• 생약학회지
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• 제37권1호통권144호
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• pp.60-66
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• 2006

Norditerpene alkaloids are the main toxic principles of traditional oriental herb 'chuawu(bu-shi),' which have been used in Chinese materia medica mainly for the treatment of musculoskeletal disorders. They are biosynthesized via cyclization of geranylgeranyl pyrophosphate, incoration of 2-aminoethanol and decarboxylation not via amino acid pathway, and the structural characteristics have tempted several oxidative reactions. In this study various norditerpene alkaloids were subjected to react active manganese dioxide and oxoammonium salt as oxidants. The oxidation was proceeded as dealkylation with aconitine type and dehydrogenations with lycoctonin and heteratisine type.

• 생약학회지
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• 제35권2호통권137호
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• pp.128-133
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• 2004

Aconitum triphyllum Nakai, the Korean spontaneous perennial herb, is one of the most important materials of oriental drug Fu-zi(aconite) and has long been used as cardiotonic for arrhythmia, analgesic and antiinflammatory drug in oriental countries. Although the plant is widely used for the preparation of aconite, the composition and amount of the toxic aconitine type alkaloids have not studied so far. As the preliminary study for seasonal variation of major constituents in mother tuber and daughter tuber of the plant, the authors tried to elucidate phytochemical characteristics of $C_{19}-diterpenoid alkaloids by $^{13}C-NMR$ spectra and seasonal variation of the alkaloidal contents by high performance liquid chromatography.