• 한국환경보건학회지
• /
• 제32권5호
• /
• pp.412-417
• /
• 2006

A self-administrated non-malignant respiratory symptoms questionnaire was sent to 1,099 citizens who take subway running in Seoul city. Symptom prevalence rate was high: 70.6% of subjects reported 'chest tightness', 43.4%, 'dysphnea'; 76.2%, 'dry cough'; 49.5%, 'runny nose'; 94.4%, 'drowsiness' when they take subway. The groups responding significant higher respiratory and drowsiness symptoms were 'young passengers' (vs elderly passengers), 'the female' (vs male), 'using subway everyday' (vs often), 'using subway for rush-hour time' (vs other than rush-hour), 'using transfer subway' (no transfer), 'using underground track' (vs ground track). Logistic. regression model was employed to find personal and subway characteristics affecting non-malignant respiratory symptoms. This study concluded that respiratory diseases history such as asthma, rhinitis, sinusitis, hypersensitivity pneumonitis significantly affect 'dry cough' and 'runny nose'. Thus, passengers with respiratory diseases history shows 2.8 times greater 'dry cough' than and 3.4 times greater 'runny nose' than those passengers without respiratory diseases history felt. This results indicated that several measures have to take to protect sensitive groups such as passengers with respiratory diseases, children and elderly people. Also passenger who use to transfer shows 1.7 times higher runny nose symptoms than that passenger who do not transfer felt.

• 한국산업보건학회지
• /
• 제17권1호
• /
• pp.1-12
• /
• 2007

We have reviewed all cases and epidemiological studies that have reported the association between worker's exposure to metalworking fluids(MWF) and non-malignant respiratory diseases. The followings are main conclusions we critically reviewed. Exposure to MWF was believed to be significantly related to the risk of cough and phlegm. Relative risk caused by straight MWF was found to be higher in exposure to straight MWF than water-soluble MWF. We also found that exposure to water-soluble MWF significantly caused hypersensitivity pneumonitis (HP) and occupational asthma. The main culprits that cause the development of HP and asthma are believed to be microbes contaminated in MWF, ethanolamine and biocides. HP and asthma could be developed at even exposure to lower than $0.5mg/m^3$, exposure level recommended by NIOSH. Most epidemiological studies have reported that relationship between chronic bronchitis and exposure to MWF was significant. Although there were several studies that suggested the significant association between exposure to MWF and the development of rhinitis and sinusitis, we could not conclude the causal relationship because of lack of evidences.

• Tuberculosis and Respiratory Diseases
• /
• 제78권3호
• /
• pp.272-275
• /
• 2015

Malignant melanoma occurs most frequently on the skin. However, it can also arise in other organs and tissues of the body. Primary pulmonary malignant melanoma is a very rare non-epithelial neoplasm accounting for 0.01% of all primary pulmonary tumors. The treatment of choice is surgical resection of the tumor with an oncologically adequate margin as in lobectomy or pneumonectomy. The prognosis of this condition is rather poor. Based on previous data, its 5-year survival is at least 10%. Here, we report a case of an 82-year-old woman whose primary pulmonary melanoma was detected incidentally.

• Tuberculosis and Respiratory Diseases
• /
• 제57권2호
• /
• pp.148-159
• /
• 2004

연구 배경 : 본 연구는 비외상성 객혈을 주소로 내원한 환자에서 기관지 동맥 색전술의 생존 효과를 파악하고자 시행하였다. 방 법 : 환자에 대한 임상적인 정보는 의무기록, 전자처방기록(Order Communication System), 방사선 기록 등을 통하여 수집하였으며, 사망 관련 정보는 통계청 사망 자료를 통하여 획득하였다. 전체 환자를 최대 2년 동안 관찰하였으며, 기관지 동맥 시행 여부에 따라 시행군과 비시행군 등 두 군으로 나누어 관련 요인별로 생존과 사망에 대한 단변량 분석을 시행하였다. 기관지 동맥 색전술 시행 여부로 층화하여 Kaplan-Meier 생존곡선을 구한 후, 관련 요인을 보정하여 Cox-proportio-nal hazard regression analysis를 시행하여 기관지 동맥 색전술에 따른 생존 효과를 평가하였다. 결 과 : 대상 환자는 총 272명으로 이 중 기관지 동맥 색전술을 시행 받은 환자는 63명, 시행 받지 않은 환자는 209명이었으며, 원인 질환별로 악성 폐종양군은 69명, 양성 만성 폐질환군은 149명, 기타 질환군은 54명이었고 이 중 2년 이내에 사망한 경우는 69명이었다. 전체 환자를 대상으로, 그리고 악성 폐종양군, 양성 만성 질환군 등 세부 군을 대상으로 기관지 동맥 색전술의 생존효과를 평가하였을 때, 유의한 결과를 보여주지 않았다. 결 론 : 2년 동안의 관찰 기간 동안, 비외상성 객혈환자에서 기관지 동맥 색전술은 유의한 생존 효과를 보여주지 못하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권4호
• /
• pp.2443-2446
• /
• 2013

Published data have shown that the levels of vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sVEGFR-1) in plasma and pleural effusion might be usefulness for lung cancer diagnosis. Here, we performed a prospective study to investigate the utility of VEGF and sVEGFR-1 in bronchoalveolar lavage fluid (BALF) for differential diagnosis of primary lung cancer. A total of 56 patients with solitary pulmonary massed by chest radiograph or CT screening were enrolled in this study. BALF and plasma samples were obtained from all patients and analyzed for VEGF and sVEGFR-1 using a commercially available sandwich ELISA kit. The results showed that the levels of VEGF in BALF were significantly higher in patients with a malignant pulmonary mass compared with patients with a benign mass (P < 0.001). However, no significant difference of sVEGFR-1 in BALF was found between malignant and non-malignant groups (P = 0.43). With a cut-off value of 214 pg/ml, VEGF showed a sensitivity and specificity of 81.8% and 84.2%, respectively, in predicting the malignant nature of a solitary pulmonary mass. Our study suggests that VEGF is significantly increased in BALF among patients with lung cancer than in benign diseases. Measurement of VEGF in BALF might be helpful for differential diagnosis of primary lung cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권11호
• /
• pp.5551-5556
• /
• 2012

Cytological examination is widely used as a diagnostic tool because of the ease of collecting cells from the involved area. However, the diagnostic yield of cytological examination is unsatisfactory; the reasons include sampling error, poorly prepared samples, small numbers of malignant cells, and low grades of cellular atypia. In this study, we focused on the high infectivity of adenovirus towards epithelial cells and applied the luciferase-expressing adenoviral vector to a new cancer cell detection tool. In addition, adenoviral infectivity was enhanced by modifying viral fiber proteins. The sensitivity of the diagnostic tool was tested using the NCI-H1299 lung cancer cell line, and validated in body fluid samples from cancer patients with a variety of etiology. Results showed that the adenovirus efficiently transfected NCI-H1299 with high sensitivity. Only 10 cancer cells were sufficient for detection of luciferase signals. In body fluid samples, the adenovirus confirmed the diagnosis for malignant and benign cancer, but not in non-epithelial cell derived samples. This study provides proof-of-concept for a more reliable and sensitive diagnostic tool for epithelium-derived cancer.

• Tuberculosis and Respiratory Diseases
• /
• 제77권4호
• /
• pp.188-192
• /
• 2014

We present a case of an unusual infectious complication of a ruptured mediastinal abscess after endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), which led to malignant pleural effusion in a patient with stage IIIA non-small-cell lung cancer. EBUS-TBNA was performed in a 48-year-old previously healthy male, and a mediastinal abscess developed at 4 days post-procedure. Video-assisted thoracoscopic surgery was performed for debridement and drainage, and the intraoperative findings revealed a large volume pleural effusion that was not detected on the initial radiographic evaluation. Malignant cells were unexpectedly detected in the aspirated pleural fluid, which was possibly due to increased pleural permeability and transport of malignant cells originating in a ruptured subcarinal lymph node from the mediastinum to the pleural space. Hence, the patient was confirmed to have squamous cell lung carcinoma with malignant pleural effusion and his TNM staging was changed from stage IIIA to IV.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권17호
• /
• pp.7029-7035
• /
• 2014

Certain types of human papillomaviruses (HPVs) are undoubtedly involved in genesis of human malignancies. HPV plays an etiological role in cervical cancer, but also in many vaginal, vulvar, anal and penile cancers, as well as head and neck cancers. In addition, a number of non-malignant diseases such as genital warts and recurrent respiratory papillomatosis are attributable to HPV. Moreover, HPV forms have detected in several other cancers including esophageal squamous cell carcinoma, lung, prostate, ovarian, breast, skin, colorectal and urinary tract cancers, but associations with etiology in these cases is controversial. The aim of this systematic assessment was to estimate the prevalence of HPV infection and HPV types in HPV-associated cancers, HPV-related non-malignant diseases and in cancers that may be associated with HPV in Iran. The present investiagtion covered 61 studies on a variety of cancers in Iranian populations. HPV prevalence was 77.5 % and 32.4% in cervical cancer and head and neck cancers, respectively. HPV was detected in 23.1%, 22.2%, 10.4%, 30.9%, 14% and 25.2% of esophageal squamous cell, lung, prostate, urinary tract cancers, breast and skin cancers, respectively. HPV16 and 18 were the most frequent HPV types in all cancers. The findings of present study imply that current HPV vaccines for cervical cancer may decrease the burden of other cancers if they are really related to HPV.

• Tuberculosis and Respiratory Diseases
• /
• 제40권2호
• /
• pp.192-196
• /
• 1993

저자들은 10일간의 우측 흉통을 주소로 내원한 17세 남자환자에서 흉벽에 발생한 악성 T 세포형 임파종 1예를 경험 하였기에 문헌 고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
• /
• 제45권5호
• /
• pp.1031-1038
• /
• 1998

목 적: 악성 종양과 연관된 흉막삼출에서 혈액상을 보이는 빈도를 확인하고 혈액상 여부와 세포진 검사나 흉막조직 검사의 양성률 그리고 흉막액 CEA 양성률과의 연관 관계를 확인해 보고자 하였다. 또한 일반적으로 흉막액 CEA의 증가는 세포진 양성률과 밀접한 연관관계를 보인다고 하는데, 이에 대한 의미를 재조명하고자 하였다. 방 법: 1995년 3월부터 1996년 12월까지 연세대학교 의과 대학 세브란스 병원에서 악성 종양으로 진단된 환자중 흉막삼출이 발생한 98예를 대상으로 흉막액의 통상검사(pH, cell count, glucose, protein, LDH)와 함께 흉막액의 외견, 적혈구 수, CEA, 그리고 세포 조직학적 검사를 시행하였다. 결 과: 악성 종양과 연관된 흉막삼출의 44.9%에서 혈액상이었고 55.1%에서 장액상으로 나타났다. 흉막액의 적혈구 수가 $100,000/mm^3$ 이상 증가된 경우 흉막액 세포진 검사의 양성률은 42.8%였으며 흉막액의 적혈구수와 흉막액 세포진 검사의 양성률 그리고 CEA 양성률 등의 상호간에 연관관계는 없었다. 세포조직검사장 확진된 악성 흉막삼출의 경우 흉막액 CEA는 72.7%에서 10ng/ml 이상으로 증가된 소견을 보였고, 흉막액 CEA가 10ng/ml 이상으로 증가된 경우 새포조직검사의 양성률은 58.2%였다. 종양 진단후 흉막액이 발현되기까지의 기간과 흉막액 세포진 검사의 양성률, 흉막액 CEA의 양성률, 그리고 흉막액 적혈구수 등의 상호간에 연관관계를 발견할 수 없었다. 결 론: 소견을 악성 종양과 연관된 흉막삼출의 44.9%에서 혈액상보였으며 흉막액내 적혈구 수의 증가와 세포조직학적 검사의 양성률이나 CEA의 양성률간에 유의한 상관관계는 없었다. 흉막액 CEA의 측정은 세포조직학적인 양성률과 일치하지는 않았지만 일부 비종양성 흉막삼출에 의한 증가를 임상적으로 배제하면 흉막생검, 세포진 검사와 함께, 악성 흉막삼출의 진단적 접근에서 보조적인 역할을 감당할 수 있을 것으로 생각된다.