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Using Harmonic Analysis and Optimization to Study Macromolecular Dynamics

  • Kim Moon-K.;Jang Yun-Ho;Jeong Jay-I.
    • International Journal of Control, Automation, and Systems
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    • v.4 no.3
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    • pp.382-393
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    • 2006
  • Mechanical system dynamics plays an important role in the area of computational structural biology. Elastic network models (ENMs) for macromolecules (e.g., polymers, proteins, and nucleic acids such as DNA and RNA) have been developed to understand the relationship between their structure and biological function. For example. a protein, which is basically a folded polypeptide chain, can be simply modeled as a mass-spring system from the mechanical viewpoint. Since the conformational flexibility of a protein is dominantly subject to its chemical bond interactions (e.g., covalent bonds, salt bridges, and hydrogen bonds), these constraints can be modeled as linear spring connections between spatially proximal representatives in a variety of coarse-grained ENMs. Coarse-graining approaches enable one to simulate harmonic and anharmonic motions of large macromolecules in a PC, while all-atom based molecular dynamics (MD) simulation has been conventionally performed with an aid of supercomputer. A harmonic analysis of a macroscopic mechanical system, called normal mode analysis, has been adopted to analyze thermal fluctuations of a microscopic biological system around its equilibrium state. Furthermore, a structure-based system optimization, called elastic network interpolation, has been developed to predict nonlinear transition (or folding) pathways between two different functional states of a same macromolecule. The good agreement of simulation and experiment allows the employment of coarse-grained ENMs as a versatile tool for the study of macromolecular dynamics.

Nature of the Wiggle Instability of Galactic Spiral Shocks

  • Kim, Woong-Tae;Kim, Yonghwi;Kim, Jeong-Gyu
    • The Bulletin of The Korean Astronomical Society
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    • v.39 no.1
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    • pp.37.2-37.2
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    • 2014
  • Gas in disk galaxies interacts nonlinearly with a underlying stellar spiral potential to form galactic spiral shocks. Numerical simulations typically show that these shocks are unstable to the wiggle instability, forming non-axisymmetric structures with high vorticity. While previous studies suggested that the wiggle instability may arise from the Kelvin-Helmholtz instability or orbit crowding of gas elements near the shock, its physical nature remains uncertain. It was even argued that the wiggle instability is of numerical origin, caused by the inability of a numerical code to resolve a shock that is inclined to numerical grids. In this work, we perform a normal-mode linear stability analysis of galactic spiral shocks as a boundary-value problem. We find that the wiggle instability originates physically from the potential vorticity generation at a distorted shock front. As the gas follows galaxy rotation, it periodically passes through multiple shocks, successively increasing its potential vorticity. This sets up a normal-mode that grows exponentially, with a growth rate comparable to the orbital angular frequency. We show that the results of our linear stability analysis are in good agreement with the those of local hydrodynamic simulations of the wiggle instability.

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Control Method of Distributed-Module Type Photovoltaic Power Conditioners under Stand-alone Operation (분산모듈형 태양광 전력조절기의 독립운전 제어)

  • Seo, Jung-Won;Park, Joung-Hu;Kim, Hye-Rim
    • The Transactions of the Korean Institute of Power Electronics
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    • v.18 no.5
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    • pp.448-457
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    • 2013
  • This paper proposes a control method under stand-alone operating mode for distributed-module type photovoltaic power conditioners. In conventional schemes, there are some problems of a controller saturation in the DC-link (or load) voltage controller when overly-heavy load, light load, and the generated PV power reduction occurs, as well as when a transition occurs from an overly-loaded to normal conditions. To overcome these problems, the proposed controller method switches the main control target from DC-link voltage to the maximum power point, which is closer to the stable operating point when it returns to normal operating conditions. For the analysis, a state-plane trajectory was given and the circuit analysis by PSIM simulation was done. For the verification, a prototype hardware with 110[W] and 50[W] dual photovoltaic modules has been implemented. From the results, it can be seen that PV power tracking is successfully done with the proposed method even under a stand-alone operation mode.

Development of the Gait Rehabilitation Equipment for Hemiplegic Patients after Stroke (편마비 환자를 위한 보행 재활기구 개발)

  • Nam, T.W.;Cho, J.M.;Kim, S.H.;Lim, J.H.
    • Journal of Biomedical Engineering Research
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    • v.27 no.5
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    • pp.245-249
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    • 2006
  • The aim of this study is to design and develop the gait rehabilitation equipment that judge patient's movement of his/her center of gravity using pressure sensors, and to aid hemiplegic patients to balance themselves using an automatic stepper that changes the patient's center of gravity. It is hard to bear the weight on the affected side for hemiplegic patients. The gait rehabilitation equipment detects the footing phase of hemiplegic patient during training and moves the unaffected footing side of the stepper up and moves the affected footing side down simultaneously so that the patient's center of gravity can shift from unaffected side to affected side. The gait rehabilitation system was developed and applied for hemiplegic patients during exercise. Eight hemiplegic patients and one normal adult were studied. The developed gait rehabilitation system could judge not only the normal adult's intention but also the patient's intention to move his/her center of gravity. Even though the most of hemiplegic patients exercised in automatic mode and a few hemiplegic patients exercised in manual mode, the developed gait rehabilitation system can aid the hemiplegic patients to train more easily.

The Thermal Stability Analysis of Fumes and Mists During the Drying Process of a PCB (PCB 건조공정의 흄과 미스트에 대한 열안정성 분석)

  • Chu, Chang Yeop;Lee, Jung Suk;Baek, Jong Bae
    • Journal of the Korean Society of Safety
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    • v.34 no.4
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    • pp.32-40
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    • 2019
  • During the manufacturing process of a printed circuit board(PCB), fumes and mists are generated as the ink dries on the PCB surface. The generated fumes and mists are deposited in the dryer wall and the exhaust duct. Deposited fumes and mists may present a fire hazard if the dryer temperature control system fails. In this study, the thermal stability of the fumes and mists deposited in the dryer and ducts has been analyzed by experimental methods such as thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), auto ignition temperature (AIT), and multiple mode calorimetry(MMC). According to the experimental analyses, experimental samples are likely to generate gas at the temperature ($180{\sim}240^{\circ}C$) that deviates from the normal operating temperature ($150{\sim}156^{\circ}C$). It has been shown that the thermal stability is degraded when the temperature is deviated from the normal operating temperature. In the end, engineering and management safety measures of accidental prevention have been suggested.

Effect of prior cesarean delivery on the outcomes of intracytoplasmic sperm injection

  • Suzan Atteya Gewida;Mohamed Salah Eldeen Abd Rabbo;Mohammed Abd Elmoety El Samra;Hesham Mahmoud Adel Abdel Moneim
    • Clinical and Experimental Reproductive Medicine
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    • v.51 no.1
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    • pp.63-68
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    • 2024
  • Objective: This study was conducted to investigate the impact of previous delivery mode on pregnancy outcomes in patients with secondary infertility after frozen-thawed embryo transfer. Methods: This prospective observational study included 140 patients experiencing secondary infertility. Of these, 70 patients had a previous cesarean delivery (CD), while the remaining 70 patients had a previous normal vaginal delivery (NVD). The primary outcome was the implantation rate. The secondary outcomes included rates of clinical pregnancy, chemical pregnancy, miscarriage, and ectopic pregnancy. Results: The comparison of all fertility outcomes between the two groups revealed no statistically significant differences. The implantation rate was 40.4% in the CD group and 41.7% in the NVD group (p=0.842). The clinical pregnancy rate was 50% in the CD group and 49.3% in the NVD group (p=0.932), while the chemical pregnancy rate was 14.6% in the CD group and 19% in the NVD group (p=0.591). The miscarriage rates in the CD and NVD groups were 20% and 17.6%, respectively (p=0.803). One case of tubal ectopic pregnancy occurred in the NVD group (1.4%). Conclusion: The mode of prior delivery did not significantly impact pregnancy outcomes following frozen-thawed embryo transfer.

Research on the Factors Influencing College Students' Wsillingness to sParticipate in Sports Online Competitions

  • Rui Liu;Myeong-Cheol Choi
    • International Journal of Advanced Culture Technology
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    • v.12 no.3
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    • pp.345-354
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    • 2024
  • The sports cloud competition based on the network online platform breaks through the limitation of the time and space of traditional sports competition, changes the competitive environment and mode of sports competition, and is a new mode of sports competition. The detailed possibility model has been widely used in the study of information processing and attitude change. In order to better explore the sports cloud competition, we take 463 college students in Lingnan Normal University as the survey object based on the concept of detailed possibility model, and collects data through a pre-compiled questionnaire, so as to obtain the factors that affect the willingness of college students to participate in sports cloud competition, and explore the possibility of promoting sports cloud competition. Our results show that the convenience characteristics of the central path level are important factors for college students to participate in sports cloud competitions, and the credits, examinations and exercises at the edge path level can become important factors for college students to participate in sports cloud competitions, which play a positive role in promoting college students' participation in sports cloud competitions and are conducive to the promotion and application of sports cloud competitions.

Wind-sand coupling movement induced by strong typhoon and its influences on aerodynamic force distribution of the wind turbine

  • Ke, Shitang;Dong, Yifan;Zhu, Rongkuan;Wang, Tongguang
    • Wind and Structures
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    • v.30 no.4
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    • pp.433-450
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    • 2020
  • The strong turbulence characteristic of typhoon not only will significantly change flow field characteristics surrounding the large-scale wind turbine and aerodynamic force distribution on surface, but also may cause morphological evolution of coast dune and thereby form sand storms. A 5MW horizontal-axis wind turbine in a wind power plant of southeastern coastal areas in China was chosen to investigate the distribution law of additional loads caused by wind-sand coupling movement of coast dune at landing of strong typhoons. Firstly, a mesoscale Weather Research and Forecasting (WRF) mode was introduced in for high spatial resolution simulation of typhoon "Megi". Wind speed profile on the boundary layer of typhoon was gained through fitting based on nonlinear least squares and then it was integrated into the user-defined function (UDF) as an entry condition of small-scaled CFD numerical simulation. On this basis, a synchronous iterative modeling of wind field and sand particle combination was carried out by using a continuous phase and discrete phase. Influencing laws of typhoon and normal wind on moving characteristics of sand particles, equivalent pressure distribution mode of structural surface and characteristics of lift resistance coefficient were compared. Results demonstrated that: Compared with normal wind, mesoscale typhoon intensifies the 3D aerodynamic distribution mode on structural surface of wind turbine significantly. Different from wind loads, sand loads mainly impact on 30° ranges at two sides of the lower windward region on the tower. The ratio between sand loads and wind load reaches 3.937% and the maximum sand pressure coefficient is 0.09. The coupling impact effect of strong typhoon and large sand particles is more significant, in which the resistance coefficient of tower is increased by 9.80% to the maximum extent. The maximum resistance coefficient in typhoon field is 13.79% higher than that in the normal wind field.

Receiver-centric Buffer Blocking-aware Multipath Data Distribution in MPTCP-based Heterogeneous Wireless Networks

  • Cao, Yuanlong;Liu, Qinghua;Zuo, Yi;Ke, Fenfen;Wang, Hao;Huang, Minghe
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.10 no.10
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    • pp.4642-4660
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    • 2016
  • One major concern of applying Multipath TCP (MPTCP) to data delivery in heterogeneous wireless networks is that the utilization of asymmetric paths with diverse networking-related parameters may cause severe packet reordering and receive buffer blocking (RB2LOC). Although many efforts are devoting to addressing MPTCP's packet reordering problems, their sender-controlled solutions do not consider balancing overhead between an MPTCP sender and receiver, and their fully MPTCP mode cannot make MPTCP achieve a desired performance. This paper proposes a novel receiver-centric buffer blocking-aware data scheduling strategy for MPTCP (dubbed MPTCP-rec) necessitating the following aims: (1) alleviating MPTCP's packet reordering and RB2LOC problems, (2) improving the MPTCP performance, and (3) balancing load between the MPTCP sender and receiver. Simulation results show that the proposed MPTCP-rec solution outperforms the existing MPTCP solutions in terms of data delivery performance in heterogeneous wireless networks.

A transient CFD simulation of ventilation system operation for smoke control in a subway station equipped with a Platform Screen Door(PSD) when a train under fire is approaching the station (화재열차의 역사 접근 시 PSD가 설치된 역사 제연을 위한 환기장치 운전 비정상상태 해석)

  • Shin, Kyu-Ho;Hur, Nahm-Keon;Won, Chan-Shik
    • 유체기계공업학회:학술대회논문집
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    • 2006.08a
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    • pp.269-272
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    • 2006
  • The heat and smoke which generated by subway under fire is one of the most harmful factor in air tighten underground station. To prevent this, Trackway Exhaust System(TES) can be used. The heat released from the train running in the tunnel raises the temperature at the platform and the trackway, and thus proper ventilation system is required for comfortable underground environment. When the fire is occurred, TES is operated as smoke exhaust mode from normal ventilation mode. In the present study, the subway station which is one of the line number 9 in Seoul subway is modeled, and fired situation is simulated with several ventilation mode of ventilation system in trackway. For this simulation whole station is modeled. Non steady state 3D simulation which considered train under fire is entering to the station is performed. Temperature and smoke distribution in platform and trackway are compared. To represent heat by fire, heat flux was given to the fired carriage, also to describe smoke by fire, concentration of CO is represented. As the result of present study, temperature and smoke distribution is different as the method of ventilation in trackway and platform is changed. In over side of trackway, the fan must be operated as exhaust mode for efficient elimination of heat and smoke, and supply mode of fan operation in under side shows better distribution of heat and smoke. The ventilation system which is changed from ventilation mode to exhaust mode can be applied to control heat and smoke under fire.

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