• Journal of Genetic Medicine
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• 제14권1호
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• pp.18-22
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• 2017

Pseudohypoparathyroidism type 1b (PHP 1b) is the result of end organ resistance to parathyroid hormone (PTH) in the absence of any features of Albright's hereditary osteodystrophy. There are two subtypes of PHP 1b with different genetic mechanisms. One subtype is related to a maternally derived 3kb microdeletion involving STX 16 gene, and is inherited in an autosomal dominant mode. Familial autosomal dominant inheritance of PHP 1b is relatively rare. The other subtype is associated with more extensive loss of imprinting at the GNAS locus that affects at least one additional differential methylated (hypermethylation at neuroendocrine secretory protein and hypomethylation at antisense transcript and or extra-large stimulatory G protein region) without microdeletion of the STX 16 or AS gene. It can be sporadic due to an imprinting defect in the GNAS gene. In our case, an 8-year-old girl was referred for suspected PHP with no feature of Albright hereditary osteodystrophy. Blood test results revealed hypocalcemia and hyperphosphatemia. Elevated PTH was also checked. There was no family history of endocrine or developmental problem. Her intelligence was normal, but she had inferior sociability at that time. Based on above, we diagnosed a rare case of paternal uniparental disomy of the long arm of chromosome 20 as the cause of PHP 1b by microsatellite marker test of chromosome 20.

• 대한핵의학회지
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• 제34권4호
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• pp.265-275
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• 2000

The thyroid gland is an interesting endocrine organ where a spectrum of tumors with different behavior arise. At one end of spectrum there is differentiated thyroid carcinoma (DTC) with excellent prognosis, whereas at the other end of the spectrum is anaplastic thyroid cancer which has universally poor outcome. Radioiodine (I-131) therapy has been in use for the treatment of thyroid diseases since 1946. It was introduced by Seidlin et al. 1) Although the use of I-131 has been vouge for a long time, its use in therapy for well differentiated thyroid cancer is still controversial 2). This is because, thyroid cancers (TC) are generally slow growing tumors, with low mortality and normal spans of survival. To record recurrence and mortality, long term follow up studies over a period of two to three decades are needed to establish definite conclusions on the acceptable mode of treatment The incidence of the disease being very low a large number of cases needed to establish a meaningful statistical data is lacking as most published reports feat with small series. Here again in the problem encountered are the differing protocols for treatment with I-131, the indications for treatment which may include or exclude ablation of residual thyroid tissue, cervical nodal and distal metastases. The dosage of I-131 used for ablation of residual thyroid tissue and metastatic disease also vary. The most reliable conclusion regarding I-131 treatment are obtained from studies reported on a large series of patients followed over a period of 2 decades or more from a single institute with a more or less unchanged protocol of management.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2000년도 추계학술대회논문집
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• pp.282-286
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• 2000

In this paper, magneto-rheological(MR) damper is studied for vibration control of large infra structures under earthquake. Generally, active control devices need a large control force and a high power supply system to reduce the vibration effectively. Large and miss tuned control force may induce the dangerous situation such that the generated large control force acts to amplify the structural vibration. Recently, to overcome the weaknesses of the active control, the semi-active control method is suggested by many researchers. Semi-active control uses the passive control device of which the characteristics can be modified. Control force of the semi-active device is not generated from the actuator with power supply. It is generated as a dynamic reaction force of the device same as in the passive control case, so the control system is inherently stable and robust. Unlike the case of passive control, control force of semi-active control is adjusted depending on the measured response of the structure, so the vibration can be reduced more effectively against various unknown environmental loads. Magneto-rheological(MR) damper is one of the semi-active devices. Dynamic characteristics of the MR material can be changed by applying the magnetic fields. So the control of MR damper needs only small power. Response time of MR to the input voltage is very short, so the high performance control is possible. MR damper has a high force capacity so it is adequate to the vibration control of large infra structure. Because MR damper has a nonlinear property, normal control method used in active control may not be effective. Clipped optimal control, modified bang-bang control etc. have been suggested to MR damper by many researchers. In this study, sliding mode fuzzy control(SMFC) is applied to MR damper. Genetic algorithm is used for the controller tuning. To verify the applicability of MR damper and suggested algorithm, numerical simulation on the aseismic control is carried out. Simulation model is three-story building structure, which was used in the paper of Dyke, et al. The control performance is compared with clipped optimal control. The present results indicate that the SMFC algorithm can reduce the earthquake-induced vibration very effectively.

• 한국시뮬레이션학회논문지
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• 제25권3호
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• pp.15-28
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• 2016

수중환경에서 운영되는 무기체계 획득을 위한 설계/개발을 진행하기 위해 수중음향채널 모델링 및 시뮬레이션을 통한 분석은 필수적이다. 일반적으로 수중음향채널 분석을 위해 사용되는 수중음향 전파 수치해석 모델은 음선이론 법, 정규방식 법, 포물선방정식 법, 파수적분 법이 있으나 다중 주파수 분석일 경우 유효성과 신호처리 및 분석에 제한적이다. 본 논문은 단일 및 다중 주파수 분석 및 신호처리 및 분석이 용이한 기존 의사 스펙트럼 시간영역 법 수중음향 수치해석 모델에 수중환경 소음 모델을 적용하여 실제 수중환경과 유사한 합성환경 수중음향채널을 모델링 하였다. 이렇게 구현된 합성환경 수중음향채널 모델의 유효성을 확인하기 위해 단일 주파수 신호 시나리오 4가지 다중 주파수 신호 시나리오 4가지 및 잠수함 기동에 따른 방사소음 분석 시나리오 시뮬레이션을 통해 의사 스펙트럼 시간영역 법 합성환경 수중음향채널 모델 유효성을 확인하였다.

• Tribology and Lubricants
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• 제34권6호
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• pp.292-299
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• 2018

The objective of this research is to investigate the impact of engine oil aging on PM(Particulate Matter), exhaust gases, and DPF. It is widely known that the specification of a lubricant and its consumption in an ICE considerably influences the release of regulated harmful emissions under normal engine operating conditions. Considering DPF clogging phenomena associated with lubricant-derived soot/ash components, a simulated aging mode is designed for DPF to facilitate engine dynamometer testing. A PM/ash accumulation cycle is developed by considering real-world engine operating conditions for the increment of engine oil consumption and natural DPF regeneration for ash accumulation. The test duration for DPF aging is approximately 300 h with high- and low-SAPs engine oils. Detailed engine lubricant properties of new and aged oils are analyzed to evaluate the effect of engine oil degradation on vehicle mileage. Furthermore, physical and chemical analyses are performed using X-CT, ICP, and TGA/DSC to quantify the engine oil contribution on the PM composition. This is achieved by sampling with various filters using specially designed PM sampling equipment. Using high SAPs engine oil causes more PM/ash accumulation compared with low SAPs engine oils and this could accelerate fouling of the EGR in the engine, which results in an increase in harmful exhaust gas emissions. These test results on engine lubricants under operating conditions will assist in the establishment of regulated and unregulated toxic emissions policies and lubricant quality standards.

• Investigative Magnetic Resonance Imaging
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• 제23권1호
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• pp.55-64
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• 2019

Purpose: One of the suggested potential mechanisms of tinnitus is an alteration in perception in the neural auditory pathway. The aim of this study was to investigate the difference in laterality in functional connectivity between tinnitus patients and healthy controls using resting state functional MRI (rs-fMRI). Materials and Methods: Thirty-eight chronic tinnitus subjects and 45 age-matched healthy controls were enrolled in this study. Connectivity was investigated using independent component analysis, and the laterality index map was calculated based on auditory (AN) and dorsal attention (DAN), default mode (DMN), sensorimotor, salience (SalN), and visual networks (VNs). The laterality index (LI) of tinnitus subjects was compared with that of normal controls using region-of-interest (ROI) and voxel-based methods and a two-sample unpaired t-test. Pearson correlation was conducted to assess the associations between the LI in each network and clinical variables. Results: The AN and VN showed significant differences in LI between the two groups in ROI analysis (P < 0.05), and the tinnitus group had clusters with significantly decreased laterality of AN, SalN, and VN in voxel-based comparisons. The AN was positively correlated with tinnitus distress (tinnitus handicap inventory), and the SalN was negatively correlated with symptom duration (P < 0.05). Conclusion: The results of this study suggest that various functional networks related to psychological distress can be modified by tinnitus, and that this interrelation can present differently on the right and left sides, according to the dominance of the network.

• 한국융합학회논문지
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• 제10권7호
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• pp.23-31
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• 2019

2016년 한국에 미군의 사드 미사일이 배치된 이후 중국으로부터 단체관광은 전면 중단되었다. 이후 중국인의 한국 관광은 개인 중심의 여행일정으로 이루어지고 있다. 본 연구에서는 2018년 1월부터 12월 까지 온라인 여행노트를 통해 데이터를 수집하고, 소셜 네트워크 분석을 활용하여 개별방문 중국인의 계절별 한국관광 여정 특성을 분석하였다. 분석 결과 서울은 중국인의 한국여행 허브이며 개별 방문 중국인의 주요 방문지는 서울, 부산, 제주도, 경주 및 강릉에 집중되어 있고 계절에 따라 큰 차이가 있는 것으로 나타났다. 연구 결과는 개별 중국인의 한국 관광을 위한 관광코스의 개발, 관광 서비스 제공 및 관광 시설배치의 최적화를 위한 기초자료로 활용될 수 있다. 향후 연구는 여행 방문지와 관광명소 사이의 이동 교통방식을 연구하여 관광 일정 계획 설계에 참고를 제공할 수 있다.

• 한국추진공학회지
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• 제25권2호
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• pp.88-97
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• 2021

가스터빈엔진의 제어기는 수출입 규제로 인하여 엔진 제작사로부터 기술이전이 불가능하여 가스터빈엔진의 독자개발을 위하여 자체 개발이 필요한 분야이다. 한국항공우주연구원에서는 엔진제어로직연구의 일환으로 소형 가스터빈엔진을 활용하여 고장탐구 연구를 진행하였다. 엔진의 지상 시험설비를 활용하여 정상상태에서의 엔진의 거동 및 성능을 분석한 후, 제어로직 분석시험 환경을 구축하여 엔진의 각종 고장을 모사한 후, 고장이 발생하였을 때, 해당 엔진이 정상상태와 어떻게 다르게 거동하는지 파악하고 이에 대하여 정리하였다. 이를 통하여 향후 엔진 제어기 관련 연구에서 엔진의 각종 이상 상태 발생 시의 제어로직 연구를 수행하는 데 있어 배경지식을 제공하고자 하였다.

• 한국구조물진단유지관리공학회 논문집
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• 제25권2호
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• pp.23-34
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• 2021

최근 국내외 사용빈도가 높고 향후 건설계획이 많은 사장교의 주부재인 케이블을 대상으로 하였다. 우선 케이블의 온도 변화와 대기온도 변화 등으로 영구적으로 사용되는 온도하중에 대해 보통지방의 온도변화를 고려하여 실험을 수행하였다. 케이블의 온도변화를 가하여 동적특성의 변화를 여러 가지 시스템을 적용하여 케이블의 동적특성을 비교 분석하였다. 케이블의 동적특성을 비교분석한 결과 온도상승에 따른 케이블의 가속도, 고유진동수 및 장력은 감소하는 경향이 뚜렷하였으며 케이블의 변위의 영향정도를 분석하였으며 케이블의 모드특성에 대한 결과를 분석하였다. 특히 케이블의 온도변화에 따른 케이블의 가속도, 고유진동수 및 장력에 대해 상관관계를 분석한 결과 가속도 및 고유진동수 대비 케이블 장력의 민감도가 큰 것으로 나타났다.

• Nuclear Engineering and Technology
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• 제54권2호
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• pp.661-665
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• 2022

The 3 MeV proton irradiation effects on SiGe low noise amplifier (LNA) (NXP BGU7005) performance under different voltage supply VCC (0 V, 2.5 V) conditions were firstly experimental studied in this present work. The S parameters including S₁₁, S₂₂, S₂₁, 1 dB compression point and noise figure (NF) of the test samples under different bias voltage supply were measured and compared before and after 3 MeV proton irradiation. The total proton irradiation fluence was 1 × 10¹⁵ protons/cm². The maximum degradation quantities of the gain S₂₁ and NF of the test samples under zero bias are measured respectively 1.6 dB and 1.2 dB. Compared with the samples under 2.5 V bias supply, the maximum degradation of S₂₁ and NF are respectively 1.1 dB and 0.8 dB in the whole frequency band. It is noteworthy that the gain and NF of SiGe LNAs under zero-bias mode suffer enhanced degradation compared with those under normal bias supply. The key influence factors are discussed based on the correlation of the SiGe device and the LNA circuit. Different process of the ionization damage and displacement damage under zero-bias and 2.5 V bias voltage supply contributed to the degradation difference. The underlying physical mechanisms are analyzed and investigated.