• Proceeding of EDISON Challenge
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• 2014.03a
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• pp.141-155
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• 2014

Peptide bond hydrolysis는 세포 내외의 생화학반응에 있어서 핵심이다. 하지만 amide Hydrolysis Mechanism은 아직 명확하게 규명되지 않았다. pH가 중성인 물에서의 비 촉매 가수분해가 발생하는 몇몇 실험적 증거가 있지만, 해당 반응 매커니즘은 4 가지(non-assisted concerted, non-assisted step-wise, assisted concerted, assisted step-wise)로 여전히 논란이 있다. 이번 연구에서는, Formamide의 가능한 Hydrolysis Mechanism을 자세히 연구해보고자 한다. 먼저, Ab-initio 계산을 통해 4가지 반응 메커니즘의 다시 한번 확인하고, quantum chemical calculations과 quantum mechanical molecular dynamic이 결합된 (QMMD) simulation을 통하여 water solvent에서의 반응 메커니즘의 에너지관계를 규명하였다. 결론적으로 아직 계산이 끝나지 않은 supported concerted mechanism을 제외한 모든 계산에서 non-supported, supported 두 system 모두에서 step-wise가 일어나기 쉬웠고, non-supported 보다 supported mechanism이 선호됨을 보였다. Intermediate인 amino-gem-diol의 수용액 상에서 안정화 또한 나타났다. 이는 Ab-initio 계산만 통해서는 정확하게 산출할 수 없는 엔트로피의 영향을 잘 보여준다.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.1
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• pp.96-102
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• 2004

For sensitivity enhancement, the general assisted-GPS acquisition method adopts not only the coherent accumulation technique but also the non-coherent accumulation technique since the long coherent accumulation period increases the number of frequency search cells. But the non-coherent accumulation technique causes tile squaring loss, which is a dominant factor among the acquisition losses of assisted GPS dealing with weak GPS signals. This paper derives the squaring loss of the previous assisted-GPS acquisition method and proposes an assisted-GPS acquisition method for solving the problem of squaring loss in weak signal environment. In this paper, it is explained that the proposed assisted-GPS acquisition method prevents the squaring loss using a coupled coherent accumulation technique and the number of search cells of the proposed assisted-GPS acquisition method is much smaller than that of the previous assisted-GPS acquisition method. Finally, through the simulation by the GPS simulator, the acquisition success rate of the proposed assisted-GPS acquisition method is compared with that of the previous assisted-GPS acquisition method and the acquisition improvements are shown in weak signal environment.

• Korean Journal of Adult Nursing
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• v.24 no.2
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• pp.99-108
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• 2012

Purpose: The study was done to identify factors influencing the quality of life of elderly in non-paid or paid assisted living facilities. Methods: Data were collected by questionnaires from 634 elderly in Seoul and Gyeonggi province. Measures were self-esteem, activities of daily living, depression, family support, health status, facility adaptation, care facility's quality, and quality of life. Data were analyzed using $x^2$-test, independent t-test, ANCOVA, Pearson correlation coefficients, and stepwise multiple regression with SPSS/WIN 15.0 version. Results: The significant factors influencing quality of life of elderly in non-paid assisted living facilities were care facility's quality, depression, self-esteem, family support, education, and activity of daily living, which explained about 40.4% of the variance. The significant factors influencing quality of life of elderly in paid assisted living facilities were activity of daily living, depression, family support, education, care facility's quality, and facility adaptation, which explained about 83.9% of the variance. Conclusion: The results suggest that type of assisted living facilities in developing nursing interventions to improve quality of life of elderly should be considered.

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.33.6-33
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• 2002

For RF sensitivity enhancement, the previous assisted GPS acquisition architecture adopts not only the coherent integration technique but also the non-coherent integration technique since the long coherent integration time increases the number of the frequency search cells. But the non-coherent integration technique induces the squaring loss, which is the dominant factor among the acquisition losses of assisted GPS dealing with weak GPS signals. This paper proposes an efficient architecture for weak signal acquisition in assisted GPS. In this paper, it is explained that the proposed architecture reduces the squaring loss using a modified non-coherent integration technique. Furthermore, it is..

• Journal of Chest Surgery
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• v.54 no.4
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• pp.266-278
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• 2021

Lobectomy is the standard treatment for early non-small cell lung cancer. Various surgical techniques for lobectomy have been developed, and minimally invasive thoracic surgery, such as video-assisted thoracic surgery or robot-assisted thoracic surgery, has been considered as an alternative to conventional open thoracotomy. The recently robotic lobectomy technique has developed since the first case series was published in 2002. Several studies have reported that robotic lobectomy has comparable oncologic and perioperative outcomes to those of video-assisted thoracic surgery lobectomy and open lobectomy. However, robotic lobectomy remains a challenge for surgeons because of the steep learning curve, reduced tactile sensation, difficulty in port placement, and challenges in cooperation between the surgeon and assistant. Many studies have reported on robotic lobectomy, but few have presented surgical techniques for robotic lobectomy. In this article, the surgical techniques and optimal performance of robotic lobectomy are described in detail for all 5 types of lobectomy for surgeons beginning with robotic lobectomy.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.28 no.1
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• pp.71-80
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• 2022

Background: This study investigated the effect of robot-assisted arm training on muscle activity of arm and weight bearing in stroke patients. Methods: The study subjects were selected 20 stroke patients who met the selection criteria. 10 people in the robot-assisted arm training group and 10 people in the task-oriented arm training group were randomly assigned. The experimental group performed robot-assisted arm training, and the control group performed task-oriented arm training for 6 weeks, 5 days a week, 30 minutes a day. The measurement tools included surface electromyography and smart insole system. Data were analyzed using independent sample t-test and the paired sample t-test. Results: Comparing the muscle activity of arm within the group, the experimental group and the control group showed significant differences in muscle activity in the biceps brachii, triceps brachii, anterior deltoid, upper trapezius, middle trapezius, and lower trapezius. Comparing the muscle activity of arms between the groups, the experimental group showed significant difference in all muscle activity of arm compared to the control group. Comparing the weight bearing within the groups, the experimental group showed significant difference in the affected side and non-affected side weight bearings and there were significant differences in anterior and posterior weight bearing. The control group showed significant difference only in the non-affected side weight bearing. Comparing the weight bearings between groups, the experimental group showed significant difference in the affected side and non-affected side weight bearings compared to the control group. Conclusion: This study confirmed that robot-assisted arm training applied to stroke patients for 6 weeks significantly improved muscle activity of arm and weight bearing. Based on these results, it is considered that robot-assisted arm training can be a useful treatment in clinical practice to improve the kinematic variables in chronic stroke patients.

• Nuclear Engineering and Technology
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• v.54 no.10
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• pp.3778-3787
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• 2022

The stress-assisted oxidation behaviour of Inconel 52 M/316 austenitic stainless-steel (SS) dissimilar weld joints (DMWJ) in a simulated pressurised water reactor environment was investigated. A corrosion galvanic couple formed between the Inconel 52 M and 316 SS due to differences in their nonferrous metal content. The electric field from the corrosion couple attracted metal cations (e.g. Fe²⁺, Cr³⁺) to the Inconel 52 M that were deposited as FeCr₂O₄. An additional corrosion galvanic couple was generated due to variations in the plastic deformation of the DMWJ. The superposition of electric fields from the different couples resulted in ridge-like oxide depositions in the fusion zone.

• Journal of Chest Surgery
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• v.55 no.5
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• pp.417-421
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• 2022

Minimally invasive strategies are increasingly popular in patients with myasthenia gravis (MG)-associated thymomas. Within the context of video-assisted thoracoscopic surgery (VATS) as a widely known minimally invasive option, the most recent achievement is uniportal subxiphoid VATS. In MG patients, it is mandatory (1) to minimize perioperative interference with administered anesthetics to avoid complications and (2) to achieve a complete surgical resection, as the prognosis essentially depends on radical tumor resection. In order to fulfill these criteria, we merged this surgical technique with its anesthesiologic counterpart: regional anesthesia with the maintenance of spontaneous ventilation via a laryngeal mask. Non-intubated uniportal subxiphoid VATS for extended thymectomy allowed radical thymectomy in all MG patients with both rapid symptom control and fast recovery.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.30 no.4
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• pp.184-190
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• 2022

In an attempt to apply hybrid rocket to the RATO (Rocket-Assisted Take Off) system, combustion characteristics of the non-circular grain were figured out in this study. Having larger combustion area, it was reconfirmed that the non-circular grain has advantages over regression rate, characteristic velocity and chamber pressure in which all gave higher values. Experiments were performed to understand the effect of the non-circular grain geometry over time where local regression rates depending on grain location were analyzed. It was found that the regression rate of five distinct locations were different. Partial conclusion driven was that these differences are due to the heat transfer caused by dissimilar distances from the flame layer. Besides, as combustion duration increased, the fuel port became circular, and the regression rate converged to a single value over the whole grain.

• Journal of Gastric Cancer
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• v.16 no.2
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• pp.93-97
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• 2016

Several prospective studies on laparoscopy-assisted distal gastrectomy for early gastric cancer have been initiated, but no prospective study evaluating laparoscopy-assisted total gastrectomy or laparoscopy-assisted proximal gastrectomy has been completed to date. A non-randomized confirmatory trial was commenced in April 2015 to evaluate the safety of laparoscopy-assisted total gastrectomy and laparoscopy-assisted proximal gastrectomy for clinical stage I gastric cancer. A total of 245 patients will be accrued from 42 Japanese institutions over 3 years. The primary endpoint is the proportion of patients with anastomotic leakage. The secondary endpoints are overall survival, relapse-free survival, proportion of patients with completed laparoscopy-assisted total gastrectomy or laparoscopy-assisted proximal gastrectomy, proportion of patients with conversion to open surgery, adverse events, and short-term clinical outcomes. The UMIN Clinical Trials Registry number is UMIN000017155.