low ratio, indicating that they have bigger waist circumference than any other body parts. By analyzing the ratio of circumference of body parts divided by waist circumference, three factors were identified as contributing to obesity. Using the factor loadings of the upper, distal and lower body obesity, a cluster analysis was carried out and three different categories of obesity were defined; abdominal obesity, distal obesity and proximal obesity.