• Journal of the Korean Statistical Society
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• 제8권1호
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• pp.15-21
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• 1979

A zone of sensitivity is developed to investigate the effect of nonnormality on the Bayes decision function for testing mean of a normal population when either parent or prior belongs to Edgeworthian family of moderately nonnormal probability density functions.

• 품질경영학회지
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• 제15권2호
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• pp.61-68
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• 1987

This paper considers the estimation of the parameters of a normal population from which a sample which has been censored at a known point is obtained. Simple estimators are presented which are given in closed forms. It is shown that maximum likelihood estimators are obtained by using the estimation procedure iteratively. Some computer simulation results are given.

• 약학회지
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• 제41권2호
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• pp.195-202
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• 1997

The purpose of this study was to determine pharmacokinetic parameters of vancomycin using two point calculation(TPC) and Bayesian methods in 16 Korean normal volunteers and 15 g astric cancer patients. Nonparametric expected maximum(NPEM) algorithm for calculation of population pharmacokinetic parameter was used, and these parameters were applied for clinical pharmacokinetic parameters by Bayesian analysis. Vancomycin was administered 1.0g every 12 hrs for 3 days by IV infusion over 60 minutes. The volume of distribution(Vd), elimination rate constant(Kel) and total body clearance(CLt) of vancomycin in normal volunteers using TPC method were $0.34{\pm}0.06 L/kg,\; 0.19{\pm}0.01 hr^{-1}$ and $4.08 {\pm} 0.93 L/hr$, respectively, The Vd, Kel and CLt of vancomycin in gastric cancer patients using TPC method were $0.46 {\pm} 0.06 L/kg, 0.17{\pm}0.02 hr^{-1}$ and $4.84 {\pm} 0.57 L/hr$ respectively. There were significant differences(p<0.05) in Vd. Kel and CLt between normal volunteers and gastric cancer patients. Polpulation pharmacokinetic parameter, the slope(KS) of the relationship beetween Kel versus creatinine Clearance, and the Vd were $0.00157{\pm}0.00029(hr{\cdot}mL/min/1.73m^2)^{-1},\; 0.631 {\pm} 0.0036 L/kg$ in gastric cancer patients using NPEM algorithm respectively. The Vd and Kel were $0.63{\pm}0.005 L/kg, 0.15 {\pm}0.027 hr^{-1}$ for gastric cancer patients using Bayesian method. There were significant differences(p<0.05) in vancomycin pharmacokinetics between Bayesian and TPC methods. It is considered that the population parameter in the patient population is necessary for effective Bayesian method in clinical pharmacy practise.

• 한국수산과학회지
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• 제53권4호
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• pp.492-498
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• 2020

Despite its economic importance, olive flounder Paralichthys olivaceus aquaculture industry is facing a crisis with a continuous production decline. There have been many solutions to overcome the complicate predicament proposed. Increasing genetic diversity and discovering new commercial value through selective breeding are among them. The aims of the present study are to increase the selection power of the golden flounders. We examined the genetic diversity of the breeder population of golden flounders and developed selective markers for the golden flounder population. The 6 microsatellite (MS) markers were selected from melanogenesis-related genes, which are believed to be involved in the pigmentation of fish. All markers were polymorphic (except PO4) and 5 of them had PIC value of 0.6 or above. All makers had distinctive alleles indicating either normal or golden individuals. For examples, from PO4 marker, the frequency of an allele (316) in the golden population was 100% and in normal population was 0% (P<0.001). Although some more studies with more samples at the later generations should be performed to confirm this result, the 316 allele from PO4 marker could be a distinctive tool for decision of the colors in olive flounders at an early stage of the life cycle.

• East Asian mathematical journal
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• 제34권3호
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• pp.317-330
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• 2018

We develop a mathematical model for the obesity dynamics to investigate the long term obesity trend with the consideration of psychological and social factors due to the increasing prevalence of obesity around the world. Many mathematical models for obesity dynamics adopted the modeling idea of infectious disease and treated overweight and obese people infectious and spreading obesity to normal weight. However, this modeling idea is not proper in obesity modeling because obesity is not an infectious disease. In fact, weight gain and loss are related to social interactions among different weight groups not only in the direction from overweight/obese to normal weight but also the other way around. Thus, we consider these aspects in our model and implement personal weight gain feature, a psychological factor such as body image dissatisfaction, and social interactions such as positive support on weight loss and negative criticism on weight status from various weight groups. We show that the equilibrium point with no normal weight population will be unstable and that an equilibrium point with positive normal weight population should have all other components positive. We conduct computer simulations on Korean demography data with our model and demonstrate the long term obesity trend of Korean male as an example of the use of our model.

• Journal of Nutrition and Health
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• 제32권1호
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• pp.90-100
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• 1999

In order to investigate dietary risk factors for hypertension in th elderly, dietary intakes and dietary habits of 405 elderly subjects, aged 60-94, were assessed by the questionnaire, anthropometric measurement and a 24-hour dietary recall. The prevalence of definite (>95mmHg for diastolic or>160mmHg for systeolic blood pressue) and borderline(90-95mmHg for diastolic or 140-160mmHg for systolic blood pressure) hypertensive subjects 33.3% and 19.3%, respectively. The distribution of the subjects for Body Mass Index(BMI), waist-hip ratio, and alcohol consumption were significantly different among definite, borderline, and normal groups(p<0.05). The distribution of the subjects for smoking, exercise, and preference of salty food were not significantly different among definite, borderline, and normal groups(p>0.05). From the generalized logistic regression analysis of the risk factors for the hypertension, the subjects with over 27 of BMI had significantly higher risk of hypertension. Alcohol consumption and preference of salty food were significant risk factors of hypertension in the elderly. Dietary risk factors for the hypertension that had significant relationship to the hypertension were intakes of potassium, calcium, phosphate, sodium, vitamin B1, niacin, and folate. There was no significant difference of consumption frequencies of food and dish among definite, borderline, and normal groups(p>0.05). The amount of intakes for cereals and grain product, bean and their products, eggs were significantly different among definite, borderline, and normal groups(p<0.05). In summary, the amount of dietary intakes to hypertension in elderly population. Longitudinal studies for dietary risk factors on incidence of hypertension are needed in general population, especially in the elderly.

• 한국동물학회지
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• 제26권3호
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• pp.211-217
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• 1983

한국인집단에서 Transferrin C subtypes와 Haptoglobin polymorphism의 분포 및 유전자 빈도에 관한 본 연구에서 얻은 결과는 다음과 같다. 제주집단에서 관찰된 Transferrin C subtypes은 주로 $T_{f}C_{1}, T_{f}C_{2}$ 및 $T_{f}C_{1}-C_{2}$형이었는데 $T_{f}C_{1}$과 $T_{f}C_{1}-C_{2}$이 51%와 42%로 나타났으며, 유전자 빈도는 $T_{f}C^{1}, T_{f}C^{2} 및 T_{f}D^{Jeju}$가 각각 0.7220, 0.2743 및 0.0037이었다. Haptoglobin의 유전자 빈도는 서울집단에서 460명, 제주집단에서 502명을 대상으로 추정한 결과 서울집단에서 $Hp^1 = 0.304, Hp^2 = 0.696$이었고, 제주집단에서는 0.269와 0.731이었으며 두 집단사이에 빈도 차이는 유의하지 않았다.

• 한국동물학회지
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• 제6권2호
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• pp.21-27
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• 1963

This study is concerned with alterations in chromosomes (numbers and morphology) when the culture of Chinese hamster cells (FAF-28 strain) was treated by steroids, testosterone and DOC. 1. In 200 cells of normal untreated cells as control population the chromosome of stemline was decided as which was contained in 158 cells ; that is , in 79 percent of the population. The average chromosome number in above 20 cells observed was calculated as 23.95 with minimum limit at 20 and maximum limit at 70. 2. Many different chromosome numbers, ranging from 19 to 352 were observed in the 200 cells treated by testosterone. The diploid number of 22 showed the peak of variation curve was counted in 71 cells (35.5%) and an average chromosome number of stemline was 22 which was counted in 74 cells (37%). While all of the chromosome number of stemline was 22 which was counted in 74 cells (37%). While all of the chromosome numbers in the 200 cells observed ranged from 20 to 181 , an average chromosome number was also found to be 30.09. 4. The chromosome component in the cultured normal FAF-28 cells with 22 diploid chromosomeswas as follows ; 9a) 2 paris were long and metacentric (LM), (b) 3 pairs were medium length and metacentric (MM), (c) 3 pairs were small and subtelocentric (SS) and (d) 3 pairs were small and metacentric (SM). 5. The twenty cells with 44 chromosomes were selected at random from each cell population treated with testosterone and DOC , so that chromosome idiogram and morphology could be studies. In the twenty cells of the testosterone treated population the average ratio of above four groups, LM ; MM;Ss:SM, was found to be 8.6 : 10.8:13.5:10.7. On the other hand, the average ratio in the same number of cells of the DOC treated one was 7.7 :11.4:12.5:12.7. 6. The five types of the altered chromosomes morphologically in the hundred cells selected at random from each cell population treated by testosterone and DOC were observed (Type I-V). The thirty-one altered chromosomes were found to be in the testosterone treated cell population and the sixteen in DOC treated.

• Genomics & Informatics
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• 제19권2호
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• pp.19.1-19.9
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• 2021

Plant height is an important component of plant architecture and significantly affects crop breeding practices and yield. We studied DNA variations derived from F5 recombinant inbred lines (RILs) with 96.8% homozygous genotypes. Here, we report DNA variations between the normal and dwarf members of four lines harvested from a single seed parent in an F6 RIL population derived from a cross between Glycine max var. Peking and Glycine soja IT182936. Whole genome sequencing was carried out, and the DNA variations in the whole genome were compared between the normal and dwarf samples. We found a large number of DNA variations in both the dwarf and semi-dwarf lines, with one single nucleotide polymorphism (SNP) per at least 3.68 kb in the dwarf lines and 1 SNP per 11.13 kb of the whole genome. This value is 2.18 times higher than the expected DNA variation in the F6 population. A total of 186 SNPs and 241 SNPs were discovered in the coding regions of the dwarf lines 1282 and 1303, respectively, and we discovered 33 homogeneous nonsynonymous SNPs that occurred at the same loci in each set of dwarf and normal soybean. Of them, five SNPs were in the same positions between lines 1282 and 1303. Our results provide important information for improving our understanding of the genetics of soybean plant height and crop breeding. These polymorphisms could be useful genetic resources for plant breeders, geneticists, and biologists for future molecular biology and breeding projects.

• Tuberculosis and Respiratory Diseases
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• 제58권3호
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• pp.230-242
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• 2005

연구배경 : 우리나라 국민을 대상으로 실시한 폐활량검사의 판정과 해석은 우리나라 국민을 대상으로 구한 폐활량 예측식이 사용되어야 한다. 그 동안 외국인을 대상으로 구한 폐활량 예측치가 사용되어 오류가 있었다. 본 연구에서는 전 국민을 대상으로 대표성 있고 신뢰할 수 있는 노력성 폐활량과 일초간 노력성 폐활량, 6초간 노력성 폐활량, 일초율에 대한 정상 예측식을 개발 하고자 하였다. 연구방법 : 전 국민을 대상으로 층화표본 추출법을 사용하여 조사대상을 선정하였으며, 폐활량검사기와 검사방법, 검사과정, 결과의 선택을 미국흉부학회에서 권고하는 기준에 따라 체계적인 정도관리와 질관리를 실시하였다. 폐활량 검사를 실시한 대상자 4,816명 중에서 비흡연자이면서 폐활량에 영향을 미칠 수 있는 호흡기 질환 및 증상이 없고, 흉부방사선학적 검사에서 심폐 이상 소견이 없으면서, 폐활량에 영향을 미치는 유해인자에의 노출력이 없는 대상자는 1,212명으로 남자 206명, 여자 1,006명이었다. 이들은 지역과 연령별로 우리나라 국민을 대표할 수 있었다. 통계분석에서 혼합효과모델을 적용하여 AIC 값이 가장 작은 모델로서 남자와 여자에 공통적으로 포함된 변수들을 일반선형회귀분석에 적용하여 폐활량 예측식을 구하였다. 결 과 : 노력성 폐활량의 예측식은 남자 -4.8434 - 0.00008633*연령$^2$(년) + 0.05292*신장(cm) + 0.01095*체중(kg)이었으며, 여자 -3.0006 - 0.0001273 *연령$^2$(년) + 0.03951*신장(cm) + 0.006892*체중(kg)이었다. 일초간 노력성 폐활량의 예측식은 남자 -3.4132 -0.0002484*연령$^2$(년) + 0.04578*신장(cm)이었으며, 여자 -2.4114 - 0.0001920*연령$^2$(년) + 0.03558*신장(cm)이었다. 6초간 노력성 폐활량의 예측식은 남자 -4.4244 -0.0001367*연령$^2$(년) + 0.05156*신장(cm) + 0.008246*체중(kg)이었으며, 여자 -3.1433 - 0.0001442*연령$^2$(년) + 0.04018*신장(cm) + 0.007077*체중(kg)이었다. 일초율의 예측식은 남자 119.9004 - 0.3902*연령(년) - 0.1268*신장(cm)이었으며, 여자 97.8567 - 0.2800*연령(년) - 0.01564*신장(cm)이었다. 결 론 : 본 예측식은 미국흉부학회에서 제시하고 있는 연령과 신장 변수에 체중이 포함되어 차이가 있었다. 이러한 이유는 연령효과와 젊은 연령에서 신장과 체중이 급격하게 변화하는 체격효과가 복합적으로 작용하기 때문이라고 해석된다. 본 예측식과 다른 국내 및 국외 예측식을 비교할 때 본 예측식이 노력성 폐활량과 일초간 노력성 폐활량, 일초율의 예측치를 높게 추정하였으나 대부분 그 차이가 10% 이내로 비슷하였다. 코카시안인 백인을 대상으로 구한 외국의 예측식보다 본 연구의 정상 예측치가 낮지 않았다. 이러한 이유로는 우리나라 젊은 사람들의 체격조건의 변화와 함께 엄격한 정상인의 선정기준, 검사방법과 검사결과의 정도관리 및 질관리에 기인하는 것으로 판단되었다.