• Journal of the Korean association of regional geographers
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• v.14 no.5
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• pp.492-506
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• 2008

This paper aims to explore the characteristics of regional network of Korean firms in Dalian City, China, which is focused on social, cultural and institutional characteristics. To achieve this goal, the paper attempts to analyze the supply of raw material and parts, sales and cooperative relations of the firms. Among Korean firms in Dalian City, the characteristic of non-local network can be seen in supply enterprise of raw material, parts and semi products. On the other hand, a tighter local network relationship can be seen in sales. Large companies appear stronger in non-local network than small businesses and small businesses are stronger in local network. In terms of cooperation among enterprises, many firms have networks of joint marketing, joint use of equipments, exchange of techniques and information with the supply enterprise. With the customer enterprise, there is a network in joint marketing and manpower training. Especially, most of the customer enterprises are Chinese ones, which have extensive networks in big cities, such as in Beijing, Shanghai, Guangzhou, Tianjin and Dalian. In local network, the Korean firms in Dalian cooperate in product development, finance and manpower training with local firms. And in non-local cooperation, Korean firms are active in tech support, information exchange and R&D.

• Journal of Practical Engineering Education
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• v.13 no.3
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• pp.559-566
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• 2021

The aggregate gradation analysis is a study that evaluates the accuracy of a specific purpose for the aggregate gradation analysis results essential for construction-related major education. This study is to evaluate the effect of aggregate moisture content on aggregate gradation analysis. The change in the moisture content of the aggregate stored in the asphalt plant cold bin and stock piles was monitored for one year, and based on the results, a sample of aggregate with different moisture content was produced. The gradation curve for each aggregate sample was analyzed to evaluate the effect of aggregate moisture content on aggregate gradation analysis. As a result of the gradation evaluation, it was confirmed that as the moisture content increased, the particle size error for particles less than 5 mm increased in the gradation analysis of the oven-dried aggregate, and this error increased as the particle size decreased. In addition, for aggregate particles of 5 mm or more, it was confirmed that the error in gradation analysis rapidly decreased due to the increase in the moisture content. An analysis was performed on the effect of the error in gradation analysis on the management of hot-bin aggregates in asphalt plants. As a result of the analysis, it was found that the minimum aggregate size of the first hot-bin in a general asphalt plant was 2.38 mm or more, so the maximum gradation error due to the non oven-dry aggregate was less than 2%. Therefore, it seems possible to use the results of the gradation analysis of cold bin non oven-dry aggregate for quality management of asphalt mixture production.

• Journal of Veterinary Science
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• v.25 no.1
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• pp.15.1-15.15
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• 2024

Background: The anti-programmed death 1 (PD-1) antibody has led to durable clinical responses in a wide variety of human tumors. We have previously developed the caninized anti-canine PD-1 antibody (ca-4F12-E6) and evaluated its therapeutic properties in dogs with advance-staged oral malignant melanoma (OMM), however, their therapeutic effects on other types of canine tumors remain unclear. Objective: The present clinical study was carried out to evaluate the safety profile and clinical efficacy of ca-4F12-E6 in dogs with advanced solid tumors except for OMM. Methods: Thirty-eight dogs with non-OMM solid tumors were enrolled prospectively and treated with ca-4F12-E6 at 3 mg/kg every 2 weeks of each 10-week treatment cycle. Adverse events (AEs) and treatment efficacy were graded based on the criteria established by the Veterinary Cooperative Oncology Group. Results: One dog was withdrawn, and thirty-seven dogs were evaluated for the safety and efficacy of ca-4F12-E6. Treatment-related AEs of any grade occurred in 13 out of 37 cases (35.1%). Two dogs with sterile nodular panniculitis and one with myasthenia gravis and hypothyroidism were suspected of immune-related AEs. In 30 out of 37 dogs that had target tumor lesions, the overall response and clinical benefit rates were 6.9% and 27.6%, respectively. The median progression-free survival and overall survival time were 70 days and 215 days, respectively. Conclusions: The present study demonstrated that ca-4F12-E6 was well-tolerated in non-OMM dogs, with a small number of cases showing objective responses. This provides evidence supporting large-scale clinical trials of anti-PD-1 antibody therapy in dogs.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2465-2472
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• 2014

Background: The American Joint Committee on Cancer (AJCC) published a new staging system ($7^{th}$ edition) in 2009. In our study, we evaluated the survival results and prognostic factors among T4 local advanced non-small cell lung cancer (LA-NSCLC) patients in a large heterogeneous group, in accordance with this new system. Materials and Methods: We retrospectively evaluated the files of 122 T4 N0-3 M0 LA-NSCLC patients, identified according to the new staging system, treated at two centers between November 2003 and June 2012. Variables correlating with univariate survival at p<0.20 were later included in multivariate Cox regression analysis. Here, selection of relevant predictors of survival was carried out in accordance with the likelihood ratio formula with p<0.05 regarded as significant. Results: The median age was 60 and the median follow-up period was 17.4 months. Median overall survival (OS) was 18.3 months, the 1 year overall survival (OS) rate was 72%, and the 5 year OS rate was 28%. Statistically significant predictors of survival were (p<0.20) ECOG-PS (Eastern Cooperative Oncology Group Performance Status), age, T4 factor subgroup, stage and primary treatment in OS univariate analysis. On multivariate analysis for OS ECOG-PS (p=0.001), diagnostic stage (p=0.021), and primary treatment (p=0.004) were significant. In the group receiving non-curative treatment, the median OS was 11.0 months, while it was 19.0 months in the definitive RT group and 26.6 months in the curative treatment group. There was a significant difference between the non-curative group and the groups which had definitive RT and curative operations (respectively p<0.001 and p=0.001) in terms of OS, but not between the groups which had definitive RT and curative operations. The median event free survival (EFS) rate was 9.9 months, with rates of 46% and 19% at 3 and 5 years, respectively. On univariate analysis of EFS rate with ECOG-PS, weight loss and staging, statistical significance was found only for thorax computerized tomography (CT)+18F-fluorodeoxy-glucose positron emission tomography-CT (PET-CT) use, stage and primary treatment (p<0.20). In multivariate analysis with EFS, only the primary treatment was statistically significant (p=0.001). In the group receiving non-curative treatment, the median EFS was 10.5 months while in the curative operation group it was 14.7 months. When all the primary treatment groups were taken into consideration, grade III/IV side effect swas observed in 57 patients (46.6%). Esophagitis was most prominent among those that received definitive radiotherapy. Conclusions: Independent prognostic factors among these 122 heterogeneous LA-NSCLC T4 N0-3 M0 patients were age at diagnosis, ECOG-PS, stage and primary treatment, the last also being a significant prognostic indicator of EFS. Our findings point to the importance of appropriate staging and a multidisciplinary approach with modern imaging methods in this patient group. In those with T4 lesions, treatment selection and the effective use of curative potential should be the most important goal of clinical care.

• Journal of the Korean School Mathematics Society
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• v.11 no.1
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• pp.1-18
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• 2008

This study aims to provide answers to two questions regarding the supervision of pre-service mathematics teachers: 'Who should carry out the work of supervision?' and 'How can it most skillfully be done?' The answer to the first question seems to be that, for a variety of reasons, university teachers and mentors appear best suited to do the supervision in a cooperative relationship with pre-service teachers. The assumption that seems to underlie the collaborative supervision is that field-based experiences are necessary and useful components of professional development in pre-service teacher preparation programs. With respect to the second question, it is suggested that a non-judgemental approach should be considered, along with strategies and techniques for judgemental supervision, as a way to make math teacher supervision more meaningful and helpful for the improvement of teaching and long-term professional development. It is hoped that a continued exploration of models of teacher supervision and evaluation of their effectiveness will help pre-service math teachers, supervisors and mentors learn more about teaching and improve their own teaching.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.05a
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• pp.747-749
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• 2012

This paper is analyzing the SoC policy of major nations as the U.S, Japan, Europe, Taiwan, China and draw the suggestions for the development of semiconductor industry in Korea. SoC is the non-memory semiconductor to support and put into action the function of system. SoC is big market over the 200billion dollars and have a huge potential for new IT convergence market. Developed countries as the US, Japan, and Europe have enforced the industrial competitiveness by company investment and Taiwan supported the SoC Industry by government fund. Korea is No.1 superpower in DRAM semiconductor, but very weak in SoC Industry. We should secure the competitiveness of SoC Industry by the development of core technology, planning the growth policy, and building the cooperative model to leap the SoC power nation.

• Wind and Structures
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• v.26 no.3
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• pp.147-161
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• 2018

For wind engineering applications downbursts are, presently, almost exclusively modeled, both experimentally and numerically, as transient impinging momentum jets (IJ), even though that model contains none of the physics of real events. As a result, there is no connection between the IJ-simulated downburst wind fields and the conditions of formation of the event. The cooling source (CS) model offers a significant improvement since it incorporates the negative buoyancy forcing and baroclinic vorticity generation that occurs in nature. The present work aims at using large-scale numerical simulation of downburst-producing thunderstorms to develop a simpler model that replicates some of the key physics whilst maintaining the relative simplicity of the IJ model. Using an example of such a simulated event it is found that the non-linear scaling of the velocity field, based on the peak potential temperature (and, hence, density) perturbation forcing immediately beneath the storm cloud, produces results for the radial location of the peak radial outflow wind speeds near the ground, the magnitude of that peak and the time at which the peak occurs that match well (typically within 5%) of those produced from a simple axi-symmetric constant-density dense source simulation. The evolution of the downdraft column within the simulated thunderstorm is significantly more complex than in any axi-symmetric model, with a sequence of downdraft winds that strengthen then weaken within a much longer period (>17 minutes) of consistently downwards winds over almost all heights up to at least 2,500 m.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.7 s.98
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• pp.709-719
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• 2005

The forward link of the 3 G CDMA system may become limited under the increasing of the number of users. The conventional channelization code, Walsh code, has not enough sizes for much possible non, therefore, the quasi orthogonal function(QOF), which process optimal cross-correlation with Walsh code, is considered. In this paper, we investigate quasi orthogonal function on Jacket matrices, which can lead lower correlations values and better performance in 3 G CDMA system. Moreover, to simple the detector and improve the BER performance, a novel detection for QOF CDMA system is proposed. Finally, the simple recursive generation of the bent sequences for QOF mask function is discussed.

• Korean journal of communication and information
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• v.67
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• pp.62-87
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• 2014

The purpose of this study is to understand the social and cultural implication of the activities of taking 'selfies' and the use of Social Network Service(SNS)s through the personal story of a 20s female researcher. She analyzes her own digital photography activities based on the experience of the use of Cyworld photo albums for three years and the use of pictures in iPhone album for fifteen months. The other researcher(40s male) cooperates to answer the questions about how to understand the digital photography activities. We understand the digital photography activities including digital cameras, social network services and smart phones as acts of personal identity configuration and acts of making the personal documentary. As a result, digital photos are used more for archive purpose rather than for document purpose. Also, we found that the digital photography activities can be understood as the interactions between human and non-human actors in the perspective of Actor-Network Theory (ANT).

• The korean journal of orthodontics
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• v.50 no.6
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• pp.383-390
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• 2020

Objective: To investigate the distribution, side involvement, phenotype, and associated anomalies of Korean patients with craniofacial clefts (CFC). Methods: The samples consisted of 38 CFC patients, who were treated at Seoul National University Dental Hospital during 1998-2018. The Tessier cleft type, sex, side involvement, phenotype, and associated anomalies were investigated using non-parametric statistical analysis. Results: The three most common types were #7 cleft, followed by #0 cleft and #14 cleft. There was no difference between the frequency of male and female. Patients with #0 cleft exhibited nasal deformity, bony defect, and missing teeth in the premaxilla, midline cleft lip, and eye problems. A patient with #3 cleft (unilateral type) exhibited bilateral cleft lip and alveolus. All patients with #4 cleft were the bilateral type, including a combination of #3 and #4 clefts, and had multiple missing teeth. A patient with #5 cleft (unilateral type) had a posterior openbite. In patients with #7 cleft, the unilateral type was more prevalent than the bilateral type (87.0% vs. 13.0%, p < 0.001). Sixteen patients showed hemifacial microsomia (HFM), Goldenhar syndrome, and unilateral cleft lip and palate (UCLP). There was a significant match in the side involvement of #7 cleft and HFM (87.5%, p < 0.01). Patients with #14 cleft had plagiocephaly, UCLP, or hyperterorbitism. A patient with #30 cleft exhibited tongue tie and missing tooth. Conclusions: Due to the diverse associated craniofacial anomalies in patients with CFC, a multidisciplinary approach involving a well-experienced cooperative team is mandatory for these patients.