• Communications for Statistical Applications and Methods
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• 제27권6호
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• pp.701-714
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• 2020

Quantitative high throughput screening (qHTS) assays are used to assess toxicity for many chemicals in a short period by collectively analyzing them at several concentrations. Data are routinely analyzed using nonlinear regression models; however, we propose a new method to analyze qHTS data using a nonlinear mixed effects model. qHTS data are generated by repeating the same experiment several times for each chemical; therefor, they can be viewed as if they are repeated measures data and hence analyzed using a nonlinear mixed effects model which accounts for both intra- and inter-individual variabilities. Furthermore, we apply a one-step approach incorporating robust estimation methods to estimate fixed effect parameters and the variance-covariance structure since outliers or influential observations are not uncommon in qHTS data. The toxicity of chemicals from a qHTS assay is classified based on the significance of a parameter related to the efficacy of the chemicals using the proposed method. We evaluate the performance of the proposed method in terms of power and false discovery rate using simulation studies comparing with one existing method. The proposed method is illustrated using a dataset obtained from the National Toxicology Program.

• Structural Engineering and Mechanics
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• 제24권5호
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• pp.543-560
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• 2006

In this paper, first, the equations of motion for a rectangular isotropic plate have been derived. This derivation is based on the Von Karmann theory and the effects of shear deformation have been considered. Introducing an Airy stress function, the equations of motion have been transformed to a nonlinear coupled equation. Using Galerkin method, this equation has been separated into position and time functions. By means of the dimensional analysis, it is shown that the orders of magnitude for nonlinear terms are small with respect to linear terms. The Multiple Scales Method has been applied to the equation of motion in the forced vibration and free vibration cases and closed-form relations for the nonlinear natural frequencies, displacement and frequency response of the plate have been derived. The obtained results in comparison with numerical methods are in good agreements. Using the obtained relation, the effects of initial displacement, thickness and dimensions of the plate on the nonlinear natural frequencies and displacements have been investigated. These results are valid for a special range of the ratio of thickness to dimensions of the plate, which is a characteristic of the Multiple Scales Method. In the forced vibration case, the frequency response equation for the primary resonance condition is calculated and the effects of various parameters on the frequency response of system have been studied.

• Structural Engineering and Mechanics
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• 제73권5호
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• pp.565-584
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• 2020

The nonlinear thermo-electro-elastic buckling behavior of viscoelastic nanoplates under magnetic field is investigated based on nonlocal elasticity theory. Employing nonlinear strain-displacement relations, the geometrical nonlinearity is modeled while governing equations are derived through Hamilton's principle and they are solved applying semi-analytical generalized differential quadrature (GDQ) method. Eringen's nonlocal elasticity theory considers the effect of small size, which enables the present model to become effective in the analysis and design of nano-sensors and nano actuators. Based on Kelvin-Voigt model, the influence of the viscoelastic coefficient is also discussed. It is demonstrated that the GDQ method has high precision and computational efficiency in the buckling analysis of viscoelastic nanoplates. The good agreement between the results of this article and those available in literature validated the presented approach. The detailed mathematical derivations are presented and numerical investigations are performed while the emphasis is placed on investigating the effect of the several parameters such as electric voltage, small scale effects, elastomeric medium, magnetic field, temperature effects, the viscidity and aspect ratio of the nanoplate on its nonlinear buckling characteristics. It is explicitly shown that the thermo-electro-elastic nonlinear buckling behavior of viscoelastic nanoplates is significantly influenced by these effects. Numerical results are presented to serve as benchmarks for future analyses of viscoelastic nanoplates as fundamental elements in nanoelectromechanical systems.

• Structural Engineering and Mechanics
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• 제70권5호
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• pp.601-621
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• 2019

This study presents a comprehensive nonlinear dynamic approach to investigate the linear and nonlinear vibration of sandwich plates fabricated from functionally graded materials (FGMs) resting on an elastic foundation. Higher-order shear deformation theory and Hamilton's principle are employed to obtain governing equations. The Runge-Kutta method is employed together with the commercially available mathematical software MAPLE 14 to solve the set of nonlinear dynamic governing equations. Method validity is evaluated by comparing the results of this study and those of previous research. Good agreement is achieved. The effects of temperature change on frequencies are investigated considering various temperatures and various volume fraction index values, N. As the temperature increased, the plate frequency decreased, whereas with increasing N, the plate frequency increased. The effects of the side-to-thickness ratio, c/h, on natural frequencies were investigated. With increasing c/h, the frequencies increased nonlinearly. The effects of foundation stiffness on nonlinear vibration of the sandwich plate were also studied. Backbone curves presenting the variation of maximum displacement with respect to plate frequency are presented to provide insight into the nonlinear vibration and dynamic behavior of FGM sandwich plates.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2001년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall 2001
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• pp.235-242
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• 2001

Inelastic seismic response of steel moment frame structures, which are usually quite gravity load and subject to large displacement under severe earthquake, may be severly influenced by the structure P-Δ effects. The P-Δ effect may have an important impact on the dynamic behavior of the structure in the nonlinear seismic analysis. In multi degree of freedom systems P-Δ effects may significantly affect only a subset of stories or a single story alone. Therefore, a story drift amplification of structure is happened by P-Δeffects and such nonlinear dynamic behaviors are very difficult to evaluate in the structures. In this study, two systems having different design methods of steel moment frame structures are investigated to evaluate the P-Δ effects due to gravity load. The plastic hinge formations, maximum rotational ductility demands, and energy distribution will be compared and evaluated following whether the P-Δ effects are considered or not. And design methods are proposed for the prevention of the instability of structures which due to the P-Δ effects.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
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• pp.391-394
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• 1996

The effects of time-sampling on nonlinear output regulation problem is investigated. Output regulatedness is preserved under time sampling as in linear systems, however output regulatability is not robust with respect to time-sampling, and thus one needs to seek an approximate nonlinear sampled-data output regulator.

• Geomechanics and Engineering
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• 제32권2호
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• pp.125-135
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• 2023

Nonlinear vibration analysis of composite beam reinforced by carbon nanotubes resting on the nonlinear viscoelastic foundation is investigated in this study. The material properties of the composite beam is considered as a polymeric matrix by reinforced carbon nanotubes according to different distributions. With using Hamilton's principle, the governing nonlinear partial differential equations are derived based on the Euler-Bernoulli beam theory. In the nonlinear kinematic assumption, the Von Kármán nonlinearity is used. The Galerkin's decomposition technique is utilized to discretize the governing nonlinear partial differential equation to nonlinear ordinary differential equation and then is solved by using of multiple time scale method. The nonlinear natural frequency and the nonlinear free response of the system is obtained. In addition, the effects of different patterns of reinforcement, linear and nonlinear damping coefficients of the viscoelastic foundation on the nonlinear vibration responses and phase trajectory of the carbon nanotube reinforced composite beam are investigated.

• Steel and Composite Structures
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• 제21권5호
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• pp.1121-1144
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• 2016

This paper presents a displacement-based finite element procedure for second-order distributed plasticity analysis of planar steel frames with semi-rigid beam-to-column connections under static loadings. A partially strain-hardening elastic-plastic beam-column element, which directly takes into account geometric nonlinearity, gradual yielding of material, and flexibility of semi-rigid connections, is proposed. The second-order effects and distributed plasticity are considered by dividing the member into several sub-elements and meshing the cross-section into several fibers. A new nonlinear solution procedure based on the combination of the Newton-Raphson equilibrium iterative algorithm and the constant work method for adjusting the incremental load factor is proposed for solving nonlinear equilibrium equations. The nonlinear inelastic behavior predicted by the proposed program compares well with previous studies. Coupling effects of three primary sources of nonlinearity, geometric imperfections, and residual stress are investigated and discussed in this paper.

• 대한조선학회지
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• 제22권3호
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• pp.1-8
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• 1985

In this paper, the motion response and wave load of a container ship are treated by a nonlinear motion theory, which is similar to that used by Yamamoto et. al.[1]. This paper deals with the vertical motion response in oblique waves and the effect of the Smith correction in buoyancy force calculation. In the present computation, for S-175 container ship model our result also shows that the ratio of the motion peak to peak value to the wave height decreases as the wave height increases, which was obtained earlier by Yamamoto et.al.[3]. On the other hand the nondimensional midship bending moment increases as the wave height increases. These nonlinear effects are dominant near the resonance frequency, and depend on the hull form and forward speed. However, it is found that these nonlinear effects are significant for tanker model.

• Geomechanics and Engineering
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• 제11권1호
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• pp.95-116
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• 2016

A novel higher order shear-deformable beam model, which provides linear variation of transversal normal strain and quadratic variation of shearing strain, is proposed to describe the beam resting on foundation. Then, the traditional two-parameter Pasternak foundation model is modified to capture the effects of the axial deformation of beam. The Masing's friction law is incorporated to deal with nonlinear interaction between the foundation and the beam bottom, and the nonlinear properties of the beam material are also considered. To solve the mathematical problem, a displacement-based finite element is formulated, and the reliability of the proposed model is verified. Finally, numerical examples are presented to study the effects of the interfacial friction between the beam and foundation, and the mechanical behavior due to the tensionless characteristics of the foundation is also examined. Numerical results indicate that the effects of tensionless characteristics of foundation and the interfacial friction have significant influences on the mechanical behavior of the beam-foundation system.