• Progress in Medical Physics
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• v.13 no.3
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• pp.120-128
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• 2002

To investigate differences between the metabolic ratios of normal controls and brain tumors such as astrocytomas and glioblastoma multiforme (GM) by proton MR spectroscopy (MRS) at 37 high field system. Using 3T MRI/MRS system, localized water-suppressed single-voxel technique in patients with brain tumors was employed to evaluate spectra with peaks of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine/phosphocreatine (Cr) and lactate. On the basis of Cr, these peak areas were quantificated as a relative ratio. The variation of metabolites measurements of the designated region in 10 normal volunteers was less than 10%. Normal ranges of NAA/Cr and Cho/Cr ratios were 1.67$\pm$018 and 1.16$\pm$0.15, respectively. NAA/Cr ratio of all tumor tissues was significantly lower than that of the normal tissues (P=0.005). Cho/Cr ratio of glioblastoma multiforme was significantly higher than that of astrocytomas (P=0.001). Lactate was observed in all tumor cases. The present study demonstrated that the neuronal degradation or loss was observed in all tumor tissues. Higher grade of brain tumors was correlated with higher Cho/Cr ratio, indicating a significant dependence of Cho levels on malignancy of gliomas. This results suggest that clinical proton MR spectroscopy could be useful to predict tumor malignancy.

• Analytical Science and Technology
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• v.18 no.2
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• pp.163-167
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• 2005

In this study, a novel analytical method has been developed for the rapid determination of L-carnitine in human plasma using electrospray ionization tandem mass spectrometry. Free carnitine (FC) was analyzed after extraction with 80% methanol and total carnitine (TC) was analyzed after hydrolysis and extraction. Acyl carnitine (AC) was subtracted FC from TC. Analytical methods used multiple reaction monitoring (MRM) scan modes. A correlation coefficient of linear regression ($r^2$) was 0.9995, recovery was 97%, reproducibility was less than 10%, and limit of detection (LOD) was $0.0016{\mu}mol/L$. This method reduced sample preparation time and showed high resolution and good reproducibility compared to that with liquid chromatographic methods. Normal control showed AC was lower than FC. Clinical management of patients with inborn error of metabolism showed FC was lower than AC. Thus, carnitine fraction level was very important to monitoring patients with metabolic disorder.

• Journal of the Korean Institute of Gas
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• v.15 no.6
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• pp.34-37
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• 2011

This paper presents sealing contact stress and deformation behaviors of an elastomeric contact seal for a pipe connection. In this study, a pipe connection is used by a joint nut and an elastomeric contact seal with a sealing interference of 0.2~0.5mm. A sealing interference in which compresses an elastomeric contact seal is generated by fastening a joint nut between two pipes. The FEM computed results show that the contact normal stress of contact model 1 with an inclined sealing surface is 1.5~1.75 times high in compared with that of contact model 2 with a parallel sealing surface. This indicates that the sealing contact surface recommends a wedge contact mode between two pipe connections for a high sealing compression stress.

• Journal of Korean Society for Atmospheric Environment
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• v.29 no.5
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• pp.656-667
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• 2013

The non-exhaust coarse, fine, and ultrafine particles were characterized by on-road driving measurements using a mobile sampling system. The on-road driving measurements under constant speed driving revealed that mass concentrations of roadway particles (RWPs) were distributed mainly in a size range of 2~3 ${\mu}m$ and slightly increased with increasing vehicle speed. Under braking conditions, the mode diameters of the particles were generally similar with those obtained under constant speed conditions. However, the PM concentrations emitted during braking condition were significantly higher than those produced under normal driving conditions. Higher number concentrations of ultrafine particles smaller than 70 nm were observed during braking conditions, and the number concentration of particles sampled 90 mm above the pavement was 6 times higher than that obtained 40 mm above the pavement. Under cornering conditions, the number concentrations of RWPs sampled 40 mm above the pavement surface were higher than those sampled 90 mm above the pavement. This might be explained that a nucleation burst of a lot of vapor evaporated from the interaction between the tire and the road pavement under braking conditions continuously occurred by cooling during the transport to the sampling height 90 mm, while, for the case of cornering situations, the ultrafine particle formation was completed before the transport to the sampling height of 40 mm.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.1
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• pp.45-52
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• 2015

Since the broadcast message in satellite signals the security of the data is extremely poor compared to other communication technologies such as the broadcast signal. Thus, encryption of the communication satellite has become a very important issue, an analysis of the communication performance of a general service is always required. In this paper, In order to analyze the encrypted communication the turbo code in an IP-based satellite communication applies the code rate compatible punctured and The wireless channel in consideration of the actual satellite communication was constructed by placing a weight on the Rayleigh fading and the Rician fading two channels. Retransmission-based error control scheme were constructed in the best performance of H-ARQ Type-II, III scheme of a number of ways that are recently considered. we analyzed the effects of normal service against a satellite communication network The security services were configured with encryption algorithms AES, ARIA (CTR, CBC mode).

• Advances in aircraft and spacecraft science
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• v.3 no.4
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• pp.427-445
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• 2016

Star sensors are the attitude estimation sensors of the satellite orbiting in its path. It gives information to the control station on the earth about where the satellite is heading towards. It captures the images of a predetermined reference star. By comparing this image with that of the one captured from the earth, exact position of the satellite is determined. In the process of imaging, stray lights are eliminated from reaching the optic lens by the mechanical enclosures of the star sensors called Baffles. Research in space domain in the last few years is mainly focused on increased payload capacity and reduction in launch cost. In this paper, a star sensor baffle made of Aluminium is considered for the study. In order to minimize the component weight, material wastage and to improve the structural performance, an alternate material to Aluminium is investigated. Carbon Fiber Reinforced Polymer is found to be a better substitute in this regard. Design optimisation studies are carried out by adopting suitable design modifications like implementing an additional L-shaped flange, Upward flange projections, downward flange projections etc. A better configuration of the baffle, satisfying the design requirements and achieving manufacturing feasibility is attained. Geometrical modeling of the baffle is done by using UNIGRAPHICS-Nx7.5(R). Structural behavior of the baffle is analysed by FE analysis such as normal mode analysis, linear static analysis, and linear buckling analysis using MSC/PATRAN(R), MSC-NASTRAN(R) as the solver to validate the stiffness, strength and stability requirements respectively. Effect of the layup sequence and the fiber orientation angle of the composite layup on the stiffness are also studied.

• Clinical and Experimental Pediatrics
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• v.45 no.7
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• pp.902-905
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• 2002

The most common form of genetic nephrogenic diabetes insipidus(NDI), a rare inherited disorder, is congenital and is transmitted in an X-linked recessive mode. It is refractory to the antidiuretic effect of normal to moderately increased levels of plasma arginine vasopressin(AVP) but, in some cases, may respond to high levels of the hormone or its analogue, deamino-D-arginine vasopressin(DDAVP). X-linked congenital NDI has now been linked to over 128 different mutations in diverse coding regions of the AVP receptor 2(AVPR2) gene. The functional effects of these mutations vary from complete loss of responsiveness to a simple shift to the right in the dose response curve. We report a case of congenital partial NDI, with transversion of A to G at codon 280 of the AVPR2 gene, resulting in a subsequent change of amino acid from tyrosine to cysteine, and that has been effective with hydrochlorothiazide and high dose of DDAVP.

• Magazine of the Korea Concrete Institute
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• v.11 no.2
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• pp.177-186
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• 1999

The purpose of this study is to analyze the interface debonding of RC beams strengthened by carbon fiber sheet(CFS). The behavior of damaged RC beams strengthened with CFS is analytically investigated next using linear elastic fracture mechanics(LEFM) approach and the finite element method. The study includes an investigation of the separation mode by interface fracture of the strengthening materials due to the interfacial shear and normal stresses. The numerical method is presented to obtain the value of interfacial fracture parameter such as the strain energy release rate. Based on the results of this study, it is found that the critical case occurs when the interfacial cracks occur within a short region of the flexural crack. The CFS strengthening has not an adequate factor of safety against interfacial debonding of CFS. Furthermore, for the thicknesses of the adhesive studied[1mm~3mm], it is no noticeable effect on the strain energy release rate.

• Composites Research
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• v.14 no.1
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• pp.1-7
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• 2001

In this study, damage evaluation of glass fiber reinforced thermoplastic composites was investigated with acoustic emission method. Specimens of 1.7mm thickness laminate were made from PET and 7 layers o171ass fabrics. Notch and impact loading were added to the specimen and normal tensile test and tensile test with the dead load were carried out. AE signal was measured as the functions of notch ratio to the width0 and impact energy in order to find out the correlation between fracture mode and AE parameters. The result has shown that low amplitude of AE signal was due to the microcrack of matrix and its growth, whereas the amplitude in the mid range was the response to the delamination and interfacial separation. In the range of high amplitude above 90dB. the fracture of glass fabric was found. Tensile strength decreased with increasing notch ratio to the width and impact energy because of tile effect or delamination, the cracking of matrix and stress concentration. In proportion to the size of damaged area. AE signal showed its wider range of frequency and energy as well as increased number of hits.

• Molecules and Cells
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• v.27 no.6
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• pp.673-680
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• 2009

Conversion of the normal soluble form of prion protein, PrP ($PrP^C$), to proteinase K-resistant form ($PrP^{Sc}$) is a common molecular etiology of prion diseases. Proteinase K-resistance is attributed to a drastic conformational change from ${\alpha}$-helix to ${\beta}$-sheet and subsequent fibril formation. Compelling evidence suggests that membranes play a role in the conformational conversion of PrP. However, biophysical mechanisms underlying the conformational changes of PrP and membrane binding are still elusive. Recently, we demonstrated that the putative transmembrane domain (TMD; residues 111-135) of Syrian hamster PrP penetrates into the membrane upon the reduction of the conserved disulfide bond of PrP. To understand the mechanism underlying the membrane insertion of the TMD, here we explored changes in conformation and membrane binding abilities of PrP using wild type and cysteine-free mutant. We show that the reduction of the disulfide bond of PrP removes motional restriction of the TMD, which might, in turn, expose the TMD into solvent. The released TMD then penetrates into the membrane. We suggest that the disulfide bond regulates the membrane binding mode of PrP by controlling the motional freedom of the TMD.